Overexpression of YAP 1 contributes to progressive features and poor prognosis of human urothelial carcinoma of the bladder

BMC Cancer

Volumn 13, Issue , 2013, Pages

  Liu, Jian Ye ^a   Li, Yong Hong ^a   Lin, Huan Xin ^a   Liao, Yi Ji ^a   Mai, Shi Juan ^a   Liu, Zhou Wei ^a   Zhang, Zhi Ling ^a   Jiang, Li Juan ^a   Zhang, Jia Xing ^a   Kung, Hsiang Fu ^a   Zeng, Yi Xin ^a   Zhou, Fang Jian ^a   Xie, Dan ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

Immunohistochemistry; Prognosis; Urothelial carcinoma of the bladder; YAP 1

Indexed keywords

KI 67 ANTIGEN; MESSENGER RNA; TUMOR PROTEIN; UNCLASSIFIED DRUG; YES ASSOCIATED PROTEIN 1; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TUMOR MARKER; YAP1 (YES-ASSOCIATED) PROTEIN, HUMAN;

ADULT; ARTICLE; BLADDER CARCINOMA; CANCER GRADING; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CELL PROLIFERATION; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TISSUE MICROARRAY; TRANSITIONAL CELL CARCINOMA; TUMOR GENE; WESTERN BLOTTING; YES ASSOCIATED PROTEIN 1 GENE; AGED; BIOSYNTHESIS; BLADDER TUMOR; KAPLAN MEIER METHOD; METABOLISM; MIDDLE AGED; MORTALITY; PATHOLOGY; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; UPREGULATION; VERY ELDERLY; YOUNG ADULT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; CARCINOMA, TRANSITIONAL CELL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; PHOSPHOPROTEINS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; REAL-TIME POLYMERASE CHAIN REACTION; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION; URINARY BLADDER NEOPLASMS; YOUNG ADULT;

EID: 84880335400     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-13-349     Document Type: Article

References (30)

1. Greenlee RT, Hill-Harmon MB, Murray T, Thun M. Cancer statistics, 2001. CA Cancer J Clin 2001, 51:15-36. 10.3322/canjclin.51.1.15, 11577478.
2. Kirkali Z, Chan T, Manoharan M, Algaba F, Busch C, Cheng L, Kiemeney L, Kriegmair M, Montironi R, Murphy WM, Sesterhenn IA, Tachibana M, Weider J. Bladder cancer: epidemiology, staging and grading, and diagnosis. Urology 2005, 66:4-34.
3. Van Brussel JP, Mickisch GH. Prognostic factors in renal cell and bladder cancer. BJU Int 1999, 83:902-908. quiz 908-909.
4. Harvey KF, Pfleger CM, Hariharan IK. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 2003, 114:457-467. 10.1016/S0092-8674(03)00557-9, 12941274.
5. Lai ZC, Wei X, Shimizu T, Ramos E, Rohrbaugh M, Nikolaidis N, Ho LL, Li Y. Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell 2005, 120:675-685. 10.1016/j.cell.2004.12.036, 15766530.
6. Edgar BA. From cell structure to transcription: Hippo forges a new path. Cell 2006, 124:267-273. 10.1016/j.cell.2006.01.005, 16439203.
7. Hariharan IK, Bilder D. Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila. Annu Rev Genet 2006, 40:335-361. 10.1146/annurev.genet.39.073003.100738, 16872256.
8. Harvey K, Tapon N. The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network. Nat Rev Cancer 2007, 7:182-191. 10.1038/nrc2070, 17318211.
9. Sudol M. Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product. Oncogene 1994, 9:2145-2152.
10. Bork P, Sudol M. The WW domain: a signalling site in dystrophin?. Trends Biochem Sci 1994, 19:531-533. 10.1016/0968-0004(94)90053-1, 7846762.
11. Zender L, Spector MS, Xue W, Flemming P, Cordon-Cardo C, Silke J, Fan ST, Luk JM, Wigler M, Hannon GJ, Mu D, Lucito R, Powers S, Lowe SW. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell 2006, 125:1253-1267. 10.1016/j.cell.2006.05.030, 3026384, 16814713.
12. Overholtzer M, Zhang J, Smolen GA, Muir B, Li W, Sgroi DC, Deng CX, Brugge JS, Haber DA. Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci USA 2006, 103:12405-12410. 10.1073/pnas.0605579103, 1533802, 16894141.
13. Modena P, Lualdi E, Facchinetti F, Veltman J, Reid JF, Minardi S, Janssen I, Giangaspero F, Forni M, Finocchiaro G, Genitori L, Giordano F, Riccardi R, Schoenmakers EF, Massimino M, Sozzi G. Identification of tumor-specific molecular signatures in intracranial ependymoma and association with clinical characteristics. J Clin Oncol 2006, 24:5223-5233. 10.1200/JCO.2006.06.3701, 17114655.
14. Steinhardt AA, Gayyed MF, Klein AP, Dong J, Maitra A, Pan D, Montgomery EA, Anders RA. Expression of Yes-associated protein in common solid tumors. Hum Pathol 2008, 39:1582-1589. 10.1016/j.humpath.2008.04.012, 2720436, 18703216.
15. Xu MZ, Yao TJ, Lee NP, Ng IO, Chan YT, Zender L, Lowe SW, Poon RT, Luk JM. Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma. Cancer 2009, 115:4576-4585. 10.1002/cncr.24495, 2811690, 19551889.
16. Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J, Xie J, Ikenoue T, Yu J, Li L, Zheng P, Ye K, Chinnaiyan A, Halder G, Lai ZC, Guan KL. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev 2007, 21:2747-2761. 10.1101/gad.1602907, 2045129, 17974916.
17. Dong J, Feldmann G, Huang J, Wu S, Zhang N, Comerford SA, Gayyed MF, Anders RA, Maitra A, Pan D. Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 2007, 130:1120-1133. 10.1016/j.cell.2007.07.019, 2666353, 17889654.
18. Camargo FD, Gokhale S, Johnnidis JB, Fu D, Bell GW, Jaenisch R, Brummelkamp TR. YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol 2007, 17:2054-2060. 10.1016/j.cub.2007.10.039, 17980593.
19. Greene FL, Page DL, Fleming ID, April F, Balch CM, Haller DG, Monica M. American Joint Committee on Cancer (AJCC) staging manual 2002, Philadelphia: Springer, 6.
20. Xie D, Sham JS, Zeng WF, Lin HL, Che LH, Wu HX, Wen JM, Fang Y, Hu L, Guan XY. Heterogeneous expression and association of beta-catenin, p16 and c-myc in multistage colorectal tumorigenesis and progression detected by tissue microarray. Int J Cancer 2003, 107:896-902. 10.1002/ijc.11514, 14601048.
21. Wang Y, Dong Q, Zhang Q, Li Z, Wang E, Qiu X. Overexpression of yes-associated protein contributes to progression and poor prognosis of non-small-cell lung cancer. Cancer Sci 2010, 101:1279-1285. 10.1111/j.1349-7006.2010.01511.x, 20219076.
22. Gospodarowicz MK. Staging of bladder cancer. Semin Surg Oncol 1994, 10:51-59. 10.1002/ssu.2980100109, 8115786.
23. Schrier BP, Hollander MP, van Rhijn BW, Kiemeney LA, Witjes JA. Prognosis of muscle-invasive bladder cancer: difference between primary and progressive tumours and implications for therapy. Eur Urol 2004, 45:292-296. 10.1016/j.eururo.2003.10.006, 15036673.
24. Hussain SA, James ND. Molecular markers in bladder cancer. Semin Radiat Oncol 2005, 15:3-9. 10.1016/j.semradonc.2004.07.007, 15662601.
25. Wu S, Liu Y, Zheng Y, Dong J, Pan D. The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway. Dev Cell 2008, 14:388-398. 10.1016/j.devcel.2008.01.007, 18258486.
26. Kang W, Tong JH, Chan AW, Lee TL, Lung RW, Leung PP, So KK, Wu K, Fan D, Yu J, Sung JJ, To KF. Yes-associated protein 1 exhibits oncogenic property in gastric cancer and its nuclear accumulation associates with poor prognosis. Clin Cancer Res 2011, 17:2130-2139. 10.1158/1078-0432.CCR-10-2467, 21346147.
27. Zhang L, Ye DX, Pan HY, Wei KJ, Wang LZ, Wang XD, Shen GF, Zhang ZY. Yes-associated protein promotes cell proliferation by activating Fos Related Activator-1 in oral squamous cell carcinoma. Oral Oncol 2011, 47:693-697. 10.1016/j.oraloncology.2011.06.003, 21708480.
28. Ge L, Smail M, Meng W, Shyr Y, Ye F, Fan KH, Li X, Zhou HM, Bhowmick NA. Yes-associated protein expression in head and neck squamous cell carcinoma nodal metastasis. PLoS One 2011, 6:e27529. 10.1371/journal.pone.0027529, 3212574, 22096589.
29. Hall CA, Wang R, Miao J, Oliva E, Shen X, Wheeler T, Hilsenbeck SG, Orsulic S, Goode S. Hippo pathway effector Yap is an ovarian cancer oncogene. Cancer Res 2010, 70:8517-8525. 10.1158/0008-5472.CAN-10-1242, 2970655, 20947521.
30. Muramatsu T, Imoto I, Matsui T, Kozaki K, Haruki S, Sudol M, Shimada Y, Tsuda H, Kawano T, Inazawa J. YAP is a candidate oncogene for esophageal squamous cell carcinoma. Carcinogenesis 2011, 32:389-398. 10.1093/carcin/bgq254, 21112960.