Alpha-1 antitrypsin augmentation therapy and biomarkers of elastin degradation

COPD: Journal of Chronic Obstructive Pulmonary Disease

Volumn 10, Issue 4, 2013, Pages 473-481

  Ma, Shuren ^a,b,d   Lin, Yong Y ^a,b   He, Jiangtao ^a,b,d   Rouhani, Farshid N ^c   Brantly, Mark ^c   Turino, Gerard M ^a,b,d  

^a James P Mara Center for Lung Disease   (United States)

^b ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

^d Columbia College of Physicians and Surgeons ^*  (United States)

Author keywords

Alpha 1 antitrypsin deficiency (AATD); Augmentation therapy; Elastin biomarkers; Neutrophil elastase

Indexed keywords

ALPHA 1 ANTITRYPSIN; DESMOSINE; ELASTIN; ISODESMOSINE; LEUKOCYTE ELASTASE;

ADULT; AEROSOL; AGED; ALPHA 1 ANTITRYPSIN DEFICIENCY; ARTICLE; AUGMENTATION THERAPY; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG THERAPY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LUNG LAVAGE; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CROSS LINKING; PROTEIN DEGRADATION; PROTEIN URINE LEVEL; TANDEM MASS SPECTROMETRY; TREATMENT OUTCOME;

AGED; ALPHA 1-ANTITRYPSIN; ALPHA 1-ANTITRYPSIN DEFICIENCY; BIOLOGICAL MARKERS; BRONCHOALVEOLAR LAVAGE FLUID; ELASTIN; FEMALE; HOMOZYGOTE; HUMANS; ISODESMOSINE; LEUKOCYTE ELASTASE; MALE; MIDDLE AGED; PHENOTYPE; TRYPSIN INHIBITORS;

EID: 84880726176     PISSN: 15412555     EISSN: 15412563     Source Type: Journal    
DOI: 10.3109/15412555.2013.771163     Document Type: Article

References (20)

1. Wewers MD, Casalaro MA, Sellers SE, et al. Replacement therapy for alpha-1 antitrypsin deficiency associated with emphysema. NEJM 1987; 316(17):1055-1062.
2. Stone PJ, Morris LA 3rd, Franzblau C, Snider GL. Preliminary evidence that augmentation therapy diminishes degradation of cross-linked elastin in alpha-1-antitrypsin-deficient humans. Respiration 1995, 62:76-79.
3. Gottlieb DJ, Luisetti M, Stone PJ, et al. Short-term supplementation therapy does not affect elastin degradation in severe alpha-antitrypsin deficiency. The American-Italian AATD Study Group. AJRCCM 2000; 162:2069-2072.
4. Stone PJ, Bryan-Rhafdi J, Lucey EC, et al. Measurement of urinary desmosine by isotope dilution and high performance liquid chromatography. Correlation between elastase-induced air-space enlargement in the hamster and elevation of urinary desmosine. Am Rev Respir Dis 1991; 144:2844-2890.
5. Ma S, Lin YY, Turino GM. Measurement of desmosine and isodesmosine by mass spectrometry in COPD. Chest 2007; 131:1363-1371.
6. Stoller JK, Rouhani F, Brantly M, et al. Biochemical efficacy and safety of a new pooled human plasma alpha-1 antitrypsin, respitin. Chest 2002; 122:66-74.
7. King GS, Mohan VS, Starcher BC. Radioimmunoassay for desmosine. Connect Tissue Res 1980; 7:263-267.
8. Ma S, Lieberman S, Turino GM, Lin YY. The detection and quantitation of free desmosine and isodesmosine in human urine and their peptide-bound forms in sputum: Proc Natl Acad Sci USA 2003; 100:12941-12943.
9. Ma S, Turino GM, Lin YY. Quantitation of desmosine and isodesmosine in urine, plasma, and sputum by LC-MS/MS as biomarkers for elastin degradation. J Chromatogr B 2011; 879:1893-1898.
10. Rodriguez JR, Seals JE, Radin A, Lin JS, Mandl I, Turino GM. Neutrophil lysosomal elastase activity in normal subjects and in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis 1979; 119:409-417.
11. 1 antitrypsin. NEJM 2005; 352:19.
12. Rennard SI, Basset G, Lecossier D, O'Donnell KM, Pinkston P, Martin PG, Crystal R: Estimation of volume of epithelial lining fl uid recovered by lavage using urea as marker of dilution. J Appl Physiol 1986; 60(2):532-538.
13. Atanasova M, Konova E, Georgieva M, et al. Age-related changes of anti-elastin antibodies in senescence-accelerated mice. Gerontology 2010; 56:310-318.
14. Watanaabe M, Sawai T, Nagura H, et al. Age-related alteration of cross-linking amino acids of elastin in human aorta. Tohoku J. Exp Med 1996; 180:115-130.
15. Cantor JO, Shteyngart B, Cerreta JM, et al. Synergistic effect of hydrogen peroxide and elastase on elastin injury in vitro. Exper Biol Med 2006; 231(1):107-111.
16. Umeda H, Aikawa M, Libby P. Liberation of desmosine and isodesmosine as amino acids from insoluble elastin by elastolytic proteases. Biochem Biophys Res Commun 2011; 411;281-286.
17. Lindberg CA, Engstrom G, Gerhardsson de Verdier M, Nihlen U, Anderson M, Forsman-Semb K, Svartengren M. Total desmosine in plasma and urine correlate with lung function. ERJ 2012; 29:839-845.
18. Huang JT-J, Chaudhuri R, Albarbarawi O, Barton A, Grievson C, Rauchhaus P, Weir CW, Messow M, Stevens N, McSharry C, Feuerstein G, Mukhopadhyay S, Brady J, Palmer CAN, Miller D, Thomson NC. Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary disease. Thorax 2012; 67:502-508.
19. Stockley RA, Bayley DL, Unsal I, Dowson LJ. The effect of augmentation therapy on bronchial infl ammation in alpha-1 antitrypsin deficiency. AJRCCM 2002; 165:1494-1498.
20. Fregonese L, Ferrari F, Fumagalli F, et al. Long-term variability of desmosine/isodesmosine as biomarker in alplha-1 antitrypsin deficience related COPD. COPD 2011; 8:329-333.