Ploidy and S-phase fraction are correlated with lymphovascular space invasion that is predictive of outcomes in endometrial cancer

International Journal of Clinical Oncology

Volumn 17, Issue 6, 2012, Pages 590-597

  Song, Taejong ^a   Lee, Jeong Won ^b   Choi, Chel Hun ^b   Kim, Tae Joong ^b   Bae, Duk Soo ^b   Sung, Chang Ohk ^b   Song, Sang Yong ^b   Kim, Byoung Gie ^b  

^a CHA University   (South Korea)

^b Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Aneuploidy; DNA ploidy; Endometrial cancer; Lymphovascular space invasion; S phase fraction

Indexed keywords

ESTROGEN RECEPTOR; K RAS PROTEIN; PROGESTERONE RECEPTOR; PROTEIN P53;

ACCURACY; ADULT; ARTICLE; CANCER PROGNOSIS; CANCER RISK; CANCER SURVIVAL; CELL CYCLE S PHASE; CLINICAL EVALUATION; CONTROLLED STUDY; ENDOMETRIUM CANCER; FEMALE; FLOW CYTOMETRY; HIGH RISK PATIENT; HUMAN; LYMPHOVASCULAR SPACE INVASION; MAJOR CLINICAL STUDY; MEDICAL RECORD REVIEW; MUTATIONAL ANALYSIS; ONCOGENE K RAS; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PLOIDY; PRIORITY JOURNAL; RECURRENCE FREE SURVIVAL; RECURRENCE RISK; RISK ASSESSMENT; RISK FACTOR; TUMOR INVASION; TUMOR SUPPRESSOR GENE; TUMOR VOLUME;

AGED; DISEASE-FREE SURVIVAL; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; LYMPHATIC METASTASIS; LYMPHATIC VESSELS; MIDDLE AGED; ODDS RATIO; PLOIDIES; PROGNOSIS; S PHASE;

EID: 84880700813     PISSN: 13419625     EISSN: 14377772     Source Type: Journal    
DOI: 10.1007/s10147-011-0329-9     Document Type: Article

References (22)

1. Creutzberg CL, van Putten WL, Warlam-Rodenhuis CC et al (2004) Outcome of high-risk stage IC, grade 3, compared with stage I endometrial carcinoma patients: the Postoperative Radiation Therapy in Endometrial Carcinoma Trial. J Clin Oncol 22:1234-1241
2. Jeong NH, Lee JM, Lee SK (2010) Current status in the management of uterine corpus cancer in Korea. J Gynecol Oncol 21:151-162
3. Scholten AN, Smit VT, Beerman H et al (2004) Prognostic significance and interobserver variability of histologic grading systems for endometrial carcinoma. Cancer 100:764-772
4. Abeler VM, Kjorstad KE, Berle E (1992) Carcinoma of the endometrium in Norway: a histopathological and prognostic survey of a total population. Int J Gynecol Cancer 2:9-22
5. Nordstrom B, Strang P, Lindgren A et al (1996) Carcinoma of the endometrium: do the nuclear grade and DNA ploidy provide more prognostic information than do the FIGO and WHO classifications? Int J Gynecol Pathol 15:191-201
6. Hogberg T, Fredstorp-Lidebring M, Alm P et al (2004) A prospective population-based management program including primary surgery and postoperative risk assessment by means of DNA ploidy and histopathology. Adjuvant radiotherapy is not necessary for the majority of patients with FIGO stage I-II endometrial cancer. Int J Gynecol Cancer 14:437-450
7. Liao BS, Twiggs LB, Leung BS et al (1986) Cytoplasmic estrogen and progesterone receptors as prognostic parameters in primary endometrial carcinoma. Obstet Gynecol 67:463-467
8. Semczuk A, Berbec H, Kostuch M et al (1998) K-ras gene point mutations in human endometrial carcinomas: correlation with clinicopathological features and patients' outcome. J Cancer Res Clin Oncol 124:695-700
9. Kohler MF, Berchuck A, Davidoff AM et al (1992) Overexpression and mutation of p53 in endometrial carcinoma. Cancer Res 52:1622-1627
10. Lundgren C, Auer G, Frankendal B et al (2002) Nuclear DNA content, proliferative activity, and p53 expression related to clinical and histopathologic features in endometrial carcinoma. Int J Gynecol Cancer 12:110-118
11. Gal D, Recio FO, Zamurovic D (1992) The new International Federation of Gynecology and Obstetrics surgical staging and survival rates in early endometrial carcinoma. Cancer 69:200-202
12. Hiddemann W, Schumann J, Andreef M et al (1984) Convention on nomenclature for DNA cytometry. Committee on Nomenclature, Society for Analytical Cytology. Cancer Genet Cytogenet 13:181-183
13. Benedet JL, Bender H, Jones H 3rd et al (2000) FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers. FIGO Committee on Gynecologic Oncology. Int J Gynaecol Obstet 70:209-262
14. Cowles TA, Magrina JF, Masterson BJ et al (1985) Comparison of clinical and surgical-staging in patients with endometrial carcinoma. Obstet Gynecol 66:413-416
15. Hanson MB, van Nagell JR Jr, Powell DE et al (1985) The prognostic significance of lymph-vascular space invasion in stage I endometrial cancer. Cancer 55:1753-1757
16. Mariani A, Webb MJ, Galli L et al (2000) Potential therapeutic role of para-aortic lymphadenectomy in node-positive endometrial cancer. Gynecol Oncol 76:348-356
17. Terada K, Mattson D, Goo D et al (2004) DNA aneuploidy is associated with increased mortality for stage I endometrial cancer. Gynecol Oncol 95:483-487
18. Susini T, Amunni G, Molino C et al (2007) Ten-year results of a prospective study on the prognostic role of ploidy in endometrial carcinoma: dNA aneuploidy identifies high-risk cases among the so-called 'low-risk' patients with well and moderately differentiated tumors. Cancer 109:882-890
19. Mangili G, Montoli S, De Marzi P et al (2008) The role of DNA ploidy in postoperative management of stage I endometrial cancer. Ann Oncol 19:1278-1283
20. Hansson J, Tribukait B, Lewensohn R et al (1982) Flow cytofluorometric DNA analyses of metastases of human malignant melanomas. Anal Quant Cytol 4:99-104
21. Podratz KC, Wilson TO, Gaffey TA et al (1993) Deoxyribonucleic acid analysis facilitates the pretreatment identification of high-risk endometrial cancer patients. Am J Obstet Gynecol 168:1206-1213 (discussion 1213-1205)
22. Huang HY, Huang WW, Wu JM et al (2008) Flow cytometric analysis of DNA ploidy and S-phase fraction in primary localized myxofibrosarcoma: correlations with clinicopathological factors, Skp2 expression, and patient survival. Ann Surg Oncol 15:2239-2249