A Clinical Tool for Reducing Central Nervous System Depression among Neonates Exposed to Codeine through Breast Milk

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Kelly, Lauren E ^a,b,c   Chaudhry, Shahnaz A ^d,e   Rieder, Michael J ^a,b   't Jong, Geert ^d,e   Moretti, Myla E ^e   Lausman, Andrea ^h   Ross, Colin ^f   Berger, Howard ^h   Carleton, Bruce ^f,g   Hayden, Michael R ^f   Madadi, Parvaz ^d,e   Koren, Gideon ^c,d,e  

^a WESTERN UNIVERSITY   (Canada)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e HOSPITAL FOR SICK CHILDREN   (Canada)

^f UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^g UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^h ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE; COCODAMOL; CYTOCHROME P450 2D6; GLUCURONOSYLTRANSFERASE 2B7; MU OPIATE RECEPTOR; MULTIDRUG RESISTANCE PROTEIN 1;

ABCB1 GENE; ADULT; ARTICLE; BOTTLE FEEDING; BREAST MILK; CENTRAL NERVOUS SYSTEM DEPRESSION; CESAREAN SECTION; COMT GENE; CONSTIPATION; CYP2D6 GENE; DIZZINESS; DRUG DISPOSITION; DRUG METABOLISM; DRUG SAFETY; DRUG WITHDRAWAL; EVIDENCE BASED MEDICINE; FEMALE; GENE; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NAUSEA; NEWBORN; OPRM1 GENE; PERINATAL DRUG EXPOSURE; POSTOPERATIVE PAIN; PRACTICE GUIDELINE; PREDICTION; SALIVA ANALYSIS; SEDATION; SIDE EFFECT; TREATMENT DURATION; TREATMENT RESPONSE; UGT 2B7 GENE;

BREAST FEEDING; CENTRAL NERVOUS SYSTEM; CODEINE; CYTOCHROME P-450 CYP2D6; DEPRESSION; FEMALE; HUMANS; INFANT, NEWBORN; MALE; MILK, HUMAN; P-GLYCOPROTEIN; PREGNANCY; PROSPECTIVE STUDIES; RECEPTORS, OPIOID, MU;

EID: 84880807011     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070073     Document Type: Article

References (24)

1. Juurlink DN, Gomes T, Guttmann A, Hellings C, Sivilotti MLA, et al. (2012) Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: a retrospective cohort study. Clinical Toxicology 50: 390-395.
2. American Academy of Pediatrics Committee on Drugs (2001) Transfer of drugs and other chemicals into human milk. Pediatrics 108: 776-789.
3. World Health Organization Facts on Breastfeeding (2012) Available: http://www.who.int/features/factfiles/breastfeeding/en/index.html.Accessed 2013 Jan 18.
4. Statistics Canada- Breastfeeding (2009) Available: http://www.statcan.gc.ca/pub/82-625-x/2010002/article/11269-eng.html.Accessed 2012 Dec 11.
5. Canadian Institute for Health Information-Childbirth indicators by place of residence, 2009-2010. Available: http://apps.cihi.ca/MicroStrategy/asp/Main.aspx?server=torapprd30.cihi.ca&project=QuickStats&uid=pce_pub_en&pwd=&evt=2048001&visualizationMode=0&documentID=029DB170438205AEBCC75B8673CCE822. Accessed 2012 Dec 11.
6. Center for Disease Control-Births Methods of Delivery. Available: http://www.cdc.gov/nchs/fastats/delivery.html. Accessed 2012 Dec 11.
7. Crews KR, Gaedigk A, Dunnenberger HM, Klein TE, Shen DD, et al. (2012) Clinical Pharmacogenetics Implememntation Consortrium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype. Clin Pharmacol Ther 91: 321-326.
8. Kirchheiner J, Schmidt H, Tzvetkov M, Keulen JTHA, Lotsch J, et al. (2007) Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication. Pharmacogenomics 7: 257-265.
9. Madadi P, Ross CJD, Hayden MR, Carleton BC, Gaedigk A, et al. (2009) Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study. Clin Pharmacol Ther 85: 31-35.
10. Koren G, Cairns J, Chitayat D, Gaedigk A, Leeder SJ, (2006) Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother. Lancet 368: 704.
11. U.S. Food and Drug Administration (FDA). Public Health Advisory: Use of Codeine by Some Breastfeeding Mothers May Lead to Life-threatening Side Effects in Nursing Babies (2008) Available: http://www.fda.gov/cder/drug/advisory/codeine.html. Accessed 2012 Dec 11.
12. Health Canada - Use of Codeine Products by Nursing Mothers (2008). Available: http://www.hc-sc.gc.ca/ahc-asc/media/advisories-avis/_2008/2008_164-eng.php.Accessed on 2012 Dec 11.
13. Lam J, Kelly L, Ciszkowski C, Landsmeer MLA, Nauta M, et al. (2012) Central nervous system depression of neonates breastfed by mothers receiving oxycodone for postpartum analgesia. J Peds 160: 33-37.
14. Madadi P, Moretti M, Djokanovic N, Bozzo P, Nulman I, et al. (2009) Guidelines for maternal codeine use during breastfeeding. Can Fam Physician 55: 1077-1078.
15. Willmann S, Edginton AN, Coboeken K, Ahr G, Lippert J, (2009) Risk to the breast-fed neonate from codeine treatment to the mother: a quantitative mechanistic modeling study. Clin Pharmacol Ther 86: 634-643.
16. Sistonen J, Fuselli S, Levo A, Sajantila A, (2005) CYP2D6 genotyping by a multiplex primer extension reaction. Clin Chem 51: 1291-1295.
17. Gaedigk A, Simon SD, Pearce RE, Bradford LD, Kennedy MJ, et al. (2008) The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype. Clin Pharmacol Ther 83: 234-242.
18. Sistonen J, Madadi P, Ross CJ, Yazdanpanah M, Lee JW, et al. (2012) Prediction of codeine toxicity in infants and their mothers using a novel combination of maternal genetic markers. Clin Pharmacol Ther 91: 692-699.
19. Sawyer MB, Innocenti F, Das S, Cheng C, Ramirez J, et al. (2003) A pharmacogenetic study of Uridine diphosphate-glucuronosyltransferase 2B7 in patients receiving morphine. Clin Pharmacol Ther 73: 566-574.
20. Ross JR, Riley J, Taegetmeyer AB, Sato H, Gretton S, et al. (2008) Genetic variation and response to morphine in cancer patients: catechol-O-methyltransferase and multidrug resistance-1 gene polymorphisms are associated with central side effects. Cancer 112: 1390-1403.
21. Lotsch J Geisslinger G, (2005) Are mu-opioid receptor polymorphisms important for clinical opioid therapy? Trends Mol Med 11: 82-89.
22. Rakvag TT, Klepstad P, Baar C, Kvan TM, Dale O, et al. (2005) The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients. Pain 116: 73-78.
23. Madadi P, Koren G, (2008) Pharmacogenetic insights into codeine analgesia: implications to pediatric codeine use. Pharmacogenomics 9: 1267-1284.
24. Nauta M, Landsmeer ML, Koren G, (2009) Codeine-acetaminophen versus nonsteroidal anti-inflammatory drugs in the treatment of post-abdominal surgery pain: a systematic review of randomized trials. Am J Surg 198: 256-261.