Heparin-induced multiple electrode aggregometry is a promising and useful functional tool for heparin-induced thrombocytopenia diagnosis: Confirmation in a prospective study

Platelets

Volumn 24, Issue 6, 2013, Pages 441-447

  Galea, Vassiliki ^a   Khaterchi, Amir ^a   Robert, Francoise ^a   Gerotziafas, Grigoris ^a   Hatmi, Mohamed ^a,b   Elalamy, Ismail ^a  

^a HÔPITAL TENON   (France)

^b INSTITUT PASTEUR   (France)

Author keywords

Heparin induced thrombocytopenia; Multiple electrode aggregometry; Platelet aggregation; Serotonin release assay

Indexed keywords

HEPARIN; THROMBOCYTE ANTIBODY;

ADULT; ARTICLE; BLOOD SAMPLING; COMPARATIVE EFFECTIVENESS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; FUNCTION TEST; HEPARIN INDUCED MULTIPLE ELECTRODE AGGREGOMETRY; HEPARIN INDUCED THROMBOCYTOPENIA; HUMAN; IMMUNOASSAY; INTERMETHOD COMPARISON; LABORATORY DIAGNOSIS; MAJOR CLINICAL STUDY; PREDICTIVE VALUE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SEROTONIN RELEASE; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION ANALYZER; THROMBOCYTE RICH PLASMA;

EID: 84880863596     PISSN: 09537104     EISSN: 13691635     Source Type: Journal    
DOI: 10.3109/09537104.2012.724736     Document Type: Article

References (26)

1. Rauova L, Zhai L, Kowalska MA, Arepally GM, Cines DB, Poncz M. The role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: Diagnostic and therapeutic implications. Blood 2006;107:2346-2353.
2. Kelton JG, Sheridan D, Santos A, Smith J, Steves K, Smith C, Brown C, Murphy WG. Heparin-induced thrombocytopenia: Laboratory studies. Blood 1988;72:925-930.
3. Pouplard C, Iochmann S, Renard B, Herault O, Colombat P, Amiral J, Gruel Y. Induction of monocyte tissue factor expression by antibodies to heparin-platelet factor 4 complexes developed in heparin-induced thrombocytopenia. Blood 2001;97:3300-3302.
4. Rauova L, Aperally G, McKenzie SE, Konkle BA, Cines DB, Poncz M. Platelet and monocyte antigenic complexes in the pathogenesis of heparin-induced thrombocytopenia (HIT). J Thromb Haemost 2009;7:249-252.
5. Otis SA, Zehnder JL. Heparin-induced thrombocytopenia: Current status and diagnostic challenges. Am J Hematol 2010;85:700-706.
6. Greinacher A, Levy JH. HIT happens: Diagnosing and evaluating the patient with heparin-induced thrombocytopenia. Anesth Analg 2008;107:356-358.
7. Prechel M, Walenga JM. The laboratory diagnosis and clinical management of patients with heparin-induced thrombocytopenia: An update. Semin Thromb Hemost 2008;34:86-89.
8. Cuker A, Ortel TL. ASH evidence-based guidelines: Is the IgG specific anti-PF4/heparin ELISA superior to the polyspecific ELISA in the laboratory diagnosis of HIT? Hematology Am Soc Hematol Educ Program 2009:250-252.
9. Price EA, Hayward CP, Moffat KA, Moore JC, Warkentin TE, Zehnder JL. Laboratory testing for heparin-induced thrombocytopenia is inconsistent in North-America: A survey of North American specialized coagulation laboratories. Thromb Haemost 2007;98:1357-1361.
10. Pouplard C, Amiral J, Borg JY, Laporte-Simitsidis S, Delahousse B, Gruel Y. Decision analysis for use of platelet aggregation test, carbon 14-serotonin release assay, and heparinplatelet factor 4 enzyme-linked immunosorbent assay for diagnosis of heparin-induced thrombocytopenia. Am J Clin Pathol 1999;111:700-706.
11. Elalamy I, Lecrubier C, Horellou MH, Conard J, Samama MM. Heparin-induced thrombocytopenia: Laboratory diagnosis and management. Ann Med 2000;32:60-67.
12. Elalamy I, Galea V, Hatmi M, Gerotziafas GT. Heparin-induced multiple electrode aggregometry: A potential tool for improvement of heparin-induced thrombocytopenia diagnosis. J Thromb Haemost 2009;7:1932-1934.
13. Pouplard C, Leroux D, Regina S, Rollin J, Gruel Y. Effectiveness of a new immuno-assay for the diagnosis of heparin-induced thrombocytopenia and improved specificity when detecting IgG antibodies. Thromb Haemost 2010;103:145-150.
14. Sheridan D, Carter C, Kelton JG. A diagnostic test for heparininduced thrombocytopenia. Blood 1986;67:27-30.
15. Farantoni JC, Pollet R, Granlick HR. Heparin-induced thrombocytopenia: Confirmation of diagnosis with in vitro methods. Blood 1975;43:395-401.
16. Lo GK, Sigouin CS, Warkentin TE. What is the potential for overdiagnosis of heparin-induced thrombocytopeniã Am J Hematol 2007;82:1037-1043.
17. Elalamy I, Tardy-Poncet B, Mulot A, de Maistre E, Pouplard C, Nguyen P, Cleret B, Gruel Y, Lecompte T, Tardy B. GEHT HIT study group. Risk factors for unfavourable clinical outcome in patients with documented heparin-induced thrombocytopenia. Thromb Res 2009;124:554-559.
18. Greinacher A. Too many hits in HIT? Am J Hematol 2007;82:1035-1036.
19. Morel-Kopp M, Tan CW, Brighton TA, McRae S, Baker R, Tran H, Mollee P, Kershaw G, Joseph J, Ward C, ASTH Clinical Trials Group. Validation of whole blood impedance aggregometry as a new tool for HIT. Thromb Haemost 2012;107:575-583.
20. Warkentin TE, Sheppard JI, Horsewood P, Simpson PJ, Moore JC, Kelton JG. Impact of the patient population on the risk of heparin-induced thrombocytopenia. Blood 2000;96:1703-1708.
21. Bauer TL, Arepally G, Konkle BA, Mestichelli B, Shapiro SS, Cines DB, Poncz M, McNulty S, Amiral J, Hauck WW, et al. Prevalence of heparin-associated antibodies without thrombosis in patients undergoing cardiopulmonary bypass surgery. Circulation 1997;95:1242-1246.
22. Untch B, Ahmad S, Jeske WP, Messmore HL, Hoppensteadt DA, Walenga JM, Lietz H, Fareed J. Prevalence, isotype and functionality of antiheparin-platelet factor 4 antibodies in patients treated with heparin and clinically suspected for heparin-induced thrombocytopenia. The pathogenic role of IgG. Thromb Res 2002;105:117-123.
23. Greinacher A, Juhl D, Strobel U, Wessel A, Lubenow N, Selleng K, Eichler P, Warkentin TE. Heparin-induced thrombocytopenia: A prospective study on the incidence, plateletactivating capacity and clinical significance of antiplatelet factor 4/heparin antibodies of the IgG, IgM and IgA classes. J Thromb Haemost 2007;5:1666-1673.
24. Warkentin TE, Sheppard JI, Moore JC, Cook RJ, Kelton JG. Studies of the immune response in heparin-induced thrombocytopenia. Blood 2009;113:4963-4969.
25. Chong BH, Burgess J, Ismail F. The clinical usefulness of the platelet aggregation test for the diagnosis of heparin-induced thrombocytopenia. Thromb Haemost 1993;69:344-350.
26. Toth O, Calatzis A, Penz S, Losonczy H, Siess W. Multiple electrode aggregometry: A new device to measure platelet aggregation in whole blood. Thromb Haemost 2006;96:781-788.