Contribution of interleukin-12 p35 (il-12p35) and il-12p40 to protective immunity and pathology in mice infected with chlamydia muridarum

Infection and Immunity

Volumn 81, Issue 8, 2013, Pages 2962-2971

  Chen, Lili ^a   Lei, Lei ^b   Zhou, Zhou ^a   He, Jie ^a   Xu, Sha ^a   Lu, Chunxue ^a   Chen, Jianlin ^b   Yang, Zhangsheng ^b   Wu, Gangqiu ^b   Yeh, I Tien ^b   Zhong, Guangming ^b   Wu, Yimou ^a  

^a UNIVERSITY OF SOUTH CHINA   (China)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12P35; INTERLEUKIN 12P40;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHLAMYDIA; CHLAMYDIASIS; CONTROLLED STUDY; FEMALE; GENOTYPE; HUMAN; HUMAN CELL; HYDROSALPINX; IMMUNE RESPONSE; KIDNEY PARENCHYMA; KNOCKOUT MOUSE; MOUSE; NONHUMAN; OVIDUCT; PRIMARY INFECTION; PRIORITY JOURNAL; PROTEIN FUNCTION; PYELONEPHRITIS; REINFECTION; TH2 CELL; TIME; VAGINITIS;

ANIMALS; CHLAMYDIA INFECTIONS; CHLAMYDIA MURIDARUM; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; HELA CELLS; HUMANS; INTERLEUKIN-12 SUBUNIT P35; INTERLEUKIN-12 SUBUNIT P40; MICE; MICE, KNOCKOUT;

EID: 84880647917     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00161-13     Document Type: Article

References (39)

1. Sherman KJ, Daling JR, Stergachis A, Weiss NS, Foy HM, Wang SP, Grayston JT. 1990. Sexually transmitted diseases and tubal pregnancy. Sex Transm Dis. 17:115-121.
2. Morrison RP, Feilzer K, Tumas DB. 1995. Gene knockout mice establish a primary protective role for major histocompatibility complex class II-restricted responses in Chlamydia trachomatis genital tract infection. Infect. Immun. 63:4661-4668.
3. Watford WT, Moriguchi M, Morinobu A, O'Shea JJ. 2003. The biology of IL-12: coordinating innate and adaptive immune responses. Cytokine Growth Factor Rev. 14:361-368.
4. Hunter CA. 2005. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat. Rev. Immunol. 5:521-531.
5. Happel KI, Dubin PJ, Zheng M, Ghilardi N, Lockhart C, Quinton LJ, Odden AR, Shellito JE, Bagby GJ, Nelson S, Kolls JK. 2005. Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J. Exp. Med. 202:761-769.
6. Khader SA, Pearl JE, Sakamoto K, Gilmartin L, Bell GK, Jelley-Gibbs DM, Ghilardi N, deSauvage F, Cooper AM. 2005. IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available. J. Immunol. 175:788-795.
7. Lieberman LA, Cardillo F, Owyang AM, Rennick DM, Cua DJ, Kaste-lein RA, Hunter CA. 2004. IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12. J. Immunol. 173: 1887-1893.
8. Schulz SM, Kohler G, Schutze N, Knauer J, Straubinger RK, Chackerian AA, Witte E, Wolk K, Sabat R, Iwakura Y, Holscher C, Muller U, Kastelein RA, Alber G. 2008. Protective immunity to systemic infection with attenuated Salmonella enterica serovar enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22, but not IL-17. J. Immunol. 181:7891-7901.
9. Vom Berg J, Prokop S, Miller KR, Obst J, Kalin RE, Lopategui-Cabezas I, Wegner A, Mair F, Schipke CG, Peters O, Winter Y, Becher B, Heppner FL. 2012. Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline. Nat. Med. 18:1812-1819.
10. Krueger GG, Langley RG, Leonardi C, Yeilding N, Guzzo C, Wang Y, Dooley LT, Lebwohl M. 2007. A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis. N. Engl. J. Med. 356:580-592.
11. Lu H, Zhong G. 1999. Interleukin-12 production is required for chla-mydial antigen-pulsed dendritic cells to induce protection against live Chlamydia trachomatis infection. Infect. Immun. 67:1763-1769.
12. Shaw J, Grund V, Durling L, Crane D, Caldwell HD. 2002. Dendritic cells pulsed with a recombinant chlamydial major outer membrane protein antigen elicit a CD4(+) type 2 rather than type 1 immune response that is not protective. Infect. Immun. 70:1097-1105.
13. Jupelli M, Selby DM, Guentzel MN, Chambers JP, Forsthuber TG, Zhong G, Murthy AK, Arulanandam BP. 2010. The contribution of interleukin-12/interferon-gamma axis in protection against neonatal pulmonary Chlamydia muridarum challenge. J. Interferon Cytokine Res. 30: 407-415.
14. Lu H, Shen C, Brunham RC. 2000. Chlamydia trachomatis infection of epithelial cells induces the activation of caspase-1 and release of mature IL-18. J. Immunol. 165:1463-1469.
15. Bai H, Cheng J, Gao X, Joyee AG, Fan Y, Wang S, Jiao L, Yao Z, Yang X. 2009. IL-17/Th17 promotes type 1 T cell immunity against pulmonary intracellular bacterial infection through modulating dendritic cell function. J. Immunol. 183:5886-5895.
16. Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G. 2009. A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum. J. Immunol. 183:1291-1300.
17. Perry LL, Feilzer K, Caldwell HD. 1997. Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-gamma-dependent and -independent pathways. J. Immunol. 158:3344-3352.
18. Scurlock AM, Frazer LC, Andrews CW, Jr, O'Connell CM, Foote IP, Bailey SL, Chandra-Kuntal K, Kolls JK, Darville T. 2011. Interleukin-17 contributes to generation of Th1 immunity and neutrophil recruitment during Chlamydia muridarum genital tract infection but is not required for macrophage influx or normal resolution of infection. Infect. Immun. 79:1349-1362.
19. Cheng W, Shivshankar P, Li Z, Chen L, Yeh IT, Zhong G. 2008. Caspase-1 contributes to Chlamydia trachomatis-induced upper urogenital tract inflammatory pathologies without affecting the course of infection. Infect. Immun. 76:515-522.
20. Chen C, Chen D, Sharma J, Cheng W, Zhong Y, Liu K, Jensen J, Shain R, Arulanandam B, Zhong G. 2006. The hypothetical protein CT813 is localized in the Chlamydia trachomatis inclusion membrane and is im-munogenic in women urogenitally infected with C. trachomatis. Infect. Immun. 74:4826-4840.
21. Shah AA, Schripsema JH, Imtiaz MT, Sigar IM, Kasimos J, Matos PG, Inouye S, Ramsey KH. 2005. Histopathologic changes related to fibrotic oviduct occlusion after genital tract infection of mice with Chlamydia muridarum. Sex Transm. Dis. 32:49-56.
22. Chen L, Lei L, Chang X, Li Z, Lu C, Zhang X, Wu Y, Yeh IT, Zhong G. 2010. Mice deficient in MyD88 develop a Th2-dominant response and severe pathology in the upper genital tract following Chlamydia muridarum infection. J. Immunol. 184:2602-2610.
23. Svensson M, Yadav M, Holmqvist B, Lutay N, Svanborg C, Godaly G. 2011. Acute pyelonephritis and renal scarring are caused by dysfunctional innate immunity in mCxcr2 heterozygous mice. Kidney Int. 80:1064-1072.
24. Zhong G, Fan P, Ji H, Dong F, Huang Y. 2001. Identification of a chlamydial protease-like activity factor responsible for the degradation of host transcription factors. J. Exp. Med. 193:935-942.
25. Sharma J, Bosnic AM, Piper JM, Zhong G. 2004. Human antibody responses to a Chlamydia-secreted protease factor. Infect. Immun. 72: 7164-7171.
26. Zhong G, Toth I, Reid R, Brunham RC. 1993. Immunogenicity evaluation of a lipidic amino acid-based synthetic peptide vaccine for Chla-mydia trachomatis. J. Immunol. 151:3728-3736.
27. Zhong GM, Brunham RC. 1990. Immunoaccessible peptide sequences of the major outer membrane protein from Chlamydia trachomatis serovar C. Infect. Immun. 58:3438-3441.
28. Cooper AM, Khader SA. 2008. The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis. Immunol. Rev. 226:191-204.
29. Gee K, Guzzo C, Che Mat NF, Ma W, Kumar A. 2009. The IL-12 family of cytokines in infection, inflammation and autoimmune disorders. In-flamm. Allergy Drug Targets 8:40-52.
30. Langrish CL, McKenzie BS, Wilson NJ, de Waal Malefyt R, Kastelein RA, Cua DJ. 2004. IL-12 and IL-23: master regulators of innate and adaptive immunity. Immunol. Rev. 202:96-105.
31. Morrison RP, Caldwell HD. 2002. Immunity to murine chlamydial genital infection. Infect. Immun. 70:2741-2751.
32. Cotter TW, Ramsey KH, Miranpuri GS, Poulsen CE, Byrne GI. 1997. Disseminationof Chlamydia trachomatis chronic genital tract infection in gamma interferon gene knockout mice. Infect. Immun. 65:2145-2152.
33. Bombeiro AL, Goncalves LA, Penha-Goncalves C, Marinho CR, D'Imperio Lima MR, Chadi G, Alvarez JM. 2012. IL-12p40 deficiency leadsto uncontrolled Trypanosoma cruzi disseminationinthe spinal cord resulting in neuronal death and motor dysfunction. PLoS One 7:e49022. doi: 10.1371/journal.pone.0049022.
34. Dimitrakov J, Ganev V, Zlatanov T, Detchev I, Horvat A, Kirov S, Vatchkova I, Dimitrakov D. 1998. PCR studies on the presence of Chla-mydia trachomatis in the upper urinary tract of patients with obstructive pyelonephritis. Folia Med. (Plovdiv) 40:24-28.
35. Khader SA, Gopal R. 2010. IL-17 in protective immunity to intracellular pathogens. Virulence 1:423-427.
36. Wozniak TM, Saunders BM, Ryan AA, Britton WJ. 2010. Mycobacte-rium bovis BCG-specific Th17 cells confer partial protection against My-cobacterium tuberculosis infection in the absence of gamma interferon. Infect. Immun. 78:4187-4194.
37. Basu R, O'Quinn DB, Silberger DJ, Schoeb TR, Fouser L, Ouyang W, Hatton RD, Weaver CT. 2012. Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria. Immunity 37:1061-1075.
38. Lilly LM, Gessner MA, Dunaway CW, Metz AE, Schwiebert L, Weaver CT, Brown GD, Steele C. 2012. The beta-glucan receptor dectin-1 promotes lung immunopathology during fungal allergy via IL-22. J. Immunol. 189:3653-3660.
39. Ota N, Wong K, Valdez PA, Zheng Y, Crellin NK, Diehl L, Ouyang W. 2011. IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter roden-tium. Nat. Immunol. 12:941-948.