Vitamin D2 vs. vitamin D3: Are they one and the same?

Nutrition Bulletin

Volumn 38, Issue 2, 2013, Pages 243-248

  Tripkovic, L ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Calcitriol; Meta analysis; Systematic review; Vitamin D status; Vitamin D2; Vitamin D3

Indexed keywords

EID: 84880937507     PISSN: 14719827     EISSN: 14673010     Source Type: Journal    
DOI: 10.1111/nbu.12029     Document Type: Article

References (21)

1. Armas LAG, Hollis BW. & Heaney RP (2004) Vitamin D(2) is much less effective than vitamin D(3) in humans. The Journal of Clinical Endocrinology. & Metabolism 89: 5387-91.
2. Biancuzzo RM, Young A, Bibuld D et al. (2010) Fortification of orange juice with vitamin D(2) or vitamin D(3) is as effective as an oral supplement in maintaining vitamin D status in adults. The American Journal of Clinical Nutrition 91: 1621-6.
3. Binkley N, Gemar D, Engelke J et al. (2011) Evaluation of Ergocalciferol or Cholecalciferol Dosing, 1600 IU Daily or 50 000 IU Monthly in Older Adults. The Journal of Clinical Endocrinology, & Metabolism 96: 981-8.
4. Calman K, ed. (1998) Nutrition and Bone Health with Particular Reference to Calcium and Vitamin D: Report of the Subgroup on Bone Health (Working Group on the Nutritional Status of the Population) of the Committee on Medical Aspects of Food and Nutrition Policy. The Stationary Office: London.
5. Finch S, Doyle W, Lowe C et al. (1998) National Diet, & Nutrition Survey: People Aged 65 Years and Over. Volume 1: Report of the Diet and Nutrition Survey. The Stationary Office: London.
6. Glendenning P, Chew GT, Seymour HM et al. (2009) Serum 25-hydroxyvitamin D levels in vitamin d-insufficient hip fracture patients after supplementation with ergocalciferol and cholecalciferol. Bone 45: 870-5.
7. Heaney RP, Recker RR, Grote J et al. (2011) Vitamin D(3) Is More Potent Than Vitamin D(2) in Humans. The Journal of Clinical Endocrinology, & Metabolism 96: E447-E452.
8. Holick MF (2007) Vitamin D deficiency. The New England Journal of Medicine 357: 266-81.
9. Holick MF, Biancuzzo RM, Chen TC et al. (2008) Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. The Journal of Clinical Endocrinology and Metabolism 93: 677-81.
10. Hollis BW (1984) Comparison of equilibrium and disequilibrium assay conditions for ergocalciferol, cholecalciferol and their major metabolites. The Journal of Steroid Biochemistry and Molecular Biology 21: 81-6.
11. Holmberg I, Berlin T, Ewerth S et al. (1986) 25-Hydroxylase activity in subcellular-fractions from human-liver -evidence for different rates of mitochondrial hydroxylation of vitamin-D2 and vitamin-D3. Scandinavian Journal of Clinical and Laboratory Investigation 46: 785-90.
12. Horst RL, Reinhardt TA, Ramberg CF et al. (1986) 24-hydroxylation of 1,25-dihydroxyergocalciferol -an unambiguous deactivation process. The Journal of Biological Chemistry 261: 9250-6.
13. Houghton LA, & Vieth R (2006) The case against ergocalciferol (vitamin D-2) as a vitamin supplement. The American Journal of Clinical Nutrition 84: 694-7.
14. Hypponen E, & Power C (2007) Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors. The American Journal of Clinical Nutrition 85: 860-8.
15. Leventis P, & Kiely PDW (2009) The tolerability and biochemical effects of high-dose bolus vitamin D2 and D3 supplementation in patients with vitamin D insufficiency. Scandinavian Journal of Rheumatology 38: 149-53.
16. Naewbanij M, Seib PA, Burroughs R et al. (1984) Determination of ergosterol using thin-layer chromatography and ultraviolet spectroscopy. Cereal Chemistry 61: 385-8.
17. Romagnoli E, Mascia ML, Cipriani C et al. (2008) Short and longterm variations in serum calciotropic hormones after a single very large dose of ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3) in the elderly. The Journal of Clinical Endocrinology and Metabolism 93: 3015-20.
18. Ross CA, Taylor CL, & Yaktime AL et al., eds (2010) Dietary Reference Intakes for Calcium and Vitamin D. Committee to Review Dietary Reference Intakes for Vitamin D and Calcium; Institute of Medicine. National Academies Press: Washington, DC.
19. Tjellesen L, Hummer L, Christiansen C et al. (1986) Serum concentration of vitamin-D metabolites during treatment with vitamin-D2 and vitamin-D3 in normal premenopausal women. Bone and Mineral 1: 407-13.
20. Trang HM, Cole DE, Rubin LA et al. (1998) Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2. The American Journal of Clinical Nutrition 68: 854-8.
21. Tripkovic L, Lambert H, Hart K et al. (2012) Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and metaanalysis. The American Journal of Clinical Nutrition 95: 1357-64.