Estrogen and recurrent UTI: What are the facts?

Science Translational Medicine

Volumn 5, Issue 190, 2013, Pages

  Hannan, Thomas J ^a   Hooton, Thomas M ^b   Hultgren, Scott J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; PLACEBO;

BACTERIAL LOAD; BLADDER DISEASE; DRUG EFFICACY; DRUG MEGADOSE; ESTROGEN THERAPY; HORMONAL REGULATION; HORMONE ACTION; HUMAN; IMMUNOMODULATION; INFECTION SENSITIVITY; INNATE IMMUNITY; KIDNEY INFECTION; MUCOSAL IMMUNITY; NONHUMAN; OVARIECTOMY; POSTMENOPAUSE; PRIORITY JOURNAL; PROTECTION; RECURRENT INFECTION; REVIEW; RISK FACTOR; URINARY TRACT INFECTION; UROPATHOGENIC ESCHERICHIA COLI; VAGINA FLORA;

ANIMALS; ESTROGENS; FEMALE; HUMANS; UROTHELIUM;

EID: 84880553442     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3006423     Document Type: Review

References (10)

1. R. Raz, Urinary tract infection in postmenopausal women. Korean J Urol 52, 801-808 (2011).
2. C. R. Wira, J. V. Fahey, M. Ghosh, M. V. Patel, D. K. Hickey, D. O. Ochiel, Sex hormone regulation of innate immunity in the female reproductive tract: The role of epithelial cells in balancing reproductive potential with protection against sexually transmitted pathogens. Am. J. Reprod. Immunol. 63, 544-565 (2010).
3. R. Raz, W. E. Stamm, A controlled trial of intravaginal estriol in postmenopausal women with recurrent urinary tract infections. N. Engl. J. Med. 329, 753-756 (1993).
4. P. Lüthje, H. Brauner, N. L. Ramos, A. Övregaard, R. Gläser, A. L. Hirschberg, P. Aspenström, A. Brauner, Estrogen supports urothelial defense mechanisms. Sci. Transl. Med. 5, 190ra80 (2013).
5. C. S. Hung, K. W. Dodson, S. J. Hultgren, A murine model of urinary tract infection. Nat. Protoc. 4, 1230-1243 (2009).
6. E. M. Curran, A. H. Tassell, B. M. Judy, B. Nowicki, V. Montgomery- Rice, D. M. Estes, S. Nowicki, Estrogen increases menopausal host susceptibility to experimental ascending urinary-tract infection. J. Infect. Dis. 195, 680-683 (2007).
7. T. J. Hannan, I. U. Mysorekar, C. S. Hung, M. L. Isaacson- Schmid, S. J. Hultgren, Early severe infl ammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection. PLoS Pathog. 6, e1001042 (2010).
8. C. Wang, J. W. Symington, E. Ma, B. Cao, I. U. Mysorekar, Estrogenic modulation of uropathogenic Escherichia coli infection pathogenesis in a murine menopause model. Infect. Immun. 81, 733-739 (2013).
9. M. Anand, C. Wang, J. French, M. Isaacson-Schmid, L. L. Wall, I. U. Mysorekar, Estrogen affects the glycosaminoglycan layer of the murine bladder. Female Pelvic Med. Reconst. Surg. 18, 148-152 (2012).
10. J. Song, B. L. Bishop, G. Li, R. Grady, A. Stapleton, S. N. Abraham, TLR4-mediated expulsion of bacteria from infected bladder epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 106, 14966-14971 (2009).