Significant morbidity and mortality attributable to Rothia mucilaginosa infections in children with hematological malignancies or following hematopoietic stem cell transplantation

Pediatric Hematology and Oncology

Volumn 30, Issue 5, 2013, Pages 445-454

  Chavan, Rishikesh S ^a   Pannaraj, Pia S ^b   Luna, Ruth Ann ^c   Szabo, Sara ^d   Adesina, Adekunle ^c   Versalovic, James ^c   Krance, Robert A ^c   Kennedy Nasser, Alana A ^c  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c TEXAS CHILDREN S HOSPITAL   (United States)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Bacteremia; Leukemia; Meningitis; Rothia mucilaginosa; SCT

Indexed keywords

AMIKACIN; ANTINEOPLASTIC AGENT; CEFEPIME; CEFOTAXIME; CEFTAZIDIME; CILASTATIN PLUS IMIPENEM; GENTAMICIN; IMIPENEM; RIFAMPICIN; TIMENTIN; TOBRAMYCIN SULFATE; VANCOMYCIN;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ANASTOMOSIS; ANTIBIOTIC THERAPY; ARTICLE; ATTRIBUTABLE RISK; BACTERIAL INFECTION; BACTERIAL MENINGITIS; BACTERIAL STRAIN; BACTERIUM ISOLATE; BRAIN VENTRICLE PERITONEUM SHUNT; CANCER CHEMOTHERAPY; CANCER PATIENT; CATHETER; CHILD; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; FEMALE; HEMATOLOGIC MALIGNANCY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; LIVER BIOPSY; LOBAR PNEUMONIA; MALE; MORBIDITY; MORTALITY; MYELOABLATIVE CONDITIONING; NEUROLOGICAL COMPLICATION; NEUTROPENIA; NEUTROPHIL; NONHODGKIN LYMPHOMA; PRESCHOOL CHILD; PYROSEQUENCING; ROTHIA MUCILAGINOSA; ROTHIA MUCILAGINOSA INFECTION; SCHOOL CHILD; THORAX RADIOGRAPHY;

ACTINOMYCETALES INFECTIONS; ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; FEMALE; FOLLOW-UP STUDIES; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MALE; MICROCOCCACEAE; PROGNOSIS; RETROSPECTIVE STUDIES; SURVIVAL RATE; YOUNG ADULT;

EID: 84880372668     PISSN: 08880018     EISSN: 15210669     Source Type: Journal    
DOI: 10.3109/08880018.2013.783893     Document Type: Article

References (26)

1. Zinner SH. Changing epidemiology of infections in patients with neutropenia and cancer: Emphasis on gram-positive and resistant bacteria. Clin Infect Dis. 1999;29:490-494
2. Aquino VM, Pappo A, Buchanan GR, et al.Thechanging epidemiology of bacteremia in neutropenic children with cancer. Pediatr Infect Dis J. 1995;14:140-143
3. Rubin SJ, Lyons RW, Murcia AJ. Endocarditis associated with cardiac catheterization due to a Gram-positive coccus designated Micrococcus mucilaginosus incertae sedis. J Clin Microbiol. 1978;7:546-549
4. McWhinney PH, Kibbler CC, Gillespie SH. Stomatococcusmucilaginosus: An emerging pathogen in neutropenic patients. Clin Infect Dis. 1992;14:641-646
5. Kaufhold A, Reinert RR, Kern W. Bacteremia caused by Stomatococcus mucilaginosus: Report of seven cases and review of the literature. Infection 1992;20:213-220
6. Mateos MC, et al. Rothia mucilaginosa bacteremia in a patient with acute monoblastic leukemia. Haematologica 2008:93:531 Abs.1392
7. Weinblatt ME, Sahdev I, Berman M. Stomatococcus mucilaginosus infections in children with leukemia. Pediatr Infect Dis J. 1990;9:678-679
8. Gruson D, Hilbert G, Pigneux A et al. Severe infection caused by Stomatococcus mucilaginosus in a neutropenic patient: Case report and review of the literature. Hematol Cell Ther. 1998;40:167- 169
9. Trevino M, Garcia-Zabarte A, Quintas A et al. Stomatococcusmucilaginosus septicemia in a patient with acute lymphoblastic leukaemia. Eur J Clin Microbiol Infect Dis. 1998;17:505-507
10. Souillet G, Chomarat M, Barbe G et al. Stomatococcus mucilaginosus meningitis in a child with leukemia. Clin Infect Dis. 1992;15:1045
11. Abraham J, Bilgrami S, Dorsky D et al. Stomatococcus mucilaginosus meningitis in a patient with multiple myeloma following autologous stem cell transplantation. Bone Marrow Transplant. 1997;19:639-641
12. Luna RA, Fasciano LR, Jones SC, Boyanton BL, Jr., Ton TT, Versalovic J. DNA pyrosequencing-based bacterial pathogen identification in a pediatric hospital setting. J ClinMicrobiol 2007;45:2985-2992
13. GoldmanM, Chaudhary UB, Greist A, Fausel CA. Central nervous system infections due to Stomatococcusmucilaginosus in immunocompromised hosts. Clin Infect Dis. 1998;27:1241-1246
14. Henwick S, Koehler M, Patrick CC. Complications of bacteremia due to Stomatococcus mucilaginosus in neutropenic children. Clin Infect Dis. 1993;17:667-671
15. Chanock SJ, Toltzis P, Wilson C. Cross-reactivity between Stomatococcus mucilaginosus and latex agglutination for cryptococcal antigen. Lancet 1993;342:1119-1120
16. Guermazi A, Miaux Y, Laval-Jeantet M. Imaging of choroid plexus infection by Stomatococcus mucilaginosus in neutropenic patients. AJNR Am J Neuroradiol. 1995;16:1331-1334
17. Park MK, Khan J, Stock F, Lucey DR. Successful treatment of Stomatococcus mucilaginosus meningitis with intravenous vancomycin and intravenous ceftriaxone. Clin Infect Dis. 1997;24:278
18. Lee AB, Harker-Murray P, Ferrieri P, et al. Bacterial meningitis from Rothia mucilaginosa in patients with malignancy or undergoing hematopoietic stem cell transplantation. Pediatr Blood Cancer. 2008;50:673-676
19. Ascher DP, Zbick C, White C, et al. Infections due to Stomatococcus mucilaginosus: 10 cases and review. Rev Infect Dis. 1991;13:1048-1052
20. AndströmE, Bygdeman S, Ahĺen S. et al. Stomatococcusmucilaginosus septicemia in two bonemarrow transplanted patients. Scand J Infect Dis. 1994;26:209-214
21. Skogen PG, Kolmannskog S, Bergh K et al. Bactericidal activity in cerebrospinal fluid by treating meningitis caused by Stomatococcus mucilaginosus with rifampicin, cefotaxime and vancomycin in a neutropenic child. Clin Microbiol Infect. 2001;7:39-42
22. Fanourgiakis P, Georgala A, Vekemans M, et al. Bacteremia due to Stomatococcusmucilaginosus in neutropenic patients in the setting of a cancer institute. Clin Microbiol Infect. 2003;9:1068-1072
23. Al-Fiar F, Ellis M, Qadri SM. et al. Stomatococcus mucilaginosus meningitis in a patient with acute lymphoblastic leukemia. Ann Saudi Med. 1995;15:393-395
24. Clausen CR. Central nervous system infection due to Stomatococcusmucilaginosus. Clin Microbiol Newsl 1992;14:87-88
25. Mustafa MM, Carlson LR, Krisher K. Stomatococcus mucilaginosus fatal sepsis in a child with leukemia. Pediatr Infect Dis J. 1993;9:784-786
26. Faiad G, Singh M, Narasimhan A et al. Rothiamucilaginosa life threatening infection in nonneutropenic hosts. Open Journal of Internal Medicine, 2011;1:68-71