Multicenter phase II study of modified FOLFOX6 as neoadjuvant chemotherapy for patients with unresectable liver-only metastases from colorectal cancer in Japan: ROOF study

International Journal of Clinical Oncology

Volumn 18, Issue 2, 2013, Pages 335-342

  Takahashi, Takao ^a   Shibata, Yoshihisa ^b   Tojima, Yuichiro ^c   Tsuboi, Kenji ^d   Sakamoto, Eiji ^e   Kunieda, Katsuyuki ^f   Matsuoka, Hiroshi ^g   Suzumura, Kazuyoshi ^h   Sato, Mikinori ⁱ   Naganuma, Tatsushi ^j   Sakamoto, Junichi ^k   Morita, Satoshi ^l   Kondo, Ken ^m  

^a GIFU UNIVERSITY   (Japan)

^b TOYOHASHI MUNICIPAL HOSPITAL   (Japan)

^c CHUKYO HOSPITAL   (Japan)

^d TOSEI GENERAL HOSPITAL   (Japan)

^e NAGOYA DAINI RED CROSS HOSPITAL   (Japan)

^f GIFU PREFECTURAL GIFU HOSPITAL   (Japan)

^g FUJITA HEALTH UNIVERSITY   (Japan)

^h AICHI MEDICAL UNIVERSITY   (Japan)

ⁱ NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^j SAISEIKAI MATSUSAKA GENERAL HOSPITAL   (Japan)

^k NAGOYA UNIVERSITY   (Japan)

^l YOKOHAMA CITY UNIVERSITY   (Japan)

^m NATIONAL HOSPITAL ORGANIZATION NAGOYA MEDICAL CENTER   (Japan)

more..

Author keywords

Colorectal cancer; Liver resection; mFOLFOX6; ROOF study; Unresectable liver only metastases

Indexed keywords

FLUOROURACIL; FOLINIC ACID; OXALIPLATIN;

ADULT; AGED; ANEMIA; ANOREXIA; ARTICLE; BLOOD TOXICITY; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER CONTROL; CANCER GROWTH; CANCER SURGERY; CHEMOTHERAPY INDUCED EMESIS; CLINICAL ARTICLE; COLORECTAL CANCER; CONTINUOUS INFUSION; DIARRHEA; DISEASE COURSE; DRUG EFFICACY; DRUG FATALITY; DRUG FEVER; DRUG RESPONSE; DYSGEUSIA; FATIGUE; FEMALE; HEPATIC SEGMENTECTOMY; HUMAN; INOPERABLE CANCER; JAPAN; LEUKOPENIA; LIVER LOBECTOMY; LIVER METASTASIS; LIVER RESECTION; MALE; MULTICENTER STUDY; MULTIPLE CYCLE TREATMENT; NAUSEA; NEUTROPENIA; PARTIAL HEPATECTOMY; PATIENT COMPLIANCE; PERIPHERAL NEUROPATHY; PHASE 2 CLINICAL TRIAL; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; RADIOFREQUENCY ABLATION; STOMATITIS; THROMBOCYTOPENIA; TUMOR VOLUME;

AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COLORECTAL NEOPLASMS; COMBINED MODALITY THERAPY; DRUG TOXICITY; FEMALE; FLUOROURACIL; HUMANS; JAPAN; LEUCOVORIN; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; ORGANOPLATINUM COMPOUNDS; SURVIVAL RATE;

EID: 84880919956     PISSN: 13419625     EISSN: 14377772     Source Type: Journal    
DOI: 10.1007/s10147-012-0382-z     Document Type: Article

References (23)

1. Finan PJ, Marshall RJ, Cooper EH et al (1985) Factors affecting survival in patients presenting with synchronous hepatic metastases from colorectal cancer: a clinical and computer analysis. Br J Surg 72:373-377
2. Goslin R, Steele G, Zamcheck N et al (1982) Factors influencing survival in patients with hepatic metastases from adenocarcinoma of the colon or rectum. Dis Colon Rectum 25:749-754
3. Bengtsson G, Carlsson G, Hafström L et al (1981) Natural history of patients with untreated liver metastases from colorectal cancer. Am J Surg 141:586-589
4. Fong Y, Fortner J, Sun RL et al (1999) Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg 230:309-318
5. Adam R, Delvart V, Pascal G et al (2004) Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy: a model to predict long-term survival. Ann Surg 240:644-657
6. Adam R, Wicherts DA, de Haas RJ et al (2009) Patients with initially unresectable colorectal liver metastases: is there a possibility of cure? J Clin Oncol 27:1829-1835
7. Simmonds PC, Primrose JN, Colquitt JL et al (2006) Surgical resection of hepatic metastases from colorectal cancer: a systematic review of published studies. Br J Cancer 94:982-999
8. Fong Y (1999) Surgical therapy of hepatic colorectal metastasis. CA Cancer J Clin 49:231-255
9. Bismuth H, Adam R, Lëvi F et al (1996) Resection of nonresectable liver metastases from colorectal cancer after neoadjuvant chemotherapy. Ann Surg 224:509-520
10. Alberts SR, Horvath WL, Sternfeld WC et al (2005) Oxaliplatin, fluorouracil, and leucovorin for patients with unresectable liver-only metastases from colorectal cancer: a North Central Cancer Treatment Group Phase II Study. J Clin Oncol 23:9243-9249
11. General Rules for Clinical and Pathological Studies on Cancer of the Colon, Rectum and Anus: 7th Edition, 2009: Japanese Society for Cancer of the Colon and Rectum
12. Adam R, Avisar E, Ariche A et al (2001) Five-year survival following hepatic resection after neoadjuvant therapy for nonresectable colorectal. Ann Surg Oncol 8:347-353
13. Delaunoit T, Alberts SR, Sargent DJ et al (2005) Chemotherapy permits resection of metastatic colorectal cancer: experience from Intergroup N9741. Ann Oncol 16:425-429
14. Tournigand C, André T, Achille E et al (2004) FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol 15:229-237
15. Falcon A, Ricci S, Brunetti I et al (2007) Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest. J Clin Oncol 25:1670-1676
16. de Gramont A, Figer A, Seymour M et al (2000) Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 18:2938-2947
17. Okines A, del Puerto O, Cunningham D et al (2009) Surgery with curative-intent in patients treated with first-line chemotherapy plus bevacizumab for metastatic colorectal cancer First BEAT and the randomised phase-III NO 16966 trial. Br J Cancer 101:1033-1038
18. Van Cutsem E, Köhne CH, Hitre E et al (2009) Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 360:1408-1417
19. Bokemeyer C, Bondarenko I, Makhson A et al (2009) Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol 27:663-671
20. Folprecht G, Gruenberger T, Bechstein WO et al (2010) Tumour response and secondary respectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomized phase 2 trial. Lancet Oncol 11:38-47
21. Folprecht G, Grothey A, Albert S et al (2005) Neoadjuvant treatment of unresectable colorectal liver metastases: correlation between tumor response and resection rates. Ann Oncol 16:1311-1319
22. Vauthey JN, Pawlik TM, Ribero D et al (2006) Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases. J Clin Oncol 24:2065-2072
23. Ribero D, Wang H, Donadon M et al (2007) Bevacizumab improves pathologic response and protects against hepatic injury in patients treated with oxaliplatin-based chemotherapy for colorectal liver metastasis. Cancer 110:2761-2767