The type III TGFβ receptor regulates filopodia formation via a Cdc42-mediated IRSp53-N-WASP interaction in epithelial cells

Biochemical Journal

Volumn 454, Issue 1, 2013, Pages 79-89

  Oh, Sun Young ^a   Knelson, Erik H ^a   Blobe, Gerard C ^a   Mythreye, Karthikeyan ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Arrestin2; Cell division cycle 42 (cdc42); Filopodium; Irsp53; Type iii transforming growth factor receptor (t riii)

Indexed keywords

BETA ARRESTIN 2; IRSP53 PROTEIN; NEURAL WISKOTT ALDRICH SYNDROME PROTEIN; PROTEIN C; PROTEIN CDC42; PROTEIN P53; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 3; UNCLASSIFIED DRUG; BAIAP2 PROTEIN, RAT; N WASP PROTEIN, RAT; N-WASP PROTEIN, RAT; NERVE PROTEIN; TGFB3 PROTEIN, RAT; TRANSFORMING GROWTH FACTOR BETA3; PROTEIN BINDING; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ACTIN FILAMENT; ARTICLE; BREAST EPITHELIUM; CANCER GROWTH; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TRANSIENT TRANSFECTION; WESTERN BLOTTING; ANIMAL; CELL LINE; CYTOLOGY; MAMMARY GLAND; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; PSEUDOPODIUM; RAT; TRANSFORMED CELL LINE;

ANIMALS; CDC42 GTP-BINDING PROTEIN; CELL LINE, TRANSFORMED; EPITHELIAL CELLS; HUMANS; MAMMARY GLANDS, HUMAN; NERVE TISSUE PROTEINS; PROTEIN BINDING; PSEUDOPODIA; RATS; TRANSFORMING GROWTH FACTOR BETA3; WISKOTT-ALDRICH SYNDROME PROTEIN, NEURONAL; ADAPTOR PROTEINS, SIGNAL TRANSDUCING;

EID: 84880868665     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20121701     Document Type: Article

References (1)

1. Mythreye, K., Knelson, E. H., Gatza, C. E., Gatza, M. L. and Blobe, G. C. (2012) TβRIII/β-Arrestin2 regulates integrin α5β1 trafficking, function, and localization in epithelial cells. Oncogene 32, 1416-1427.