Acclimatization improves submaximal exercise economy at 5533 m

Scandinavian Journal of Medicine and Science in Sports

Volumn 23, Issue 4, 2013, Pages 458-467

  Latshang, T D ^a,b   Turk, A J ^a,b   Hess, T ^c   Schoch, O D ^d   Bosch, M M ^a   Barthelmes, D ^a   Merz, T M ^e   Hefti, U ^f   Hefti, J Pichler ^f   Maggiorini, M ^a,b   Bloch, K E ^a,b  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c CANTONAL HOSPITAL WINTERTHUR   (Switzerland)

^d CANTONAL HOSPITAL ST GALLEN   (Switzerland)

^e UNIVERSITY OF BERN   (Switzerland)

^f CANTONAL HOSPITAL AARAU   (Switzerland)

Author keywords

Altitude; Exercise; Hypoxia

Indexed keywords

ACCLIMATIZATION; ADULT; ALTITUDE; ALTITUDE DISEASE; ANOXIA; ARTICLE; ENERGY METABOLISM; EXERCISE; EXERCISE TOLERANCE; FEMALE; HUMAN; HYPOXIA; MALE; MIDDLE AGED; MOUNTAINEERING; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PHYSIOLOGY;

ALTITUDE; EXERCISE; HYPOXIA;

ACCLIMATIZATION; ADULT; ALTITUDE; ALTITUDE SICKNESS; ANOXIA; ENERGY METABOLISM; EXERCISE; EXERCISE TOLERANCE; FEMALE; HUMANS; MALE; MIDDLE AGED; MOUNTAINEERING; OXYGEN CONSUMPTION;

EID: 84880509703     PISSN: 09057188     EISSN: 16000838     Source Type: Journal    
DOI: 10.1111/j.1600-0838.2011.01403.x     Document Type: Article

References (40)

1. ATS/ACCP. ATS/ACCP Statement on cardiopulmonary exercise testing. Am J Respir Crit Care Med 2003: 167: 211-277.
2. Bender PR, Groves BM, McCullough RE, McCullough RG, Huang SY, Hamilton AJ, Wagner PD, Cymerman A, Reeves JT. Oxygen transport to exercising leg in chronic hypoxia. J Appl Physiol 1988: 65: 2592-2597.
3. Bender PR, McCullough RE, McCullough RG, Huang SY, Wagner PD, Cymerman A, Hamilton AJ, Reeves JT. Increased exercise SaO2 independent of ventilatory acclimatization at 4, 300m. J Appl Physiol 1989: 66: 2733-2738.
4. Bloch KE, Latshang TD, Turk AJ, Hess T, Hefti U, Merz TM, Bosch MM, Barthelmes D, Hefti JP, Maggiorini M, Schoch OD. Nocturnal periodic breathing during acclimatization at very high altitude at Mount Muztagh Ata (7, 546m). Am J Respir Crit Care Med 2010: 182: 562-568.
5. Bloch KE, Turk AJ, Maggiorini M, Hess T, Merz T, Bosch MM, Barthelmes D, Hefti U, Pichler J, Senn O, Schoch OD. Effect of ascent protocol on acute mountain sickness and success at Muztagh Ata, 7546m. High Alt Med Biol 2009: 10: 25-32.
6. Bosch MM, Merz TM, Barthelmes D, Petrig BL, Truffer F, Bloch KE, Turk A, Maggiorini M, Hess T, Schoch OD, Hefti U, Sutter FK, Pichler J, Huber A, Landau K. New insights into ocular blood flow at very high altitudes. J Appl Physiol 2009: 106: 454-460.
7. Brack T, Jubran A, Tobin MJ. Effect of elastic loading on variational activity of breathing. Am J Respir Crit Care Med 1997: 155: 1341-1348.
8. Brack T, Thuer I, Clarenbach CF, Senn O, Noll G, Russi EW, Bloch KE. Daytime Cheyne-Stokes respiration in ambulatory patients with severe congestive heart failure is associated with increased mortality. Chest 2007: 132: 1463-1471.
9. Calbet JA, Boushel R, Radegran G, Sondergaard H, Wagner PD, Saltin B. Why is VO2 max after altitude acclimatization still reduced despite normalization of arterial O2 content? Am J Physiol Regul Integr Comp Physiol 2003a: 284: R304-R316.
10. Calbet JA, Boushel R, Radegran G, Sondergaard H, Wagner PD, Saltin B. Why is VO2 max after altitude acclimatization still reduced despite normalization of arterial O2 content? Am J Physiol Regul Integr Comp Physiol 2003b: 284: R304-R316.
11. Calbet JA, Lundby C. Air to muscle O2 delivery during exercise at altitude. High Alt Med Biol 2009: 10: 123-134.
12. Calbet JA, Radegran G, Boushel R, Sondergaard H, Saltin B, Wagner PD. Effect of blood haemoglobin concentration on V(O2, max) and cardiovascular function in lowlanders acclimatised to 5260m. J Physiol 2002: 545: 715-728.
13. Cymerman A, Reeves JT, Sutton JR, Rock PB, Groves BM, Malconian MK, Young PM, Wagner PD, Houston CS. Operation Everest II: maximal oxygen uptake at extreme altitude. J Appl Physiol 1989: 66: 2446-2453.
14. Dempsey JA. Crossing the apnoeic threshold: causes and consequences. Exp Physiol 2005: 90: 13-24.
15. Faoro V, Huez S, Giltaire S, Pavelescu A, van Osta A, Moraine JJ, Guenard H, Martinot JB, Naeije R. Effects of acetazolamide on aerobic exercise capacity and pulmonary hemodynamics at high altitudes. J Appl Physiol 2007: 103: 1161-1165.
16. Gaesser GA, Brooks GA. Muscular efficiency during steady-rate exercise: effects of speed and work rate. J Appl Physiol 1975: 38: 1132-1139.
17. Gore CJ, Hahn AG, Aughey RJ, Martin DT, Ashenden MJ, Clark SA, Garnham AP, Roberts AD, Slater GJ, McKenna MJ. Live high: train low increases muscle buffer capacity and submaximal cycling efficiency. Acta Physiol Scand 2001: 173: 275-286.
18. Grassi B, Marzorati M, Kayser B, Bordini M, Colombini A, Conti M, Marconi C, Cerretelli P. Peak blood lactate and blood lactate vs. workload during acclimatization to 5, 050m and in deacclimatization. J Appl Physiol 1996: 80: 685-692.
19. Green H, Roy B, Grant S, Burnett M, Tupling R, Otto C, Pipe A, McKenzie D. Downregulation in muscle Na(+)-K(+)-ATPase following a 21-day expedition to 6, 194m. J Appl Physiol 2000a: 88: 634-640.
20. Green HJ, Roy B, Grant S, Hughson R, Burnett M, Otto C, Pipe A, McKenzie D, Johnson M. Increases in submaximal cycling efficiency mediated by altitude acclimatization. J Appl Physiol 2000b: 89: 1189-1197.
21. van Hall G, Calbet JA, Sondergaard H, Saltin B. The re-establishment of the normal blood lactate response to exercise in humans after prolonged acclimatization to altitude. J Physiol 2001: 536: 963-975.
22. van Hall G, Lundby C, Araoz M, Calbet JA, Sander M, Saltin B. The lactate paradox revisited in lowlanders during acclimatization to 4100m and in high-altitude natives. J Physiol 2009: 587: 1117-1129.
23. Jones NL, Makrides L, Hitchkock C, Chypchar T, Maccartney N. Normal standards for an incremental progressive cycle ergometer test. Am Rev Respir Dis 1985: 131: 700-708.
24. Jubran A, Grant BJ, Tobin MJ. Effect of hyperoxic hypercapnia on variational activity of breathing. Am J Respir Crit Care Med 1997: 156: 1129-1139.
25. Levine BD, Stray-Gundersen J. "Living high-training low": effect of moderate-altitude acclimatization with low-altitude training on performance. J Appl Physiol 1997: 83: 102-112.
26. Lundby C, Calbet JA, van Hall G, Saltin B, Sander M. Pulmonary gas exchange at maximal exercise in Danish lowlanders during 8wk of acclimatization to 4, 100m and in high-altitude Aymara natives. Am J Physiol Regul Integr Comp Physiol 2004: 287: R1202-R1208.
27. Lundby C, Calbet JA, Sander M, van Hall G, Mazzeo RS, Stray-Gundersen J, Stager JM, Chapman RF, Saltin B, Levine BD. Exercise economy does not change after acclimatization to moderate to very high altitude. Scand J Med Sci Sports 2007: 17: 281-291.
28. Lundby C, Sander M, van Hall G, Saltin B, Calbet JA. Maximal exercise and muscle oxygen extraction in acclimatizing lowlanders and high altitude natives. J Physiol 2006: 573: 535-547.
29. Maher JT, Jones LG, Hartley LH. Effects of high-altitude exposure on submaximal endurance capacity of men. J Appl Physiol 1974: 37: 895-898.
30. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J. Standardisation of spirometry. Eur Respir J 2005: 26: 319-338.
31. Quanjer PH, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R, Yernault JC. Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl 1993: 16: 5-40.
32. Roach R, Kayser B. Exercise and hypoxia. Performance, limits and training. In: Hornbein TF, Schoene RB, eds. High altitude. An exploration of human adaptation. New York: Marcel Dekker, Inc, 2001: 663-705.
33. Robach P, Dechaux M, Jarrot S, Vaysse J, Schneider JC, Mason NP, Herry JP, Gardette B, Richalet JP. Operation Everest III: role of plasma volume expansion on VO(2)(max) during prolonged high-altitude exposure. J Appl Physiol 2000: 89: 29-37.
34. Sampson JB, Cymerman A, Burse RL, Maher JT, Rock PB. Procedures for the measurement of acute mountain sickness. Aviat Space Environ Med 1983: 54: 1063-1073.
35. Schuler B, Thomsen JJ, Gassmann M, Lundby C. Timing the arrival at 2340m altitude for aerobic performance. Scand J Med Sci Sports 2007: 17: 588-594.
36. Senn O, Clarenbach CF, Fischler M, Thalmann R, Brunner-La Rocca H, Egger P, Maggiorini M, Bloch KE. Do changes in lung function predict high-altitude pulmonary edema at an early stage? Med Sci Sports Exerc 2006: 38: 1565-1570.
37. Stock MJ, Norgan NG, Ferro-Luzzi A, Evans E. Effect of altitude on dietary-induced thermogenesis at rest and during light exercise in man. J Appl Physiol 1978: 45: 345-349.
38. Stray-Gundersen J, Chapman RF, Levine BD. "Living high-training low" altitude training improves sea level performance in male and female elite runners. J Appl Physiol 2001: 91: 1113-1120.
39. Whipp BJ, Wasserman K. Efficiency of muscular work. J Appl Physiol 1969: 26: 644-648.
40. Wolfel EE, Groves BM, Brooks GA, Butterfield GE, Mazzeo RS, Moore LG, Sutton JR, Bender PR, Dahms TE, McCullough RE. Oxygen transport during steady-state submaximal exercise in chronic hypoxia. J Appl Physiol 1991: 70: 1129-1136.