Altered expression of interleukin-6, interleukin-8 and their receptors in decidua of women with sporadic miscarriage

Human Reproduction

Volumn 28, Issue 8, 2013, Pages 2075-2086

  Pitman, Hedele ^a   Innes, Barbara A ^a   Robson, Stephen C ^a   Bulmer, Judith N ^a   Lash, Gendie E ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

decidua; interleukin 6; interleukin 8; spiral artery remodelling; sporadic miscarriage

Indexed keywords

CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; INTERLEUKIN 6; INTERLEUKIN 8; MICROSOMAL AMINOPEPTIDASE;

ARTICLE; CELL ISOLATION; CELL POPULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DECIDUA; FEMALE; GESTATIONAL AGE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MENSTRUAL CYCLE; MYOMETRIUM; NATURAL KILLER CELL; PREGNANCY TERMINATION; PROTEIN EXPRESSION; SPONTANEOUS ABORTION; STROMA CELL; TROPHOBLAST;

EID: 84880569211     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/det233     Document Type: Article

References (39)

1. Ball E, Bulmer JN, Aysi S, Lyall F, Robson SC. Late sporadic miscarriage is associated with abnormalities in spiral artery transformation and trophoblast invasion. J Pathol 2006a;208:535-542. (Pubitemid 43329340)
2. Ball E, Robson SC, Ayis S, Lyall F, Bulmer JN. Early embryonic demise: no evidence of abnormal spiral artery transformation or trophoblast invasion. J Pathol 2006b;208:528-534. (Pubitemid 43329339)
3. Calleja-Agius J, Jauniaux E, Pizzey AR, Muttukrishna S. Investigation of systemic inflammatory response in first trimester pregnancy failure. Hum Reprod 2012;27:349-357.
4. Champion H, Innes BA, Robson SC, Lash GE, Bulmer JN. Effects of interleukin-6 on extravillous trophoblast invasion in early human pregnancy. Mol Hum Reprod 2012;18:391-400.
5. De Oliveira LG, Lash GE, Murray-Dunning C, Bulmer JN, Innes BA, Searle RF, Sass N, Robson SC. Role of interleukin 8 in regulation of extravillous trophoblast cell invasion. Placenta 2010;31:595-601.
6. Engert S, Rieger L, Kapp M, Becker JC, Dietl J, Kammerer U. Profiling chemokines, cytokines and growth factors in human early pregnancy decidua by protein array. Am J Reprod Immunol 2007;58:129-137. (Pubitemid 47097379)
7. Everett C. Incidence and outcome of bleeding before the 20th week of pregnancy: prospective study from general practice. BMJ 1997; 315:32-34. (Pubitemid 27271683)
8. Galazios G, Tsoulou S, Zografou C, Tripsianis G, Koutlaki N, Papazoglou D, Tsikouras P, Maltezos E, Liberis V. The role ofcytokines IL-6 and IL-8in the pathogenesis ofspontaneous abortions. J Matern Fetal Neonatal Med 2011; 24:1283-1285.
9. Hanna J, Goldman-Wohl D, Hamani Y, Avraham I, Greenfield C, Natanson-Yaron S, Prus D, Cohen-Daniel L, Arnon TI, Manaster I et al. Decidual NK cells regulate key developmental processes at the human fetal-maternal interface. Nat Med 2006;12:1065-1074. (Pubitemid 44353388)
10. Heinrich PC, Behrmann I, Haan S, Hermanns HM, Muller-Newen G, Schaper F. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 2003;374:1-20. (Pubitemid 37046923)
11. Hustin J, Jauniaux E, Schaaps JP. Histological study of the materno-embryonic interface in spontaneous abortion. Placenta 1990;11:477-486.
12. Jasper MJ, Tremellen KP, Robertson SA. Reduced expression of IL-6 and IL-1alpha mRNAs in secretory phase endometrium of women with recurrent miscarriage. J Reprod Immunol 2007;73:74-84. (Pubitemid 46161830)
13. Jauniaux E, Watson AL, Hempstock J, Bao YP, Skepper JN, Burton GJ. Onset of maternal arterial blood flow and placental oxidative stress. A possible factorinhuman early pregnancy failure. Am J Pathol 2000;157:2111-2122.
14. Jovanović M, Vićovac L. Interleukin-6 stimulates cell migration, invasion and integrin expression in HTR-8/SVneo cell line. Placenta 2009;30:320-328.
15. Jovanovic M, Stefanoska I, Radojcic L, Vicovac L. Interleukin-8 (CXCL8) stimulates trophoblast cell migration and invasion by increasing levels of matrix metalloproteinase (MMP)2 and MMP9 and integrins alpha5 and beta1. Reproduction 2010;139:789-798.
16. Kanayama N, Kajiwara Y, Goto J, El Maradny E, Maehara K, Andou K, Terao T. Inactivation of interleukin-8 by aminopeptidase N (CD13). J Leukoc Biol 1995;57:129-134.
17. Li C, Houser BL, Nicotra ML, Strominger JL. HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells. Proc Natl Acad Sci USA 2009; 106:5767-5772.
18. Lin MT, Lin BR, Chang CC, Chu CY, Su HJ, Chen ST, Jeng YM, Kuo ML. IL-6 induces AGS gastric cancer cell invasion via activation of the c-Src/RhoA/ROCK signaling pathway. Int J Cancer 2007;120:2600-2608.
19. Madhappan B, Kempuraj D, Christodoulou S, Tsapikidis S, Boucher W, Karagiannis V, Athanassiou A, Theoharides TC. High levels of intra-uterine corticotropin-releasing hormone, urocortin, tryptase, and interleukin-8 in spontaneous abortions. Endocrinology 2003;144: 2285-2290. (Pubitemid 36629879)
20. Martin D, Galisteo R, Gutkind JS. CXCL8/IL8 stimulates vascular endothelial growth factor (VEGF) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM (Carma3/Bcl10/Malt1) complex. J Biol Chem 2009;284:6038-6042.
21. Matsushima K, Morishita K, Yoshimura T, Lavu S, Kobayashi Y, Lew W, Appella E, Kung HF, Leonard EJ, Oppenheim JJ. Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor. J Exp Med 1988;167:1883-1893.
22. Nilsson MB, Langley RR, Fidler IJ. Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine. Cancer Res 2005; 65:10794-10800. (Pubitemid 41713347)
23. Pijnenborg R, Bland JM, Robertson WB, Dixon G, Brosens I. The pattern of interstitial trophoblastic invasion of the myometrium in early human pregnancy. Placenta 1981;2:303-316. (Pubitemid 11022999)
24. Pijnenborg R, Bland JM, Robertson WB, Brosens I. Uteroplacental arterial changes related to interstitial trophoblast migration in early human pregnancy. Placenta 1983;4:397-413. (Pubitemid 13005635)
25. Pijnenborg R, Vercruysse L, Hanssens M. The uterine spiral arteries in human pregnancy: facts and controversies. Placenta 2006;27:939-958. (Pubitemid 44204033)
26. Pongcharoen S, Searle RF, Bulmer JN. Placental Fas and Fas ligand expression in normal early, term and molar pregnancy. Placenta 2004;25:321-330. (Pubitemid 38514941)
27. Regan L, Rai R. Epidemiology and the medical causes of miscarriage. Baillieres Clin Obstet Gynaecol 2000;14:839-854.
28. Robson SC, Simpson H, Ball E, Lyall F, Bulmer JN. Punch biopsy of the human placental bed. Am J Obstet Gynecol 2002;187:1349-1355. (Pubitemid 35397485)
29. Robson A, Harris LK, Innes BA, Lash GE, Aljunaidy MM, Aplin JD, Baker PN, Robson SC, Bulmer JN. Uterine natural killer cells initiate spiral artery remodeling in human pregnancy. FASEB J 2012;26:4876-4885.
30. Rosenkilde MM, Schwartz TW. The chemokine system - a major regulator of angiogenesis in health and disease. APMIS 2004;112: 481-495. (Pubitemid 39626055)
31. Salker M, Teklenburg G, Molokhia M, Lavery S, Trew G, Aojanepong T, Mardon HJ, Lokugamage AU, Rai R, Landles C et al. Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss. PLoS One 2010;5:e10287.
32. Scaife PJ, Searle RF, Robson SC, Innes BA, Bulmer JN. Comparisonofdecidual leucocyte populations in spontaneous early pregnancy loss. J Soc Gynecol Investig 2004;11:285A.
33. Schiessl B, Innes BA, Bulmer JN, Otun HA, Chadwick TJ, Robson SC, Lash GE. Localization of angiogenic growth factors and their receptors in the human placental bed throughout normal human pregnancy. Placenta 2009;30:79-87.
34. Seli E, Senturk LM, Bahtiyar OM, Kayisli UA, Arici A. Expression of aminopeptidase N in human endometrium and regulation of its activity by estrogen. Fertil Steril 2001;75:1172-1176. (Pubitemid 32522616)
35. Smith SD, Dunk CE, Aplin JD, Harris LK, Jones RL. Evidence for immune cell involvement in decidual spiral arteriole remodeling in early human pregnancy. Am J Pathol 2009;174:1959-1971.
36. Teklenburg G, Salker M, Molokhia M, Lavery S, Trew G, Aojanepong T, Mardon HJ, Lokugamage AU, Rai R, Landles C et al. Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation. PLoS One 2010;5:e10258.
37. Vacca P, Cantoni C, Prato C, Fulcheri E, Moretta A, Moretta L, Mingari MC. Regulatory role of NKp44, NKp46, DNAM-1 and NKG2D receptors in the interaction between NK cells and trophoblast cells. Evidence for divergent functional profiles of decidual versus peripheral NK cells. Int Immunol 2008;20:1395-1405.
38. Wulfaenger J, Niedling S, Riemann D, Seliger B. Aminopeptidase N (APN)/CD13-dependent CXCR4 downregulation is associated with diminished cell migration, proliferation and invasion. Mol Membr Biol 2008; 25:72-82.
39. Zenclussen AC, blois S, Stumpo R, Olmos S, Arias K, Borel IM, Roux ME, Margni RA. Murine abortion is associated with enhanced interleukin-6 levels at the feto-maternal interface. Cytokine 2003; 24:150-160. (Pubitemid 37297878)