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Volumn 16, Issue 3, 2013, Pages 411-419

A phase II study of modified FOLFOX as first-line chemotherapy for metastatic gastric cancer in elderly patients with associated diseases

Author keywords

Elderly; Metastatic gastric cancer; Oxaliplatin; Palliative chemotherapy

Indexed keywords

ERYTHROPOIETIN; FLUOROURACIL; FOLINIC ACID; GLUTATHIONE; GRANULOCYTE COLONY STIMULATING FACTOR; OXALIPLATIN;

EID: 84880788958     PISSN: 14363291     EISSN: 14363305     Source Type: Journal    
DOI: 10.1007/s10120-012-0204-z     Document Type: Article
Times cited : (38)

References (29)
  • 3
    • 33750949065 scopus 로고    scopus 로고
    • Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: A report of the V325 Study Group
    • 17075117 10.1200/JCO.2006.06.8429
    • Van Cutsem E, Moiseyenko VM, Tjulandin S, Majlis A, Constenla M, Boni C, et al. Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 Study Group. J Clin Oncol. 2006;24:4991-7.
    • (2006) J Clin Oncol , vol.24 , pp. 4991-4997
    • Van Cutsem, E.1    Moiseyenko, V.M.2    Tjulandin, S.3    Majlis, A.4    Constenla, M.5    Boni, C.6
  • 4
    • 38049047178 scopus 로고    scopus 로고
    • Capecitabine and oxaliplatin for advanced esophagogastric cancer
    • 18172173 10.1056/NEJMoa073149 1:CAS:528:DC%2BD1cXisFSktg%3D%3D
    • Cunningham D, Starling N, Rao S, Iveson T, Nicolson M, Coxon F, et al. Capecitabine and oxaliplatin for advanced esophagogastric cancer. N Engl J Med. 2008;358:36-46.
    • (2008) N Engl J Med , vol.358 , pp. 36-46
    • Cunningham, D.1    Starling, N.2    Rao, S.3    Iveson, T.4    Nicolson, M.5    Coxon, F.6
  • 5
    • 16544371710 scopus 로고    scopus 로고
    • Enrollment of elderly patients in clinical trials for cancer drug registration: A 7-year experience by the US Food and Drug Administration
    • 15542812 10.1200/JCO.2004.02.175
    • Talarico L, Chen G, Pazdur R. Enrollment of elderly patients in clinical trials for cancer drug registration: a 7-year experience by the US Food and Drug Administration. J Clin Oncol. 2004;22:4626-31.
    • (2004) J Clin Oncol , vol.22 , pp. 4626-4631
    • Talarico, L.1    Chen, G.2    Pazdur, R.3
  • 7
    • 41149154862 scopus 로고    scopus 로고
    • Phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil, leucovorin plus either oxaliplatin or cisplatin: A study of the Arbeitsgemeinschaft Internistische Onkologie
    • Al Batran SE, Hartmann JT, Probst S, Schmalenberg H, Hollerbach S, Hofheinz R, et al. Phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil, leucovorin plus either oxaliplatin or cisplatin: a study of the Arbeitsgemeinschaft Internistische Onkologie. J Clin Oncol 2008;26:1435-42.
    • (2008) J Clin Oncol , vol.26 , pp. 1435-1442
    • Al Batran, S.E.1    Hartmann, J.T.2    Probst, S.3    Schmalenberg, H.4    Hollerbach, S.5    Hofheinz, R.6
  • 8
    • 0036893770 scopus 로고    scopus 로고
    • Phase II study of oxaliplatin, fluorouracil, and folinic acid in locally advanced or metastatic gastric cancer patients
    • 12454110 10.1200/JCO.2002.02.021 1:CAS:528:DC%2BD38XovVeisLw%3D
    • Louvet C, André T, Tigaud JM, Gamelin E, Douillard JY, Brunet R, et al. Phase II study of oxaliplatin, fluorouracil, and folinic acid in locally advanced or metastatic gastric cancer patients. J Clin Oncol. 2002;20:4543-8.
    • (2002) J Clin Oncol , vol.20 , pp. 4543-4548
    • Louvet, C.1    André, T.2    Tigaud, J.M.3    Gamelin, E.4    Douillard, J.Y.5    Brunet, R.6
  • 9
    • 1442307855 scopus 로고    scopus 로고
    • Phase II trial of biweekly infusional fluorouracil, folinic acid, and oxaliplatin in patients with advanced gastric cancer
    • 14966088 10.1200/JCO.2004.07.042 1:CAS:528:DC%2BD2cXpsVajs7Y%3D
    • Al-Batran SE, Atmaca A, Hegewisch-Becker S, Jaeger D, Hahnfeld S, Rummel MJ, et al. Phase II trial of biweekly infusional fluorouracil, folinic acid, and oxaliplatin in patients with advanced gastric cancer. J Clin Oncol. 2004;22:658-63.
    • (2004) J Clin Oncol , vol.22 , pp. 658-663
    • Al-Batran, S.E.1    Atmaca, A.2    Hegewisch-Becker, S.3    Jaeger, D.4    Hahnfeld, S.5    Rummel, M.J.6
  • 10
    • 4243135036 scopus 로고    scopus 로고
    • Phase II study of weekly oxaliplatin and 24-h infusion of high-dose 5-fluorouracil and folinic acid in the treatment of advanced gastric cancer
    • 15226770 10.1038/sj.bjc.6601985 1:CAS:528:DC%2BD2cXlvF2lsb4%3D
    • Chao Y, Yeh KH, Chang CJ, Chen LT, Chao TY, Wu MF, et al. Phase II study of weekly oxaliplatin and 24-h infusion of high-dose 5-fluorouracil and folinic acid in the treatment of advanced gastric cancer. Br J Cancer. 2004;91:453-8.
    • (2004) Br J Cancer , vol.91 , pp. 453-458
    • Chao, Y.1    Yeh, K.H.2    Chang, C.J.3    Chen, L.T.4    Chao, T.Y.5    Wu, M.F.6
  • 11
    • 21144476975 scopus 로고    scopus 로고
    • A phase II study of biweekly oxaliplatin plus infusional 5-fluorouracil and folinic acid (FOLFOX-4) as first-line treatment of advanced gastric cancer patients
    • 15856038 10.1038/sj.bjc.6602573
    • De Vita F, Orditura M, Matano E, Bianco R, Carlomagno C, Infusino S, et al. A phase II study of biweekly oxaliplatin plus infusional 5-fluorouracil and folinic acid (FOLFOX-4) as first-line treatment of advanced gastric cancer patients. Br J Cancer. 2005;92:1644-9.
    • (2005) Br J Cancer , vol.92 , pp. 1644-1649
    • De Vita, F.1    Orditura, M.2    Matano, E.3    Bianco, R.4    Carlomagno, C.5    Infusino, S.6
  • 12
    • 23744457430 scopus 로고    scopus 로고
    • Phase II study of weekly oxaliplatin plus infusional fluorouracil and folinic acid (FUFOX regimen) as first-line treatment in metastatic gastric cancer
    • 16012522 10.1038/sj.bjc.6602697 1:CAS:528:DC%2BD2MXmt1yhurg%3D
    • Lordick F, Lorenzen S, Stollfuss J, Vehling-Kaiser U, Kullmann F, Hentrich M, et al. Phase II study of weekly oxaliplatin plus infusional fluorouracil and folinic acid (FUFOX regimen) as first-line treatment in metastatic gastric cancer. Br J Cancer. 2005;93:190-4.
    • (2005) Br J Cancer , vol.93 , pp. 190-194
    • Lordick, F.1    Lorenzen, S.2    Stollfuss, J.3    Vehling-Kaiser, U.4    Kullmann, F.5    Hentrich, M.6
  • 13
    • 70350638760 scopus 로고    scopus 로고
    • Oxaliplatin, 5-FU, folinic acid as first-line palliative chemotherapy in elderly patients with metastatic or recurrent gastric cancer
    • 19746224 10.4143/crt.2007.39.3.99
    • Choi IS, Oh D-Y, Kim B-S, Lee K-W, Kim JH, Lee J-S. Oxaliplatin, 5-FU, folinic acid as first-line palliative chemotherapy in elderly patients with metastatic or recurrent gastric cancer. Cancer Res Treat. 2007;39:99-103.
    • (2007) Cancer Res Treat , vol.39 , pp. 99-103
    • Choi, I.S.1    Oh, D.-Y.2    Kim, B.-S.3    Lee, K.-W.4    Kim, J.H.5    Lee, J.-S.6
  • 14
    • 33846953183 scopus 로고    scopus 로고
    • FOLFOX-4 regimen as fist-line chemotherapy in elderly patients with advanced gastric cancer: A safety study
    • 17309856 1:CAS:528:DC%2BD2sXislSgs78%3D
    • Nardi M, Azzarello D, Maisano R, Del Medico P, Giannicola R, Raffaele M, et al. FOLFOX-4 regimen as fist-line chemotherapy in elderly patients with advanced gastric cancer: a safety study. J Chemother. 2007;19:85-9.
    • (2007) J Chemother , vol.19 , pp. 85-89
    • Nardi, M.1    Azzarello, D.2    Maisano, R.3    Del Medico, P.4    Giannicola, R.5    Raffaele, M.6
  • 15
    • 44949176223 scopus 로고    scopus 로고
    • Biweekly oxaliplatin in combination with continuous infusional 5-fluorouracil and leucovorin (modified FOLFOX-4 regimen) as first-line chemotherapy for elderly patients with advanced gastric cancer
    • 18525305 10.1097/COC.0b013e31815d43ee
    • Liu ZF, Guo QS, Zhang XQ, Yang XG, Guan F, Fu Z, et al. Biweekly oxaliplatin in combination with continuous infusional 5-fluorouracil and leucovorin (modified FOLFOX-4 regimen) as first-line chemotherapy for elderly patients with advanced gastric cancer. Am J Clin Oncol. 2008;31:259-63.
    • (2008) Am J Clin Oncol , vol.31 , pp. 259-263
    • Liu, Z.F.1    Guo, Q.S.2    Zhang, X.Q.3    Yang, X.G.4    Guan, F.5    Fu, Z.6
  • 16
    • 63449126697 scopus 로고    scopus 로고
    • A phase II study of modified FOLFOX as first-line chemotherapy in elderly patients with advanced gastric cancer
    • 19247179 10.1097/CAD.0b013e328324bbc1 1:CAS:528:DC%2BD1MXivFSht7o%3D
    • Zhao JG, Qiu F, Xiong JP, Zhang L, Xiang XJ, Yu F, et al. A phase II study of modified FOLFOX as first-line chemotherapy in elderly patients with advanced gastric cancer. Anticancer Drugs. 2009;20:281-6.
    • (2009) Anticancer Drugs , vol.20 , pp. 281-286
    • Zhao, J.G.1    Qiu, F.2    Xiong, J.P.3    Zhang, L.4    Xiang, X.J.5    Yu, F.6
  • 17
    • 77957827587 scopus 로고    scopus 로고
    • 5-fluorouracil, leucovorin, and oxaliplatin with or without docetaxel in elderly (65 years or older) patients with esophagogastric cancer: FLOT65 ± trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO)
    • abstract 4013
    • Al-Batran S, Homann N, Hartmann JT, Moehler MH, Pauligk C, Probst S, et al. 5-fluorouracil, leucovorin, and oxaliplatin with or without docetaxel in elderly (65 years or older) patients with esophagogastric cancer: FLOT65 ± trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO). J Clin Oncol 2010;28(15 suppl): abstract 4013.
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Al-Batran, S.1    Homann, N.2    Hartmann, J.T.3    Moehler, M.H.4    Pauligk, C.5    Probst, S.6
  • 18
    • 0030935080 scopus 로고    scopus 로고
    • Functional health status as a predictor of mortality in men and women over 65
    • 9120528 10.1016/S0895-4356(96)00365-4 1:STN:280:DyaK2s3ks1Kluw%3D%3D
    • Scott WK, Macera CA, Cornman CB, Sharpe PA. Functional health status as a predictor of mortality in men and women over 65. J Clin Epidemiol. 1997;50:291-6.
    • (1997) J Clin Epidemiol , vol.50 , pp. 291-296
    • Scott, W.K.1    Macera, C.A.2    Cornman, C.B.3    Sharpe, P.A.4
  • 19
    • 33745104452 scopus 로고    scopus 로고
    • Weekly oxaliplatin, 5-fluorouracil and folinic acid (OXALF) as first-line chemotherapy for elderly patients with advanced gastric cancer: Results of a phase II trial
    • 16686939 10.1186/1471-2407-6-125 1:STN:280:DC%2BD28zltFSmtA%3D%3D
    • Santini D, Graziano F, Catalano V, Di Seri M, Testa E, Baldelli AM, et al. Weekly oxaliplatin, 5-fluorouracil and folinic acid (OXALF) as first-line chemotherapy for elderly patients with advanced gastric cancer: results of a phase II trial. BMC Cancer. 2006;6:125.
    • (2006) BMC Cancer , vol.6 , pp. 125
    • Santini, D.1    Graziano, F.2    Catalano, V.3    Di Seri, M.4    Testa, E.5    Baldelli, A.M.6
  • 20
    • 67650287649 scopus 로고    scopus 로고
    • Validation of the Royal Marsden hospital prognostic index in advanced esophagogastric cancer using individual patient data from the REAL 2 study
    • 19470917 10.1200/JCO.2009.22.0863
    • Chau I, Ashley S, Cunningham D. Validation of the Royal Marsden hospital prognostic index in advanced esophagogastric cancer using individual patient data from the REAL 2 study. J Clin Oncol. 2009;27:e3-4.
    • (2009) J Clin Oncol , vol.27
    • Chau, I.1    Ashley, S.2    Cunningham, D.3
  • 21
    • 0036100183 scopus 로고    scopus 로고
    • A case for geriatric oncology
    • 12067806 10.1016/S1470-2045(02)00730-1
    • Repetto L, Balducci L. A case for geriatric oncology. Lancet Oncol. 2002;3:289-97.
    • (2002) Lancet Oncol , vol.3 , pp. 289-297
    • Repetto, L.1    Balducci, L.2
  • 22
    • 34249779624 scopus 로고    scopus 로고
    • International society of geriatric oncology chemotherapy taskforce: Evaluation of chemotherapy in older patients - An analysis of the medical literature
    • 17488981 10.1200/JCO.2007.10.6583 1:CAS:528:DC%2BD2sXmtl2itLc%3D
    • Lichtman SM, Wildiers H, Chatelut E, Steer C, Budman D, Morrison VA, et al. International society of geriatric oncology chemotherapy taskforce: evaluation of chemotherapy in older patients - an analysis of the medical literature. J Clin Oncol. 2007;25:1832-43.
    • (2007) J Clin Oncol , vol.25 , pp. 1832-1843
    • Lichtman, S.M.1    Wildiers, H.2    Chatelut, E.3    Steer, C.4    Budman, D.5    Morrison, V.A.6
  • 23
  • 24
    • 19444366654 scopus 로고    scopus 로고
    • Systematic review of barriers to the recruitment of older patients with cancer onto clinical trials
    • 15860871 10.1200/JCO.2005.00.141
    • Townsley CA, Selby R, Siu LL. Systematic review of barriers to the recruitment of older patients with cancer onto clinical trials. J Clin Oncol. 2005;23:3112-24.
    • (2005) J Clin Oncol , vol.23 , pp. 3112-3124
    • Townsley, C.A.1    Selby, R.2    Siu, L.L.3
  • 25
    • 77954896526 scopus 로고    scopus 로고
    • Gastric cancer in the elderly: An overview
    • 20542657 10.1016/j.ejso.2010.05.023 1:STN:280:DC%2BC3cnovFGlsw%3D%3D
    • Saif MW, Makrilia N, Zalonis A, Merikas M, Syrigos K. Gastric cancer in the elderly: an overview. Eur J Surg Oncol. 2010;36:709-17.
    • (2010) Eur J Surg Oncol , vol.36 , pp. 709-717
    • Saif, M.W.1    Makrilia, N.2    Zalonis, A.3    Merikas, M.4    Syrigos, K.5
  • 27
    • 33646196614 scopus 로고    scopus 로고
    • Efficacy and tolerability of chemotherapy in elderly patients with advanced oesophago-gastric cancer: A pooled analysis of three clinical trials
    • 16466913 10.1016/j.ejca.2005.08.044 1:CAS:528:DC%2BD28XksVOitLs%3D
    • Trumper M, Ross PJ, Cunningham D, Norman AR, Hawkins R, Seymour M, et al. Efficacy and tolerability of chemotherapy in elderly patients with advanced oesophago-gastric cancer: a pooled analysis of three clinical trials. Eur J Cancer. 2006;42:827-34.
    • (2006) Eur J Cancer , vol.42 , pp. 827-834
    • Trumper, M.1    Ross, P.J.2    Cunningham, D.3    Norman, A.R.4    Hawkins, R.5    Seymour, M.6
  • 28
    • 33746796828 scopus 로고    scopus 로고
    • Oxaliplatin in combination with 5-fluorouracil (5-FU) and leucovorin (LV) in patients with metastatic gastric cancer (MGC)
    • 16891864 10.1097/01.coc.0000221358.57089.f2 1:CAS:528: DC%2BD28XptVKisbk%3D
    • Cavanna L, Artioli F, Codignola C, Lazzaro A, Rizzi A, Gamboni A, et al. Oxaliplatin in combination with 5-fluorouracil (5-FU) and leucovorin (LV) in patients with metastatic gastric cancer (MGC). Am J Clin Oncol. 2006;29:371-5.
    • (2006) Am J Clin Oncol , vol.29 , pp. 371-375
    • Cavanna, L.1    Artioli, F.2    Codignola, C.3    Lazzaro, A.4    Rizzi, A.5    Gamboni, A.6
  • 29
    • 80052344343 scopus 로고    scopus 로고
    • Evaluation of efficacy and safety of FOLFIRI for elderly patients with gastric cancer: A first-line phase II study
    • 21907007 10.1016/j.clinre.2011.08.002 1:CAS:528:DC%2BC3MXhsF2rtL%2FI
    • Fonck M, Brunet R, Becouarn Y, Legoux JL, Dauba J, Cany L, et al. Evaluation of efficacy and safety of FOLFIRI for elderly patients with gastric cancer: a first-line phase II study. Clin Res Hepatol Gastroenterol. 2011;35:823-30.
    • (2011) Clin Res Hepatol Gastroenterol , vol.35 , pp. 823-830
    • Fonck, M.1    Brunet, R.2    Becouarn, Y.3    Legoux, J.L.4    Dauba, J.5    Cany, L.6


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