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Volumn 32, Issue 30, 2013, Pages 3491-3499

Rac1 is required for Prkar1a-mediated Nf2 suppression in Schwann cell tumors

Author keywords

Merlin; PKA; PRKAR1A; Rac1; Schwann cell tumor

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; MERLIN; PRKAR1A PROTEIN; RAC1 PROTEIN; UNCLASSIFIED DRUG;

EID: 84880917461     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.374     Document Type: Article
Times cited : (19)

References (50)
  • 3
    • 0034642302 scopus 로고    scopus 로고
    • Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the Carney complex
    • Kirschner LS, Sandrini F, Monbo J, Lin JP, Carney JA, Stratakis CA. Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the carney complex. Hum Mol Genet 2000; 9: 3037-3046. (Pubitemid 32000777)
    • (2000) Human Molecular Genetics , vol.9 , Issue.20 , pp. 3037-3046
    • Kirschner, L.S.1    Sandrini, F.2    Monbo, J.3    Lin, J.-P.4    Carney, J.A.5    Stratakis, C.A.6
  • 4
    • 0033812849 scopus 로고    scopus 로고
    • Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex
    • Kirschner LS, Carney JA, Pack SD, Taymans SE, Giatzakis C, Cho YS et al. Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex. Nat Genet 2000; 26: 89-92.
    • (2000) Nat Genet , vol.26 , pp. 89-92
    • Kirschner, L.S.1    Carney, J.A.2    Pack, S.D.3    Taymans, S.E.4    Giatzakis, C.5    Cho, Y.S.6
  • 5
    • 0030791708 scopus 로고    scopus 로고
    • CAMP-dependent protein kinase a is required for Schwann cell growth: Interactions between the cAMP and neuregulin/tyrosine kinase pathways
    • DOI 10.1002/(SICI)1097-4547(19970715)49:2<236::AID-JNR12>3.0.CO;2-Z
    • Kim HA, DeClue JE, Ratner N. cAMP-dependent protein kinase A is required for Schwann cell growth: interactions between the cAMP and neuregulin/tyrosine kinase pathways. J Neurosci Res 1997; 49: 236-247. (Pubitemid 27332722)
    • (1997) Journal of Neuroscience Research , vol.49 , Issue.2 , pp. 236-247
    • Kim, H.A.1    DeClue, J.E.2    Ratner, N.3
  • 6
    • 0034658336 scopus 로고    scopus 로고
    • Retroviral inhibition of cAMP-dependent protein kinase inhibits myelination but not schwann cell mitosis stimulated by interaction with neurons
    • Howe DG, McCarthy KD. Retroviral inhibition of cAMP-dependent protein kinase inhibits myelination but not Schwann cell mitosis stimulated by interaction with neurons. J Neurosci 2000; 20: 3513-3521. (Pubitemid 30266212)
    • (2000) Journal of Neuroscience , vol.20 , Issue.10 , pp. 3513-3521
    • Howe, D.G.1    McCarthy, K.D.2
  • 7
    • 0029897881 scopus 로고    scopus 로고
    • Phosphorylation of neurofibromatosis type 1 gene product (neurofibromin) by cAMP-dependent protein kinase
    • DOI 10.1016/0014-5793(96)00137-8
    • Izawa I, Tamaki N, Saya H. Phosphorylation of neurofibromatosis type 1 gene product (neurofibromin) by cAMP-dependent protein kinase. FEBS Lett 1996; 382: 53-59. (Pubitemid 26092233)
    • (1996) FEBS Letters , vol.382 , Issue.1-2 , pp. 53-59
    • Izawa, I.1    Tamaki, N.2    Saya, H.3
  • 8
    • 2442629479 scopus 로고    scopus 로고
    • Cyclic AMP-dependent Protein Kinase Phosphorylates Merlin at Serine 518 Independently of p21-activated Kinase and Promotes Merlin-Ezrin Heterodimerization
    • DOI 10.1074/jbc.M313916200
    • Alfthan K, Heiska L, Gronholm M, Renkema GH, Carpen O. Cyclic AMP-dependent protein kinase phosphorylates merlin at serine 518 independently of p21-activated kinase and promotes merlin-ezrin heterodimerization. J Biol Chem 2004; 279: 18559-18566. (Pubitemid 38623276)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.18 , pp. 18559-18566
    • Alfthan, K.1    Heiska, L.2    Gronholm, M.3    Renkema, G.H.4    Carpen, O.5
  • 9
    • 44349185725 scopus 로고    scopus 로고
    • Protein kinase A-mediated phosphorylation of the NF2 tumor suppressor protein merlin at serine 10 affects the actin cytoskeleton
    • DOI 10.1038/sj.onc.1210988, PII 1210988
    • Laulajainen M, Muranen T, Carpen O, Gronholm M. Protein kinase A-mediated phosphorylation of the NF2 tumor suppressor protein merlin at serine 10 affects the actin cytoskeleton. Oncogene 2008; 27: 3233-3243. (Pubitemid 351733388)
    • (2008) Oncogene , vol.27 , Issue.23 , pp. 3233-3243
    • Laulajainen, M.1    Muranen, T.2    Carpen, O.3    Gronholm, M.4
  • 10
    • 0037155916 scopus 로고    scopus 로고
    • Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization
    • DOI 10.1074/jbc.M200083200
    • Kissil JL, Johnson KC, Eckman MS, Jacks T. Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization. J Biol Chem 2002; 277: 10394-10399. (Pubitemid 34968159)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.12 , pp. 10394-10399
    • Kissil, J.L.1    Johnson, K.C.2    Eckman, M.S.3    Jacks, T.4
  • 12
    • 33846349243 scopus 로고    scopus 로고
    • Phosphorylation of the NF2 tumor suppressor in Schwann cells is mediated by Cdc42-Pak and requires paxillin binding
    • DOI 10.1016/j.mcn.2006.11.003, PII S1044743106002429
    • Thaxton C, Lopera J, Bott M, Baldwin ME, Kalidas P, Fernandez-Valle C. Phosphorylation of the NF2 tumor suppressor in Schwann cells is mediated by Cdc42-Pak and requires paxillin binding. Mol Cell Neurosci 2007; 34: 231-242. (Pubitemid 46136999)
    • (2007) Molecular and Cellular Neuroscience , vol.34 , Issue.2 , pp. 231-242
    • Thaxton, C.1    Lopera, J.2    Bott, M.3    Baldwin, M.E.4    Kalidas, P.5    Fernandez-Valle, C.6
  • 13
    • 0035866093 scopus 로고    scopus 로고
    • Schwann cell proliferative responses to cAMP and Nf1 are mediated by cyclin D1
    • Kim HA, Ratner N, Roberts TM, Stiles CD. Schwann cell proliferative responses to cAMP and Nf1 are mediated by cyclin D1. J Neurosci 2001; 21: 1110-1116. (Pubitemid 32128756)
    • (2001) Journal of Neuroscience , vol.21 , Issue.4 , pp. 1110-1116
    • Kim, H.A.1    Ratner, N.2    Roberts, T.M.3    Stiles, C.D.4
  • 14
    • 0345689420 scopus 로고    scopus 로고
    • Tyrosinase-cre mice for tissue-specific gene ablation in neural crest and neuroepithelial-derived tissues
    • DOI 10.1002/gene.10242
    • Tonks ID, Nurcombe V, Paterson C, Zournazi A, Prather C, Mould AW et al. Tyrosinase-Cre mice for tissue-specific gene ablation in neural crest and neuroepithelial-derived tissues. Genesis 2003; 37: 131-138. (Pubitemid 37486874)
    • (2003) Genesis , vol.37 , Issue.3 , pp. 131-138
    • Tonks, I.D.1    Nurcombe, V.2    Paterson, C.3    Zournazi, A.4    Prather, C.5    Mould, A.W.6    Kay, G.F.7
  • 15
    • 55849135795 scopus 로고    scopus 로고
    • Tissue-specific ablation of Prkar1a causes schwannomas by suppressing neurofibromatosis protein production
    • Jones GN, Tep C, Towns 2nd WH, Mihai G, Tonks ID, Kay GF et al. Tissue-specific ablation of Prkar1a causes schwannomas by suppressing neurofibromatosis protein production. Neoplasia 2008; 10: 1213-1221.
    • (2008) Neoplasia , vol.10 , pp. 1213-1221
    • Jones, G.N.1    Tep, C.2    Towns, I.I.W.H.3    Mihai, G.4    Tonks, I.D.5    Kay, G.F.6
  • 16
    • 77955001407 scopus 로고    scopus 로고
    • Neural crest-specific loss of Prkar1a causes perinatal lethality resulting from defects in intramembranous ossification
    • Jones GN, Pringle DR, Yin Z, Carlton MM, Powell KA, Weinstein MB et al. Neural crest-specific loss of Prkar1a causes perinatal lethality resulting from defects in intramembranous ossification. Mol Endocrinol 2010; 24: 1559-1568.
    • (2010) Mol Endocrinol , vol.24 , pp. 1559-1568
    • Jones, G.N.1    Pringle, D.R.2    Yin, Z.3    Carlton, M.M.4    Powell, K.A.5    Weinstein, M.B.6
  • 17
    • 34247609343 scopus 로고    scopus 로고
    • Shedding light on Merlin's wizardry
    • DOI 10.1016/j.tcb.2007.03.006, PII S0962892407000839
    • Okada T, You L, Giancotti FG. Shedding light on Merlin's wizardry. Trends Cell Biol 2007; 17: 222-229. (Pubitemid 46679247)
    • (2007) Trends in Cell Biology , vol.17 , Issue.5 , pp. 222-229
    • Okada, T.1    You, L.2    Giancotti, F.G.3
  • 18
    • 40949119860 scopus 로고    scopus 로고
    • Development of a pituitary-specific Cre line targeted to the Pit-1 lineage
    • DOI 10.1002/dvg.20362
    • Yin Z, Williams-Simons L, Rawahneh L, Asa S, Kirschner LS. Development of a pituitary-specific cre line targeted to the Pit-1 lineage. Genesis 2008; 46: 37-42. (Pubitemid 351413586)
    • (2008) Genesis , vol.46 , Issue.1 , pp. 37-42
    • Yin, Z.1    Williams-Simons, L.2    Rawahneh, L.3    Asa, S.4    Kirschner, L.S.5
  • 20
  • 21
    • 0028343217 scopus 로고
    • Mutations of the neurofibromatosis type 2 gene and lack of the gene product in vestibular schwannomas
    • Sainz J, Huynh DP, Figueroa K, Ragge NK, Baser ME, Pulst SM. Mutations of the neurofibromatosis type 2 gene and lack of the gene product in vestibular schwannomas. Hum Mol Genet 1994; 3: 885-891. (Pubitemid 24189953)
    • (1994) Human Molecular Genetics , vol.3 , Issue.6 , pp. 885-891
    • Sainz, J.1    Huynh, D.P.2    Figueroa, K.3    Ragge, N.K.4    Baser, M.E.5    Pulst, S.-M.6
  • 23
    • 27744521323 scopus 로고    scopus 로고
    • Role of group A p21-activated kinases in activation of extracellular- regulated kinase by growth factors
    • DOI 10.1074/jbc.M502306200
    • Beeser A, Jaffer ZM, Hofmann C, Chernoff J. Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors. J Biol Chem 2005; 280: 36609-36615. (Pubitemid 41587737)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.44 , pp. 36609-36615
    • Beeser, A.1    Jaffer, Z.M.2    Hofmann, C.3    Chernoff, J.4
  • 24
    • 0036148093 scopus 로고    scopus 로고
    • The neurofibromatosis type 2 gene product, merlin, reverses the F-actin cytoskeletal defects in primary human schwannoma cells
    • DOI 10.1128/MCB.22.4.1150-1157.2002
    • Bashour AM, Meng JJ, Ip W, MacCollin M, Ratner N. The neurofibromatosis type 2 gene product, merlin, reverses the F-actin cytoskeletal defects in primary human Schwannoma cells. Mol Cell Biol 2002; 22: 1150-1157. (Pubitemid 34094851)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.4 , pp. 1150-1157
    • Bashour, A.-M.1    Meng, J.-J.2    Ip, W.3    MacCollin, M.4    Ratner, N.5
  • 25
    • 0032578798 scopus 로고    scopus 로고
    • Ruffling membrane, stress fiber, cell spreading and proliferation abnormalities in human Schwannoma cells
    • Pelton PD, Sherman LS, Rizvi TA, Marchionni MA, Wood P, Friedman RA et al. Ruffling membrane, stress fiber, cell spreading and proliferation abnormalities in human Schwannoma cells. Oncogene 1998; 17: 2195-2209. (Pubitemid 28515373)
    • (1998) Oncogene , vol.17 , Issue.17 , pp. 2195-2209
    • Pelton, P.D.1    Sherman, L.S.2    Rizvi, T.A.3    Marchionni, M.A.4    Wood, P.5    Friedman, R.A.6    Ratner, N.7
  • 26
    • 0036181428 scopus 로고    scopus 로고
    • The evolutionary history of effectors downstream of Cdc42 and Rac
    • REVIEWS0002
    • Cotteret S, Chernoff J. The evolutionary history of effectors downstream of Cdc42 and Rac. Genome Biol 2002; 3: REVIEWS0002.
    • (2002) Genome Biol , vol.3
    • Cotteret, S.1    Chernoff, J.2
  • 28
    • 67349256384 scopus 로고    scopus 로고
    • PAK kinase regulates Rac GT Pase and is a potential target in human schwannomas
    • Flaiz C, Chernoff J, Ammoun S, Peterson JR, Hanemann CO. PAK kinase regulates Rac GT Pase and is a potential target in human schwannomas. Exp Neurol 2009; 218: 137-144.
    • (2009) Exp Neurol , vol.218 , pp. 137-144
    • Flaiz, C.1    Chernoff, J.2    Ammoun, S.3    Peterson, J.R.4    Hanemann, C.O.5
  • 30
    • 61549106017 scopus 로고    scopus 로고
    • The function of Rho GT Pases in axon ensheathment and myelination
    • Feltri ML, Suter U, Relvas JB. The function of Rho GT Pases in axon ensheathment and myelination. Glia 2008; 56: 1508-1517.
    • (2008) Glia , vol.56 , pp. 1508-1517
    • Feltri, M.L.1    Suter, U.2    Relvas, J.B.3
  • 31
    • 34250741953 scopus 로고    scopus 로고
    • Myelination: All about Rac 'n' roll
    • DOI 10.1083/jcb.200705105
    • Chan JR. Myelination: all about Rac 'n' roll. J Cell Biol 2007; 177: 953-955. (Pubitemid 46955700)
    • (2007) Journal of Cell Biology , vol.177 , Issue.6 , pp. 953-955
    • Chan, J.R.1
  • 32
    • 52949092409 scopus 로고    scopus 로고
    • Small Rho GT Pases are key regulators of peripheral nerve biology in health and disease
    • Krause S, Stendel C, Senderek J, Relvas JB, Suter U. Small Rho GT Pases are key regulators of peripheral nerve biology in health and disease. J Peripher Nerv Syst 2008; 13: 188-199.
    • (2008) J Peripher Nerv Syst , vol.13 , pp. 188-199
    • Krause, S.1    Stendel, C.2    Senderek, J.3    Relvas, J.B.4    Suter, U.5
  • 34
    • 0030040750 scopus 로고    scopus 로고
    • Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes
    • Lang P, Gesbert F, Delespine-Carmagnat M, Stancou R, Pouchelet M, Bertoglio J. Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes. Embo J 1996; 15: 510-519. (Pubitemid 26044564)
    • (1996) EMBO Journal , vol.15 , Issue.3 , pp. 510-519
    • Lang, P.1    Gesbert, F.2    Delespine-Carmagnat, M.3    Stancou, R.4    Pouchelet, M.5    Bertoglio, J.6
  • 35
    • 0035930585 scopus 로고    scopus 로고
    • Protein kinase A regulates Rac and is required for the growth factor-stimulated migration of carcinoma cells
    • O'Connor KL, Mercurio AM. Protein kinase A regulates Rac and is required for the growth factor-stimulated migration of carcinoma cells. J Biol Chem 2001; 276: 47895-47900.
    • (2001) J Biol Chem , vol.276 , pp. 47895-47900
    • O'Connor, K.L.1    Mercurio, A.M.2
  • 36
    • 27544514090 scopus 로고    scopus 로고
    • Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane
    • DOI 10.1083/jcb.200503165
    • Okada T, Lopez-Lago M, Giancotti FG. Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane. J Cell Biol 2005; 171: 361-371. (Pubitemid 41540027)
    • (2005) Journal of Cell Biology , vol.171 , Issue.2 , pp. 361-371
    • Okada, T.1    Lopez-Lago, M.2    Giancotti, F.G.3
  • 37
    • 0242298576 scopus 로고    scopus 로고
    • Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1
    • DOI 10.1016/S1097-2765(03)00382-4
    • Kissil JL, Wilker EW, Johnson KC, Eckman MS, Yaffe MB, Jacks T. Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1. Mol Cell 2003; 12: 841-849. (Pubitemid 37352778)
    • (2003) Molecular Cell , vol.12 , Issue.4 , pp. 841-849
    • Kissil, J.L.1    Wilker, E.W.2    Johnson, K.C.3    Eckman, M.S.4    Yaffe, M.B.5    Jacks, T.6
  • 38
    • 0038344831 scopus 로고    scopus 로고
    • Upregulation of the Rac1/JNK signaling pathway in primary human schwannoma cells
    • DOI 10.1093/hmg/ddg146
    • Kaempchen K, Mielke K, Utermark T, Langmesser S, Hanemann CO. Upregulation of the Rac1/JNK signaling pathway in primary human schwannoma cells. Hum Mol Genet 2003; 12: 1211-1221. (Pubitemid 36722601)
    • (2003) Human Molecular Genetics , vol.12 , Issue.11 , pp. 1211-1221
    • Kaempchen, K.1    Mielke, K.2    Utermark, T.3    Langmesser, S.4    Hanemann, C.O.5
  • 39
    • 42549093636 scopus 로고    scopus 로고
    • Neuregulin and laminin stimulate phosphorylation of the NF2 tumor suppressor in Schwann cells by distinct protein kinase A and p21-activated kinase-dependent pathways
    • DOI 10.1038/sj.onc.1210923, PII 1210923
    • Thaxton C, Lopera J, Bott M, Fernandez-Valle C. Neuregulin and laminin stimulate phosphorylation of the NF2 tumor suppressor in Schwann cells by distinct protein kinase A and p21-activated kinase-dependent pathways. Oncogene 2008; 27: 2705-2715. (Pubitemid 351581460)
    • (2008) Oncogene , vol.27 , Issue.19 , pp. 2705-2715
    • Thaxton, C.1    Lopera, J.2    Bott, M.3    Fernandez-Valle, C.4
  • 41
    • 14844355090 scopus 로고    scopus 로고
    • The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression
    • DOI 10.1128/MCB.25.6.2384-2394.2005
    • Xiao GH, Gallagher R, Shetler J, Skele K, Altomare DA, Pestell RG et al. The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression. Mol Cell Biol 2005; 25: 2384-2394. (Pubitemid 40354632)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.6 , pp. 2384-2394
    • Xiao, G.-H.1    Gallagher, R.2    Shetler, J.3    Skele, K.4    Altomare, D.A.5    Pestell, R.G.6    Jhanwar, S.7    Testa, J.R.8
  • 42
    • 0036154164 scopus 로고    scopus 로고
    • Transduction of wild-type merlin into human schwannoma cells decreases schwannoma cell growth and induces apoptosis
    • Schulze KM, Hanemann CO, Muller HW, Hanenberg H. Transduction of wild-type merlin into human schwannoma cells decreases schwannoma cell growth and induces apoptosis. Hum Mol Genet 2002; 11: 69-76. (Pubitemid 34100769)
    • (2002) Human Molecular Genetics , vol.11 , Issue.1 , pp. 69-76
    • Schulze, K.M.M.1    Hanemann, C.O.2    Muller, H.W.3    Hanenberg, H.4
  • 43
    • 0033941950 scopus 로고    scopus 로고
    • CD44 acts both as a growth-and invasiveness-promoting molecule and as a tumor-suppressing cofactor
    • discussion 18-20
    • Herrlich P, Morrison H, Sleeman J, Orian-Rousseau V, Konig H, Weg-Remers S et al. CD44 acts both as a growth-and invasiveness-promoting molecule and as a tumor-suppressing cofactor. Ann N Y Acad Sci 2000; 910: 106-118; discussion 18-20.
    • (2000) Ann N y Acad Sci , vol.910 , pp. 106-118
    • Herrlich, P.1    Morrison, H.2    Sleeman, J.3    Orian-Rousseau, V.4    Konig, H.5    Weg-Remers, S.6
  • 44
    • 0037199912 scopus 로고    scopus 로고
    • Mutant products of the NF2 tumor suppressor gene are degraded by the ubiquitin-proteasome pathway
    • DOI 10.1074/jbc.C200125200
    • Gautreau A, Manent J, Fievet B, Louvard D, Giovannini M, Arpin M. Mutant products of the NF2 tumor suppressor gene are degraded by the ubiquitin-proteasome pathway. J Biol Chem 2002; 277: 31279-31282. (Pubitemid 34968924)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.35 , pp. 31279-31282
    • Gautreau, A.1    Manent, J.2    Fievet, B.3    Louvard, D.4    Giovannini, M.5    Arpin, M.6
  • 45
    • 34247244657 scopus 로고    scopus 로고
    • The microRNA let-7a modulates interleukin-6-dependent STAT-3 survival signaling in malignant human cholangiocytes
    • DOI 10.1074/jbc.M607712200
    • Meng F, Henson R, Wehbe-Janek H, Smith H, Ueno Y, Patel T. The MicroRNA let-7a modulates interleukin-6-dependent STAT-3 survival signaling in malignant human cholangiocytes. J Biol Chem 2007; 282: 8256-8264. (Pubitemid 47093612)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.11 , pp. 8256-8264
    • Meng, F.1    Henson, R.2    Wehbe-Janek, H.3    Smith, H.4    Ueno, Y.5    Patel, T.6
  • 46
    • 77952299667 scopus 로고    scopus 로고
    • Inhibition of p21-activated kinase 6 (PAK6) increases radiosensitivity of prostate cancer cells
    • Zhang M, Siedow M, Saia G, Chakravarti A. Inhibition of p21-activated kinase 6 (PAK6) increases radiosensitivity of prostate cancer cells. Prostate 2010; 70: 807-816.
    • (2010) Prostate , vol.70 , pp. 807-816
    • Zhang, M.1    Siedow, M.2    Saia, G.3    Chakravarti, A.4
  • 48
    • 0032923739 scopus 로고    scopus 로고
    • Generalized lacZ expression with the ROSA26 Cre reporter strain [1]
    • DOI 10.1038/5007
    • Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 1999; 21: 70-71. (Pubitemid 29036285)
    • (1999) Nature Genetics , vol.21 , Issue.1 , pp. 70-71
    • Soriano, P.1
  • 50
    • 0018381233 scopus 로고
    • Studies on cultured rat Schwann cells. I. Establishment of purified populations from cultures of peripheral nerve
    • DOI 10.1016/0006-8993(79)90048-9
    • Brockes JP, Fields KL, Raff MC. Studies on cultured rat Schwann cells. I. Establishment of purified populations from cultures of peripheral nerve. Brain Res 1979; 165: 105-118. (Pubitemid 9148699)
    • (1979) Brain Research , vol.165 , Issue.1 , pp. 105-118
    • Brockes, J.P.1    Fields, K.L.2    Raff, M.C.3


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