Eldecalcitol is more effective for the prevention of osteoporotic fractures than alfacalcidol

Journal of Bone and Mineral Metabolism

Volumn 31, Issue 4, 2013, Pages 417-422

  Nakamura, Toshitaka ^a   Takano, Toshiyuki ^b   Fukunaga, Masao ^c   Shiraki, Masataka ^d   Matsumoto, Toshio ^e  

^a NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^b CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^c KAWASAKI MEDICAL SCHOOL   (Japan)

^d RESEARCH INSTITUTE AND PRACTICE FOR INVOLUTIONAL DISEASES   (Japan)

^e UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Eldecalcitol; Fracture; FRAX; Osteoporosis; Vitamin D

Indexed keywords

ALFACALCIDOL; ELDECALCITOL; HYDROXYCOLECALCIFEROL; VITAMIN D;

AGED; ARTICLE; BONE DENSITY; FEMALE; FRAGILITY FRACTURE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; OSTEOPOROSIS; PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; RISK REDUCTION; SPINE FRACTURE; WORLD HEALTH ORGANIZATION; ANALOGS AND DERIVATIVES; CLINICAL TRIAL; KAPLAN MEIER METHOD; OSTEOPOROTIC FRACTURES; PHASE 3 CLINICAL TRIAL;

AGED; FEMALE; HUMANS; HYDROXYCHOLECALCIFEROLS; INCIDENCE; KAPLAN-MEIER ESTIMATE; MALE; OSTEOPOROTIC FRACTURES; RISK ASSESSMENT; VITAMIN D; WORLD HEALTH ORGANIZATION;

EID: 84880305266     PISSN: 09148779     EISSN: 14355604     Source Type: Journal    
DOI: 10.1007/s00774-012-0418-5     Document Type: Article

References (11)

1. Matsumoto T, Miki T, Hagino H, Sugimoto T, Okamoto S, Hirota T, Tanigawara Y, Hayashi Y, Fukunaga M, Shiraki M, Nakamura T (2005) A new active vitamin D, ED-71, increases bone mass in osteoporotic patients under vitamin D supplementation: a randomized, double-blind, placebo-controlled clinical trial. J Clin Endocrinol Metab 90:5031-5036 (Pubitemid 41262250)
2. 3 analog, eldecalcitol, prevents the risk of osteoporotic fractures: a randomized, active comparator, double-blind study. Bone (NY) 49:605-612
3. Kanis JA, on behalf of the World Health Organisation Scientific Group (2007) Assessment of osteoporosis at the primary health care level. WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield
4. Kanis JA, Oden A, Johnell O, Jonsson B, De Laet C, Dawson A (2001) The burden of osteoporotic fractures: a method for setting intervention thresholds. Osteoporos Int 12:417-427 (Pubitemid 32606468)
5. Raisz LG (2008) Overview of pathogenesis. In: Rosen CJ (ed) Primer on the metabolic bone diseases and disorders of mineral metabolism, 7th edn. American Society for Bone and Mineral Research, Washington, DC, pp 203-206
6. Raisz LG (2005) Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest 115:3318-3325 (Pubitemid 43121814)
7. Ito M, Nakamura T, Fukunaga M, Shiraki M, Matsumoto T (2011) Effect of eldecalcitol, an active vitamin D analog, on hip structure and biomechanical properties: 3D assessment by clinical CT. Bone (NY) 49:328-334
8. Klotzbuecher CM, Ross PD, Landsman PB, Abbott TA III, Berger M (2000) Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis. J Bone Miner Res 4:721-739 (Pubitemid 30174026)
9. Kanis JA, Johnell O, De Laet C, Johansson H, Oden A, Delmas P, Eisman J, Fujiwara S, Garnero P, Kroger H, McCloskey EV, Mellstrom D, Melton LJ, Pols H, Reeve J, Silman A, Tenenhouse A (2004) A meta-analysis of previous fracture and subsequent fracture risk. Bone (NY) 35:375-382 (Pubitemid 38953182)
10. Robinson CM, Royds M, Abraham A, McQueen MM, Court-Brown CM, Christie J (2002) Refractures in patients at least forty-five years old: a prospective analysis of twenty-two thousand and sixty patients. J Bone Joint Surg Am 84A:1528-1533 (Pubitemid 35014701)
11. Center JR, Bliuc D, Nguyen TV, Eisman JA (2007) Risk of subsequent fracture after low-trauma fracture in men and women. JAMA 297:387-394 (Pubitemid 46155800)