Is the primary mechanism underlying COPD: Inflammation or ischaemia?

COPD: Journal of Chronic Obstructive Pulmonary Disease

Volumn 10, Issue 4, 2013, Pages 536-541

  Pearson, Michael ^a  

^a UNIVERSITY HOSPITAL AINTREE   (United Kingdom)

Author keywords

Bronchiolar vessels; COPD; Hypothesis; Mechanisms; Vasoconstriction

Indexed keywords

BRONCHODILATING AGENT; CIGARETTE SMOKE; COAL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NICOTINE; STEROID;

ARTERIOLE; ARTERY SPASM; BRONCHIAL ARTERY; BRONCHIOLE; CD8+ T LYMPHOCYTE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DISEASE COURSE; DUST EXPOSURE; ENVIRONMENTAL EXPOSURE; HUMAN; HYPOTHESIS; ISCHEMIA; LUNG INFARCTION; LUNG PARENCHYMA; LUNG VASOCONSTRICTION; OCCUPATIONAL EXPOSURE; OCCUPATIONAL LUNG DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; REVIEW; SIGNAL TRANSDUCTION; SMOKING; SMOKING CESSATION; STEROID THERAPY;

BRONCHIOLES; DISEASE PROGRESSION; HUMANS; INFLAMMATION; ISCHEMIA; NICOTINE; OCCUPATIONAL EXPOSURE; PARTICULATE MATTER; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING; VASOCONSTRICTION;

EID: 84880738377     PISSN: 15412555     EISSN: 15412563     Source Type: Journal    
DOI: 10.3109/15412555.2013.763781     Document Type: Review

References (23)

1. BTS guidelines for the management of chronic obstructive pulmonary disease. Thorax 1997; 52(supp 5):S1-28.
2. Chung KF, Adcock IM. Multifaceted mechanisms in COPD: Infl ammation, immunity, and tissue repair and destruction. Eur Respir J 2008; 31:1334-1356.
3. Cosio MG, Saetta M, Agusti A. Immunological aspects of chronic obstructive pulmonary disease. N Engl J Med 2009; 360:2445-2454.
4. MacNee W, Donaldson K. Mechanism of lung injury caused by PM10 and ultrafine particles with special reference to COPD. Eur Respir J 2003; 21 suppl:47s-51s.
5. Lawesa CMM, Thornley S, Young R, et al. Statin use in COPD patients is associated with a reduction in mortality. Prim Care Respir J 2011; 20:35-40.
6. Pearson M. Statins for COPD: A challenge to conventional beliefs? Prim Care Respir J 2012; 21:5-7.
7. Surgeon General, U.S. Public Health Service. The health consequences of smoking. Cancer and chronic obstructive lung disease in the workplace. A report of the Surgeon General. U.S. Office on Smoking and Health, Rockville, MD, 1985.
8. Zhu BQ, Parmley WW. Hemodynamic and vascular effects of active and passive smoking. Am Heart J 1995 Dec; 130(6):1270-1275.
9. Fraser RG, Pare P, Pare J, Fraser RS, Genereux G. The normal chest. In Fraser RG, Pare P, Pare J, Fraser RS, Genereux G, editors, Diagnosis of Diseases of the Chest. W.B. Saunders: Philadelphia, PA, 1988, pp. 79-83.
10. Pearson MG, Chamberlain MJ, Morgan WKC, Vinitski S. Particle deposition in the lung during cigarette smoking. J Appl Physiol 1985, 59:1828-1833.
11. U.S. National Research Council. 10. Tobacco Smoke and Toxicology. Clearing the Smoke: Assessing the Science Base for Tobacco Harm Reduction. The National Academies Press, Washington, DC, 2001.
12. Heath D, Harris R. The Human Pulmonary Circulation. Churchill Livingstone: London, 1977, p. 601.
13. West JB. Ventilation/Blood Flow and Gas Exchange. Blackwell: Oxford, UK, 1977.
14. Schwab JM, Nguyen TD, Meyermann R, Schluesener HJ. Human focal cerebral infarctions induce differential lesional interleukin-16 (IL-16) expression confined to infiltrating granulocytes, CD8+ T-lymphocytes and activated microglia/macrophages. J Neuroimmunol 2001; 114:232-224.
15. Matsuba K, Thurlbeck WM. The number and dimensions of small airways in emphysematous lungs. Am J Pathol 1972; 67:265-275.
16. McDonough JE, Yuan R, Suzuki M. Small-airway obstruction and emphysema in chronic obstructive pulmonary disease. N Engl J Med 2011; 365:1567-1575.
17. Washko GR, Hunninghake GM, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, Estépar RS, Lynch DA, Brehm JM, Andriole KP, Diaz AA, Khorasani R, DAco K, Sciurba FC, Silverman EK, Hatabu H, Rosas IO, COPD Gene Investigators. Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med 2011; 364:897-906.
18. Morgan MD, Edwards CW, Morris J, Matthews HR Origin and behaviour of emphysematous bullae. Thorax 1989; 44:533-538.
19. Schwartz J. A spine for our time. Thorax 2011; 66:841-842.
20. Rogan JM, Attfield MD, Jacobsen M, Rae S, Walker DD, Walton WH. Role of dust in the working environment in development of chronic bronchitis in British coal miners. Br J lnd Med 1973; 30: 217-226.
21. Xu X, Laird N, Dockery DW, Schouten JP, Rijcken B, Weiss ST. Age, period, and cohort effects on pulmonary function in a 24-year longitudinal study. J Epidemiol 1995; 141:554-566.
22. Doll R, Peto R, Wheatley K, Gray R, Sutherland I. Mortality in relation to smoking: 40 years observation on male British doctors. BMJ 1994; 309:901-910.
23. Spence DPS, Hay JG, Carter J, Pearson MG, Calverley PMA. The effect of anticholinergic bronchodilatation on oxygen saturation and breathlessness in chronic obstructive pulmonary disease. Thorax 1993; 48:1145-1150.