Chemical genetic screen in fission yeast reveals roles for vacuolar acidification, mitochondrial fission, and cellular GMP levels in lifespan extension

Aging Cell

Volumn 12, Issue 4, 2013, Pages 574-583

  Stephan, Jessica ^a   Franke, Jacqueline ^b   Ehrenhofer Murray, Ann E ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b Dept of Electrical Engineering   (Germany)

Author keywords

Autophagy; Chronological lifespan; Mitochondria; S. pombe; Vacuole

Indexed keywords

3,3' DIINDOLYLMETHANE; ACIVICIN; ADENOSINE TRIPHOSPHATASE; DYNAMIN I; G PROTEIN COUPLED GLUCOSE RECEPTOR GIT3; GLUCORECEPTOR; GUANINE NUCLEOTIDE; GUANOSINE PHOSPHATE; MANGOSTEEN; MITOCHONDRIAL PROTEIN; MONENSIN; MYCOPHENOLIC ACID; NIGERICIN; PHYTOESTROGEN; PLANT MEDICINAL PRODUCT; POLYPEPTIDE; PROSTAGLANDIN J2; PROTEIN VMA1; PROTEIN VMA3; TSCHIMGANINE; UNCLASSIFIED DRUG; DIINDOLYLMETHANE; DNM1 PROTEIN, S POMBE; DYNAMIN; G PROTEIN COUPLED RECEPTOR; GIT3 PROTEIN, S POMBE; HYDROXYBENZOIC ACID DERIVATIVE; INDOLE DERIVATIVE; ISOXAZOLE DERIVATIVE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE; SCHIZOSACCHAROMYCES POMBE PROTEIN; TSCHIMGANIDIN;

ACIDIFICATION; ARTICLE; CELL AGING; CELL LEVEL; CELL VACUOLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG SCREENING; GENETIC SCREENING; LIFESPAN; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; SCHIZOSACCHAROMYCES POMBE; DRUG EFFECTS; GARCINIA MANGOSTANA; GENETICS; METABOLISM; MITOCHONDRIAL DYNAMICS; PHYSIOLOGY; SCHIZOSACCHAROMYCES; TIME;

GARCINIA MANGOSTANA; SCHIZOSACCHAROMYCES POMBE; SCHIZOSACCHAROMYCETACEAE;

DYNAMINS; GARCINIA MANGOSTANA; GUANOSINE MONOPHOSPHATE; HYDROXYBENZOATES; INDOLES; ISOXAZOLES; MITOCHONDRIAL DYNAMICS; MONENSIN; MYCOPHENOLIC ACID; NIGERICIN; REACTIVE OXYGEN SPECIES; RECEPTORS, G-PROTEIN-COUPLED; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; TIME FACTORS; VACUOLAR PROTON-TRANSLOCATING ATPASES; VACUOLES;

EID: 84880510538     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12077     Document Type: Article

References (45)

1. Aggarwal BB, Ichikawa H (2005) Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Cell Cycle 4, 1201-1215.
2. Alvers AL, Fishwick LK, Wood MS, Hu D, Chung HS, Dunn WA Jr, Aris JP (2009) Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae. Aging Cell 8, 353-369.
3. Bass TM, Weinkove D, Houthoofd K, Gems D, Partridge L (2007) Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mech. Ageing Dev. 128, 546-552.
4. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444, 337-342.
5. Bedalov A, Gatbonton T, Irvine WP, Gottschling DE, Simon JA (2001) Identification of a small molecule inhibitor of Sir2p. Proc. Natl Acad. Sci. USA 98, 15113-15118.
6. Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvari M, Piper MD, Hoddinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez-Manrique RP, Orfila AM, Ackerman D, Au C, Vinti G, Riesen M, Howard K, Neri C, Bedalov A, Kaeberlein M, Soti C, Partridge L, Gems D (2011) Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature 477, 482-485.
7. Castanon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P (2012) Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br. J. Cancer 106, 45-52.
8. Chen BR, Runge KW (2009) A new Schizosaccharomyces pombe chronological lifespan assay reveals that caloric restriction promotes efficient cell cycle exit and extends longevity. Exp. Gerontol. 44, 493-502.
9. Dinter A, Berger EG (1998) Golgi-disturbing agents. Histochem. Cell Biol. 109, 571-590.
10. Fabrizio P, Hoon S, Shamalnasab M, Galbani A, Wei M, Giaever G, Nislow C, Longo VD (2010) Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation. PLoS Genet. 6, e1001024.
11. Fan S, Meng Q, Saha T, Sarkar FH, Rosen EM (2009) Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent manner. Cancer Res. 69, 6083-6091.
12. Fontana L, Partridge L, Longo VD (2010) Extending healthy life span-from yeast to humans. Science 328, 321-326.
13. Goldberg AA, Richard VR, Kyryakov P, Bourque SD, Beach A, Burstein MT, Glebov A, Koupaki O, Boukh-Viner T, Gregg C, Juneau M, English AM, Thomas DY, Titorenko VI (2010) Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes. Aging (Albany NY) 2, 393-414.
14. Gustavsson M, Barmark G, Larsson J, Muren E, Ronne H (2008) Functional genomics of monensin sensitivity in yeast: implications for post-Golgi traffic and vacuolar H+-ATPase function. Mol. Genet. Genomics 280, 233-248.
15. Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425, 191-196.
16. Hughes AL, Gottschling DE (2012) An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast. Nature 492, 261-265.
17. Ikeda K, Arao Y, Otsuka H, Nomoto S, Horiguchi H, Kato S, Kayama F (2002) Terpenoids found in the umbelliferae family act as agonists/antagonists for ER(alpha) and ERbeta: differential transcription activity between ferutinine-liganded ER(alpha) and ERbeta. Biochem. Biophys. Res. Commun. 291, 354-360.
18. Iwaki T, Goa T, Tanaka N, Takegawa K (2004) Characterization of Schizosaccharomyces pombe mutants defective in vacuolar acidification and protein sorting. Mol. Genet. Genomics 271, 197-207.
19. Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK (2005) Substrate-specific activation of sirtuins by resveratrol. J. Biol. Chem. 280, 17038-17045.
20. Kanfi Y, Naiman S, Amir G, Peshti V, Zinman G, Nahum L, Bar-Joseph Z, Cohen HY (2012) The sirtuin SIRT6 regulates lifespan in male mice. Nature 483, 218-221.
21. Kenyon CJ (2010) The genetics of ageing. Nature 464, 504-512.
22. Kim DU, Hayles J, Kim D, Wood V, Park HO, Won M, Yoo HS, Duhig T, Nam M, Palmer G, Han S, Jeffery L, Baek ST, Lee H, Shim YS, Lee M, Kim L, Heo KS, Noh EJ, Lee AR, Jang YJ, Chung KS, Choi SJ, Park JY, Park Y, Kim HM, Park SK, Park HJ, Kang EJ, Kim HB, Kang HS, Park HM, Kim K, Song K, Song KB, Nurse P, Hoe KL (2010) Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 28, 617-623.
23. Lee SJ, Hwang AB, Kenyon C (2010) Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity. Curr. Biol. 20, 2131-2136.
24. Liu Q, Leng XH, Newman PR, Vasilyeva E, Kane PM, Forgac M (1997) Site-directed mutagenesis of the yeast V-ATPase A subunit. J. Biol. Chem. 272, 11750-11756.
25. Longo VD, Shadel GS, Kaeberlein M, Kennedy B (2012) Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab. 16, 18-31.
26. Melendez A, Talloczy Z, Seaman M, Eskelinen EL, Hall DH, Levine B (2003) Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 301, 1387-1391.
27. Mishra N, Kar R, Singha PK, Venkatachalam MA, McEwen DG, Saikumar P (2010) Inhibition of mitochondrial division through covalent modification of Drp1 protein by 15 deoxy-Delta(12, 14)-prostaglandin J2. Biochem. Biophys. Res. Commun. 395, 17-24.
28. Nakamura J, Straub K, Wu J, Lou L (1995) The glutamine hydrolysis function of human GMP synthetase. Identification of an essential active site cysteine. J. Biol. Chem. 270, 23450-23455.
29. Narumiya S, Sugimoto Y, Ushikubi F (1999) Prostanoid receptors: structures, properties, and functions. Physiol. Rev. 79, 1193-1226.
30. Obolskiy D, Pischel I, Siriwatanametanon N, Heinrich M (2009) Garcinia mangostana L.: a phytochemical and pharmacological review. Phytother. Res. 23, 1047-1065.
31. Palermo V, Falcone C, Calvani M, Mazzoni C (2010) Acetyl-L-carnitine protects yeast cells from apoptosis and aging and inhibits mitochondrial fission. Aging Cell 9, 570-579.
32. Pan Y (2011) Mitochondria, reactive oxygen species, and chronological aging: a message from yeast. Exp. Gerontol. 46, 847-852.
33. Park SJ, Ahmad F, Philp A, Baar K, Williams T, Luo H, Ke H, Rehmann H, Taussig R, Brown AL, Kim MK, Beaven MA, Burgin AB, Manganiello V, Chung JH (2012) Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell 148, 421-433.
34. Powers RW 3rd, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S (2006) Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev. 20, 174-184.
35. Roux AE, Quissac A, Chartrand P, Ferbeyre G, Rokeach LA (2006) Regulation of chronological aging in Schizosaccharomyces pombe by the protein kinases Pka1 and Sck2. Aging Cell 5, 345-357.
36. Roux AE, Chartrand P, Ferbeyre G, Rokeach LA (2010) Fission yeast and other yeasts as emergent models to unravel cellular aging in eukaryotes. J. Gerontol. A Biol. Sci. Med. Sci. 65, 1-8.
37. Sahranavard S, Naghibi F, Mosaddegh M, Esmaeili S, Sarkhail P, Taghvaei M, Ghafari S (2009) Cytotoxic activities of selected medicinal plants from Iran and phytochemical evaluation of the most potent extract. Res. Pharm. Sci. 4, 133-137.
38. Scheckhuber CQ, Erjavec N, Tinazli A, Hamann A, Nystrom T, Osiewacz HD (2007) Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models. Nat. Cell Biol. 9, 99-105.
39. Scheckhuber CQ, Wanger RA, Mignat CA, Osiewacz HD (2011) Unopposed mitochondrial fission leads to severe lifespan shortening. Cell Cycle 10, 3105-3110.
40. Scorrano L (2007) Multiple functions of mitochondria-shaping proteins. Novartis Found. Symp. 287, 47-55. discussion 55-49.
41. Sinclair DA, Guarente L (1997) Extrachromosomal rDNA circles-a cause of aging in yeast. Cell 91, 1033-1042.
42. Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D (2004) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430, 686-689.
43. Xue C, Hsueh YP, Heitman J (2008) Magnificent seven: roles of G protein-coupled receptors in extracellular sensing in fungi. FEMS Microbiol. Rev. 32, 1010-1032.
44. Yang CC, Chen D, Lee SS, Walter L (2011) The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity. Aging Cell 10, 724-728.
45. Zuin A, Castellano-Esteve D, Ayte J, Hidalgo E (2010) Living on the edge: stress and activation of stress responses promote lifespan extension. Aging (Albany NY) 2, 231-237.