Tranexamic acid and trauma: Current status and knowledge gaps with recommended research priorities

Shock

Volumn 40, Issue 2, 2013, Pages 160-161

  Reade, Michael C ^a   Pitt, Veronica ^b   Gruen, Russell L ^b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROCORTISONE; TRANEXAMIC ACID;

ARMY; BLEEDING; BLOOD COMPONENT THERAPY; BLOOD TRANSFUSION; DEEP VEIN THROMBOSIS; DEVELOPED COUNTRY; DRUG EFFICACY; DRUG MECHANISM; EARLY INTERVENTION; EQUIPOISE; GOVERNMENT; HUMAN; INJURY; LETTER; LUNG EMBOLISM; MEDICAL CARE; MORTALITY; OBSERVATIONAL STUDY; PRACTICE GUIDELINE; RESEARCH PRIORITY; RESUSCITATION; RISK BENEFIT ANALYSIS; SEPTIC SHOCK; SHOCK; SURGERY; THERMOREGULATION; TIME TO TREATMENT;

ANTIFIBRINOLYTIC AGENTS; HEMORRHAGE; HUMANS; TRANEXAMIC ACID; WOUNDS AND INJURIES;

EID: 84880803051     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e31829ab240     Document Type: Letter

References (10)

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2. Hodgetts T, Bland S, yers M, Davis P, Mahoney P, Russell R, Terrell A, Wilson D, Woolrich-Burt L, Green A, et al. JDP 4-03.1: Clinical Guidelines for Operations. London: UK Ministry of Defence; 2011.
3. Russell R, Bess A: JSP 999: Clinical Guidelines for Operations. London: UK Ministry of Defence; 2012.
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5. Dickey NW, Jenkins D: Recommendations Regarding the Addition of Tranexamic Acid to the Tactical Combat Casualty Care Guidelines 2011-06. Falls Church, VA: Defense Health Board; 2011.
6. Ker K, Kiriya J, Perel P, Edwards P, Shakur H, Roberts I: Avoidable mortality from giving tranexamic acid to bleeding trauma patients: An estimation based on WHO mortality data, a systematic literature review and data from the CRASH-2 trial. BMC Emerg Med 12:3, 2012.
7. Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): A randomised, placebo-controlled trial. Lancet 376(9734):23-32, 2010.
8. Morrison JJ, DuBose JJ, Rasmussen TE, Midwinter MJ: Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERS) study. Arch Surg 147(2):113-119, 2012.
9. Victorian State Trauma Registry 2008-2009 Summary Report. Melbourne, Victoria, Australia: Victorian Government; 2010.
10. Sprung CL, Annane D, Keh D, Moreno R, Singer M, Freivogel K, Weiss YG, Benbenishty J, Kalenka A, Forst H, et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med 358(2):111-124, 2008.