Dual ALK and MYC rearrangements leading to an aggressive variant of anaplastic large cell lymphoma

Journal of Pediatric Hematology/Oncology

Volumn 35, Issue 5, 2013, Pages

  Liang, Xiayuan ^a,c   Branchford, Brian ^b,c   Greffe, Brian ^b,c   McGavran, Loris ^c,d   Carstens, Billie ^c,d   Meltesen, Lynne ^c,d   Albano, Edith A ^b,c   Quinones, Ralph ^b,c   Cook, Bruce ^b,c   Graham, Douglas K ^b,c  

^a CHILDREN S HOSPITAL COLORADO   (United States)

^b Children's Hospital Colorado   (United States)

^c Department of Pediatrics ^*  (United States)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

ALK; Anaplastic large cell lymphoma; Lymphoma; MYC

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; CARBOPLATIN; CYCLOSPORIN A; DOXORUBICIN; ETOPOSIDE; IFOSFAMIDE; MERCAPTOPURINE; METHOTREXATE; MYC PROTEIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; VINCRISTINE;

ANAPLASTIC LYMPHOMA KINASE GENE; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER STAGING; CASE REPORT; CHILD; CHROMOSOME ANALYSIS; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DISEASE ASSOCIATION; FLUORESCENCE IN SITU HYBRIDIZATION; GENE REARRANGEMENT; GENETIC ASSOCIATION; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LARGE CELL LYMPHOMA; MALE; METASTASIS; MOLECULAR DIAGNOSIS; NEEDLE BIOPSY; NUCLEAR MAGNETIC RESONANCE IMAGING; ONCOGENE MYC; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SCHOOL CHILD; TUMOR BIOPSY; WHOLE BODY RADIATION;

CHILD; GENE REARRANGEMENT; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; LYMPHOMA, LARGE-CELL, ANAPLASTIC; MALE; ONCOGENE PROTEINS, FUSION; PROTO-ONCOGENE PROTEINS C-MYC; RECEPTOR PROTEIN-TYROSINE KINASES; TRANSLOCATION, GENETIC;

EID: 84880315586     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/MPH.0b013e3182815046     Document Type: Article

References (20)

1. Kinney MC, Higgins RA, Medina EA. Anaplastic large cell lymphoma. Arch Pathol Lab Med. 2011;135:19-43.
2. Damm-Welk C, Kapper W, Oschlies I, et al. Distribution of NPM1-ALK and X-ALK fusion transcripts in paediatric anaplastic large cell lymphoma: a molecular-histologic correlation. Br J Haematol. 2009;146:306-309.
3. Delsol G, Falini B, Muller-Hermelink HK, et al. Anaplastic large cell lymphoma (ALCL), ALK-positive. In: Swerdlow SH, Campo E, Harris NL, et al, eds. World Health Organization Classification of Tumours of Hematopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2008:312-316.
4. Liang X, Meech SJ, Odom LF, et al. Assessment of t(2;5) (p23;q35) translocation and variants in pediatric ALK+ anaplastic large cell lymphoma. Am J Clin Pathol. 2004; 121:496-506.
5. Perkins SL, Pickering D, Lowe EJ, et al. Childhood anaplastic large cell lymphoma has a high incidence of ALK gene rearrangement as determined by immunohistochemical staining and fluorescent in situ hybridization: a genetic and pathological correlation. Br J Haematol. 2005;131:627-627.
6. Stein H, Foss HD, Durkop H, et al. CD30(+) anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features. Blood. 2000;96:3681-3695.
7. Duyster J, Bai RY, Morris SW. Translocations involving anaplastic lymphoma kinase (ALK). Oncogene. 2001;20: 5623-5637.
8. Pulford K, Morris SW, Turturro F. Anaplastic lymphoma kinase proteins in growth control and cancer. J Cell Physiol. 2004;199:330-358.
9. Monaco S, Tsao L, Murty VV, et al. Pediatric ALK+ anaplastic large cell lymphoma with t(3;8)(q26.2;q24) translocation and c-myc rearrangement terminating in a leukemic phase. Am J Hematol. 2007;82:59-64.
10. Moritake H, Shimonodan H, Marutsuka K, et al. C-MYC rearrangement may induce an aggressive phenotype in anaplastic lymphoma kinase positive large cell lymphoma: identification of a novel fusion gene AL017/C-MYC. Am J Hematol. 2011;86:75-78.
11. Klapproth K, Wirth T. Advances in the understanding of MYC-induced lymphomagenesis. Br J Haematol. 2010;149: 484-497.
12. Raetz EA, Perkins SL, Carlson MA, et al. The nucleophosminanaplastic lymphoma kinase fusion protein induces c-Myc expression in pediatric anaplastic large cell lymphomas. Am J Pathol. 2002;161:875-883.
13. Le Deley MC, Reiter A, Williams D, et al. Prognostic factors in childhood anaplastic large cell lymphoma: results of a large European intergroup study. Blood. 2008;111:1560-1566.
14. Damm-Welk C, Busch K, Burkhardt B, et al. Prognostic significance of circulating tumor cells in bone marrow or peripheral blood as detected by qualitative and quantitative PCR in pediatric NPM-ALK-positive anaplastic large-cell lymphoma. Blood. 2007;110:670-677.
15. Mussolin L, Pillon M, d'Amore ES, et al. Prevalence and clinical implication of bone marrow involvement in pediatric anaplastic large cell lymphoma. Leukemia. 2005;19: 1643-1647.
16. Onciu M, Behm FG, Raimondi SC, et al. ALK-positive anaplastic large cell lymphoma with leukemic peripheral blood involvement is a clinicopathologic entity with an unfavorable prognosis. Report of three cases and review of the literature. Am J Clin Pathol. 2003;120:617-625.
17. Ait-Tahar K, Damm-Welk C, Burkhardt B, et al. Correlation of autoantibody response to the ALK oncoantigen in pediatric anaplastic lymphoma kinase-positive anaplastic large cell lymphoma with tumor dissemination and relapse risk. Blood. 2010;115:3314-3319.
18. Mussolin L, Bonvini P, Ait-Tahar K, et al. Kinetics of humoral response to ALK and its relationship with minimal residual disease in pediatric ALCL. Leukemia. 2009;23:400-402.
19. Suzuki R, Kagami Y, Takeuchi K, et al. Prognostic significance of CD56 expression for ALK-positive and ALKnegative anaplastic large-cell lymphoma of T/null cell phenotype. Blood. 2000;96:2993-3000.
20. Lin P, Medeiros LJ, Yin CC, et al. Translocation (3;8) (q26;q24): a recurrent chromosomal abnormality in myelodysplastic syndrome and acute myeloid leukemia. Cancer Genet Cytogenet. 2006;166:82-85.