Activation of Wnt/β-Catenin Pathway in Monocytes Derived from Chronic Kidney Disease Patients

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Al Chaqmaqchi, Heevy Abdulkareem Musa ^a   Moshfegh, Ali ^b   Dadfar, Elham ^b   Paulsson, Josefin ^b   Hassan, Moustapha ^b   Jacobson, Stefan H ^c   Lundahl, Joachim ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c DANDERYD HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; WNT PROTEIN; RNA;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; CHRONIC KIDNEY DISEASE; CLINICAL ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GLOMERULUS FILTRATION RATE; HUMAN; HUMAN CELL; INFECTION SENSITIVITY; MICROARRAY ANALYSIS; MONOCYTE; PATHOPHYSIOLOGY; RNA EXTRACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; CASE CONTROL STUDY; CELL LINEAGE; CHRONIC KIDNEY FAILURE; DENSITOMETRY; DONOR; GENE EXPRESSION PROFILING; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MIDDLE AGED; PATHOLOGY; WNT SIGNALING PATHWAY;

AGED; BLOTTING, WESTERN; CASE-CONTROL STUDIES; CELL LINEAGE; DENSITOMETRY; GENE EXPRESSION PROFILING; HUMANS; MIDDLE AGED; MONOCYTES; RENAL INSUFFICIENCY, CHRONIC; RNA; TISSUE DONORS; UP-REGULATION; WNT SIGNALING PATHWAY;

EID: 84880758820     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068937     Document Type: Article

References (45)

1. Cohen G, Haag-Weber M, Horl WH (1997) Immune dysfunction in uremia. Kidney Int Suppl 62: S79-82.
2. Hauser AB, Stinghen AE, Kato S, Bucharles S, Aita C, et al. (2008) Characteristics and causes of immune dysfunction related to uremia and dialysis. Perit Dial Int 28Suppl 3: S183-187.
3. Haag-Weber M, Horl WH, (1996) Dysfunction of polymorphonuclear leukocytes in uremia. Semin Nephrol 16: 192-201.
4. Kato S, Chmielewski M, Honda H, Pecoits-Filho R, Matsuo S, et al. (2008) Aspects of immune dysfunction in end-stage renal disease. Clin J Am Soc Nephrol 3: 1526-1533.
5. Amann K, Tyralla K, Gross ML, Eifert T, Adamczak M, et al. (2003) Special characteristics of atherosclerosis in chronic renal failure. Clin Nephrol 60Suppl 1: S13-21.
6. Yilmaz MI, Carrero JJ, Axelsson J, Lindholm B, Stenvinkel P, (2007) Low-grade inflammation in chronic kidney disease patients before the start of renal replacement therapy: sources and consequences. Clin Nephrol 68: 1-9.
7. Leon B, Lopez-Bravo M, Ardavin C, (2005) Monocyte-derived dendritic cells. Semin Immunol 17: 313-318.
8. Rees AJ, (2010) Monocyte and macrophage biology: an overview. Semin Nephrol 30: 216-233.
9. Worthylake RA, Burridge K, (2001) Leukocyte transendothelial migration: orchestrating the underlying molecular machinery. Curr Opin Cell Biol 13: 569-577.
10. Wedepohl S, Beceren-Braun F, Riese S, Buscher K, Enders S, et al. (2012) L-Selectin- a dynamic regulator of leukocyte migration. Eur J Cell Biol 91: 257-264.
11. Faure V, Cerini C, Paul P, Berland Y, Dignat-George F, et al. (2006) The uremic solute p-cresol decreases leukocyte transendothelial migration in vitro. Int Immunol 18: 1453-1459.
12. Ramirez R, Carracedo J, Merino A, Soriano S, Ojeda R, et al. (2011) CD14+CD16+ monocytes from chronic kidney disease patients exhibit increased adhesion ability to endothelial cells. Contrib Nephrol 171: 57-61.
13. Osterud B, Bjorklid E, (2003) Role of monocytes in atherogenesis. Physiol Rev 83: 1069-1112.
14. Alcorta D, Preston G, Munger W, Sullivan P, Yang JJ, et al. (2002) Microarray studies of gene expression in circulating leukocytes in kidney diseases. Exp Nephrol 10: 139-149.
15. Logan CY, Nusse R, (2004) The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 20: 781-810.
16. Clevers H, (2006) Wnt/beta-catenin signaling in development and disease. Cell 127: 469-480.
17. Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, et al. (2003) Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4: 249-264.
18. Siegfried E, Chou TB, Perrimon N, (1992) wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate. Cell 71: 1167-1179.
19. Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, et al. (1996) A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem 271: 4468-4476.
20. Wodarz A, Nusse R, (1998) Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 14: 59-88.
21. Huelsken J, Behrens J, (2002) The Wnt signalling pathway. J Cell Sci 115: 3977-3978.
22. Behrens J, von Kries JP, Kuhl M, Bruhn L, Wedlich D, et al. (1996) Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 382: 638-642.
23. Gordon MD, Nusse R, (2006) Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem 281: 22429-22433.
24. Carrero JJ, Yilmaz MI, Lindholm B, Stenvinkel P, (2008) Cytokine dysregulation in chronic kidney disease: how can we treat it? Blood Purif 26: 291-299.
25. Silverstein DM, (2009) Inflammation in chronic kidney disease: role in the progression of renal and cardiovascular disease. Pediatr Nephrol 24: 1445-1452.
26. Recio-Mayoral A, Banerjee D, Streather C, Kaski JC, (2011) Endothelial dysfunction, inflammation and atherosclerosis in chronic kidney disease-a cross-sectional study of predialysis, dialysis and kidney-transplantation patients. Atherosclerosis 216: 446-451.
27. Heine GH, Ortiz A, Massy ZA, Lindholm B, Wiecek A, et al. (2012) Monocyte subpopulations and cardiovascular risk in chronic kidney disease. Nat Rev Nephrol 8: 362-369.
28. Rogacev KS, Seiler S, Zawada AM, Reichart B, Herath E, et al. (2011) CD14++CD16+ monocytes and cardiovascular outcome in patients with chronic kidney disease. Eur Heart J 32: 84-92.
29. Kikuchi A, Yamamoto H, Sato A, Matsumoto S, (2012) Wnt5a: its signalling, functions and implication in diseases. Acta Physiol (Oxf) 204: 17-33.
30. Cadigan KM, Nusse R, (1997) Wnt signaling: a common theme in animal development. Genes Dev 11: 3286-3305.
31. George SJ, (2008) Wnt pathway: a new role in regulation of inflammation. Arterioscler Thromb Vasc Biol 28: 400-402.
32. Pereira CP, Bachli EB, Schoedon G, (2009) The wnt pathway: a macrophage effector molecule that triggers inflammation. Curr Atheroscler Rep 11: 236-242.
33. Sen M, Lauterbach K, El-Gabalawy H, Firestein GS, Corr M, et al. (2000) Expression and function of wingless and frizzled homologs in rheumatoid arthritis. Proc Natl Acad Sci U S A 97: 2791-2796.
34. Polzer K, Diarra D, Zwerina J, Schett G, (2008) Inflammation and destruction of the joints-the Wnt pathway. Joint Bone Spine 75: 105-107.
35. Bienz M, (2005) beta-Catenin: a pivot between cell adhesion and Wnt signalling. Curr Biol 15: R64-67.
36. Katoh M, Katoh M, (2007) STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis and cancer (Review). Int J Mol Med 19: 273-278.
37. Katoh M, Katoh M, (2009) Transcriptional mechanisms of WNT5A based on NF-kappaB, Hedgehog, TGFbeta, and Notch signaling cascades. Int J Mol Med 23: 763-769.
38. Pereira C, Schaer DJ, Bachli EB, Kurrer MO, Schoedon G, (2008) Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10. Arterioscler Thromb Vasc Biol 28: 504-510.
39. Lehtonen A, Ahlfors H, Veckman V, Miettinen M, Lahesmaa R, et al. (2007) Gene expression profiling during differentiation of human monocytes to macrophages or dendritic cells. J Leukoc Biol 82: 710-720.
40. Chaussabel D, Semnani RT, McDowell MA, Sacks D, Sher A, et al. (2003) Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites. Blood 102: 672-681.
41. Valencia J, Hernandez-Lopez C, Martinez VG, Hidalgo L, Zapata AG, et al. (2011) Wnt5a skews dendritic cell differentiation to an unconventional phenotype with tolerogenic features. J Immunol 187: 4129-4139.
42. Tickenbrock L, Schwable J, Strey A, Sargin B, Hehn S, et al. (2006) Wnt signaling regulates transendothelial migration of monocytes. J Leukoc Biol 79: 1306-1313.
43. Lee DK, Nathan Grantham R, Trachte AL, Mannion JD, Wilson CL, (2006) Activation of the canonical Wnt/beta-catenin pathway enhances monocyte adhesion to endothelial cells. Biochem Biophys Res Commun 347: 109-116.
44. Kim J, Kim J, Kim DW, Ha Y, Ihm MH, et al. (2010) Wnt5a induces endothelial inflammation via beta-catenin-independent signaling. J Immunol 185: 1274-1282.
45. Christman MA, 2nd, Goetz DJ, Dickerson E, McCall KD, Lewis CJ, et al (2008) Wnt5a is expressed in murine and human atherosclerotic lesions. Am J Physiol Heart Circ Physiol 294: H2864-2870.