The Role of Apelin in the Retina of Diabetic Rats

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Lu, Qiang ^a,b   Feng, Jing ^a,b   Jiang, Yan rong ^a,b  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APELIN; GLIAL FIBRILLARY ACIDIC PROTEIN; MESSENGER RNA; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC RETINOPATHY; DISEASE COURSE; GLIOSIS; IN VIVO STUDY; MALE; MUELLER CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; RETINA;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; RATS; RATS, SPRAGUE-DAWLEY; RETINA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84880483395     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0069703     Document Type: Article

References (47)

1. Negi A, Vernon SA, (2003) An overview of the eye in diabetes. J R Soc Med 96: 266-272.
2. Tielsch JM, Sommer A, Witt K, Katz J, Royall RM, (1990) Blindness and visual impairment in an American urban population. The Baltimore Eye Survey. Arch Ophthalmol 108: 286-290.
3. Simo R, Carrasco E, Garcia-Ramirez M, Hernandez C, (2006) Angiogenic and antiangiogenic factors in proliferative diabetic retinopathy. Curr Diabetes Rev 2: 71-98.
4. Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, et al. (1994) Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 331: 1480-1487.
5. Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, et al. (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun 251: 471-476.
6. Kawamata Y, Habata Y, Fukusumi S, Hosoya M, Fujii R, et al. (2001) Molecular properties of apelin: tissue distribution and receptor binding. Biochim Biophys Acta 1538: 162-171.
7. Kalin RE, Kretz MP, Meyer AM, Kispert A, Heppner FL, et al. (2007) Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis. Dev Biol 305: 599-614.
8. De Falco M, Fedele V, Russo T, Virgilio F, Sciarrillo R, et al. (2004) Distribution of apelin, the endogenous ligand of the APJ receptor, in the lizard Podarcis sicula. J Mol Histol 35: 521-527.
9. Saint-Geniez M, Masri B, Malecaze F, Knibiehler B, Audigier Y, (2002) Expression of the murine msr/apj receptor and its ligand apelin is upregulated during formation of the retinal vessels. Mech Dev 110: 183-186.
10. Loewen N, Chen J, Dudley VJ, Sarthy VP, Mathura JR Jr, (2009) Genomic response of hypoxic Muller cells involves the very low density lipoprotein receptor as part of an angiogenic network. Exp Eye Res 88: 928-937.
11. Lee DK, Cheng R, Nguyen T, Fan T, Kariyawasam AP, et al. (2000) Characterization of apelin, the ligand for the APJ receptor. J Neurochem 74: 34-41.
12. O'Donnell LA, Agrawal A, Sabnekar P, Dichter MA, Lynch DR, et al. (2007) Apelin, an endogenous neuronal peptide, protects hippocampal neurons against excitotoxic injury. J Neurochem 102: 1905-1917.
13. Castan-Laurell I, Boucher J, Dray C, Daviaud D, Guigne C, et al. (2005) Apelin, a novel adipokine over-produced in obesity: friend or foe? Mol Cell Endocrinol 245: 7-9.
14. Sorhede Winzell M, Magnusson C, Ahren B, (2005) The apj receptor is expressed in pancreatic islets and its ligand, apelin, inhibits insulin secretion in mice. Regul Pept 131: 12-17.
15. Boucher J, Masri B, Daviaud D, Gesta S, Guigne C, et al. (2005) Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology 146: 1764-1771.
16. Kasai A, Shintani N, Oda M, Kakuda M, Hashimoto H, et al. (2004) Apelin is a novel angiogenic factor in retinal endothelial cells. Biochem Biophys Res Commun 325: 395-400.
17. Tao Y, Lu Q, Jiang YR, Qian J, Wang JY, et al. (2010) Apelin in plasma and vitreous and in fibrovascular retinal membranes of patients with proliferative diabetic retinopathy. Invest Ophthalmol Vis Sci 51: 4237-4242.
18. Qian J, Lu Q, Tao Y, Jiang YR, (2011) Vitreous and plasma concentrations of apelin and vascular endothelial growth factor after intravitreal bevacizumab in eyes with proliferative diabetic retinopathy. Retina 31: 161-168.
19. Simpkin JC, Yellon DM, Davidson SM, Lim SY, Wynne AM, et al. (2007) Apelin-13 and apelin-36 exhibit direct cardioprotective activity against ischemia-reperfusion injury. Basic Res Cardiol 102: 518-528.
20. Reaux A, Gallatz K, Palkovits M, Llorens-Cortes C, (2002) Distribution of apelin-synthesizing neurons in the adult rat brain. Neuroscience 113: 653-662.
21. Li W, Petrimpol M, Molle KD, Hall MN, Battegay EJ, et al. (2007) Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2. Circ Res 100: 79-87.
22. Medhurst AD, Jennings CA, Robbins MJ, Davis RP, Ellis C, et al. (2003) Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem 84: 1162-1172.
23. Roberts EM, Newson MJ, Pope GR, Landgraf R, Lolait SJ, et al. (2009) Abnormal fluid homeostasis in apelin receptor knockout mice. J Endocrinol 202: 453-462.
24. Tang SY, Xie H, Yuan LQ, Luo XH, Huang J, et al. (2007) Apelin stimulates proliferation and suppresses apoptosis of mouse osteoblastic cell line MC3T3-E1 via JNK and PI3-K/Akt signaling pathways. Peptides 28: 708-718.
25. Zhang Z, Yu B, Tao GZ, (2009) Apelin protects against cardiomyocyte apoptosis induced by glucose deprivation. Chin Med J (Engl) 122: 2360-2365.
26. Cox CM, D'Agostino SL, Miller MK, Heimark RL, Krieg PA, (2006) Apelin, the ligand for the endothelial G-protein-coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryo. Dev Biol 296: 177-189.
27. Lee DK, Saldivia VR, Nguyen T, Cheng R, George SR, et al. (2005) Modification of the terminal residue of apelin-13 antagonizes its hypotensive action. Endocrinology 146: 231-236.
28. Tiani C, Garcia-Pras E, Mejias M, de Gottardi A, Berzigotti A, et al. (2009) Apelin signaling modulates splanchnic angiogenesis and portosystemic collateral vessel formation in rats with portal hypertension. J Hepatol 50: 296-305.
29. Kidoya H, Naito H, Takakura N, (2010) Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia. Blood 115: 3166-3174.
30. Eyries M, Siegfried G, Ciumas M, Montagne K, Agrapart M, et al. (2008) Hypoxia-induced apelin expression regulates endothelial cell proliferation and regenerative angiogenesis. Circ Res 103: 432-440.
31. Gupta N, Brown KE, Milam AH, (2003) Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration. Exp Eye Res 76: 463-471.
32. McGillem GS, Dacheux RF, (1998) Migration of retinal microglia in experimental proliferative vitreoretinopathy. Exp Eye Res 67: 371-375.
33. Canto Soler MV, Gallo JE, Dodds RA, Hokfelt T, Villar MJ, et al. (2002) Y1 receptor of neuropeptide Y as a glial marker in proliferative vitreoretinopathy and diseased human retina. Glia 39: 320-324.
34. Mizutani M, Gerhardinger C, Lorenzi M, (1998) Muller cell changes in human diabetic retinopathy. Diabetes 47: 445-449.
35. Barber AJ, Antonetti DA, Gardner TW, (2000) Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. The Penn State Retina Research Group. Invest Ophthalmol Vis Sci 41: 3561-3568.
36. Nork TM, Wallow IH, Sramek SJ, Anderson G, (1987) Muller's cell involvement in proliferative diabetic retinopathy. Arch Ophthalmol 105: 1424-1429.
37. Ohira A, de Juan E Jr, (1990) Characterization of glial involvement in proliferative diabetic retinopathy. Ophthalmologica 201: 187-195.
38. Wang G, Anini Y, Wei W, Qi X, AM OC, et al. (2004) Apelin, a new enteric peptide: localization in the gastrointestinal tract, ontogeny, and stimulation of gastric cell proliferation and of cholecystokinin secretion. Endocrinology 145: 1342-1348.
39. Wolburg H, Liebner S, Reichenbach A, Gerhardt H, (1999) The pecten oculi of the chicken: a model system for vascular differentiation and barrier maturation. Int Rev Cytol 187: 111-159.
40. Tretiach M, Madigan MC, Wen L, Gillies MC, (2005) Effect of Muller cell co-culture on in vitro permeability of bovine retinal vascular endothelium in normoxic and hypoxic conditions. Neurosci Lett 378: 160-165.
41. Stone J, Itin A, Alon T, Pe'er J, Gnessin H, et al. (1995) Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia. J Neurosci 15: 4738-4747.
42. Han S, Wang G, Qi X, Lee HM, Englander EW, et al. (2008) A possible role for hypoxia-induced apelin expression in enteric cell proliferation. Am J Physiol Regul Integr Comp Physiol 294: R1832-1839.
43. Hellwig-Burgel T, Rutkowski K, Metzen E, Fandrey J, Jelkmann W, (1999) Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1. Blood 94: 1561-1567.
44. Daviaud D, Boucher J, Gesta S, Dray C, Guigne C, et al. (2006) TNFalpha up-regulates apelin expression in human and mouse adipose tissue. FASEB J 20: 1528-1530.
45. Zhong JC, Huang Y, Yung LM, Lau CW, Leung FP, et al. (2007) The novel peptide apelin regulates intrarenal artery tone in diabetic mice. Regul Pept 144: 109-114.
46. Goralski KB, Sinal CJ, (2007) Type 2 diabetes and cardiovascular disease: getting to the fat of the matter. Can J Physiol Pharmacol 85: 113-132.
47. Sorli SC, van den Berghe L, Masri B, Knibiehler B, Audigier Y, (2006) Therapeutic potential of interfering with apelin signalling. Drug Discov Today 11: 1100-1106.