Obesity heats up adipose tissue lymphocytes

Gastroenterology

Volumn 145, Issue 2, 2013, Pages 282-285

  O'Rourke, Robert W ^a   Lumeng, Carey N ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; INTERLEUKIN 17; INTERLEUKIN 22; INTERLEUKIN 6;

ADAPTIVE IMMUNITY; ADIPOCYTE; ADIPOSE TISSUE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL STRESS; CYTOKINE PRODUCTION; DENDRITIC CELL; HOMEOSTASIS; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; INSULIN RESISTANCE; LEUKOCYTE; LIPID STORAGE; LYMPHOCYTE; MACROPHAGE; METABOLIC REGULATION; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUTRIENT; OBESITY; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROADIPOCYTE; REGULATORY T LYMPHOCYTE; REVIEW; SUBCUTANEOUS FAT; T LYMPHOCYTE ACTIVATION; TH17 CELL;

EID: 84880594803     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.06.026     Document Type: Editorial

References (19)

1. M.F. Gregor, and G.S. Hotamisligil Inflammatory mechanisms in obesity Annu Rev Immunol 29 2011 415 445
2. + T-cell populations and insulin resistance in obese individuals Gastroenterology 145 2013 366 374
3. M.Y. Donath, and S.E. Shoelson Type 2 diabetes as an inflammatory disease Nat Rev Immunol 11 2011 98 107
4. S. Winer, Y. Chan, and G. Paltser Normalization of obesity-associated insulin resistance through immunotherapy: CD4+ T cells control glucose homeostasis Nat Med 15 2009 921 929
5. C. Duffaut, A. Zakaroff-Girard, and V. Bourlier Interplay between human adipocytes and T lymphocytes in obesity: CCL20 as an adipochemokine and T lymphocytes as lipogenic modulators Arterioscler Thromb Vasc Biol 29 2009 1608 1614
6. U. Kintscher, M. Hartge, and K. Hess T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance Arterioscler Thromb Vasc Biol 28 2008 1304 1310
7. R.W. O'Rourke, M.D. Metcalf, and A.E. White Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-gamma in inflammation in human adipose tissue Int J Obes (Lond) 33 2009 978 990
8. V.Z. Rocha, E.J. Folco, and G. Sukhova Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity Circ Res 103 2008 467 476
9. M. Jagannathan-Bogdan, M.E. McDonnell, and H. Shin Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes J Immunol 186 2011 1162 1172
10. S. Winer, G. Paltser, and Y. Chan Obesity predisposes to Th17 bias Eur J Immunol 39 2009 2629 2635
11. C.T. Weaver, E.O. Elson, and L.A. Fouser The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin Annu Rev Pathol Mech Dis 8 2013 477 512
12. M. Sumarac-Dumanovic, D. Stevanovic, and A. Ljubic Increased activity of interleukin-23/interleukin-17 proinflammatory axis in obese women Int J Obes (Lond) 33 2009 151 156
13. J. Surendar, V. Aravindhan, and M.M. Rao Decreased serum interleukin-17 and increased transforming growth factor-beta levels in subjects with metabolic syndrome (Chennai Urban Rural Epidemiology Study-95) Metabolism 60 2011 586 590
14. A. Zizza, M. Guido, and P. Grima Interleukin-17 regulates visceral obesity in HIV-1-infected patients HIV Med 13 2012 574 577
15. A. Bertola, T. Ciucci, and D. Rousseau Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients Diabetes 61 2012 2238 2247
16. J.H. Shin, D.W. Shin, and M. Noh Interleukin-17A inhibits adipocyte differentiation in human mesenchymal stem cells and regulates pro-inflammatory responses in adipocytes Biochem Pharmacol 77 2009 1835 1844
17. J.M. Harkins, N. Moustaid-Moussa, and Y.J. Chung Expression of interleukin-6 is greater in preadipocytes than in adipocytes of 3T3-L1 cells and C57BL/6J and ob/ob mice J Nutr 134 2004 2673 2677
18. C. Zeng, X. Shi, and B. Zhang The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications J Mol Med (Berl) 90 2012 175 186
19. D.L. Morris, K.W. Cho, and J. Delproposto Adipose tissue macrophages function as antigen presenting cells and regulate adipose tissue CD4+ T cells in mice Diabetes 2013 [Epub ahead of press] http://dx.doi.org/10.2337/db12-1404