CREB activation is a key player for ischemic tolerance in the brain

Clinical Neurology

Volumn 52, Issue 11, 2012, Pages 904-907

  Kitagawa, Kazuo ^a   Sasaki, Tsutomu ^a   Terasaki, Yasukazu ^a   Yagita, Yoshiki ^a   Mochizuki, Hideki ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

CREB regulated transcription co activator; Glutamate receptor; Ischemic tolerance; Salt inducible kinase; Selective vulnerability

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE I; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE IV; CALCIUM ION; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCOSE; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OXYGEN;

BRAIN; BRAIN ISCHEMIA; CALCIUM TRANSPORT; CELL SURVIVAL; CONFERENCE PAPER; CYTOPLASM; ENZYME PHOSPHORYLATION; INTRACELLULAR SPACE; ISCHEMIC TOLERANCE; NERVE CELL; NERVE CELL PLASTICITY; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN FUNCTION;

ANIMALS; BRAIN ISCHEMIA; CELLS, CULTURED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GENE EXPRESSION; HUMANS; MICE;

EID: 84880524564     PISSN: 0009918X     EISSN: None     Source Type: Journal    
DOI: 10.5692/clinicalneurol.52.904     Document Type: Conference Paper

References (8)

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3. Kitagawa K. CREB and CRE-mediated gene expression in the ischemic brain. FEBS Journal 2007;274:3210-3217.
4. Mabuchi T, Kitagawa K, Kuwabara K, et al. Phosphorylation of CREB in hippocampal neurons as a protective response after exposure to glutamate and ischemia in vivo. J Neurosci 2001;21:9204-9213.
5. Sugiura S, Kitagawa K, Omura-Matsuoka E, et al. CRE-mediated gene transcription in the peri-infarct area after focal cerebral ischemia in mice. J Neurosci Res 2004;75:401-407.
6. Sasaki T, Takemori H, Yagita Y, et al. SIK2 is a new key regulator for neuronal survival after ischemia through TORC1-CREB. Neuron 2011;69:106-119.
7. Terasaki Y, Sasaki T, Yagita Y, et al. Activation of NR2A receptors induces ischemic tolerance through CREB signaling. J Cerebral Blood Flow Metab 2010;30:1441-1449.
8. Kitagawa K. Ischemic Tolerance in the Brain-Endogenous Adaptive Machinery against Ischemic Stress-. J Neurosci Res 2012.