Improving binding affinity and stability of peptide ligands by substituting glycines with D-amino acids

ChemBioChem

Volumn 14, Issue 11, 2013, Pages 1316-1322

  Chen, Shiyu ^a   Gfeller, David ^b   Buth, Sergey A ^a   Michielin, Olivier ^b   Leiman, Petr G ^a   Heinis, Christian ^a  

^a EPFL   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Amino acids; Bicyclic peptides; Glycine; Peptides; Urokinase

Indexed keywords

4 AMINOBUTYRIC ACID DERIVATIVE; ALANINE; AMINO ACID; CYCLOPEPTIDE; DEXTRO ALANINE; DEXTRO ALPHA 4 AMINOBUTYRIC ACID; DEXTRO AMINO ACID; DEXTRO PHENYLALANINE; DEXTRO SERINE; GLOBULAR PROTEIN; GLYCINE; GLYCINE DERIVATIVE; LIGAND; UNCLASSIFIED DRUG; UROKINASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CONSENSUS SEQUENCE; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MOLECULAR INTERACTION; MUTAGENESIS; MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN STABILITY; STRUCTURE ANALYSIS; SYNTHESIS;

AMINO ACIDS; BICYCLIC PEPTIDES; GLYCINE; PEPTIDES; UROKINASE;

AMINO ACIDS; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DATABASES, PROTEIN; ENZYME INHIBITORS; GLYCINE; HUMANS; KINETICS; LIGANDS; MUTAGENESIS, SITE-DIRECTED; PEPTIDE LIBRARY; PEPTIDES; PROTEIN BINDING; PROTEIN STABILITY; PROTEOLYSIS; SUBSTRATE SPECIFICITY; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 84880639988     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201300228     Document Type: Article

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