Berberine induces apoptosis via the mitochondrial pathway in liver cancer cells

Oncology Reports

Volumn 30, Issue 3, 2013, Pages 1107-1112

  Yip, Novia K Y ^a   Ho, W S ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Anti proliferative; Apoptosis; Berberine; Caspase cascade; Huh7

Indexed keywords

BERBERINE; CASPASE; PROCASPASE 3; PROCASPASE 7; PROCASPASE 9; PROTEIN BAX; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; LIVER CANCER; M PHASE CELL CYCLE CHECKPOINT; MITOCHONDRION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

APOPTOSIS; BERBERINE; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CASPASE INHIBITORS; CASPASES; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; GENE EXPRESSION PROFILING; HUMANS; LIVER; LIVER NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR MARKERS, BIOLOGICAL;

EID: 84880592343     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2543     Document Type: Article

References (16)

1. Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin 60: 277-300, 2010.
2. Perz JF, Armstrong GL, Farrington LA, Hutin YJ and Bell BP: The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol 45: 529-538, 2006.
3. Campo RA, Rowland JH, Irwin ML, Nathan PC, Gritz ER and Kinney AY: Cancer prevention after cancer: changing the paradigm - a report from the American Society of Preventive Oncology. Cancer Epidemiol Biomarkers Prev 20: 2317-2324, 2011.
4. Parkin DM: The global health burden of infection-associated cancers in the year 2002. Int J Cancer 118: 3030-3044, 2006.
5. El-Serag HB: Epidemiology of hepatocellular carcinoma in USA. Hepatol Res 37 (Suppl 2): S88-S94, 2007.
6. Mahata S, Bharti AC, Shukla S, Tyagi A, Husain SA and Das BC: Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells. Mol Cancer 10: 39, 2011.
7. Luo Y, Hao Y, Shi TP, Deng WW and Li N: Berberine inhibits cyclin D1 expression via suppressed binding of AP-1 transcription factors to CCND1 AP-1 motif. Acta Pharmacol Sin 29: 628-633, 2008.
8. Wu HL, Hsu CY, Liu WH and Yung BY: Berberine-induced apoptosis of human leukemia HL-60 cells is associated with down-regulation of nucleophosmin/B23 and telomerase activity. Int J Cancer 81: 923-929, 1999.
9. Ghobrial IM, Witzig TE and Adjei AA: Targeting apoptosis pathways in cancer therapy. CA Cancer J Clin 55: 178-194, 2005.
10. Luo Y, Hurwitz J and Massagué J: Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1. Nature 375: 159-161, 1995.
11. Li Y, Dowbenko D and Lasky LA: AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival. J Biol Chem 277: 11352-11361, 2002.
12. Ambrosini G, Adida C and Altieri DC: A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 3: 917-921, 1997.
13. Inohara N, Ding L, Chen S and Núñez G. harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L). EMBO J 16: 1686-1694, 1997.
14. Reed JC: Bcl-2 family proteins: regulators of apoptosis and chemoresistance in hematologic malignancies. Semin Hematol 34: 9-19, 1997.
15. Earnshaw WC, Martins LM and Kaufmann SH: Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Ann Rev Biochem 68: 383-424, 1999.
16. Boulares AH, Yakovlev AG, Ivanova V, Stoica BA, Wang G, Iyer S and Smulson M: Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells. J Biol Chem 274: 22932-22940, 1999.