Genetic stability of RSV-F expression and the restricted growth phenotype of a live attenuated PIV3 vectored RSV vaccine candidate (MEDI-534) following restrictive growth in human lung cells

Vaccine

Volumn 31, Issue 36, 2013, Pages 3756-3762

  Nelson, Christine L ^a   Tang, Roderick S ^a   Stillman, Elizabeth A ^a  

^a MEDIMMUNE   (United States)

Author keywords

Attenuation; Genetic stability; Hamster; MRC 5; Parainfluenza virus type 3 (PIV3); Respiratory syncytial virus (RSV)

Indexed keywords

RESPIRATORY SYNCYTIAL VIRUS VACCINE;

ARTICLE; CELL GROWTH; CYTOPATHOGENIC EFFECT; DOWN REGULATION; GENETIC STABILITY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOGENICITY; PHASE 1 CLINICAL TRIAL (TOPIC); PHENOTYPE; POINT MUTATION; POLYADENYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; VACCINE PRODUCTION;

ATTENUATION; GENETIC STABILITY; HAMSTER; MRC-5; PARAINFLUENZA VIRUS TYPE 3 (PIV3); RESPIRATORY SYNCYTIAL VIRUS (RSV);

ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; CLINICAL TRIALS, PHASE I AS TOPIC; CRICETINAE; GENE EXPRESSION REGULATION, VIRAL; HUMANS; MESOCRICETUS; MUTATION; PARAINFLUENZA VIRUS 3, BOVINE; PARAINFLUENZA VIRUS 3, HUMAN; RESPIRATORY SYNCYTIAL VIRUSES; RNA, VIRAL; SEQUENCE ANALYSIS, RNA; VACCINES, ATTENUATED; VERO CELLS; VIRAL FUSION PROTEINS; VIRAL VACCINES; VIRUS CULTIVATION; VIRUS REPLICATION;

EID: 84880941198     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2013.04.015     Document Type: Article

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