The role of Acacia Arabica extract as an antidiabetic, antihyperlipidemic, and antioxidant in streptozotocin-induced diabetic rats

Saudi Medical Journal

Volumn 34, Issue 7, 2013, Pages 727-733

  Hegazy, Gehan A ^a,b   Alnoury, Amina M ^a,c   Gad, Hoda G ^a,d  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b NATIONAL RESEARCH CENTRE   (Egypt)

^c AIN SHAMS UNIVERSITY   (Egypt)

^d ALEXANDRIA UNIVERSITY   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

ACACIA ARABICA EXTRACT; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; PLANT EXTRACT; TRIACYLGLYCEROL; UBIDECARENONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GLUCOSE BLOOD LEVEL; HYPERLIPIDEMIA; NONHUMAN; RAT;

ACACIA; ANIMALS; ANTIOXIDANTS; BLOOD GLUCOSE; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; INSULIN; MALONDIALDEHYDE; PHYTOTHERAPY; PLANT EXTRACTS; RATS; STREPTOZOCIN; TRIGLYCERIDES; UBIQUINONE;

EID: 84880711667     PISSN: 03795284     EISSN: 16583175     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Matsui T, Tanaka T, Tamura S, Toshima A, Tamaya K, Miyata Y, et al. Alpha-Glucosidase inhibitory profile of catechins and theaflavins. J Agric Food Chem 2007; 55: 99-105
2. Shaw JA, Sicree RE, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 2010; 87: 4-14
3. Chakrabarti R, Rajagopalan R. Diabetes and insulin resistance associated disorders: disease and the therapy. Current Science- Bangalore 2002; 83:1533-1538
4. Kameswararao B, Kesavulu M, Apparao C. Evaluation of antidiabetic effect of Momordica cymbalaria fruit in alloxan- diabetic rats. Fitoterapia 2003; 74: 7-13
5. Singh LW. Traditional medicinal plants of Manipur as antidiabetics. J Med Plants Res 2011; 5: 677-687
6. Sharma SB, Nasir A, Prabhu KM, Murthy PS, Dev G. Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits. J Ethnopharmacol 2003; 85: 201-206
7. Taskinen MR. Lipoprotein lipase in diabetes. Diabetes Metab Rev 2009; 3: 551-570
8. Salardi S, Zucchini S, Elleri D, Grossi G, Bargossi AM, Gualandi S, et al. High glucose levels induce an increase in membrane antioxidants, in terms of vitamin E and coenzyme Q10, in children and adolescents with type 1 diabetes. Diabetes Care 2004; 27: 630-631
9. King GL, Loeken MR. Hyperglycemia-induced oxidative stress in diabetic complications. Histochem Cell Biol 2004; 122: 333-338
10. Fatima A, Agrawal P, Singh PP. Herbal option for diabetes: an overview. Asian Pacific Journal of Tropical Disease 2012; 2: S536-S544
11. Cetinkaya A, Kurutas EB, Buyukbese MA, Kantarceken B, Bulbuloglu E. Levels of malondialdehyde and superoxide dismutase in subclinical hyperthyroidism. Mediators Inflamm 2005; 2005: 57-59
12. Kaur J, Singh P, Sowers JR. Diabetes and cardiovascular diseases. Am J Ther 2002; 9: 510-515
13. Modi K, Vishwakarma S, Goyal R, Bhatt P. Effects of coenzyme Q10 on lipid levels and antioxidant defenses in rats with fructose induced hyperlipidemia and hyperinsulinaemia. Internet Journal of Pharmacology 2007; 5
14. Constantinescu R, McDermott MP, DiCenzo R, de Blieck EA, Hyson HC, Beal MF, et al. A randomized study of the bioavailability of different formulations of coenzyme Q10 (ubiquinone). J Clin Pharmacol 2007; 47: 1580-1586
15. Brownlee M. The pathobiology of diabetic complications a unifying mechanism. Diabetes 2005; 54: 1615-2165
16. Asad M, Aslam M, Munir TA, Nadeem A. Effect of Acacia Nilotica Leaves Extract on Hyperglycaemia, Lipid Profile And Platelet Aggregation in Streptozotocin Induced Diabetic Rats. J Ayub Med Coll Abbottabad 2011; 23
17. Patil RN, Patil RY, Ahirwar B, Ahirwar D. Evaluation of antidiabetic and related actions of some Indian medicinal plants in diabetic rats. Asian Pacific Journal of Tropical Medicine 2011; 4: 20-33
18. Patil RN, Patil RY, Ahirwar D. Study of some medicinal plants for antidiabetic activity in alloxan induced diabetes. Pharmacologyonline 2010; 1: 53-60
19. Yasir M, Shrivastava R, Jain P, Das D, Yasir M, Shrivastava R, et al. Hypoglycemic and Antihyperglycemic Effects of Different Extracts and Combinations of Withania coagulans Dunal and Acacia arabica Lamk in Normal and Alloxan Induced Diabetic Rats. Pharmacognosy Communications 2012; 2: 61-66
20. Kadnur S, Goyal R. Comparative antidiabetic activity of methanolic extract and ethyl acetate extract of Zingiber officinale Roscoe. Indian Journal of Pharmaceutical Sciences 2005; 67: 453-457
21. Matthews D, Hosker J, Rudenski A, Naylor B, Treacher D, Turner R. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419
22. Mihara M, Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 1978; 86: 271-278
23. Eliza J, Daisy P, Ignacimuthu S, Duraipandiyan V. Antidiabetic and antilipidemic effect of eremanthin from Costus speciosus (Koen.) Sm., in STZ-induced diabetic rats. Chem Biol Interact 2009; 182: 67-72
24. Coskun O, Kanter M, Korkmaz A, Oter S. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin- induced oxidative stress and beta-cell damage in rat pancreas. Pharmacol Res 2005; 51: 117-123
25. Ahmad M, Zaman F, Sharif T, Zabta ChM. Antidiabetic and hypolipidemic effects of aqueous methanolic extract of acacia nilotica pods in alloxan-induced diabetic rabbits. Scan J Lab Anim Sci 2008; 35: 29-34
26. Liu X, Kim J, Li Y, Li J, Liu F, Chen X. Tannic acid stimulates glucose transport and inhibits adipocyte differentiation in 3T3-L1 cells. J Nutr 2005; 135: 165-171
27. Chew G, Watts G. Coenzyme Q10 and diabetic endotheliopathy: oxidative stress and the 'recoupling hypothesis'. QJM 2004; 97: 537-548
28. Reyes B, Bautista N, Tanquilut N, Anunciado R, Leung A, Sanchez G, et al. Anti-diabetic potentials of Momordica charantia and Andrographis paniculata and their effects on estrous cyclicity of alloxan-induced diabetic rats. J Ethnopharmacol 2006; 105: 196-200
29. Miyake Y, Suzuki E, Ohya S, Fukumoto S, Hiramitsu M, Sakaida K, et al. Lipid-lowering effect of eriocitrin, the main flavonoid in lemon fruit, in Rats on a high-fat and high-cholesterol diet. Journal of Food Science 2006; 71: S633-S637
30. Muruganandan S, Srinivasan K, Gupta S, Gupta P, Lal J. Effect of mangiferin on hyperglycemia and atherogenicity in streptozotocin diabetic rats. J Ethnopharmacol 2005; 97: 497-501
31. Zahoor N, Usmanghani K, Akram M, Asif HM, Saleem EQ, Abdul Sami, et al. Pharmacological activities of Acacia Arabica. Crown Journal of Medicine 2011; 1: 9-11
32. Ali BH, Ziada A, Blunden G. Biological effects of gum arabic: a review of some recent research. Food and Chemical Toxicology 2009; 47: 1-8