Reference intervals for plasma free metanephrines with an age adjustment for normetanephrine for optimized laboratory testing of phaeochromocytoma

Annals of Clinical Biochemistry

Volumn 50, Issue 1, 2013, Pages 62-69

  Eisenhofer, Graeme ^a   Lattke, Peter ^a   Herberg, Maria ^a   Siegert, Gabriele ^a   Qin, Nan ^a   Därr, Roland ^a   Hoyer, Jana ^b   Villringer, Arno ^b   Prejbisz, Aleksander ^c   Januszewicz, Andrzej ^c   Remaley, Alan ^d   Martucci, Victoria ^d   Pacak, Karel ^d   Ross, H Alec ^e   Sweep, Fred C G J ^e   Lenders, Jacques W M ^e  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b MAX PLANCK INSTITUTE FOR HUMAN COGNITIVE AND BRAIN SCIENCES   (Germany)

^c INSTITUTE OF CARDIOLOGY   (Poland)

^d EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^e RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

METADRENALIN; NORMETADRENALIN;

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD SAMPLING; CHILD; FEMALE; GROUPS BY AGE; HUMAN; HYPERTENSION; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; PHEOCHROMOCYTOMA; PRESCHOOL CHILD; PRIORITY JOURNAL; REFERENCE VALUE; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; SEX DIFFERENCE; SUPINE POSITION;

ADOLESCENT; ADRENAL GLAND NEOPLASMS; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; FALSE POSITIVE REACTIONS; FEMALE; HUMANS; HYPERTENSION; MALE; METANEPHRINE; MIDDLE AGED; NORMETANEPHRINE; PHEOCHROMOCYTOMA; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; SEX FACTORS;

EID: 84880297313     PISSN: 00045632     EISSN: 17581001     Source Type: Journal    
DOI: 10.1258/acb.2012.012066     Document Type: Article

References (38)

1. Pacak K, Eisenhofer G, Ahlman H, et al. Pheochromocytoma: recommendations for clinical practice from the First International Symposium. Nat Clin Pract Endocrinol Metab 2007;3:92-102
2. Peaston RT, Ball S. Biochemical detection of phaeochromocytoma: why are we continuing to ignore the evidence? Ann Clin Biochem 2008;45:6-10
3. Whiting MJ, Doogue MP. Advances in biochemical screening for phaeochromocytoma using biogenic amines. Clin Biochem Rev 2009;30:3-17
4. Eisenhofer G. Screening for pheochromocytomas and paragangliomas. Curr Hypertens Rep 2012;14:130-7
5. Eisenhofer G, Keiser H, Friberg P, et al. Plasma metanephrines are markers of pheochromocytoma produced by catechol-O-methyltransferase within tumors. J Clin Endocrinol Metab 1998;83:2175-85
6. Raber W, Raffesberg W, Bischof M, et al. Diagnostic efficacy of unconjugated plasma metanephrines for the detection of pheochromocytoma. Arch Intern Med 2000;160:2957-63
7. Sawka AM, Jaeschke R, Singh RJ, Young WF Jr. A comparison of biochemical tests for pheochromocytoma: measurement of fractionated plasma metanephrines compared with the combination of 24-hour urinary metanephrines and catecholamines. J Clin Endocrinol Metab 2003;88:553-8
8. Lenders JW, Pacak K, Walther MM, et al. Biochemical diagnosis of pheochromocytoma: which test is best? JAMA 2002;287:1427-34
9. Unger N, Pitt C, Schmidt IL, et al. Diagnostic value of various biochemical parameters for the diagnosis of pheochromocytoma in patients with adrenal mass. Eur J Endocrinol 2006;154:409-17
10. Vaclavik J, Stejskal D, Lacnak B, et al. Free plasma metanephrines as a screening test for pheochromocytoma in low-risk patients. J Hypertens 2007;25:1427-31
11. Hickman PE, Leong M, Chang J, Wilson SR, McWhinney B. Plasma free metanephrines are superior to urine and plasma catecholamines and urine catecholamine metabolites for the investigation of phaeochromocytoma. Pathology 2009;41:173-7
12. Peaston RT, Graham KS, Chambers E, van der Molen JC, Ball S. Performance of plasma free metanephrines measured by liquid chromatography-tandem mass spectrometry in the diagnosis of pheochromocytoma. Clin Chim Acta 2010;411:546-52
13. Procopiou M, Finney H, Akker SA, et al. Evaluation of an enzyme immunoassay for plasma-free metanephrines in the diagnosis of catecholamine-secreting tumors. Eur J Endocrinol 2009;161:131-40
14. Timmers HJ, Pacak K, Huynh TT, et al. Biochemically silent abdominal paragangliomas in patients with mutations in the SDHB gene. J Clin Endocrinol Metab 2008;93:4826-32
15. Eisenhofer G, Goldstein DS, Sullivan P, et al. Biochemical and clinical manifestations of dopamine-producing paragangliomas: utility of plasma methoxytyramine. J Clin Endocrinol Metab 2005;90:2068-75
16. Yu R, Wei M. False positive test results for pheochromocytoma from 2000 to 2008. Exp Clin Endocrinol Diabetes 2009;118:400-4
17. Anas SS, Vasikaran SD. An audit of management of patients with borderline increased plasma-free metanephrines. Ann Clin Biochem 2010;47:554-8
18. Eisenhofer G, Friberg P, Pacak K, et al. Plasma metadrenalines: do they provide useful information about sympatho-adrenal function and catecholamine metabolism? Clin Sci (Lond) 1995;88:533-42
19. Lenders JW, Willemsen JJ, Eisenhofer G, et al. Is supine rest necessary before blood sampling for plasma metanephrines? Clin Chem 2007;53:352-4
20. de Jong WH, Eisenhofer G, Post WJ, Muskiet FA, de Vries EG, Kema IP. Dietary influences on plasma and urinary metanephrines: implications for diagnosis of catecholamine-producing tumors. J Clin Endocrinol Metab 2009;94:2841-9
21. Grossman A, Pacak K, Sawka A, et al. Biochemical diagnosis and localization of pheochromocytoma: can we reach a consensus? Ann N Y Acad Sci 2006;1073:332-47
22. Eisenhofer G, Lenders J. Rapid circulatory clearances and half-lives of plasma free metanephrines. Clin Endocrinol 2012;77:484-5
23. Lagerstedt SA, O'Kane DJ, Singh RJ. Measurement of plasma free metanephrine and normetanephrine by liquid chromatography-tandem mass spectrometry for diagnosis of pheochromocytoma. Clin Chem 2004;50:603-11
24. Heider EC, Davis BG, Frank EL. Nonparametric determination of reference intervals for plasma metanephrine and normetanephrine. Clin Chem 2004;50:2381-4
25. de Jong WH, Graham KS, van der Molen JC, et al. Plasma free metanephrine measurement using automated online solid-phase extraction HPLC tandem mass spectrometry. Clin Chem 2007;53:1684-93
26. Roden M, Raffesberg W, Raber W, et al. Quantification of unconjugated metanephrines in human plasma without interference by acetaminophen. Clin Chem 2001;47:1061-7
27. Sawka AM, Thabane L, Gafni A, Levine M, Young WF Jr. Measurement of fractionated plasma metanephrines for exclusion of pheochromocytoma: can specificity be improved by adjustment for age? BMC Endocr Disord 2005;5:1
28. Eisenhofer G, Lenders JW, Siegert G, et al. Plasma methoxytyramine: a novel biomarker of metastatic pheochromocytoma and paraganglioma in relation to established risk factors of tumor size, location and SDHB mutation status. Eur J Cancer 2012;48:1739-49
29. Lenders JW, Eisenhofer G, Armando I, Keiser HR, Goldstein DS, Kopin IJ. Determination of metanephrines in plasma by liquid chromatography with electrochemical detection. Clin Chem 1993;39:97-103
30. Pillai D, Callen S. Pilot quality assurance programme for plasma metanephrines. Ann Clin Biochem 2010;47:137-42
31. Ceriotti F, Hinzmann R, Panteghini M. Reference intervals: the way forward. Ann Clin Biochem 2008;46:8-17
32. R Development Core Team. R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. 2011. ISBN 3-900051-07-0. See http://www.R-project.org (last checked 30 July 2012)
33. Deutschbein T, Unger N, Jaeger A, Broecker-Preuss M, Mann K, Petersenn S. Influence of various confounding variables and storage conditions on metanephrine and normetanephrine levels in plasma. Clin Endocrinol (Oxf) 2010;73:153-60
34. Eisenhofer G, Lenders JW, Linehan WM, Walther MM, Goldstein DS, Keiser HR. Plasma normetanephrine and metanephrine for detecting pheochromocytoma in von Hippel-Lindau disease and multiple endocrine neoplasia type 2. N Engl J Med 1999;340:1872-9
35. Ritchie RF, Palomaki G. Selecting clinically relevant populations for reference intervals. Clin Chem Lab Med 2004;42:702-9
36. Griffin A, O'Shea P, FitzGerald R, O'Connor G, Tormey W. Establishment of a paediatric age-related reference interval for the measurement of urinary total fractionated metanephrines. Ann Clin Biochem 2011;48:41-4
37. Davidson DF, Hammond PJ, Murphy DL, Carachi R. Age-related medical decision limits for urinary free (unconjugated) metadrenalines, catecholamines and metabolites in random urine specimens from children. Ann Clin Biochem 2011;48:358-6
38. Eisenhofer G, Lenders JW, Timmers H, et al. Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma. Clin Chem 2011;57:411-20