Glucose-dependent insulinotropic polypeptide (GIP) receptor deletion leads to reduced bone strength and quality

Bone

Volumn 56, Issue 2, 2013, Pages 337-342

  Mieczkowska, Aleksandra ^a   Irwin, Nigel ^b   Flatt, Peter R ^b   Chappard, Daniel ^a   Mabilleau, Guillaume ^a  

^a UNIV Angers   (France)

^b UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

Bone quality; Bone strength; GIP; GIPR; Gut hormone; Nanoindentation

Indexed keywords

COLLAGEN; GLUCOSE DEPENDENT INSULINOTROPIC POLYPEPTIDE RECEPTOR; HORMONE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE CHARACTERISTICS AND FUNCTIONS; BONE MARROW; BONE MINERALIZATION; BONE QUALITY; BONE STRENGTH; BRAIN CORTEX; CONTROLLED STUDY; IMAGING; KNOCKOUT MOUSE; MALE; MICRO-COMPUTED TOMOGRAPHY; MICRORADIOGRAPHY; MORPHOMETRICS; MOUSE; NONHUMAN; OSSIFICATION; OSTEOLYSIS; PROTEIN CROSS LINKING; QUANTITATIVE BACKSCATTERED ELECTRON IMAGING; RIGIDITY; WILD TYPE;

BONE QUALITY; BONE STRENGTH; GIP; GIPR; GUT HORMONE; NANOINDENTATION;

ANIMALS; BONE AND BONES; MALE; MICE; MICE, KNOCKOUT; RECEPTORS, GASTROINTESTINAL HORMONE; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; X-RAY MICROTOMOGRAPHY;

EID: 84880592286     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2013.07.003     Document Type: Article

References (35)

1. Elnenaei M.O., Musto R., Alaghband-Zadeh J., Moniz C., Le Roux C.W. Postprandial bone turnover is independent of calories above 250kcal. Ann Clin Biochem 2010, 47:318-320.
2. Henriksen D.B., Alexandersen P., Bjarnason N.H., Vilsboll T., Hartmann B., Henriksen E.E., et al. Role of gastrointestinal hormones in postprandial reduction of bone resorption. J Bone Miner Res 2003, 18:2180-2189.
3. Andersen D.K., Elahi D., Brown J.C., Tobin J.D., Andres R. Oral glucose augmentation of insulin secretion. Interactions of gastric inhibitory polypeptide with ambient glucose and insulin levels. J Clin Invest 1978, 62:152-161.
4. Schirra J., Katschinski M., Weidmann C., Schafer T., Wank U., Arnold R., et al. Gastric emptying and release of incretin hormones after glucose ingestion in humans. J Clin Invest 1996, 97:92-103.
5. Varner A.A., Isenberg J.I., Elashoff J.D., Lamers C.B., Maxwell V., Shulkes A.A. Effect of intravenous lipid on gastric acid secretion stimulated by intravenous amino acids. Gastroenterology 1980, 79:873-876.
6. Baggio L.L., Drucker D.J. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007, 132:2131-2157.
7. Bollag R.J., Zhong Q., Phillips P., Min L., Zhong L., Cameron R., et al. Osteoblast-derived cells express functional glucose-dependent insulinotropic peptide receptors. Endocrinology 2000, 141:1228-1235.
8. Mabilleau G., Gaudin-Audrain C., Irwin N., Flatt P.R., Basle M.F., Chappard D. Deficiency in glucose-dependent insulinotropic peptide receptor results in higher bone mass in male mice. Osteoporos Int 2012, 23:S407-S408.
9. Pacheco-Pantoja E.L., Ranganath L.R., Gallagher J.A., Wilson P.J., Fraser W.D. Receptors and effects of gut hormones in three osteoblastic cell lines. BMC Physiol 2011, 11:12.
10. Zhong Q., Itokawa T., Sridhar S., Ding K.H., Xie D., Kang B., et al. Effects of glucose-dependent insulinotropic peptide on osteoclast function. Am J Physiol Endocrinol Metab 2007, 292:E543-E548.
11. Bollag R.J., Zhong Q., Ding K.H., Phillips P., Zhong L., Qin F., et al. Glucose-dependent insulinotropic peptide is an integrative hormone with osteotropic effects. Mol Cell Endocrinol 2001, 177:35-41.
12. Zhong Q., Ding K.H., Mulloy A.L., Bollag R.J., Isales C.M. Glucose-dependent insulinotropic peptide stimulates proliferation and TGF-beta release from MG-63 cells. Peptides 2003, 24:611-616.
13. Xie D., Cheng H., Hamrick M., Zhong Q., Ding K.H., Correa D., et al. Glucose-dependent insulinotropic polypeptide receptor knockout mice have altered bone turnover. Bone 2005, 37:759-769.
14. Gaudin-Audrain C., Irwin N., Mansur S., Thorens B., Flatt P.R., Basle M.F., et al. Glucose-dependent insulinotropic polypeptide receptor deficiency leads to modifications of trabecular bone mass and quality in mice. Bone 2013, 53:221-230.
15. Chappard D., Basle M.F., Legrand E., Audran M. New laboratory tools in the assessment of bone quality. Osteoporos Int 2011, 22:2225-2240.
16. Preitner F., Ibberson M., Franklin I., Binnert C., Pende M., Gjinovci A., et al. Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors. J Clin Invest 2004, 113:635-645.
17. Bassett J.H., Gogakos A., White J.K., Evans H., Jacques R.M., van der Spek A.H., et al. Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. PLoS Genet 2012, 8:e1002858.
18. Bassett J.H., van der Spek A., Gogakos A., Williams G.R. Quantitative X-ray imaging of rodent bone by Faxitron. Methods Mol Biol 2012, 816:499-506.
19. Bouxsein M.L., Boyd S.K., Christiansen B.A., Guldberg R.E., Jepsen K.J., Muller R. Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Miner Res 2010, 25:1468-1486.
20. Chappard D., Alexandre C., Riffat G. Histochemical identification of osteoclasts. Review of current methods and reappraisal of a simple procedure for routine diagnosis on undecalcified human iliac bone biopsies. Basic Appl Histochem 1983, 27:75-85.
21. Parfitt A.M., Drezner M.K., Glorieux F.H., Kanis J.A., Malluche H., Meunier P.J., et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. J Bone Miner Res 1987, 2:595-610.
22. Ammann P., Badoud I., Barraud S., Dayer R., Rizzoli R. Strontium ranelate treatment improves trabecular and cortical intrinsic bone tissue quality, a determinant of bone strength. J Bone Miner Res 2007, 22:1419-1425.
23. Gaudin-Audrain C., Irwin N., Mansur S., Flatt P.R., Thorens B., Baslé M., et al. Glucose-dependent insulinotropic polypeptide receptor deficiency leads to modifications of trabecualr bone mass and quality in mice. Bone 2013, 53:221-230.
24. Roschger P., Fratzl P., Eschberger J., Klaushofer K. Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies. Bone 1998, 23:319-326.
25. Oliver W.C., Pharr G.M. An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiments. J Mater Res 1992, 7:1564-1583.
26. Paschalis E.P., DiCarlo E., Betts F., Sherman P., Mendelsohn R., Boskey A.L. FTIR microspectroscopic analysis of human osteonal bone. Calcif Tissue Int 1996, 59:480-487.
27. Paschalis E.P., Verdelis K., Doty S.B., Boskey A.L., Mendelsohn R., Yamauchi M. Spectroscopic characterization of collagen cross-links in bone. J Bone Miner Res 2001, 16:1821-1828.
28. Bouxsein M.L., Myers K.S., Shultz K.L., Donahue L.R., Rosen C.J., Beamer W.G. Ovariectomy-induced bone loss varies among inbred strains of mice. J Bone Miner Res 2005, 20:1085-1092.
29. Judex S., Garman R., Squire M., Donahue L.R., Rubin C. Genetically based influences on the site-specific regulation of trabecular and cortical bone morphology. J Bone Miner Res 2004, 19:600-606.
30. Turner C.H., Burr D.B. Basic biomechanical measurements of bone: a tutorial. Bone 1993, 14:595-608.
31. Burguera B., Hofbauer L.C., Thomas T., Gori F., Evans G.L., Khosla S., et al. Leptin reduces ovariectomy-induced bone loss in rats. Endocrinology 2001, 142:3546-3553.
32. Hamrick M.W., Pennington C., Newton D., Xie D., Isales C. Leptin deficiency produces contrasting phenotypes in bones of the limb and spine. Bone 2004, 34:376-383.
33. Bailey A.J., Sims T.J., Ebbesen E.N., Mansell J.P., Thomsen J.S., Mosekilde L. Age-related changes in the biochemical properties of human cancellous bone collagen: relationship to bone strength. Calcif Tissue Int 1999, 65:203-210.
34. Burr D.B. The contribution of the organic matrix to bone's material properties. Bone 2002, 31:8-11.
35. Zioupos P., Currey J.D., Hamer A.J. The role of collagen in the declining mechanical properties of aging human cortical bone. J Biomed Mater Res 1999, 45:108-116.