Occurrence of Spontaneous Amphophilic-Vacuolar Renal Tubule Tumors in Sprague-Dawley Rats from Subchronic Toxicity Studies

Toxicologic Pathology

Volumn 41, Issue 6, 2013, Pages 866-871

  Crabbs, Torrie A ^a   Frame, Steve R ^b   Laast, Victoria A ^c   Patrick, Daniel J ^d   Thomas, Johnson ^e   Zimmerman, Bevin ^f   Hardisty, Jerry F ^a  

^a EXPERIMENTAL PATHOLOGY LABORATORIES INC   (United States)

^b DUPONT COMPANY   (United States)

^c Shanghai Sandai Pharmaceutical R D Co Ltd   (China)

^d MPI RESEARCH   (United States)

^e DOW CHEMICAL COMPANY   (United States)

^f WIL RESEARCH LABORATORIES   (United States)

Author keywords

amphophilic vacuolar renal tubule tumors; familial renal tumors; rat; renal tubule tumors; spontaneous neoplasia

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOPLASM; FEMALE; KIDNEY TUBULE ADENOMA; KIDNEY TUBULE CARCINOMA; KIDNEY TUBULE TUMOR; KIDNEY TUMOR; MALE; NONHUMAN; NUCLEOLUS; PHENOTYPE; PRIORITY JOURNAL; RAT; TUMOR GROWTH; TUMOR VOLUME;

AMPHOPHILIC-VACUOLAR RENAL TUBULE TUMORS; FAMILIAL RENAL TUMORS; RAT; RENAL TUBULE TUMORS; SPONTANEOUS NEOPLASIA.;

ANIMALS; FEMALE; HISTOCYTOCHEMISTRY; KIDNEY; KIDNEY NEOPLASMS; KIDNEY TUBULES; MALE; RATS; RATS, SPRAGUE-DAWLEY; RODENT DISEASES; TOXICITY TESTS, SUBCHRONIC;

EID: 84880403495     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623312467523     Document Type: Article

References (17)

1. Chandra M. Riley M. G. Johnson D. E. (1992). Spontaneous neoplasms in aged Sprague-Dawley rats. Arch Toxicol 66, 496–502.
2. Chandra M. Riley M. G. Johnson D. E. (1993). Spontaneous renal neoplasms in rats. J Appl Toxicol 13, 109–16.
3. Eker R. (1954). Familial renal adenomas in Wistar rats—A preliminary report. Acta Pathol Microbiol Scand 34, 554–62.
4. Everitt J. I. Goldsworthy T. L. Wolf D. C. Walker C. L. (1992). Hereditary renal cell carcinoma in the Eker rat: A rodent familial cancer syndrome. J Urol 148, 1932–36.
5. Hall W. C. Elder B. Walker C. L. Cai S. Peters D. G. Goodman D. G. Ulland B. M. Borzelleca J. F. (2007). Spontaneous renal tubular hyperplastic and neoplastic lesions in three Sprague-Dawley rats from a 90-day toxicity study. Toxicol Pathol 35, 233–41.
6. Hard G. C. Alden C. L. Stula E. F. Trump B. F. (1995). Proliferative lesions of the kidney in rats. In Guides for Toxicologic Pathology, pp. 1–19. STP/ARP/AFIP, Washington, DC.
7. Hard G. C. Long P. H. Crissman J. W. Everitt J. I. Yano B. L. Bertram T. A. (1994). Atypical tubule hyperplasia and renal tubule tumors in conventional rats on 90-day toxicity studies. Toxicol Pathol 22, 489–96.
8. Hard G. C. Seely J. C. Kissling G. E. Betz L. J. (2008). Spontaneous occurrence of a distinctive renal tubule tumor phenotype in rat carcinogenicity studies conducted by the National Toxicology Program (NTP). Toxicol Pathol 36, 388–96.
9. Ikezaki S. Takagi M. Tamura K. (2011). Natural occurrence of neoplastic lesions in young Sprague-Dawley rats. J Toxicol Pathol 24, 37–40.
10. Kobayashi T. Hirayama Y. Kobayashi E. Kubo Y. Hino O. (1995). A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer. Nat Gen 9, 70–74.
11. Kouchi M. Okimoto K. Matsumoto I. Tanaka K. Yasuba M. Hino O. (2006). Natural history of the Nihon (Bhd gene mutant) rat, a novel model for human Birt-Hogg-Dubé syndrome. Virchows Arch 448, 463–71.
12. Lanzoni A. Pialia A. Everitt J. Faustinelli I. DeFazio R. Cavaliere L. Cristofori P. (2007). Early onset of spontaneous renal preneoplastic and neoplastic lesions in young conventional rats in toxicity studies. Toxicol Pathol 35, 589–93.
13. McMartin D. N. Sahota P. S. Gunson D. E. Hsu H. H. Spaet R.H. (1992). Neoplasms and related proliferative lesions in control Sprague-Dawley rats from carcinogenicity studies. Historical data and diagnostic considerations. Toxicol Pathol 20, 212–25.
14. Nakazawa M. Tawaratani T. Uchimoto H. Kawaminami A. Ueda M. Ueda A. Shinoda Y. Iwakura K. Kura K. Sumi N. (2001). Spontaneous lesions in aged Sprague-Dawley rats. Exp Anim 50, 99–103.
15. Okimoto K. Kouchi M. Kikawa E. Toyosawa K. Koujitani T. Tanaka K. Matsuoka N. Sakurai J. Hino O. A. (2000). Novel “Nihon” rat model of a Mendelian dominantly inherited renal cell carcinoma. Jpn J Cancer Res 91, 1096–99.
16. Son W.-C. Gopinath C. (2004). Early occurrence of spontaneous tumors in CD-1 mice and Sprague-Dawley rats. Toxicol Pathol 32, 371–74.
17. Thurman J. D. Hailey J. R. Turturro A. Gaylor D. W. (1995). Spontaneous renal tubular carcinoma in Fischer-344 rat littermates. Vet Pathol 32, 419–22.