Effect of scaling and root planing combined with systemic doxycycline therapy on glycemic control in diabetes mellitus subjects with chronic generalized periodontitis: A clinical study

Journal of Periodontal and Implant Science

Volumn 43, Issue 2, 2013, Pages 79-86

  Gaikwad, Subodh P ^a   Gurav, Abhijit N ^a   Shete, Abhijeet R ^a   Desarda, Hitesh M ^a  

^a Tatyasaheb Kore Dental College and Research Centre   (India)

Author keywords

Chronic periodontitis; Diabetes mellitus; Glycosylated hemoglobin A; Periodontal debridement

Indexed keywords

EID: 84880592710     PISSN: 20932278     EISSN: 20932286     Source Type: Journal    
DOI: 10.5051/jpis.2013.43.2.79     Document Type: Article

References (40)

1. Stewart J.E., Wager K.A., Friedlander A.H., Zadeh H.H. The effect of periodontal treatment on glycemic control in patients with type 2 diabetes mellitus. J Clin Periodontol 2001; 28:306-10.
2. Oliver R.C., Tervonen T. Diabetes: a risk factor for periodontitis in adults? J Periodontol 1994;65(5 Suppl):530-8.
3. Emrich L.J., Shlossman M., Genco R.J. Periodontal disease in non-insulin-dependent diabetes mellitus. J Periodontol 1991;62:123-31.
4. Loe H. Periodontal disease: the sixth complication of diabetes mellitus. Diabetes Care 1993;16:329-34.
5. Grossi S.G., Genco R.J. Periodontal disease and diabetes mellitus: a two-way relationship. Ann Periodontol 1998;3: 51-61.
6. Nelson R.G., Shlossman M., Budding L.M., Pettitt D.J., Saad MF, Genco RJ, et al. Periodontal disease and NIDDM in Pima Indians. Diabetes Care 1990;13:836-40.
7. Gurav A.N.Periodontal therapy: an adjuvant for glycemic control. Diabetes Metab Syndr 2012;6:218-23.
8. Smith G.T., Greenbaum C.J., Johnson BD, Persson GR. Short-term responses to periodontal therapy in insulin-dependent diabetic patients. J Periodontol 1996;67:794-802.
9. Christgau M., Palitzsch K.D., Schmalz G., Kreiner U., Frenzel S. Healing response to non-surgical periodontal therapy in patients with diabetes mellitus: clinical, microbiological, and immunologic results. J Clin Periodontol 1998;25: 112-24.
10. Ryan M., Ramamurthy N., Golub L.M., Six CMTs, modulate MMPs, and non-enzymatic glycosylation in diabetic rats [abstract]. J Dent Res 1995;74:138.
11. Loe H. The Gingival Index, the Plaque Index and the Retention Index Systems. J Periodontol 1967;38:Suppl:610-6.
12. Mealey B.L., Oates T.W.; American Academy of Periodontology. Diabetes mellitus and periodontal diseases. J Periodontol 2006;77:1289-303.
13. Taylor G.W., Borgnakke W.S. Periodontal disease: associations with diabetes, glycemic control and complications. Oral Dis 2008;14:191-203.
14. Iacopino A.M. Periodontitis and diabetes interrelationships: role of inflammation. Ann Periodontol 2001;6:125-37.
15. Noack B., Genco R.J., Trevisan M., Grossi S, Zambon JJ, De Nardin E. Periodontal infections contribute to elevated systemic C-reactive protein level. J Periodontol 2001;72: 1221-7.
16. Loos B.G, Craandijk J., Hoek F.J., Wertheim-van Dillen P.M., van der Velden U. Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J Periodontol 2000;71:1528-34.
17. Kiran M., Arpak N., Unsal E., Erdogan M.F. The effect of improved periodontal health on metabolic control in type 2 diabetes mellitus. J Clin Periodontol 2005;32:266-72.
18. Janket S.J., Wightman A., Baird A.E., Van Dyke TE, Jones JA. Does periodontal treatment improve glycemic control in diabetic patients? A meta-analysis of intervention studies. J Dent Res 2005;84:1154-9.
19. Iwamoto Y., Nishimura F., Nakagawa M., Sugimoto H., Shikata K., Makino H, et al. The effect of antimicrobial periodontal treatment on circulating tumor necrosis factor-alpha and glycated hemoglobin level in patients with type 2 diabetes. J Periodontol 2001;72:774-8.
20. Morrison E.C., Ramfjord S.P., Hill RW. Short-term effects of initial, nonsurgical periodontal treatment (hygienic phase). J Clin Periodontol 1980;7:199-211.
21. Lowenguth R.A., Greenstein G. Clinical and microbiological response to nonsurgical mechanical periodontal therapy. Periodontol 2000 1995;9:14-22.
22. Badersten A., Nilveus R., Egelberg J. Effect of nonsurgical periodontal therapy. I. Moderately advanced periodontitis. J Clin Periodontol 1981;8:57-72.
23. Promsudthi A., Pimapansri S., Deerochanawong C, Kanchanavasita W. The effect of periodontal therapy on uncontrolled type 2 diabetes mellitus in older subjects. Oral Dis 2005;11:293-8.
24. O'Connell P.A., Taba M., Nomizo A, Foss Freitas M.C., Suaid F.A., Uyemura S.A, et al. Effects of periodontal therapy on glycemic control and inflammatory markers. J Periodontol 2008;79:774-83.
25. Grossi S.G, Skrepcinski F.B., DeCaro T., Robertson D.C., Ho A.W., Dunford R.G., et al. Treatment of periodontal disease in diabetics reduces glycated hemoglobin. J Periodontol 1997;68:713-9.
26. Llambes F., Silvestre F.J., Hernandez-Mijares A., Guiha R., Caffesse R. Effect of non-surgical periodontal treatment with or without doxycycline on the periodontium of type 1 diabetic patients. J Clin Periodontol 2005;32:915-20.
27. Sorsa T., Ingman T.,Suomalainen K., Halinen S., Saari H., Konttinen Y.T., et al. Cellular source and tetracycline-inhibition of gingival crevicular fluid collagenase of patients with labile diabetes mellitus. J Clin Periodontol 1992;19: 146-9.
28. Koromantzos P.A., Makrilakis K., Dereka X., Offenbacher S., Katsilambros N., Vrotsos IA, et al. Effect of non-surgical periodontal therapy on C-reactive protein, oxidative stress, and matrix metalloproteinase (MMP)-9 and MMP-2 levels in patients with type 2 diabetes: a randomized controlled study. J Periodontol 2012;83:3-10.
29. Rodrigues D.C., Taba M.J., Novaes A.B., Souza SL, Grisi MF. Effect of non-surgical periodontal therapy on glycemic control in patients with type 2 diabetes mellitus. J Periodontol 2003;74:1361-7.
30. Kaldahl W.B., Kalkwarf K.L., Patil K.D., Molvar M.P., Dyer J.K. Long-term evaluation of periodontal therapy: I. Response to 4 therapeutic modalities. J Periodontol 1996;67:93-102.
31. Ramfjord S.P., Caffesse R.G., Morrison EC, Hill RW, Kerry G.J. Appleberry EA, et al. 4 modalities of periodontal treatment compared over 5 years. J Clin Periodontol 1987;14:445-52.
32. Sorsa T., Lindy O., Konttinen Y.T., Suomalainen K., Ingman T., Saari H., et al. Doxycycline in the protection of serum alpha-1-antitrypsin from human neutrophil collagenase and gelatinase. Antimicrob Agents Chemother 1993;37:592-4.
33. Hanemaaijer R., Visser H., Koolwijk P., Sorsa T., Salo T., Golub L.M., et al. Inhibition of MMP synthesis by doxycycline and chemically modified tetracyclines (CMTs) in human endothelial cells. Adv Dent Res 1998;12:114-8.
34. Rifkin B.R., Vernillo A.T., Golub L.M. Blocking periodontal disease progression by inhibiting tissue-destructive enzymes: a potential therapeutic role for tetracyclines and their chemically-modified analogs. J Periodontol 1993; 64(8 Suppl):819-27.
35. Rohlfing C.L., Wiedmeyer H.M., Little RR, England JD, Tennill A, Goldstein DE. Defining the relationship between plasma glucose and HbA(1c): analysis of glucose profiles and HbA(1c) in the Diabetes Control and Complications Trial. Diabetes Care 2002;25:275-8.
36. Jones J.A., Miller D.R., Wehler CJ, Rich S, Krall E, Christiansen CL, et al. Study design, recruitment, and baseline characteristics: the Department of Veterans Affairs Dental Diabetes Study. J Clin Periodontol 2007;34:40-5.
37. Singh S., Kumar V, Kumar S, Subbappa A. The effect of periodontal therapy on the improvement of glycemic control in patients with type 2 diabetes mellitus: A randomized controlled clinical trial. Int J Diabetes Dev Ctries 2008;28:38-44.
38. Koromantzos P.A., Makrilakis K., Dereka X., Katsilambros N., Vrotsos I.A., Madianos P.N. A randomized, controlled trial on the effect of non-surgical periodontal therapy in patients with type 2 diabetes. Part I: effect on periodontal status and glycaemic control. J Clin Periodontol 2011;38: 142-7.
39. Moutsopoulos N.M., Madianos PN. Low-grade inflammation in chronic infectious diseases: paradigm of periodontal infections. Ann N Y Acad Sci 2006;1088:251-64.
40. Gurav A.N. Periodontitis and insulin resistance: casual or causal relationship? Diabetes Metab J 2012;36:404-11.