In vitro generation of glucose-responsive insulin producing cells using lentiviral based pdx-1 gene transduction of mouse (C57BL/6) mesenchymal stem cells

Biochemical and Biophysical Research Communications

Volumn 437, Issue 3, 2013, Pages 413-419

  Rahmati, Saman ^a   Alijani, Najva ^a   Kadivar, Mehdi ^a  

^a PASTEUR INSTITUTE OF IRAN   (Iran)

Author keywords

Insulin producing cells; Lentiviral vectors; Mesenchymal stem cells; Pdx 1 Gene

Indexed keywords

DITHIZONE; GLUCOSE; INSULIN; LENTIVIRUS VECTOR; TRANSCRIPTION FACTOR PDX 1;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INSULIN RELEASE; LENTIVIRINAE; MESENCHYMAL STEM CELL; MORPHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

INSULIN-PRODUCING CELLS; LENTIVIRAL VECTORS; MESENCHYMAL STEM CELLS; PDX-1 GENE;

AMINO ACID SEQUENCE; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; GENETIC VECTORS; GLUCOSE; HEK293 CELLS; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; LENTIVIRUS; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; TRANS-ACTIVATORS; TRANSDUCTION, GENETIC;

LENTIVIRUS;

EID: 84880944174     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.06.092     Document Type: Article

References (31)

1. La Torre D. Immunobiology of beta-cell destruction. Adv. Exp. Med. Biol. 2012, 771:194-218.
2. Hussain M.A., Theise N.D. Stem-cell therapy for diabetes mellitus. Lancet 2004, 364:203-205.
3. Anzalone R., Lo Iacono M., Loria T., et al. Wharton's jelly mesenchymal stem cells as candidates for beta cells regeneration: extending the differentiative and immunomodulatory benefits of adult mesenchymal stem cells for the treatment of type 1 diabetes. Stem Cell Rev. 2011, 7:342-363.
4. Cerf M.E. Transcription factors regulating β-cell function. Eur. J. Endocrinol. 2006, 155:671-679.
5. Kaneto H., Matsuoka T.A., Miyatsuka T., et al. PDX-1 functions as a master factor in the pancreas. Front. Biosci. 2008, 13:6406-6420.
6. Oliver-Krasinski J.M., Kasner M.T., Yang J., et al. The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice. J. Clin. Invest. 2009, 119:1888-1898.
7. Picanco-Castro V., de Sousa Russo-Carbolante E.M., Tadeu Covas D. Advances in lentiviral vectors: a patent review. Recent Pat DNA Gene Seq. 2012, 6:82-90.
8. Barde I., Zanta-Boussif M.A., Paisant S., et al. Efficient control of gene expression in the hematopoietic system using a single Tet-on inducible lentiviral vector. Mol. Ther. 2006, 13:382-390.
9. Chang L.J., Zaiss A.K. Lentiviral vectors. Preparation and use. Methods Mol. Med. 2002, 69:303-318.
10. Miller K., Kim A., Kilimnik G., et al. Islet formation during the neonatal development in mice. PLoS One 2009, 4. e7739 doi: 10.1371/journal.pone.0007739.
11. Minami K., Seino S. Pancreatic acinar-to-beta cell transdifferentiation in vitro. Front. Biosci. 2008, 13:5824-5837.
12. Sun Y., Chen L., Hou X.G., et al. Differentiation of bone marrow-derived mesenchymal stem cells from diabetic patients into insulin-producing cells in vitro. Chin. Med. J. 2007, 120:771-776.
13. Deans R.J., Moseley A.B. Mesenchymal stem cells: biology and potential clinical uses. Exp. Hematol. 2000, 28:875-884.
14. Meivar-Levy I., Ferber S. Adult cell fate reprogramming: converting liver to pancreas. Methods Mol. Biol. 2010, 636:251-283.
15. Tang D.Q., Cao L.Z., Burkhardt B.R., et al. In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow. Diabetes 2004, 53:1721-1732.
16. Wang Q., Ye L., Liu H., et al. Reprogramming of bone marrow-derived mesenchymal stem cells into functional insulin-producing cells by chemical regimen. Am. J. Stem Cells 2012, 1:128-137.
17. Song L., Chau L., Sakamoto Y., et al. Electric field-induced molecular vibration for noninvasive, high-efficiency DNA transfection. Mol. Ther. 2004, 9:607-616.
18. Zhang X.Y., La Russa V.F., Bao L., et al. Lentiviral vectors forsustained transgene expression in human bone marrow derived stromal cells. Mol. Ther. 2002, 5:555-565.
19. McGinley L., McMahon J., Strappe P., et al. Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia. Stem Cell Res. Ther. 2011, 2:12. 10.1186/scrt53.
20. Tang D.Q., Lu S., Sun Y., et al. Reprogramming liver-stem WB cells into functional insulin-producing cells by persistent expression of Pdx1- and Pdx1-VP16 mediated by lentiviral vectors. Lab. Invest. 2006, 86:83-93.
21. Kim M.J., Kim S., Park Z., et al. Generation of insulin-producing cells from PDX1 gene-modified human mesenchymal stem cells based on lentiviral vector system. J. Tissue Eng. Regen. Med. 2008, 5:76-83.
22. Chiou S.H., Chen S.J., Chang Y.L., et al. MafA promotes the reprogramming of placenta-derived multipotent stem cells into pancreatic islets-like and insulin cells. J. Cell Mol. Med. 2011, 15:612-624.
23. Guo Q.S., Zhu M.Y., Wang L., et al. Combined transfection of the three transcriptional factors, PDX-1, NeuroD1, and MafA, causes differentiation of bone marrow mesenchymal stem cells into insulin-producing cells. Exp. Diabetes Res. 2012, 2012:672013. 10.1155/2012/672013. Epub 2012 Jun 19.
24. He D., Wang J., Gao Y., et al. Differentiation of PDX1 gene-modified human umbilical cord mesenchymal stem cells into insulin-producing cells in vitro. Int. J. Mol. Med. 2011, 28:1019-1024.
25. Loebinger M.R., Eddaoudi A., Davies D., et al. Mesenchymal stem cell delivery of TRAIL can eliminate metastatic cancer. Cancer Res. 2009, 69:4134-4142.
26. Bonner-Weir S., Taneja M., Weir G.C., et al. In vitro cultivation of human islets from expanded ductal tissue. Proc. Natl. Acad. Sci. USA. 2000, 97:7999-8004.
27. Shiroi A., Yoshikawa M., Yokota H., et al. Identification of insulin-producing cells derived from embryonic stem cells by zinc-chelating dithizone. Stem cells 2002, 20:284-292.
28. Latif Z.A., Noel J., Alejandro R. A simple method of staining fresh and cultured islets. Transplantation 1988, 45:827-830.
29. Chausmer A.B. Zinc, insulin and diabetes. J. Am. Coll. Nutr. 1998, 17:109-115.
30. Rajagopal J., Anderson W.J., Kume S., et al. Insulin staining of ES cell progeny from insulin uptake. Science 2003, 299:363.
31. Vaca P., Martín F., Vegara-Meseguer J.M., et al. Induction of differentiation of embryonic stem cells into insulin-secreting cells by fetal soluble factors. Stem cells 2006, 24:258-265.