MRI Plaque Imaging Detects Carotid Plaques with a High Risk for Future Cerebrovascular Events in Asymptomatic Patients

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Esposito Bauer, Lorena ^a,g   Saam, Tobias ^b   Ghodrati, Iman ^a   Pelisek, Jaroslav ^a   Heider, Peter ^c   Bauer, Matthias ^d   Wolf, Petra ^e   Bockelbrink, Angelina ^f   Feurer, Regina ^a   Sepp, Dominik ^a   Winkler, Claudia ^a   Zepper, Peter ^a   Boeckh Behrens, Tobias ^a   Riemenschneider, Matthias ^g   Hemmer, Bernhard ^a   Poppert, Holger ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c Isar Medizin Zentrum   (Germany)

^d Bethesda Spital Basel ^*  (Switzerland)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^f CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^g SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; ASYMPTOMATIC DISEASE; CAROTID ARTERY OBSTRUCTION; CAROTID ATHEROSCLEROSIS; CEREBROVASCULAR DISEASE; CLINICAL EFFECTIVENESS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE CLASSIFICATION; EVENT FREE SURVIVAL; FEMALE; FOLLOW UP; HIGH RISK PATIENT; HUMAN; IMAGE ANALYSIS; IMAGE QUALITY; MAJOR CLINICAL STUDY; MALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PROSPECTIVE STUDY; RISK ASSESSMENT; SURVIVAL RATE; TRANSIENT ISCHEMIC ATTACK; TRANSITIONAL BLINDNESS;

EID: 84880769243     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067927     Document Type: Article

References (42)

1. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study (1995) Endarterectomy for asymptomatic carotid artery stenosis. Jama 273: 1421-1428.
2. Robless P, Baxter A, Byrd S, Emson M, Halliday A, (1998) Prevalence of asymptomatic CT infarcts in the ongoing Asymptomatic Carotid Surgery Trial (ACST). Int Angiol 17: 194-200.
3. Falk E, (1992) Why do plaques rupture? Circulation 86: III30-42.
4. Carr S, Farb A, Pearce WH, Virmani R, Yao JS, (1996) Atherosclerotic plaque rupture in symptomatic carotid artery stenosis. J Vasc Surg 23: 755-765; discussion 765-756.
5. Bassiouny HS, Sakaguchi Y, Mikucki SA, McKinsey JF, Piano G, et al. (1997) Juxtalumenal location of plaque necrosis and neoformation in symptomatic carotid stenosis. J Vasc Surg 26: 585-594.
6. Lusby RJ, Ferrell LD, Ehrenfeld WK, Stoney RJ, Wylie EJ, (1982) Carotid plaque hemorrhage. Its role in production of cerebral ischemia. Arch Surg 117: 1479-1488.
7. Virmani R, Kolodgie FD, Burke AP, Finn AV, Gold HK, et al. (2005) Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage. Arterioscler Thromb Vasc Biol 25: 2054-2061.
8. Mofidi R, Crotty TB, McCarthy P, Sheehan SJ, Mehigan D, et al. (2001) Association between plaque instability, angiogenesis and symptomatic carotid occlusive disease. Br J Surg 88: 945-950.
9. Chu B, Kampschulte A, Ferguson MS, Kerwin WS, Yarnykh VL, et al. (2004) Hemorrhage in the atherosclerotic carotid plaque: a high-resolution MRI study. Stroke 35: 1079-1084.
10. Hatsukami TS, Ross R, Polissar NL, Yuan C, (2000) Visualization of fibrous cap thickness and rupture in human atherosclerotic carotid plaque in vivo with high-resolution magnetic resonance imaging. Circulation 102: 959-964.
11. Yuan C, Mitsumori LM, Beach KW, Maravilla KR, (2001) Carotid atherosclerotic plaque: noninvasive MR characterization and identification of vulnerable lesions. Radiology 221: 285-299.
12. Tartari S, Rizzati R, Righi R, Deledda A, Capello K, et al. (2011) High-resolution MRI of carotid plaque with a neurovascular coil and contrast-enhanced MR angiography: one-stop shopping for the comprehensive assessment of carotid atherosclerosis. AJR Am J Roentgenol 196: 1164-1171.
13. Wang Y, Wang QJ, Cai YQ, Ma L, Cai JM, (2011) [Evaluation of atherosclerotic carotid plaque composition with magnetic resonance imaging using different sequences]. Nan Fang Yi Ke Da Xue Xue Bao 31: 299-303.
14. Qiao Y, Etesami M, Malhotra S, Astor BC, Virmani R, et al. (2011) Identification of intraplaque hemorrhage on MR angiography images: a comparison of contrast-enhanced mask and time-of-flight techniques. AJNR Am J Neuroradiol 32: 454-459.
15. Underhill HR, Yuan C, Zhao XQ, Kraiss LW, Parker DL, et al. (2008) Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: a high-resolution magnetic resonance imaging trial. Am Heart J 155: 584 e581-588.
16. Wasserman BA, (2010) Advanced contrast-enhanced MRI for looking beyond the lumen to predict stroke: building a risk profile for carotid plaque. Stroke 41: S12-16.
17. Hatsukami TS, Yuan C, (2010) MRI in the early identification and classification of high-risk atherosclerotic carotid plaques. Imaging Med 2: 63-75.
18. Stary HC, Chandler AB, Glagov S, Guyton JR, Insull W Jr, et al. (1994) A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Arterioscler Thromb 14: 840-856.
19. Stary HC, Chandler AB, Dinsmore RE, Fuster V, Glagov S, et al. (1995) A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 92: 1355-1374.
20. Cai JM, Hatsukami TS, Ferguson MS, Small R, Polissar NL, et al. (2002) Classification of human carotid atherosclerotic lesions with in vivo multicontrast magnetic resonance imaging. Circulation 106: 1368-1373.
21. Yuan C, Mitsumori LM, Ferguson MS, Polissar NL, Echelard D, et al. (2001) In vivo accuracy of multispectral magnetic resonance imaging for identifying lipid-rich necrotic cores and intraplaque hemorrhage in advanced human carotid plaques. Circulation 104: 2051-2056.
22. Demarco JK, Ota H, Underhill HR, Zhu DC, Reeves MJ, et al. (2010) MR carotid plaque imaging and contrast-enhanced MR angiography identifies lesions associated with recent ipsilateral thromboembolic symptoms: an in vivo study at 3T. AJNR Am J Neuroradiol 31: 1395-1402.
23. Esposito L, Sievers M, Sander D, Heider P, Wolf O, et al. (2007) Detection of unstable carotid artery stenosis using MRI. J Neurol 254: 1714-1722.
24. Esposito L, Saam T, Heider P, Bockelbrink A, Pelisek J, et al. (2010) MRI plaque imaging reveals high-risk carotid plaques especially in diabetic patients irrespective of the degree of stenosis. BMC medical imaging 10: 27.
25. Takaya N, Yuan C, Chu B, Saam T, Underhill H, et al. (2006) Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI-initial results. Stroke 37: 818-823.
26. Sepp D, Esposito L, Zepper P, Ott I, Feurer R, et al. (2009) Surface expression of CXCR4 on circulating CD133progenitor cells is associated with plaque instability in subjects with carotid artery stenosis. Journal of angiogenesis research 1: 10.
27. Widder B, von Reutern GM, Neuerburg-Heusler D, (1986) [Morphologic and Doppler sonographic criteria for determining the degree of stenosis of the internal carotid artery]. Ultraschall in der Medizin 7: 70-75.
28. Peduzzi P, Concato J, Feinstein AR, Holford TR, (1995) Importance of events per independent variable in proportional hazards regression analysis. II. Accuracy and precision of regression estimates. J Clin Epidemiol 48: 1503-1510.
29. Altaf N, Daniels L, Morgan PS, Auer D, MacSweeney ST, et al. (2008) Detection of intraplaque hemorrhage by magnetic resonance imaging in symptomatic patients with mild to moderate carotid stenosis predicts recurrent neurological events. J Vasc Surg 47: 337-342.
30. Altaf N, MacSweeney ST, Gladman J, Auer DP, (2007) Carotid intraplaque hemorrhage predicts recurrent symptoms in patients with high-grade carotid stenosis. Stroke 38: 1633-1635.
31. Lin K, Zhang ZQ, Detrano R, Lu B, Fan ZM, (2006) Carotid vulnerable lesions are related to accelerated recurrence for cerebral infarction magnetic resonance imaging study. Acad Radiol 13: 1180-1186.
32. Parmar JP, Rogers WJ, Mugler JP 3rd, Baskurt E, Altes TA, et al. (2010) Magnetic resonance imaging of carotid atherosclerotic plaque in clinically suspected acute transient ischemic attack and acute ischemic stroke. Circulation 122: 2031-2038.
33. Singh N, Moody AR, Gladstone DJ, Leung G, Ravikumar R, et al. (2009) Moderate carotid artery stenosis: MR imaging-depicted intraplaque hemorrhage predicts risk of cerebrovascular ischemic events in asymptomatic men. Radiology 252: 502-508.
34. Altaf N, Goode SD, Beech A, Gladman JR, Morgan PS, et al. (2011) Plaque hemorrhage is a marker of thromboembolic activity in patients with symptomatic carotid disease. Radiology 258: 538-545.
35. Kurosaki Y, Yoshida K, Endo H, Chin M, Yamagata S, (2011) Association between carotid atherosclerosis plaque with high signal intensity on T1-weighted imaging and subsequent ipsilateral ischemic events. Neurosurgery 68: 62-67; discussion 67.
36. Underhill HR, Yuan C, Yarnykh VL, Chu B, Oikawa M, et al. (2010) Predictors of surface disruption with MR imaging in asymptomatic carotid artery stenosis. AJNR Am J Neuroradiol 31: 487-493.
37. Touze E, Toussaint JF, Coste J, Schmitt E, Bonneville F, et al. (2007) Reproducibility of high-resolution MRI for the identification and the quantification of carotid atherosclerotic plaque components: consequences for prognosis studies and therapeutic trials. Stroke 38: 1812-1819.
38. Goessens BM, Visseren FL, Kappelle LJ, Algra A, van der Graaf Y, (2007) Asymptomatic carotid artery stenosis and the risk of new vascular events in patients with manifest arterial disease: the SMART study. Stroke 38: 1470-1475.
39. Spence JD, Coates V, Li H, Tamayo A, Munoz C, et al. (2010) Effects of intensive medical therapy on microemboli and cardiovascular risk in asymptomatic carotid stenosis. Arch Neurol 67: 180-186.
40. Marquardt L, Geraghty OC, Mehta Z, Rothwell PM, (2010) Low risk of ipsilateral stroke in patients with asymptomatic carotid stenosis on best medical treatment: a prospective, population-based study. Stroke 41: e11-17.
41. Nicolaides AN, Kakkos SK, Griffin M, Sabetai M, Dhanjil S, et al. (2005) Severity of asymptomatic carotid stenosis and risk of ipsilateral hemispheric ischaemic events: results from the ACSRS study. Eur J Vasc Endovasc Surg 30: 275-284.
42. Halliday A, Mansfield A, Marro J, Peto C, Peto R, et al. (2004) Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial. Lancet 363: 1491-1502.