Genomic structure and variation of nuclear factor (erythroid-derived 2)-like 2

Oxidative Medicine and Cellular Longevity

Volumn , Issue , 2013, Pages

  Cho, Hye Youn ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMEDICAL RESEARCH; COMPREHENSIVE INFORMATION; DISEASE PHENOTYPES; GENETIC CHARACTERISTICS; PHYLOGENETIC COMPARISONS; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISMS; THERAPEUTIC STRATEGY;

DNA SEQUENCES; MAMMALS;

GENES;

GENOMIC DNA; TRANSCRIPTION FACTOR NRF2;

ALLELE; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ARTICLE; ATROPHY; CANCER CELL; CAT; CATTLE; CELL SURVIVAL; CHIMPANZEE; DEGENERATIVE DISEASE; DISEASE PREDISPOSITION; DOG; EXON; GASTRITIS; GENE MUTATION; GENE SEQUENCE; GENE STRUCTURE; GENETIC ASSOCIATION; GENETIC CONSERVATION; GENETIC VARIABILITY; HAPLOTYPE; HOST RESISTANCE; HUMAN; LUNG DISEASE; MOUSE; MUTATION RATE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROMOTER REGION; PROTEIN FUNCTION; SENILE CATARACT; SEQUENCE HOMOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC MUTATION; SYSTEMIC LUPUS ERYTHEMATOSUS; VERTEBRATE; ANIMAL; CLASSIFICATION; GENETICS; METABOLISM; MUTATION; PHYLOGENY; REVIEW;

ANIMALS; GENETIC VARIATION; HAPLOTYPES; HUMANS; MUTATION; NF-E2-RELATED FACTOR 2; PHYLOGENY; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84880858384     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2013/286524     Document Type: Article

References (77)

1. Chan J. Y., Cheung M. C., Moi P., Chan K., Kan Y. W., Chromosomal localization of the human NF-E2 family of bZIP transcription factors by fluorescence in situ hybridization. Human Genetics 1995 95 3 265 269 2-s2.0-0028937071
2. Itoh K., Igarashi K., Hayashi N., Nishizawa M., Yamamoto M., Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins. Molecular and Cellular Biology 1995 15 8 4184 4193 2-s2.0-0029043995
3. Osburn W. O., Kensler T. W., NRF2 signaling: an adaptive response pathway for protection against environmental toxic insults. Mutation Research 2008 659 1-2 31 39 2-s2.0-47849083585 10.1016/j.mrrev.2007.11.006
4. Papp D., Lenti K., Modos D., Fazekas D., Dul Z., Turei D., The NRF2 -related interactome and regulome contain multifunctional proteins and fine-tuned autoregulatory loops. FEBS Letters 2012 586 13 1795 1802 10.1016/j.febslet.2012.05.016
5. Wang X., Tomso D. J., Chorley B. N., Cho H. Y., Cheung V. G., Kleeberger S. R., Bell D. A., Identification of polymorphic antioxidant response elements in the human genome. Human Molecular Genetics 2007 16 10 1188 1200 2-s2.0-34447299123 10.1093/hmg/ddm066 (Pubitemid 47062715)
6. Malhotra D., Portales-Casamar E., Singh A., Srivastava S., Arenillas D., Happel C., Shyr C., Wakabayashi N., Kensler T. W., Wasserman W. W., Biswal S., Global mapping of binding sites for NRF2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis. Nucleic Acids Research 2010 38 17 5718 5734 2-s2.0-77957237159 10.1093/nar/gkq212
7. Chan K., Lu R., Chang J. C., Kan Y. W., NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proceedings of the National Academy of Sciences of the United States of America 1996 93 24 13943 13948 2-s2.0-0030451213 10.1073/pnas.93.24. 13943 (Pubitemid 26424225)
8. Itoh K., Chiba T., Takahashi S., Ishii T., Igarashi K., Katoh Y., Oyake T., Hayashi N., Satoh K., Hatayama I., Yamamoto M., Nabeshima Y. I., An NRF2 /small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochemical and Biophysical Research Communications 1997 236 2 313 322 2-s2.0-0031577292 10.1006/bbrc.1997.6943 (Pubitemid 27373291)
9. Martin F., van Deursen J. M., Shivdasani R. A., Jackson C. W., Troutman A. G., Ney P. A., Erythroid maturation and globin gene expression in mice with combined deficiency of NF-E2 and Nrf-2. Blood 1998 91 9 3459 3466 2-s2.0-0032080193 (Pubitemid 28193899)
10. Itoh K., Wakabayashi N., Katoh Y., Ishii T., Igarashi K., Engel J. D., Yamamoto M., KEAP1 represses nuclear activation of antioxidant responsive elements by NRF2 through binding to the amino-terminal Neh2 domain. Genes and Development 1999 13 1 76 86 2-s2.0-0032953192 (Pubitemid 29045117)
11. Kobayashi A., Kang M. I., Okawa H., Ohtsuji M., Zenke Y., Chiba T., Igarashi K., Yamamoto M., Oxidative stress sensor KEAP1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of NRF2. Molecular and Cellular Biology 2004 24 16 7130 7139 2-s2.0-3543008924 10.1128/MCB.24.16. 7130-7139.2004 (Pubitemid 39014439)
12. Taguchi K., Motohashi H., Yamamoto M., Molecular mechanisms of the KEAP1-NRF2 pathway in stress response and cancer evolution. Genes to Cells 2011 16 2 123 140 2-s2.0-78751703950 10.1111/j.1365-2443.2010.01473.x
13. Mukaigasa K., Nguyen L. T., Li L., Nakajima H., Yamamoto M., Kobayashi M., Genetic evidence of an evolutionarily conserved role for NRF2 in the protection against oxidative stress. Molecular and Cellular Biology 2012 32 21 4455 4461
14. Maher J., Yamamoto M., The rise of antioxidant signaling-the evolution and hormetic actions of NRF2. Toxicology and Applied Pharmacology 2010 244 1 4 15 2-s2.0-77649271223 10.1016/j.taap.2010.01.011
15. Lo S. C., Li X., Henzl M. T., Beamer L. J., Hannink M., Structure of the KEAP1: NRF2 interface provides mechanistic insight into NRF2 signaling. The EMBO Journal 2006 25 15 3605 3617 2-s2.0-33747606306 10.1038/sj.emboj.7601243 (Pubitemid 44264871)
16. McKusick V. A., Mendelian inheritance in man and its online version, OMIM. American Journal of Human Genetics 2007 80 4 588 604 2-s2.0-34147122065 10.1086/514346 (Pubitemid 46564398)
17. Yalcin B., Adams D. J., Flint J., Keane T. M., Next-generation sequencing of experimental mouse strains. Mammalian Genome 2012 23 9-10 490 498 10.1007/s00335-012-9402-6
18. Bentley D. R., Balasubramanian S., Swerdlow H. P., Smith G. P., Milton J., Brown C. G., Hall K. P., Evers D. J., Barnes C. L., Bignell H. R., Boutell J. M., Bryant J., Carter R. J., Keira Cheetham R., Cox A. J., Ellis D. J., Flatbush M. R., Gormley N. A., Humphray S. J., Irving L. J., Karbelashvili M. S., Kirk S. M., Li H., Liu X., Maisinger K. S., Murray L. J., Obradovic B., Ost T., Parkinson M. L., Pratt M. R., Rasolonjatovo I. M. J., Reed M. T., Rigatti R., Rodighiero C., Ross M. T., Sabot A., Sankar S. V., Scally A., Schroth G. P., Smith M. E., Smith V. P., Spiridou A., Torrance P. E., Tzonev S. S., Vermaas E. H., Walter K., Wu X., Zhang L., Alam M. D., Anastasi C., Aniebo I. C., Bailey D. M. D., Bancarz I. R., Banerjee S., Barbour S. G., Baybayan P. A., Benoit V. A., Benson K. F., Bevis C., Black P. J., Boodhun A., Brennan J. S., Bridgham J. A., Brown R. C., Brown A. A., Buermann D. H., Bundu A. A., Burrows J. C., Carter N. P., Castillo N., Catenazzi M. C. E., Chang S., Neil Cooley R., Crake N. R., Dada O. O., Diakoumakos K. D., Dominguez-Fernandez B., Earnshaw D. J., Egbujor U. C., Elmore D. W., Etchin S. S., Ewan M. R., Fedurco M., Fraser L. J., Fuentes Fajardo K. V., Scott Furey W., George D., Gietzen K. J., Goddard C. P., Golda G. S., Granieri P. A., Green D. E., Gustafson D. L., Hansen N. F., Harnish K., Haudenschild C. D., Heyer N. I., Hims M. M., Ho J. T., Horgan A. M., Hoschler K., Hurwitz S., Ivanov D. V., Johnson M. Q., James T., Huw Jones T. A., Kang G. D., Kerelska T. H., Kersey A. D., Khrebtukova I., Kindwall A. P., Kingsbury Z., Kokko-Gonzales P. I., Kumar A., Laurent M. A., Lawley C. T., Lee S. E., Lee X., Liao A. K., Loch J. A., Lok M., Luo S., Mammen R. M., Martin J. W., McCauley P. G., McNitt P., Mehta P., Moon K. W., Mullens J. W., Newington T., Ning Z., Ling Ng B., Novo S. M., O'Neill M. J., Osborne M. A., Osnowski A., Ostadan O., Paraschos L. L., Pickering L., Pike A. C., Pike A. C., Chris Pinkard D., Pliskin D. P., Podhasky J., Quijano V. J., Raczy C., Rae V. H., Rawlings S. R., Chiva Rodriguez A., Roe P. M., Rogers J., Rogert Bacigalupo M. C., Romanov N., Romieu A., Roth R. K., Rourke N. J., Ruediger S. T., Rusman E., Sanches-Kuiper R. M., Schenker M. R., Seoane J. M., Shaw R. J., Shiver M. K., Short S. W., Sizto N. L., Sluis J. P., Smith M. A., Ernest Sohna Sohna J., Spence E. J., Stevens K., Sutton N., Szajkowski L., Tregidgo C. L., Turcatti G., Vandevondele S., Verhovsky Y., Virk S. M., Wakelin S., Walcott G. C., Wang J., Worsley G. J., Yan J., Yau L., Zuerlein M., Rogers J., Mullikin J. C., Hurles M. E., McCooke N. J., West J. S., Oaks F. L., Lundberg P. L., Klenerman D., Durbin R., Smith A. J., Accurate whole human genome sequencing using reversible terminator chemistry. Nature 2008 456 7218 53 59 2-s2.0-55549089660 10.1038/nature07517
19. Chain P. S. G., Grafham D. V., Fulton R. S., Fitzgerald M. G., Hostetler J., Muzny D., Ali J., Birren B., Bruce D. C., Buhay C., Cole J. R., Ding Y., Dugan S., Field D., Garrity G. M., Gibbs R., Graves T., Han C. S., Harrison S. H., Highlander S., Hugenholtz P., Khouri H. M., Kodira C. D., Kolker E., Kyrpides N. C., Lang D., Lapidus A., Malfatti S. A., Markowitz V., Metna T., Nelson K. E., Parkhill J., Pitluck S., Qin X., Read T. D., Schmutz J., Sozhamannan S., Sterk P., Strausberg R. L., Sutton G., Thomson N. R., Tiedje J. M., Weinstock G., Wollam A., Detter J. C., Genome project standards in a new era of sequencing. Science 2009 326 5950 236 237 2-s2.0-70349866672 10.1126/science.1180614
20. Waterston R. H., Lindblad-Toh K., Birney E., Rogers J., Abril J. F., Agarwal P., Initial sequencing and comparative analysis of the mouse genome. Nature 2002 420 520 562 10.1038/nature01262 (Pubitemid 35477048)
21. Keane T. M., Goodstadt L., Danecek P., White M. A., Wong K., Yalcin B., Mouse genomic variation and its effect on phenotypes and gene regulation. Nature 2011 477 289 294 10.1038/nature10413
22. Yamamoto T., Yoh K., Kobayashi A., Ishii Y., Kure S., Koyama A., Sakamoto T., Sekizawa K., Motohashi H., Yamamoto M., Identification of polymorphisms in the promoter region of the human NRF2 gene. Biochemical and Biophysical Research Communications 2004 321 1 72 79 2-s2.0-7444251509 10.1016/j.bbrc.2004.06.112
23. Marzec J. M., Christie J. D., Reddy S. P., Jedlicka A. E., Vuong H., Lanken P. N., Aplenc R., Yamamoto T., Yamamoto M., Cho H. Y., Kleeberger S. R., Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury. The FASEB Journal 2007 21 9 2237 2246 2-s2.0-34347392512 10.1096/fj.06-7759com (Pubitemid 47026458)
24. Fukushima-Uesaka H., Saito Y., Maekawa K., Kamatani N., Kajio H., Kuzuya N., Noda M., Yasuda K., Sawada J. I., Genetic variations and haplotype structures of transcriptional factor NRF2 and its cytosolic reservoir protein KEAP1 in Japanese. Drug Metabolism and Pharmacokinetics 2007 22 3 212 219 2-s2.0-34548531081 10.2133/dmpk.22.212
25. Córdova E. J., Velázquez-Cruz R., Centeno F., Baca V., Orozco L., The NRF2 gene variant, -653G/A, is associated with nephritis in childhood-onset systemic lupus erythematosus. Lupus 2010 19 10 1237 1242 2-s2.0-77956252901 10.1177/0961203310367917
26. von Otter M., Landgren S., Nilsson S., Celojevic D., Bergström P., Håkansson A., Nissbrandt H., Drozdzik M., Bialecka M., Kurzawski M., Blennow K., Nilsson M., Hammarsten O., Zetterberg H., Association of NRF2 -encoding NFE2L2 haplotypes with Parkinson's disease. BMC Medical Genetics 2010 11 1, article 36 2-s2.0-77951176535 10.1186/1471-2350-11-36
27. Hartikainen J. M., Tengstrom M., Kosma V. M., Kinnula V. L., Mannermaa A., Soini Y., Genetic polymorphisms and protein expression of NRF2 and sulfiredoxin predict survival outcomes in breast cancer. Cancer Research 2012 72 5537 5546 10.1158/0008-5472.CAN-12-1474
28. Arisawa T., Tahara T., Shibata T., Nagasaka M., Nakamura M., Kamiya Y., Fujita H., Hasegawa S., Takagi T., Wang F. Y., Hirata I., Nakano H., The relationship between Helicobacter pylori infection and promoter polymorphism of the NRF2 gene in chronic gastritis. International Journal of Molecular Medicine 2007 19 1 143 148 2-s2.0-38149075947
29. Arisawa T., Tahara T., Shibata T., Nagasaka M., Nakamura M., Kamiya Y., Fujita H., Yoshioka D., Arima Y., Okubo M., Hirata I., Nakano H., The influence of promoter polymorphism of nuclear factor-erythroid 2-related factor 2 gene on the aberrant DNA methylation in gastric epithelium. Oncology Reports 2008 19 1 211 216 2-s2.0-38749099831 (Pubitemid 351176151)
30. Arisawa T., Tahara T., Shibata T., Nagasaka M., Nakamura M., Kamiya Y., Fujita H., Yoshioka D., Okubo M., Hirata I., Nakano H., NRF2 gene promoter polymorphism and gastric carcinogenesis. Hepato-Gastroenterology 2008 55 82-83 750 754 2-s2.0-44349189804 (Pubitemid 351741541)
31. Arisawa T., Tahara T., Shibata T., Nagasaka M., Nakamura M., Kamiya Y., Fujita H., Yoshioka D., Okubo M., Sakata M., Wang F. Y., Hirata I., Nakano H., NRF2 gene promoter polymorphism is associated with ulcerative colitis in a Japanese population. Hepato-Gastroenterology 2008 55 82-83 394 397 2-s2.0-44349119778 (Pubitemid 351741468)
32. Hua C. C., Chang L. C., Tseng J. C., Chu C. M., Liu Y. C., Shieh W. B., Functional haplotypes in the promoter region of transcription factor NRF2 in chronic obstructive pulmonary disease. Disease Markers 2010 28 3 185 193 2-s2.0-77954124777 10.3233/DMA-2010-0700
33. Shaheen S. O., Newson R. B., Ring S. M., Rose-Zerilli M. J., Holloway J. W., Henderson A. J., Prenatal and infant acetaminophen exposure, antioxidant gene polymorphisms, and childhood asthma. The Journal of Allergy and Clinical Immunology 2010 126 6 1141.e7 1148.e7 2-s2.0-78649849976 10.1016/j.jaci.2010.08. 047
34. Masuko H., Sakamoto T., Kaneko Y., Iijima H., Naito T., Noguchi E., Hirota T., Tamari M., Hizawa N., Lower FEV1 in non-COPD, nonasthmatic subjects: association with smoking, annual decline in FEV1, total IgE levels, and TSLP genotypes. International Journal of Chronic Obstructive Pulmonary Disease 2011 6 181 189 2-s2.0-79960941227
35. Guan C. P., Zhou M. N., Xu A. E., Kang K. F., Liu J. F., Wei X. D., Li Y. W., Zhao D. K., Hong W. S., The susceptibility to vitiligo is associated with NF-E2-related factor 2 (NRF2) gene polymorphisms: a study on Chinese Han population. Experimental Dermatology 2008 17 12 1059 1062 2-s2.0-56349163056 10.1111/j.1600-0625.2008.00752.x
36. Bouligand J., Cabaret O., Canonico M., Verstuyft C., Dubert L., Becquemont L., Guiochon-Mantel A., Scarabin P. Y., Effect of NFE2L2 genetic polymorphism on the association between oral estrogen therapy and the risk of venous thromboembolism in postmenopausal women. Clinical Pharmacology & Therapeutics 2011 89 1 60 64 2-s2.0-78650513899 10.1038/clpt.2010.241
37. O'Mahony D. S., Glavan B. J., Holden T. D., Fong C., Black R. A., Rona G., Inflammation and immune-related candidate gene associations with acute lung injury susceptibility and severity: a validation study. PLoS ONE 2012 7 12 e51104
38. Ungvari I., Hadadi E., Virag V., Relationship between air pollution, NFE2L2 gene polymorphisms and childhood asthma in a Hungarian population. Journal of Community Genetics 2012 3 1 25 33 10.1007/s12687-011-0075-8
39. Siedlinski M., Postma D. S., Boer J. M. A., van der Steege G., Schouten J. P., Smit H. A., Boezen H. M., Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population. Respiratory Research 2009 10, article 73 2-s2.0-77149161203 10.1186/1465-9921-10-73
40. Hong C. C., Ambrosone C. B., Ahn J., Choi J. Y., McCullough M. L., Stevens V. L., Rodriguez C., Thun M. J., Calle E. E., Genetic variability in iron-related oxidative stress pathways (NRF2, NQ01, NOS3, and HO-1), iron intake, and risk of postmenopausal breast cancer. Cancer Epidemiology Biomarkers and Prevention 2007 16 9 1784 1794 2-s2.0-34548825643 10.1158/1055-9965.EPI-07- 0247 (Pubitemid 47450508)
41. Canova C., Dunster C., Kelly F. J., Minelli C., Shah P. L., Caneja C., PM10-induced hospital admissions for asthma and chronic obstructive pulmonary disease: the modifying effect of individual characteristics. Epidemiology 2012 23 4 607 615 10.1097/EDE.0b013e3182572563
42. Henderson A. J., Newson R. B., Rose-Zerilli M., Ring S. M., Holloway J. W., Shaheen S. O., Maternal NRF2 and gluthathione-S-transferase polymorphisms do not modify associations of prenatal tobacco smoke exposure with asthma and lung function in school-aged children. Thorax 2010 65 10 897 902 2-s2.0-77957195706 10.1136/thx.2009.125856
43. Xing C., Sestak A. L., Kelly J. A., Nguyen K. L., Bruner G. R., Harley J. B., Gray-McGuire C., Localization and replication of the systemic lupus erythematosus linkage signal at 4p16: interaction with 2p11, 12q24 and 19q13 in European Americans. Human Genetics 2007 120 5 623 631 2-s2.0-33845623832 10.1007/s00439-006-0248-4 (Pubitemid 44942846)
44. Wong T. F., Yoshinaga K., Monma Y., Ito K., Niikura H., Nagase S., Association of KEAP1 and NRF2 genetic mutations and polymorphisms with endometrioid endometrial adenocarcinoma survival. International Journal of Gynecological Cancer 2011 21 8 1428 1435 10.1097/IGC.0b013e31822d0eb2
45. von Otter M., Landgren S., Nilsson S., Zetterberg M., Celojevic D., Bergström P., Minthon L., Bogdanovic N., Andreasen N., Gustafson D. R., Skoog I., Wallin A., Tasa G., Blennow K., Nilsson M., Hammarsten O., Zetterberg H., NRF2 -encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer's disease and age-related cataract. Mechanisms of Ageing and Development 2010 131 2 105 110 2-s2.0-77249083614 10.1016/j.mad.2009.12.007
46. Tsang S., Sun Z., Luke B., Stewart C., Lum N., Gregory M., Wu X., Subleski M., Jenkins N. A., Copeland N. G., Munroe D. J., A comprehensive SNP-based genetic analysis of inbred mouse strains. Mammalian Genome 2005 16 7 476 480 2-s2.0-24644446373 10.1007/s00335-005-0001-7 (Pubitemid 41278424)
47. Wade C. M., Kulbokas E. J. III, Kirby A. W., Zody M. C., Mullikin J. C., Lander E. S., Lindblad-Toh K., Daly M. J., The mosaic structure of variation in the laboratory mouse genome. Nature 2002 420 6915 574 578 2-s2.0-0037028155 10.1038/nature01252 (Pubitemid 35477050)
48. Wiltshire T., Pletcher M. T., Batalov S., Whitney Barnes S., Tarantino L. M., Cooke M. P., Wu H., Smylie K., Santrosyan A., Copeland N. G., Jenkins N. A., Kalush F., Mural R. J., Glynne R. J., Kay S. A., Adams M. D., Fletcher C. F., Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse. Proceedings of the National Academy of Sciences of the United States of America 2003 100 6 3380 3385 2-s2.0-0037452982 10.1073/pnas. 0130101100 (Pubitemid 36356592)
49. Frazer K. A., Eskin E., Kang H. M., Bogue M. A., Hinds D. A., Beilharz E. J., Gupta R. V., Montgomery J., Morenzoni M. M., Nilsen G. B., Pethiyagoda C. L., Stuve L. L., Johnson F. M., Daly M. J., Wade C. M., Cox D. R., A sequence-based variation map of 8.27 million SNPs in inbred mouse strains. Nature 2007 448 7157 1050 1053 2-s2.0-34548295740 10.1038/nature06067 (Pubitemid 47345584)
50. Maddatu T. P., Grubb S. C., Bult C. J., Bogue M. A., Mouse phenome database (MPD). Nucleic Acids Research 2007 40 D887 D894
51. Kirby A., Kang H. M., Wade C. M., Cotsapas C., Kostem E., Han B., Furlotte N., Kang E. Y., Rivas M., Bogue M. A., Frazer K. A., Johnson F. M., Beilharz E. J., Cox D. R., Eskin E., Daly M. J., Fine mapping in 94 inbred mouse strains using a high-density haplotype resource. Genetics 2010 185 3 1081 1095 2-s2.0-78349254248 10.1534/genetics.110.115014
52. Cho H. Y., Jedlicka A. E., Reddy S. P. M., Zhang L. Y., Kensler T. W., Kleeberger S. R., Linkage analysis of susceptibility to hyperoxia NRF2 is a candidate gene. American Journal of Respiratory Cell and Molecular Biology 2002 26 1 42 51 2-s2.0-0036006792 (Pubitemid 34029819)
53. Cho H. Y., Jedlicka A. E., Reddy S. P. M., Kensler T. W., Yamamoto M., Zhang L. Y., Kleeberger S. R., Role of NRF2 in protection against hyperoxic lung injury in mice. American Journal of Respiratory Cell and Molecular Biology 2002 26 2 175 182 2-s2.0-0036007313 (Pubitemid 34107870)
54. Shibata T., Ohta T., Tong K. I., Kokubu A., Odogawa R., Tsuta K., Asamura H., Yamamoto M., Hirohashi S., Cancer related mutations in NRF2 impair its recognition by KEAP1 -Cul3 E3 ligase and promote malignancy. Proceedings of the National Academy of Sciences of the United States of America 2008 105 36 13568 13573 2-s2.0-51649130168 10.1073/pnas.0806268105
55. Singh A., Misra V., Thimmulappa R. K., Lee H., Ames S., Hoque M. O., Herman J. G., Baylin S. B., Sidransky D., Gabrielson E., Brock M. V., Biswal S., Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS Medicine 2006 3 10, article e420 2-s2.0-33750885385 10.1371/journal.pmed.0030420 (Pubitemid 44721825)
56. Ohta T., Iijima K., Miyamoto M., Nakahara I., Tanaka H., Ohtsuji M., Suzuki T., Kobayashi A., Yokota J., Sakiyama T., Shibata T., Yamamoto M., Hirohashi S., Loss of KEAP1 function activates NRF2 and provides advantages for lung cancer cell growth. Cancer Research 2008 68 5 1303 1309 2-s2.0-40449107193 10.1158/0008-5472.CAN-07-5003 (Pubitemid 351346836)
57. Padmanabhan B., Tong K. I., Ohta T., Nakamura Y., Scharlock M., Ohtsuji M., Kang M. I., Kobayashi A., Yokoyama S., Yamamoto M., Structural basis for defects of KEAP1 activity provoked by its point mutations in lung cancer. Molecular Cell 2006 21 5 689 700 2-s2.0-33344456501 10.1016/j.molcel.2006.01.013 (Pubitemid 43290735)
58. Shibata T., Kokubu A., Gotoh M., Ojima H., Ohta T., Yamamoto M., Hirohashi S., Genetic alteration of KEAP1 confers constitutive NRF2 activation and resistance to chemotherapy in gallbladder cancer. Gastroenterology 2008 135 4 1358.e4 1368.e4 2-s2.0-53049105119 10.1053/j.gastro.2008.06.082
59. Yoo N. J., Kim H. R., Kim Y. R., An C. H., Lee S. H., Somatic mutations of the KEAP1 gene in common solid cancers. Histopathology 2012 60 6 943 952 10.1111/j.1365-2559.2012.04178.x
60. Hu Y., Ju Y., Lin D., Wang Z., Huang Y., Zhang S., Mutation of the NRF2 gene in non-small cell lung cancer. Molecular Biology Reports 2012 39 4 4743 4747 10.1007/s11033-011-1266-4
61. Kim Y. R., Oh J. E., Kim M. S., Kang M. R., Park S. W., Han J. Y., Eom H. S., Yoo N. J., Lee S. H., Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin. The Journal of Pathology 2010 220 4 446 451 2-s2.0-76749106638 10.1002/path.2653
62. Shibata T., Kokubu A., Saito S., NRF2 mutation confers malignant potential and resistance to chemoradiation therapy in advanced esophageal squamous cancer. Neoplasia 2011 13 864 873
63. Sasaki H., Shitara M., Yokota K., Hikosaka Y., Moriyama S., Yano M., Increased NRF2 gene (NFE2L2) copy number correlates with mutations in lung squamous cell carcinomas. Molecular Medicine Reports 2012 6 2 391 394
64. Sasaki H., Shitara M., Yokota K., Hikosaka Y., Moriyama S., Yano M., RagD gene expression and NRF2 mutations in lung squamous cell carcinomas. Oncology Letters 2012 4 1167 1170
65. Singh A., Bodas M., Wakabayashi N., Bunz F., Biswal S., Gain of NRF2 function in non-small-cell lung cancer cells confers radioresistance. Antioxidants and Redox Signaling 2010 13 11 1627 1637 2-s2.0-77958129306 10.1089/ars.2010.3219
66. Yamadori T., Ishii Y., Homma S., Morishima Y., Kurishima K., Itoh K., Molecular mechanisms for the regulation of NRF2 -mediated cell proliferation in non-small-cell lung cancers. Oncogene 2012 31 4768 4777 10.1038/onc.2011.628
67. Bauer A. K., Cho H. Y., Miller-Degraff L., Walker C., Helms K., Fostel J., Targeted deletion of NRF2 reduces urethane-induced lung tumor development in mice. PLoS ONE 2011 6 10 e26590
68. Cho H. Y., Kleeberger S. R., NRF2 protects against airway disorders. Toxicology and Applied Pharmacology 2010 244 1 43 56 2-s2.0-77649273792 10.1016/j.taap.2009.07.024
69. Wang R., An J., Ji F., Jiao H., Sun H., Zhou D., Hypermethylation of the KEAP1 gene in human lung cancer cell lines and lung cancer tissues. Biochemical and Biophysical Research Communications 2008 373 1 151 154 2-s2.0-45849133744 10.1016/j.bbrc.2008.06.004
70. Zhang P., Singh A., Yegnasubramanian S., Esopi D., Kombairaju P., Bodas M., Wu H., Bova S. G., Biswal S., Loss of kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth. Molecular Cancer Therapeutics 2010 9 2 336 346 2-s2.0-76649089973 10.1158/1535-7163.MCT-09-0589
71. Hanada N., Takahata T., Zhou Q., Methylation of the KEAP1 gene promoter region in human colorectal cancer. BMC Cancer 2012 12, article 66 10.1186/1471-2407-12-66
72. Muscarella L. A., Barbano R., D'Angelo V., Copetti M., Coco M., Balsamo T., la Torre A., Notarangelo A., Troiano M., Parisi S., Icolaro N., Catapano D., Valori V. M., Pellegrini F., Merla G., Carella M., Fazio V. M., Parrella P., Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome. Epigenetics 2011 6 3 317 325 2-s2.0-79952377052 10.4161/epi.6.3.14408
73. Yu S., Khor T. O., Cheung K. L., Li W., Wu T. Y., Huang Y., Foster B. A., Kan Y. W., Kong A. N., NRF2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice. PLoS ONE 2010 5 1 2-s2.0-77649163840 10.1371/journal.pone.0008579 e8579
74. Khor T. O., Huang Y., Wu T. Y., Shu L., Lee J., Kong A. N., Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of NRF2 via promoter CpGs demethylation. Biochemical Pharmacology 2011 82 9 1073 1078 10.1016/j.bcp.2011.07.065
75. Fingerman I. M., McDaniel L., Zhang X., Ratzat W., Hassan T., Jiang Z., Cohen R. F., Schuler G. D., NCBI epigenomics: a new public resource for exploring epigenomic data sets. Nucleic Acids Research 2011 39 supplemen 1 D908 D912 2-s2.0-78651298894 10.1093/nar/gkq1146
76. Fingerman I. M., Zhang X., Ratzat W., Husain N., Cohen R. F., Schuler G. D., NCBI epigenomics: what's new for 2013. Nucleic Acids Research 2013 41 1 D221 D225 10.1093/nar/gks1171
77. Lee J. H., Khor T. O., Shu L., Su Z. Y., Fuentes F., Kong A. N., Dietary phytochemicals and cancer prevention: NRF2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression. Pharmacology & Therapeutics 2012 137 2 153 171