MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 29, 2013, Pages 12066-12071

  Lee, Jae Keun ^a   Shin, Jin Hee ^b   Hwang, Sang Gil ^a   Gwag, Byoung Joo ^b   McKee, Ann C ^c   Lee, Junghee ^c   Kowall, Neil W ^c   Ryu, Hoon ^c   Lim, Dae Sik ^d   Choi, Eui Ju ^a  

^a Korea University   (South Korea)

^b GNT Pharma   (South Korea)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Neurotoxicity; ROS

Indexed keywords

CASPASE 3; CASPASE 9; MAMMALIAN STERILE 20 LIKE KINASE 1; PHOSPHOTRANSFERASE; REACTIVE OXYGEN METABOLITE; SYNAPTOPHYSIN; THIOREDOXIN 1; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DISSOCIATION; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; MALE; MOUSE; MUTANT; NERVE CELL; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD; SURVIVAL;

NEUROTOXICITY; ROS;

ADULT; AMYOTROPHIC LATERAL SCLEROSIS; ANALYSIS OF VARIANCE; ANIMALS; AUTOPHAGY; ENZYME ACTIVATION; HUMANS; KAPLAN-MEIER ESTIMATE; MICE; MICE, KNOCKOUT; MOTOR NEURONS; MUTATION, MISSENSE; PROTEIN-SERINE-THREONINE KINASES; SPINAL CORD; SUPEROXIDE DISMUTASE; THIOREDOXINS;

EID: 84880389532     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1300894110     Document Type: Article

References (31)

1. Gurney ME, et al. (1994) Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 264(5166):1772-1775.
2. Cleveland DW, Rothstein JD (2001) From Charcot to Lou Gehrig: Deciphering selective motor neuron death in ALS. Nat Rev Neurosci 2(11):806-819.
3. Pasinelli P, Brown RH (2006) Molecular biology of amyotrophic lateral sclerosis: Insights from genetics. Nat Rev Neurosci 7(9):710-723.
4. Creasy CL, Chernoff J (1995) Cloning and characterization of a human protein kinase with homology to Ste20. J Biol Chem 270(37):21695-21700.
5. Dan I, Watanabe NM, Kusumi A (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol 11(5):220-230.
6. Taylor LK, Wang HC, Erikson RL (1996) Newly identified stress-responsive protein kinases, Krs-1 and Krs-2. Proc Natl Acad Sci USA 93(19):10099-10104.
7. Creasy CL, Ambrose DM, Chernoff J (1996) The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain. J Biol Chem 271(35):21049-21053.
8. Scheel H, Hofmann K (2003) A novel interaction motif, SARAH, connects three classes of tumor suppressor. Curr Biol 13(23):R899-R900.
9. Glantschnig H, Rodan GA, Reszka AA (2002) Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation. J Biol Chem 277(45):42987-42996.
10. de Souza PM, Lindsay MA (2004) Mammalian Sterile20-like kinase 1 and the regulation of apoptosis. Biochem Soc Trans 32(Pt3):485-488.
11. Lehtinen MK, et al. (2006) A conserved MST-FOXO signaling pathway mediates oxidativestress responses and extends life span. Cell 125(5):987-1001.
12. Yuan Z, et al. (2009) Regulation of neuronal cell death by MST1-FOXO1 signaling. J Biol Chem 284(17):11285-11292.
13. Chae JS, Gil Hwang S, Lim DS, Choi EJ (2012) Thioredoxin-1 functions as a molecular switch regulating the oxidative stress-induced activation of MST1. Free Radic Biol Med 53(12):2335-2343.
14. Söderberg O, et al. (2008) Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay. Methods 45(3):227-232.
15. Dewil M, dela Cruz VF, Van Den Bosch L, Robberecht W (2007) Inhibition of p38 mitogen activated protein kinase activation and mutant SOD1(G93A)-induced motor neuron death. Neurobiol Dis 26(2):332-341.
16. Li M, et al. (2000) Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model. Science 288(5464):335-339.
17. Graves JD, et al. (1998) Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. EMBO J 17(8):2224-2234.
18. Hara T, et al. (2006) Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441(7095):885-889.
19. Hetz C, et al. (2009) XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes Dev 23(19):2294-2306.
20. Sasaki S (2011) Autophagy in spinal cord motor neurons in sporadic amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 70(5):349-359.
21. Levine B, Klionsky DJ (2004) Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Dev Cell 6(4):463-477.
22. Kabeya Y, et al. (2000) LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19(21):5720-5728.
23. Klionsky DJ, et al. (2008) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4(2):151-175.
24. Bjørkøy G, et al. (2005) p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 171(4):603-614.
25. Turner BJ, Talbot K (2008) Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS. Prog Neurobiol 85(1):94-134.
26. Beal MF, et al. (1997) Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis. Ann Neurol 42(4):644-654.
27. Bogdanov M, et al. (2000) Increased oxidative damage to DNA in ALS patients. Free Radic Biol Med 29(7):652-658.
28. Ferrante RJ, et al. (1997) Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis. J Neurochem 69(5):2064-2074.
29. Oh S, et al. (2009) Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse. Mol Cell Biol 29(23):6309-6320.
30. Shin JH, et al. (2007) Concurrent administration of Neu2000 and lithium produces marked improvement of motor neuron survival, motor function, and mortality in a mouse model of amyotrophic lateral sclerosis. Mol Pharmacol 71(4):965-975.
31. Vandeputte C, et al. (2010) Automated quantitative gait analysis in animal models of movement disorders. BMC Neurosci 11:92.