Serum glutamate dehydrogenase-biomarker for liver cell death or mitochondrial dysfunction?

Toxicological Sciences

Volumn 134, Issue 1, 2013, Pages 221-222

  Jaeschke, Hartmut ^a   McGill, Mitchell R ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLUTAMATE DEHYDROGENASE; MALATE DEHYDROGENASE; PARACETAMOL; PURINE NUCLEOSIDE PHOSPHORYLASE; BIOLOGICAL MARKER;

BLOOD SAMPLING; CELL DAMAGE; CELL DEATH; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; HUMAN; LETTER; LIVER CELL; LIVER INJURY; LIVER TOXICITY; NONHUMAN; BLOOD; FEMALE; MALE; TOXIC HEPATITIS;

BIOLOGICAL MARKERS; DRUG-INDUCED LIVER INJURY; FEMALE; HUMANS; MALE;

EID: 84880299657     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kft087     Document Type: Letter

References (4)

1. Jaeschke, H., McGill, M. R., and Ramachandran, A. (2012). Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity. Drug Metab. Rev. 44, 88-106.
2. McGill, M. R., Sharpe, M. R., Williams, C. D., Taha, M., Curry, S. C., and Jaeschke, H. (2012a). The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. J. Clin. Invest. 122, 1574-1583.
3. McGill, M. R., Williams, C. D., Xie, Y., Ramachandran, A., and Jaeschke, H. (2012b). Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity. Toxicol. Appl. Pharmacol. 264, 387-394.
4. Schomaker, S., Warner, R., Bock, J., Johnson, K., Potter, D., Van Winkle, J., and Aubrecht, J. (2013). Assessment of emerging biomarkers of liver injury in human subjects. Toxicol. Sci. 132, 276-283.