Human parechovirus and the risk of type 1 diabetes

Journal of Medical Virology

Volumn 85, Issue 9, 2013, Pages 1619-1623

  Kolehmainen, P ^a,b   Koskiniemi, M ^b   Oikarinen, S ^a   Veijola, R ^c   Simell, O ^d   Ilonen, J ^d,e   Knip, M ^f,g,h   Hyoty H ^a,i   Tauriainen, S ^a,d  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF OULU   (Finland)

^d UNIVERSITY OF TURKU   (Finland)

^e UNIVERSITY OF EASTERN FINLAND   (Finland)

^f UNIVERSITY OF HELSINKI AND HELSINKI UNIVERSITY HOSPITAL   (Finland)

^g FOLKHÄLSAN RESEARCH CENTER   (Finland)

^h TAMPERE UNIVERSITY HOSPITAL   (Finland)

ⁱ PIRKANMAA HOSPITAL DISTRICT   (Finland)

Author keywords

Autoantibodies; Human parechovirus; RT PCR; Type 1 diabetes

Indexed keywords

AUTOANTIBODY; VIRUS RNA;

ARTICLE; AUTOIMMUNITY; CHILD; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; FECES; FEMALE; HUMAN; HYBRIDIZATION; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PARECHOVIRUS; PRESCHOOL CHILD; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK FACTOR; SCHOOL CHILD; SEROCONVERSION;

AUTOANTIBODIES; HUMAN PARECHOVIRUS; RT-PCR; TYPE 1 DIABETES;

AUTOANTIBODIES; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FECES; FEMALE; HUMANS; INFANT; INSULIN-SECRETING CELLS; MALE; NUCLEIC ACID HYBRIDIZATION; PARECHOVIRUS; PICORNAVIRIDAE INFECTIONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK ASSESSMENT; RNA, VIRAL; SEX FACTORS;

EID: 84880373121     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.23659     Document Type: Article

References (21)

1. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ. 1990. Basic local alignment search tool. J Mol Biol 215:403-410.
2. Gale EA, Gillespie KM. 2001. Diabetes and gender. Diabetologia 44:3-15.
3. Harvala H, Robertson I, Chieochansin T, McWilliam Leitch EC, Templeton K, Simmonds P. 2009. Specific association of human parechovirus type 3 with sepsis and fever in young infants, as identified by direct typing of cerebrospinal fluid samples. J Infect Dis 199:1753-1760.
4. Harvala H, Wolthers KC, Simmonds P. 2010. Parechoviruses in children: Understanding a new infection. Curr Opin Infect Dis 23:224-230.
5. Kolehmainen P, Oikarinen S, Koskiniemi M, Simell O, Ilonen J, Knip M, Hyoty H, Tauriainen S. 2012. Human parechoviruses are frequently detected in stool of healthy Finnish children. J Clin Virol 54:156-161.
6. Lonnrot M, Salminen K, Knip M, Savola K, Kulmala P, Leinikki P, Hyypia T, Akerblom HK, Hyoty H. 2000. Enterovirus RNA in serum is a risk factor for beta-cell autoimmunity and clinical type 1 diabetes: A prospective study. Childhood Diabetes in Finland (DiMe) Study Group. J Med Virol 61:214-220.
7. Nanto-Salonen K, Kupila A, Simell S, Siljander H, Salonsaari T, Hekkala A, Korhonen S, Erkkola R, Sipila JI, Haavisto L, Siltala M, Tuominen J, Hakalax J, Hyoty H, Ilonen J, Veijola R, Simell T, Knip M, Simell O. 2008. Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: A double-blind, randomised controlled trial. Lancet 372:1746-1755.
8. Niklasson B, Heller KE, Schonecker B, Bildsoe M, Daniels T, Hampe CS, Widlund P, Simonson WT, Schaefer JB, Rutledge E, Bekris L, Lindberg AM, Johansson S, Ortqvist E, Persson B, Lernmark A. 2003. Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus. Int J Exp Diabetes Res 4:35-44.
9. Oikarinen S, Martiskainen M, Tauriainen S, Huhtala H, Ilonen J, Veijola R, Simell O, Knip M, Hyoty H. 2011. Enterovirus RNA in blood is linked to the development of type 1 diabetes. Diabetes 60:276-279.
10. Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG. 2009. The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes. Diabetologia 52:1143-1151.
11. Salminen K, Sadeharju K, Lonnrot M, Vahasalo P, Kupila A, Korhonen S, Ilonen J, Simell O, Knip M, Hyoty H. 2003. Enterovirus infections are associated with the induction of beta-cell autoimmunity in a prospective birth cohort study. J Med Virol 69:91-98.
12. Salminen KK, Vuorinen T, Oikarinen S, Helminen M, Simell S, Knip M, Ilonen J, Simell O, Hyoty H. 2004. Isolation of enterovirus strains from children with preclinical Type 1 diabetes. Diabet Med 21:156-164.
13. Stanway G, Hyypia T. 1999. Parechoviruses. J Virol 73:5249-5254.
14. Tapia G, Cinek O, Rasmussen T, Witso E, Grinde B, Stene LC, Ronningen KS. 2011. Human enterovirus RNA in monthly fecal samples and islet autoimmunity in Norwegian children with high genetic risk for type 1 diabetes: The MIDIA study. Diabetes Care 34:151-155.
15. Tauriainen S, Martiskainen M, Oikarinen S, Lonnrot M, Viskari H, Ilonen J, Simell O, Knip M, Hyoty H. 2007. Human parechovirus 1 infections in young children-No association with type 1 diabetes. J Med Virol 79:457-462.
16. Tracy S, Drescher KM, Jackson JD, Kim K, Kono K. 2010. Enteroviruses, type 1 diabetes and hygiene: A complex relationship. Rev Med Virol 20:106-116.
17. Verboon-Maciolek MA, Groenendaal F, Hahn CD, Hellmann J, van Loon AM, Boivin G, de Vries LS. 2008. Human parechovirus causes encephalitis with white matter injury in neonates. Ann Neurol 64:266-273.
18. von Herrath M, Filippi C, Coppieters K. 2011. How viral infections enhance or prevent type 1 diabetes-From mouse to man. J Med Virol 83:1672.
19. Wigand R, Sabin AB. 1961. Properties of ECHO types 22, 23 and 24 viruses. Arch Gesamte Virusforsch 11:224-247.
20. Wolthers KC, Benschop KS, Schinkel J, Molenkamp R, Bergevoet RM, Spijkerman IJ, Kraakman HC, Pajkrt D. 2008. Human parechoviruses as an important viral cause of sepsislike illness and meningitis in young children. Clin Infect Dis 47:358-363.
21. Ylipaasto P, Klingel K, Lindberg AM, Otonkoski T, Kandolf R, Hovi T, Roivainen M. 2004. Enterovirus infection in human pancreatic islet cells, islet tropism in vivo and receptor involvement in cultured islet beta cells. Diabetologia 47:225-2239.