메뉴 건너뛰기




Volumn 112, Issue 4, 2013, Pages 432-441

The role of chronic prostatic inflammation in the pathogenesis and progression of benign prostatic hyperplasia (BPH)

Author keywords

acute urinary retention; benign prostatic hyperplasia (BPH); biomarkers; chronic prostatic inflammation; LUTS severity; prostatic calcifications

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; DUTASTERIDE; STEROID 5ALPHA REDUCTASE INHIBITOR;

EID: 84880842151     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/bju.12118     Document Type: Review
Times cited : (226)

References (50)
  • 1
    • 0025861680 scopus 로고
    • High prevalence of benign prostatic hypertrophy in the community
    • Garraway WM, Collins GN, Lee RJ,. High prevalence of benign prostatic hypertrophy in the community. Lancet 1991; 338: 469-471
    • (1991) Lancet , vol.338 , pp. 469-471
    • Garraway, W.M.1    Collins, G.N.2    Lee, R.J.3
  • 2
    • 72049106130 scopus 로고    scopus 로고
    • Benign prostatic hyperplasia and its aetiologies
    • Briganti A, Capitanio U, Suardi N, et al. Benign prostatic hyperplasia and its aetiologies. Eur Urol Suppl 2009; 8: 865-871
    • (2009) Eur Urol Suppl , vol.8 , pp. 865-871
    • Briganti, A.1    Capitanio, U.2    Suardi, N.3
  • 3
    • 14844301664 scopus 로고    scopus 로고
    • Benign prostatic hyperplasia: Age-related tissue-remodeling
    • Untergasser G, Madersbacher S, Berger P,. Benign prostatic hyperplasia: age-related tissue-remodeling. Exp Gerontol 2005; 40: 121-128
    • (2005) Exp Gerontol , vol.40 , pp. 121-128
    • Untergasser, G.1    Madersbacher, S.2    Berger, P.3
  • 5
    • 0014847075 scopus 로고
    • Dihydrotestosterone in prostatic hypertrophy. I. The formation and content of dihydrotestosterone in the hypertrophic prostate of man
    • Siiteri PK, Wilson JD,. Dihydrotestosterone in prostatic hypertrophy. I. The formation and content of dihydrotestosterone in the hypertrophic prostate of man. J Clin Invest 1970; 49: 1737-1745
    • (1970) J Clin Invest , vol.49 , pp. 1737-1745
    • Siiteri, P.K.1    Wilson, J.D.2
  • 6
    • 0035108041 scopus 로고    scopus 로고
    • Hyperinsulinaemia as a risk factor for developing benign prostatic hyperplasia
    • Hammarsten J, Hogstedt B,. Hyperinsulinaemia as a risk factor for developing benign prostatic hyperplasia. Eur Urol 2001; 39: 151-158
    • (2001) Eur Urol , vol.39 , pp. 151-158
    • Hammarsten, J.1    Hogstedt, B.2
  • 8
    • 33645956542 scopus 로고    scopus 로고
    • BPH: Epidemiology and comorbidities
    • McVary KT,. BPH: epidemiology and comorbidities. Am J Manag Care 2006; 12: S122-128
    • (2006) Am J Manag Care , vol.12
    • McVary, K.T.1
  • 9
    • 80052056031 scopus 로고    scopus 로고
    • Metabolic syndrome and benign prostatic hyperplasia: Evidence of a potential relationship, hypothesized etiology, and prevention
    • Abdollah F, Briganti A, Suardi N, et al. Metabolic syndrome and benign prostatic hyperplasia: evidence of a potential relationship, hypothesized etiology, and prevention. Korean J Urol 2011; 52: 507-516
    • (2011) Korean J Urol , vol.52 , pp. 507-516
    • Abdollah, F.1    Briganti, A.2    Suardi, N.3
  • 10
    • 79957957222 scopus 로고    scopus 로고
    • The controversial relationship between benign prostatic hyperplasia and prostate cancer: The role of inflammation
    • De Nunzio C, Kramer G, Marberger M, et al. The controversial relationship between benign prostatic hyperplasia and prostate cancer: the role of inflammation. Eur Urol 2011; 60: 106-117
    • (2011) Eur Urol , vol.60 , pp. 106-117
    • De Nunzio, C.1    Kramer, G.2    Marberger, M.3
  • 11
    • 60249084251 scopus 로고    scopus 로고
    • Is there evidence of a relationship between benign prostatic hyperplasia and prostate cancer? Findings of a literature review
    • Alcaraz A, Hammerer P, Tubaro A, Schroder FH, Castro R,. Is there evidence of a relationship between benign prostatic hyperplasia and prostate cancer? Findings of a literature review. Eur Urol 2009; 55: 864-873
    • (2009) Eur Urol , vol.55 , pp. 864-873
    • Alcaraz, A.1    Hammerer, P.2    Tubaro, A.3    Schroder, F.H.4    Castro, R.5
  • 12
    • 0027982930 scopus 로고
    • Phenotype and function of peripheral and prostatic lymphocytes in patients with benign prostatic hyperplasia
    • Steiner G, Gessl A, Kramer G, Schollhammer A, Forster O, Marberger M,. Phenotype and function of peripheral and prostatic lymphocytes in patients with benign prostatic hyperplasia. J Urol 1994; 151: 480-484
    • (1994) J Urol , vol.151 , pp. 480-484
    • Steiner, G.1    Gessl, A.2    Kramer, G.3    Schollhammer, A.4    Forster, O.5    Marberger, M.6
  • 15
    • 0041669594 scopus 로고    scopus 로고
    • Expression and function of pro-inflammatory interleukin IL-17 and IL-17 receptor in normal, benign hyperplastic, and malignant prostate
    • Steiner GE, Newman ME, Paikl D, et al. Expression and function of pro-inflammatory interleukin IL-17 and IL-17 receptor in normal, benign hyperplastic, and malignant prostate. Prostate 2003; 56: 171-182
    • (2003) Prostate , vol.56 , pp. 171-182
    • Steiner, G.E.1    Newman, M.E.2    Paikl, D.3
  • 16
    • 0042178346 scopus 로고    scopus 로고
    • Cytokine expression pattern in benign prostatic hyperplasia infiltrating T cells and impact of lymphocytic infiltration on cytokine mRNA profile in prostatic tissue
    • Steiner GE, Stix U, Handisurya A, et al. Cytokine expression pattern in benign prostatic hyperplasia infiltrating T cells and impact of lymphocytic infiltration on cytokine mRNA profile in prostatic tissue. Lab Invest 2003; 83: 1131-1146
    • (2003) Lab Invest , vol.83 , pp. 1131-1146
    • Steiner, G.E.1    Stix, U.2    Handisurya, A.3
  • 17
    • 33947247395 scopus 로고    scopus 로고
    • Is benign prostatic hyperplasia (BPH) an immune inflammatory disease?
    • Kramer G, Mitteregger D, Marberger M,. Is benign prostatic hyperplasia (BPH) an immune inflammatory disease? Eur Urol 2007; 51: 1202-1216
    • (2007) Eur Urol , vol.51 , pp. 1202-1216
    • Kramer, G.1    Mitteregger, D.2    Marberger, M.3
  • 18
    • 0036604284 scopus 로고    scopus 로고
    • Increased expression of lymphocyte-derived cytokines in benign hyperplastic prostate tissue, identification of the producing cell types, and effect of differentially expressed cytokines on stromal cell proliferation
    • Kramer G, Steiner GE, Handisurya A, et al. Increased expression of lymphocyte-derived cytokines in benign hyperplastic prostate tissue, identification of the producing cell types, and effect of differentially expressed cytokines on stromal cell proliferation. Prostate 2002; 52: 43-58
    • (2002) Prostate , vol.52 , pp. 43-58
    • Kramer, G.1    Steiner, G.E.2    Handisurya, A.3
  • 19
    • 70350457523 scopus 로고    scopus 로고
    • Inflammation in benign prostatic hyperplasia: A 282 patients' immunohistochemical analysis
    • Robert G, Descazeaud A, Nicolaiew N, et al. Inflammation in benign prostatic hyperplasia: a 282 patients' immunohistochemical analysis. Prostate 2009; 69: 1774-1780
    • (2009) Prostate , vol.69 , pp. 1774-1780
    • Robert, G.1    Descazeaud, A.2    Nicolaiew, N.3
  • 20
    • 0035209077 scopus 로고    scopus 로고
    • Differential expression of interleukin-15, a pro-inflammatory cytokine and T-cell growth factor, and its receptor in human prostate
    • Handisurya A, Steiner GE, Stix U, et al. Differential expression of interleukin-15, a pro-inflammatory cytokine and T-cell growth factor, and its receptor in human prostate. Prostate 2001; 49: 251-262
    • (2001) Prostate , vol.49 , pp. 251-262
    • Handisurya, A.1    Steiner, G.E.2    Stix, U.3
  • 21
    • 0034062135 scopus 로고    scopus 로고
    • Interferon-gamma and its functional receptors overexpression in benign prostatic hyperplasia and prostatic carcinoma: Parallelism with c-myc and p53 expression
    • Royuela M, de Miguel MP, Ruiz A, et al. Interferon-gamma and its functional receptors overexpression in benign prostatic hyperplasia and prostatic carcinoma: parallelism with c-myc and p53 expression. Eur Cytokine Netw 2000; 11: 119-127
    • (2000) Eur Cytokine Netw , vol.11 , pp. 119-127
    • Royuela, M.1    De Miguel, M.P.2    Ruiz, A.3
  • 22
    • 0035404541 scopus 로고    scopus 로고
    • Interleukin-8 is a paracrine inducer of fibroblast growth factor 2, a stromal and epithelial growth factor in benign prostatic hyperplasia
    • Giri D, Ittmann M,. Interleukin-8 is a paracrine inducer of fibroblast growth factor 2, a stromal and epithelial growth factor in benign prostatic hyperplasia. Am J Pathol 2001; 159: 139-147
    • (2001) Am J Pathol , vol.159 , pp. 139-147
    • Giri, D.1    Ittmann, M.2
  • 23
    • 40849105413 scopus 로고    scopus 로고
    • Chronic inflammation in benign prostatic hyperplasia: Implications for therapy
    • Wang L, Yang JR, Yang LY, Liu ZT,. Chronic inflammation in benign prostatic hyperplasia: implications for therapy. Med Hypotheses 2008; 70: 1021-1023
    • (2008) Med Hypotheses , vol.70 , pp. 1021-1023
    • Wang, L.1    Yang, J.R.2    Yang, L.Y.3    Liu, Z.T.4
  • 24
    • 55749103206 scopus 로고    scopus 로고
    • The relationship between prostate inflammation and lower urinary tract symptoms: Examination of baseline data from the REDUCE trial
    • Nickel JC, Roehrborn CG, O'Leary MP, Bostwick DG, Somerville MC, Rittmaster RS,. The relationship between prostate inflammation and lower urinary tract symptoms: examination of baseline data from the REDUCE trial. Eur Urol 2008; 54: 1379-1384
    • (2008) Eur Urol , vol.54 , pp. 1379-1384
    • Nickel, J.C.1    Roehrborn, C.G.2    O'Leary, M.P.3    Bostwick, D.G.4    Somerville, M.C.5    Rittmaster, R.S.6
  • 25
    • 21844464091 scopus 로고    scopus 로고
    • Do prostatic infarction, prostatic inflammation and prostate morphology play a role in acute urinary retention?
    • Tuncel A, Uzun B, Eruyar T, Karabulut E, Seckin S, Atan A,. Do prostatic infarction, prostatic inflammation and prostate morphology play a role in acute urinary retention? Eur Urol 2005; 48: 277-284
    • (2005) Eur Urol , vol.48 , pp. 277-284
    • Tuncel, A.1    Uzun, B.2    Eruyar, T.3    Karabulut, E.4    Seckin, S.5    Atan, A.6
  • 26
    • 76149137511 scopus 로고    scopus 로고
    • The impact of acute or chronic inflammation in baseline biopsy on the risk of clinical progression of BPH. Results from the MTOPS study
    • Abstract 1277
    • Roehrborn CG, Kaplan SA, Noble WD, Slawin KM, McVary KT, Kusek JW,. The impact of acute or chronic inflammation in baseline biopsy on the risk of clinical progression of BPH. Results from the MTOPS study. AUA Meeting 2005; Abstract 1277
    • (2005) AUA Meeting
    • Roehrborn, C.G.1    Kaplan, S.A.2    Noble, W.D.3    Slawin, K.M.4    McVary, K.T.5    Kusek, J.W.6
  • 27
    • 34447129024 scopus 로고    scopus 로고
    • Does intraprostatic inflammation have a role in the pathogenesis and progression of benign prostatic hyperplasia?
    • Mishra VC, Allen DJ, Nicolaou C, et al. Does intraprostatic inflammation have a role in the pathogenesis and progression of benign prostatic hyperplasia? BJU Int 2007; 100: 327-331
    • (2007) BJU Int , vol.100 , pp. 327-331
    • Mishra, V.C.1    Allen, D.J.2    Nicolaou, C.3
  • 28
    • 77951656146 scopus 로고    scopus 로고
    • The effect of intraprostatic chronic inflammation on benign prostatic hyperplasia treatment
    • Kwon YK, Choe MS, Seo KW, et al. The effect of intraprostatic chronic inflammation on benign prostatic hyperplasia treatment. Korean J Urol 2010; 51: 266-270
    • (2010) Korean J Urol , vol.51 , pp. 266-270
    • Kwon, Y.K.1    Choe, M.S.2    Seo, K.W.3
  • 29
    • 84874489939 scopus 로고    scopus 로고
    • Lower urinary tract symptoms in benign prostatic hyperplasia patients: Orchestrated by chronic prostatic inflammation and prostatic calculi?
    • Kim SH, Jung KI, Koh JS, Min KO, Cho SY, Kim HW,. Lower urinary tract symptoms in benign prostatic hyperplasia patients: orchestrated by chronic prostatic inflammation and prostatic calculi? Urol Int 2013; 90: 144-149
    • (2013) Urol Int , vol.90 , pp. 144-149
    • Kim, S.H.1    Jung, K.I.2    Koh, J.S.3    Min, K.O.4    Cho, S.Y.5    Kim, H.W.6
  • 30
    • 34547677616 scopus 로고    scopus 로고
    • Examination of the relationship between symptoms of prostatitis and histological inflammation: Baseline data from the REDUCE chemoprevention trial
    • Nickel JC, Roehrborn CG, O'Leary MP, Bostwick DG, Somerville MC, Rittmaster RS,. Examination of the relationship between symptoms of prostatitis and histological inflammation: baseline data from the REDUCE chemoprevention trial. J Urol 2007; 178: 896-901
    • (2007) J Urol , vol.178 , pp. 896-901
    • Nickel, J.C.1    Roehrborn, C.G.2    O'Leary, M.P.3    Bostwick, D.G.4    Somerville, M.C.5    Rittmaster, R.S.6
  • 31
    • 67049099210 scopus 로고    scopus 로고
    • Human C-reactive protein and the metabolic syndrome
    • Devaraj S, Singh U, Jialal I,. Human C-reactive protein and the metabolic syndrome. Curr Opin Lipidol 2009; 20: 182-189
    • (2009) Curr Opin Lipidol , vol.20 , pp. 182-189
    • Devaraj, S.1    Singh, U.2    Jialal, I.3
  • 32
    • 70350674101 scopus 로고    scopus 로고
    • Influence of exercise on the circulating levels and macrophage production of IL-1beta and IFNgamma affected by metabolic syndrome: An obese Zucker rat experimental animal model
    • Martin-Cordero L, Garcia JJ, Giraldo E, De la Fuente M, Manso R, Ortega E,. Influence of exercise on the circulating levels and macrophage production of IL-1beta and IFNgamma affected by metabolic syndrome: an obese Zucker rat experimental animal model. Eur J Appl Physiol 2009; 107: 535-543
    • (2009) Eur J Appl Physiol , vol.107 , pp. 535-543
    • Martin-Cordero, L.1    Garcia, J.J.2    Giraldo, E.3    De La Fuente, M.4    Manso, R.5    Ortega, E.6
  • 34
    • 36049004221 scopus 로고    scopus 로고
    • Inflamed adipose tissue: A culprit underlying the metabolic syndrome and atherosclerosis
    • Gustafson B, Hammarstedt A, Andersson CX, Smith U,. Inflamed adipose tissue: a culprit underlying the metabolic syndrome and atherosclerosis. Arterioscler Thromb Vasc Biol 2007; 27: 2276-2283
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 2276-2283
    • Gustafson, B.1    Hammarstedt, A.2    Andersson, C.X.3    Smith, U.4
  • 35
    • 33645452759 scopus 로고    scopus 로고
    • The dysregulated adipose tissue: A connecting link between insulin resistance, type 2 diabetes mellitus and atherosclerosis
    • Murdolo G, Smith U,. The dysregulated adipose tissue: a connecting link between insulin resistance, type 2 diabetes mellitus and atherosclerosis. Nutr Metab Cardiovasc Dis 2006; 16 (Suppl. 1): S35-38
    • (2006) Nutr Metab Cardiovasc Dis , vol.16 , Issue.SUPPL. 1
    • Murdolo, G.1    Smith, U.2
  • 36
    • 34548393257 scopus 로고    scopus 로고
    • Incidence and significance of prostatic stones in men with chronic prostatitis/chronic pelvic pain syndrome
    • Shoskes DA, Lee CT, Murphy D, Kefer J, Wood HM,. Incidence and significance of prostatic stones in men with chronic prostatitis/chronic pelvic pain syndrome. Urology 2007; 70: 235-238
    • (2007) Urology , vol.70 , pp. 235-238
    • Shoskes, D.A.1    Lee, C.T.2    Murphy, D.3    Kefer, J.4    Wood, H.M.5
  • 37
    • 0042237771 scopus 로고    scopus 로고
    • Prostatic calculi do not influence the level of serum prostate specific antigen in men without clinically detectable prostate cancer or prostatitis
    • Lee SE, Ku JH, Park HK, Jeong CK, Kim SH,. Prostatic calculi do not influence the level of serum prostate specific antigen in men without clinically detectable prostate cancer or prostatitis. J Urol 2003; 170: 745-748
    • (2003) J Urol , vol.170 , pp. 745-748
    • Lee, S.E.1    Ku, J.H.2    Park, H.K.3    Jeong, C.K.4    Kim, S.H.5
  • 39
    • 1242270499 scopus 로고    scopus 로고
    • Clinical correlation of prostatic lithiasis with chronic pelvic pain syndromes in young adults
    • Geramoutsos I, Gyftopoulos K, Perimenis P, et al. Clinical correlation of prostatic lithiasis with chronic pelvic pain syndromes in young adults. Eur Urol 2004; 45: 333-338
    • (2004) Eur Urol , vol.45 , pp. 333-338
    • Geramoutsos, I.1    Gyftopoulos, K.2    Perimenis, P.3
  • 40
  • 41
    • 5144229259 scopus 로고    scopus 로고
    • EAU 2004 guidelines on assessment, therapy and follow-up of men with lower urinary tract symptoms suggestive of benign prostatic obstruction (BPH guidelines)
    • Madersbacher S, Alivizatos G, Nordling J, Sanz CR, Emberton M, de la, Rosette JJ,. EAU 2004 guidelines on assessment, therapy and follow-up of men with lower urinary tract symptoms suggestive of benign prostatic obstruction (BPH guidelines). Eur Urol 2004; 46: 547-554
    • (2004) Eur Urol , vol.46 , pp. 547-554
    • Madersbacher, S.1    Alivizatos, G.2    Nordling, J.3    Sanz, C.R.4    De La, E.M.5    Rosette, J.J.6
  • 42
    • 67651111849 scopus 로고    scopus 로고
    • Evaluation of interleukin-8 in expressed prostatic secretion as a reliable biomarker of inflammation in benign prostatic hyperplasia
    • Liu L, Li Q, Han P, et al. Evaluation of interleukin-8 in expressed prostatic secretion as a reliable biomarker of inflammation in benign prostatic hyperplasia. Urology 2009; 74: 340-344
    • (2009) Urology , vol.74 , pp. 340-344
    • Liu, L.1    Li, Q.2    Han, P.3
  • 43
    • 33845570300 scopus 로고    scopus 로고
    • Seminal plasma cytokines and chemokines in prostate inflammation: Interleukin 8 as a predictive biomarker in chronic prostatitis/chronic pelvic pain syndrome and benign prostatic hyperplasia
    • Penna G, Mondaini N, Amuchastegui S, et al. Seminal plasma cytokines and chemokines in prostate inflammation: interleukin 8 as a predictive biomarker in chronic prostatitis/chronic pelvic pain syndrome and benign prostatic hyperplasia. Eur Urol 2007; 51: 524-533
    • (2007) Eur Urol , vol.51 , pp. 524-533
    • Penna, G.1    Mondaini, N.2    Amuchastegui, S.3
  • 44
    • 0037789398 scopus 로고    scopus 로고
    • Malondialdehyde in benign prostate hypertrophy: A useful marker?
    • Merendino RA, Salvo F, Saija A, et al. Malondialdehyde in benign prostate hypertrophy: a useful marker? Mediators Inflamm 2003; 12: 127-128
    • (2003) Mediators Inflamm , vol.12 , pp. 127-128
    • Merendino, R.A.1    Salvo, F.2    Saija, A.3
  • 45
    • 77949895153 scopus 로고    scopus 로고
    • Monocyte chemotactic protein-1 (MCP-1/CCL2) is associated with prostatic growth dysregulation and benign prostatic hyperplasia
    • Fujita K, Ewing CM, Getzenberg RH, Parsons JK, Isaacs WB, Pavlovich CP,. Monocyte chemotactic protein-1 (MCP-1/CCL2) is associated with prostatic growth dysregulation and benign prostatic hyperplasia. Prostate 2010; 70: 473-481
    • (2010) Prostate , vol.70 , pp. 473-481
    • Fujita, K.1    Ewing, C.M.2    Getzenberg, R.H.3    Parsons, J.K.4    Isaacs, W.B.5    Pavlovich, C.P.6
  • 46
    • 79952361851 scopus 로고    scopus 로고
    • A retrospective study: Correlation of histologic inflammation in biopsy specimens of Chinese men undergoing surgery for benign prostatic hyperplasia with serum prostate-specific antigen
    • Song L, Zhu Y, Han P, et al. A retrospective study: correlation of histologic inflammation in biopsy specimens of Chinese men undergoing surgery for benign prostatic hyperplasia with serum prostate-specific antigen. Urology 2011; 77: 688-692
    • (2011) Urology , vol.77 , pp. 688-692
    • Song, L.1    Zhu, Y.2    Han, P.3
  • 47
    • 2942584846 scopus 로고    scopus 로고
    • Interleukin-8 expression is increased in senescent prostatic epithelial cells and promotes the development of benign prostatic hyperplasia
    • Castro P, Xia C, Gomez L, Lamb DJ, Ittmann M,. Interleukin-8 expression is increased in senescent prostatic epithelial cells and promotes the development of benign prostatic hyperplasia. Prostate 2004; 60: 153-159
    • (2004) Prostate , vol.60 , pp. 153-159
    • Castro, P.1    Xia, C.2    Gomez, L.3    Lamb, D.J.4    Ittmann, M.5
  • 48
    • 80053204210 scopus 로고    scopus 로고
    • Biomarkers for the diagnosis of prostatic inflammation in benign prostatic hyperplasia
    • Robert G, Smit F, Hessels D, et al. Biomarkers for the diagnosis of prostatic inflammation in benign prostatic hyperplasia. Prostate 2011; 71: 1701-1709
    • (2011) Prostate , vol.71 , pp. 1701-1709
    • Robert, G.1    Smit, F.2    Hessels, D.3
  • 49
    • 62449309334 scopus 로고    scopus 로고
    • Anti-CTLA-4 therapy results in higher CD4+ICOShi T cell frequency and IFN-gamma levels in both nonmalignant and malignant prostate tissues
    • Chen H, Liakou CI, Kamat A, et al. Anti-CTLA-4 therapy results in higher CD4+ICOShi T cell frequency and IFN-gamma levels in both nonmalignant and malignant prostate tissues. Proc Natl Acad Sci USA 2009; 106: 2729-2734
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 2729-2734
    • Chen, H.1    Liakou, C.I.2    Kamat, A.3
  • 50
    • 84865484413 scopus 로고    scopus 로고
    • Hexanic lipidosterolic extract of Serenoa repens inhibits the expression of two key inflammatory mediators, MCP-1/CCL2 and VCAM-1, in vitro
    • Latil A, Libon C, Templier M, Junquero D, Lantoine-Adam F, Nguyen T,. Hexanic lipidosterolic extract of Serenoa repens inhibits the expression of two key inflammatory mediators, MCP-1/CCL2 and VCAM-1, in vitro. BJU Int 2012; 110: E301-307
    • (2012) BJU Int , vol.110
    • Latil, A.1    Libon, C.2    Templier, M.3    Junquero, D.4    Lantoine-Adam, F.5    Nguyen, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.