Driving performance in adults with ADHD: Results from a randomized, waiting list controlled trial with atomoxetine

European Psychiatry

Volumn 28, Issue 6, 2013, Pages 379-385

  Sobanski, E ^a   Sabljic, D ^a   Alm, B ^a   Dittmann, R W ^a   Wehmeier, P M ^a,b   Skopp, G ^a   Strohbeck Kuhner P ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Vitos Hospital for Psychiatry and Psychotherapy   (Germany)

Author keywords

ADHD; Adults; Atomoxetine; Driving

Indexed keywords

ATOMOXETINE;

ACT AND REACT TEST SYSTEM; ADULT; APPETITE; ARTICLE; ATTENTION DEFICIT DISORDER; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; COPING BEHAVIOR; DRIVER COPING QUESTIONNAIRE; DRIVING ABILITY; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG SAFETY; FATIGUE; FEMALE; GERMANY; HOSPITAL ADMISSION; HUMAN; IRRITABILITY; MALE; NAUSEA; NEUROPSYCHOLOGICAL TEST; PRACTICE GUIDELINE; PRIORITY JOURNAL; QUESTIONNAIRE; RISK ASSESSMENT; SELF CONTROL; SELF EVALUATION; SIDE EFFECT; TRAFFIC; TREATMENT DURATION; TREATMENT RESPONSE;

ADHD; ADULTS; ATOMOXETINE; DRIVING;

ADOLESCENT; ADRENERGIC UPTAKE INHIBITORS; ADULT; ATTENTION; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; AUTOMOBILE DRIVING; FEMALE; HUMANS; MALE; MIDDLE AGED; PROPYLAMINES; QUESTIONNAIRES; REACTION TIME; TREATMENT OUTCOME; WAITING LISTS;

EID: 84880724991     PISSN: 09249338     EISSN: 17783585     Source Type: Journal    
DOI: 10.1016/j.eurpsy.2012.08.001     Document Type: Article

References (38)

1. American Psychiatric Association Diagnostic and statistical manual of mental disorders 2000, American Psychiatric Press, Washington, DC. 4th edition revised.
2. Barkley R.A., Murphy K.R. Attention deficit hyperactivity disorder: a clinical workbook 2005, Guilford Press, New York. 3rd edition.
3. Barkley R.A., Guevremont D.C., Anastopoulos A.D., DuPaul G.J., Shelton T.L. Driving-related risks and outcomes of attention deficit hyperactivity disorder in adolescents and young adults: a 3-to 5-year follow-up survey. Pediatrics 1993, 92:212-218.
4. Barkley R.A., Murphy K.R., Kwasnik D. Motor vehicle driving competencies and risks in teens and young adults with attention deficit hyperactive disorder. Pediatrics 1998, 98:1089-1095.
5. Barkley R.A., Murphy K.R., DuPaul G.I., Bush T. Driving in young adults with attention deficit hyperactive disorder: knowledge, performance, adverse outcomes, and the role of executive functioning. J Int Neuropsychol Soc 2002, 8:655-672.
6. Barkley R.A., Anderson D.L., Kruesi M. A pilot study of atomoxetine on driving performance in adults with ADHD. J Atten Disord 2007, 10:306-313.
7. Begutachtungs-Leitlinien zur Kraftfahrereignung Bundesanstalt für Straßenwesen (Bast) Mensch und Sicherheit, M 115 2010, Verlag für neue Wissenschaft GmbH, Bremerhafen, Germany.
8. Bukasa B. ART2020-Das neue Multimedia-Testgerät für die Fahreignungsbegutachtung. Verkehrspsychologie auf neuen Wegen: Herausforderungen von Strasse, Wasser, Luft und Schiene (I) 1999, 381-401. Deutscher Psychologen Verlag, Bonn, Germany. F. Meyer-Gramcko (Ed.).
9. Bukasa B., Christ R., Ponocny-Seliger E., Smuc M., Wenniger U. Validitätsüberprüfung verkehrspsychologischer Leistungstests für die Fahreignungsbegutachtung. Zeitschrift für Verkehrssicherheit 2003, 49:191-197.
10. Chamberlain S.R., Sahakian B.J. The neuropsychiatry of impulsivity. Curr Opin Psychiatry 2007, 20:255-261.
11. Chamberlain S.R., Del Campo N., Dowson J., Muller U., Clark L., Robbins T.W., et al. Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorder. Biol Psychiatry 2007, 62:977-984.
12. Christiansen H., Kis B., Hirsch O., Matthies S., Hebebrand J., Uekermann J., et al. A German validation of the Conners Adult ADHD Rating Scales (CAARS) II: Reliability, validity, diagnostic sensitivity and specificity. Eur Psychiatry 2012, 27:321-328.
13. Conners C.K., Erhardt D., Sparrow E. Conners Adult ADHD Rating Scales (CAARS) 1999, Multi Health Systems Inc., North Tonawanda.
14. Cox D.J., Merkel R.L., Kovatchev B., Seward R. Effects of stimulant medication on driving performance of young adults with attention deficit/hyperactivity disorder: a preliminary double-blind placebo-controlled trial. J Nerv Ment Dis 2000, 188:230-234.
15. Cox D.J., Humphrey J.W., Merkel R.L., Penbertyh J.K., Kovatchev B. Controlled-release methylphenidate improves attention during on-road driving by adolescents with attention deficit/hyperactivity disorder. J Am Board Fam Pract 2004, 17:235-239.
16. Cox D.J., Merkel R.L., Moore M., Thorndike F., Muller C., Kovatchev B. Relative benefits of stimulant therapy with OROS methylphenidate versus mixed amphetamine salts extended release in improving the driving performance of adolescent drivers with attention deficit/hyperactivity disorder. Pediatrics 2006, 118:704-710.
17. Cox D.J., Davis M., Mikami A.Y., Sing H., Merkel R.L., Burket R. Long-acting methylphenidate reduces collision rate of young adult drivers with attention deficit-/hyperactivity disorder. J Clin Psychoharmacol 2012, 32:225-230.
18. De Zwaan M., Gruss B., Muller A., Graap H., Martin A., Glaesmer H., et al. The estimated prevalence and correlates of adult ADHD in a German community sample. Eur Arch Psychiatry Clin Neurosci 2012, 262:79-86.
19. Emol A.K., Matthews G., Funke G., Warm JS Stress vulnerability, coping and risk-taking behaviors during simulated driving. Proceedings of the Human Factors and Ergonomics Society 40th Annual Meeting 2004, 48:1228-1232.
20. Fayyad J., De Graaf R., Kessler R., et al. Cross-national prevalence and correlates of adult attention deficit/hyperactivity disorder. Br J Psychiatry 2007, 190:402-409.
21. Fischer M., Barkley R.A., Smallish L., Fletcher K. Hyperactive children as young adults: driving abilities, safe driving behaviour, and adverse driving outcomes. Acc Anal Prev 2006, 39:94-105.
22. Jerome L., Segal A., Habinski L. What we know about ADHD and driving risk: a literature review, meta-analysis and critique. J Can Acad Child Adolesc Psychiatry 2006, 15:105-125.
23. Kay G.G., Michaels A., Pakull B. Simulated driving changes in young adults with ADHD receiving mixed amphetamine salts extended release and atomoxetine. J Atten Disord 2009, 12:316-329.
24. Lehrl S. Mehrfachwahl-Wortschatz-Intelligenztest: Form B 1997, Straube, Erlangen, Germany.
25. Matthews G., Desmond P.A., Joyner L., Carcary B., Gilliland K. Validation of the driver stress inventory and driver coping questionnaire 1996, International Conference on Traffic and Transport Psychology, Valencia, Spain.
26. Medori R., Ramos-Quiroga J.A., Casas M., et al. A randomized, placebo-controlled trial of three fixed dosages of prolonged-release OROS methylphenidate in adults with attention deficit/hyperactivity disorder. Biol Psychiatry 2008, 63:981-989.
27. Nada-Raja S., Langley J.D., McGee R., Williams S.M., Buff D.J., Reeder A.I. Inattentive and hyperactive behaviors and driving offenses in adolescence. J Am Acad Child Adolesc Psychiatry 1997, 36:515-522.
28. Retz-Junginger P., Retz W., Blocher D., Stieglitz R.D., Georg T., Supprian T., et al. Validity and reliability of the German short version of the Wender-Utah rating scale for the retrospective assessment of attention deficit/hyperactivity disorder. Nervenarzt 2003, 74:987-993.
29. Roesler M., Retz W., Retz-Junginger P., et al. Instrumente zur Diagnostik der Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) im Erwachsenenalter Selbstbeurteilungsskala (ADHS-SB) und Diagnosecheckliste (ADHS-DC). Nervenarzt 2004, 75:888-895.
30. Schubert W., Wagner T. Die psychologische Fahrverhaltensbeobachtung-Grundlagen, Methodik und Anwendungsmöglichkeiten. Zeitschrift für Verkehrssicherheit 2003, 49:119-127.
31. Sobanski E., Sabljic D., Alm B., Skopp G., Kettler N., Mattern R., et al. Driving-related risks and impact of methylphenidate treatment on driving in adults with ADHD. J Neural Transm 2008, 115:347-356.
32. Sobanski E., Sabljic D., Alm B., Baehr C., Dittmann R.W., Skopp G., et al. A randomized, waiting list controlled 12-week trial of atomoxetine in adults with ADHD. Pharmacopsychiatry 2012, 45:100-107.
33. Strohbeck-Kuehner P., Mattern R., Kief S. Bewältigungsstrategien und Fahrverhalten. Kongressbericht 2007 der Deutschen Gesellschaft für Verkehrsmedizin e.V., Berichte der Bundesanstalt für Straßenwesen-Mensch und Sicherheit 2008, 195:58-61.
34. Verster J.C., Bekker E.M., de Roos M., Minova A., Eijken E.J., Kooij J.J., et al. Methylphenidate significantly improves driving performance of adults with attention deficit hyperactivity disorder: a randomized crossover trial. J Psychopharmacol 2008, 22:230-237.
35. Volkerts E.R., van Laar M.W., vanWilligenburg A.P.P., Plomp T.A., Maes R.A.A. A comparative study of on-the-road and stimulated driving performance after nocturnal treatment with lormetazepam 1mg and oxazepam 50mg. Hum Psychopharmacol 1992, 7:297-309.
36. Wittchen H.U., Wunderlich U., Gruschwitz S., Zaudig M. Strukturiertes klinisches Interview für DSM-V. SKID-I 1997, Hogrefe, Göttingen, Germany.
37. Woods S.W., Lovejoy D.W., Ball J.D. Neuropsychological characteristics of adults with ADHD: a comprehensive review of initial studies. Clin Neuropsychol 2002, 16:12-34.
38. Woodward L.J., Fergusson D.M., Horwood L.J. Driving outcomes of young people with attention difficulties in adolescence. J Am Acad Child Adolesc Psychiatry 2000, 39:627-634.