-
1
-
-
17644421000
-
-
1975-2009 (vintage 2009 populations). 2012; based on November 2011 SEER data submission, posted to the SEER website
-
Howlader N, Noone AM, Krapcho M, et al. SEER cancer statistics review, 1975-2009 (vintage 2009 populations). 2012; based on November 2011 SEER data submission, posted to the SEER website, 2012.
-
(2012)
SEER Cancer Statistics Review
-
-
Howlader, N.1
Noone, A.M.2
Krapcho, M.3
-
2
-
-
84872078210
-
Abiraterone in metastatic prostate cancer without previous chemotherapy
-
Ryan CJ, Smith MR, de Bono JS, et al. Abiraterone in metastatic prostate cancer without previous chemotherapy. N Engl J Med. 2013;368:138-148.
-
(2013)
N Engl J Med
, vol.368
, pp. 138-148
-
-
Ryan, C.J.1
Smith, M.R.2
de Bono, J.S.3
-
3
-
-
84928580276
-
Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate
-
Huggins C, Hodges CV. Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res. 1941; 1:293-297.
-
(1941)
Cancer Res
, vol.1
, pp. 293-297
-
-
Huggins, C.1
Hodges, C.V.2
-
4
-
-
84863979005
-
Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer
-
Hu R, Lu C, Mostaghel EA, et al. Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer. Cancer Res. 2012; 72:3457-3462.
-
(2012)
Cancer Res
, vol.72
, pp. 3457-3462
-
-
Hu, R.1
Lu, C.2
Mostaghel, E.A.3
-
5
-
-
34250331066
-
Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: Therapeutic implications for castration-resistant prostate cancer
-
Mostaghel EA, Page ST, Lin DW, et al. Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer. Cancer Res. 2007, 67:5033-5041.
-
(2007)
Cancer Res
, vol.67
, pp. 5033-5041
-
-
Mostaghel, E.A.1
Page, S.T.2
Lin, D.W.3
-
6
-
-
77955296562
-
Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant
-
Sun S, Sprenger CC, Vessella RL, et al. Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant. J Clin Invest. 2010, 120:2715-2730.
-
(2010)
J Clin Invest
, vol.120
, pp. 2715-2730
-
-
Sun, S.1
Sprenger, C.C.2
Vessella, R.L.3
-
7
-
-
65649090203
-
Development of a second-generation antiandrogen for treatment of advanced prostate cancer
-
Tran C, Ouk S, Clegg NJ, et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science. 2009; 324:787-790.
-
(2009)
Science
, vol.324
, pp. 787-790
-
-
Tran, C.1
Ouk, S.2
Clegg, N.J.3
-
8
-
-
0038062686
-
Effects of novel 17alpha-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis in vitro and in vivo
-
Haidar S, Ehmer PB, Barassin S, et al. Effects of novel 17alpha-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis in vitro and in vivo. J Steroid Biochem Mol Biol. 2003; 84:555-562.
-
(2003)
J Steroid Biochem Mol Biol
, vol.84
, pp. 555-562
-
-
Haidar, S.1
Ehmer, P.B.2
Barassin, S.3
-
9
-
-
77951523950
-
Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy
-
Ryan CJ, Smith MR, Fong L, et al. Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy. J Clin Oncol. 2010;28:1481-1488.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1481-1488
-
-
Ryan, C.J.1
Smith, M.R.2
Fong, L.3
-
10
-
-
79957443342
-
Abiraterone and increased survival in metastatic prostate cancer
-
de Bono JS, Logothetis CJ, Molina A, et al. Abiraterone and increased survival in metastatic prostate cancer. N Engl J Med. 2011;364:1995-2005.
-
(2011)
N Engl J Med
, vol.364
, pp. 1995-2005
-
-
de Bono, J.S.1
Logothetis, C.J.2
Molina, A.3
-
11
-
-
84858228703
-
Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: Effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys
-
Yamaoka M, Hara T, Hitaka T, et al. Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys. J Steroid Biochem Mol Biol. 2012;129:115-128.
-
(2012)
J Steroid Biochem Mol Biol
, vol.129
, pp. 115-128
-
-
Yamaoka, M.1
Hara, T.2
Hitaka, T.3
-
12
-
-
78649523986
-
Safety, pharmacokinetics, and efficacy of TAK-700 in metastatic castration-resistant prostate cancer: A phase I/II, open-label study
-
Dreicer R, Agus DB, MacVicar GR, et al. Safety, pharmacokinetics, and efficacy of TAK-700 in metastatic castration-resistant prostate cancer: a phase I/II, open-label study. J Clin Oncol. 2010;28:15s.
-
(2010)
J Clin Oncol
, vol.28
-
-
Dreicer, R.1
Agus, D.B.2
Macvicar, G.R.3
-
13
-
-
84873298103
-
Safety and activity of the investigational agent orteronel (ortl) without prednisone in men with nonmetastatic castration-resistant prostate cancer (nmCRPC) and rising prostate-specific antigen (PSA): Updated results of a phase II study
-
Abstr 4549
-
George DJ, Corn PG, Michaelson MD, et al. Safety and activity of the investigational agent orteronel (ortl) without prednisone in men with nonmetastatic castration-resistant prostate cancer (nmCRPC) and rising prostate-specific antigen (PSA): updated results of a phase II study. J Clin Oncol. 2012;30(suppl):Abstr 4549.
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL
-
-
George, D.J.1
Corn, P.G.2
Michaelson, M.D.3
-
14
-
-
0027203411
-
Flutamide withdrawal syndrome: Its impact on clinical trials in hormone-refractory prostate cancer
-
Scher HI, Kelly WK. Flutamide withdrawal syndrome: its impact on clinical trials in hormone-refractory prostate cancer. J Clin Oncol. 1993;11:1566-1572.
-
(1993)
J Clin Oncol
, vol.11
, pp. 1566-1572
-
-
Scher, H.I.1
Kelly, W.K.2
-
15
-
-
1842612441
-
Molecular determinants of resistance to antiandrogen therapy
-
Chen CD, Welsbie DS, Tran C, et al. Molecular determinants of resistance to antiandrogen therapy. Nat Med. 2004;10:33-39.
-
(2004)
Nat Med
, vol.10
, pp. 33-39
-
-
Chen, C.D.1
Welsbie, D.S.2
Tran, C.3
-
16
-
-
77952105685
-
Antitumour activity of MDV3100 in castration-resistant prostate cancer: A phase 1-2 study
-
Scher HI, Beer TM, Higano CS, et al. Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study. Lancet. 2010;375:1437-1446.
-
(2010)
Lancet
, vol.375
, pp. 1437-1446
-
-
Scher, H.I.1
Beer, T.M.2
Higano, C.S.3
-
17
-
-
84866770294
-
Increased survival with enzalutamide in prostate cancer after chemotherapy
-
Scher HI, Fizazi K, Saad F, et al. Increased survival with enzalutamide in prostate cancer after chemotherapy. N Engl J Med. 2012;367:1187-1197.
-
(2012)
N Engl J Med
, vol.367
, pp. 1187-1197
-
-
Scher, H.I.1
Fizazi, K.2
Saad, F.3
-
18
-
-
84863230424
-
ARN-509: A novel antiandrogen for prostate cancer treatment
-
Clegg NJ, Wongvipat J, Joseph JD, et al. ARN-509: a novel antiandrogen for prostate cancer treatment. Cancer Res. 2012;72:1494-1503.
-
(2012)
Cancer Res
, vol.72
, pp. 1494-1503
-
-
Clegg, N.J.1
Wongvipat, J.2
Joseph, J.D.3
-
19
-
-
84870868470
-
A phase I study of the androgen signaling inhibitor ARN-509 in patients with metastatic castration-resistant prostate cancer (mCRPC)
-
abstr 4548
-
Rathkopf DE, Morris MJ, Danila DC, et al. A phase I study of the androgen signaling inhibitor ARN-509 in patients with metastatic castration-resistant prostate cancer (mCRPC). J Clin Oncol. 2012;30(suppl):abstr 4548.
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL
-
-
Rathkopf, D.E.1
Morris, M.J.2
Danila, D.C.3
-
21
-
-
0033551070
-
New insights into tumor suppression: PTEN Suppresses Tumor Formation By Restraining the Phosphoinositide 3-kinase/AKT Pathway
-
Proc Natl Acad Sci USA
-
Cantley LC, Neel BG. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA. 1999;96:4240-4245.
-
(1999)
, vol.96
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
22
-
-
50949117490
-
Predictive value of PTEN and AR coexpression of sustained responsiveness to hormonal therapy in prostate cancera pilot study
-
El Sheikh SS, Romanska HM, Abel P, et al. Predictive value of PTEN and AR coexpression of sustained responsiveness to hormonal therapy in prostate cancera pilot study. Neoplasia. 2008;10:949-953.
-
(2008)
Neoplasia
, vol.10
, pp. 949-953
-
-
El Sheikh, S.S.1
Romanska, H.M.2
Abel, P.3
-
23
-
-
76949106361
-
Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer
-
Reid AH, Attard G, Ambroisine L, et al. Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer. Br J Cancer. 2010;102:678-684.
-
(2010)
Br J Cancer
, vol.102
, pp. 678-684
-
-
Reid, A.H.1
Attard, G.2
Ambroisine, L.3
-
24
-
-
34447121369
-
Murine cell lines derived from PTEN null prostate cancer show the critical role of PTEN in hormone refractory prostate cancer development
-
Jiao J, Wang S, Qiao R, et al. Murine cell lines derived from PTEN null prostate cancer show the critical role of PTEN in hormone refractory prostate cancer development. Cancer Res. 2007;67:6083-6091.
-
(2007)
Cancer Res
, vol.67
, pp. 6083-6091
-
-
Jiao, J.1
Wang, S.2
Qiao, R.3
-
25
-
-
16844371494
-
Effects of the mammalian target of rapamycin inhibitor CCI-779 used alone or with chemotherapy on human prostate cancer cells and xenografts
-
Wu L, Birle DC, Tannock IF. Effects of the mammalian target of rapamycin inhibitor CCI-779 used alone or with chemotherapy on human prostate cancer cells and xenografts. Cancer Res. 2005;65:2825-2831.
-
(2005)
Cancer Res
, vol.65
, pp. 2825-2831
-
-
Wu, L.1
Birle, D.C.2
Tannock, I.F.3
-
26
-
-
70349731660
-
Inhibition of tumor growth progression by antiandrogens and mTOR inhibitor in a PTEN-deficient mouse model of prostate cancer
-
Zhang W, Zhu J, Efferson CL, et al. Inhibition of tumor growth progression by antiandrogens and mTOR inhibitor in a PTEN-deficient mouse model of prostate cancer. Cancer Res. 2009;69:7466-7472.
-
(2009)
Cancer Res
, vol.69
, pp. 7466-7472
-
-
Zhang, W.1
Zhu, J.2
Efferson, C.L.3
-
27
-
-
77953100029
-
A pharmacodynamic study of rapamycin in men with intermediate- to high-risk localized prostate cancer
-
Armstrong AJ, Netto GJ, Rudek MA, et al. A pharmacodynamic study of rapamycin in men with intermediate- to high-risk localized prostate cancer. Clin Cancer Res. 2010;16:3057-3066.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3057-3066
-
-
Armstrong, A.J.1
Netto, G.J.2
Rudek, M.A.3
-
28
-
-
84870901238
-
Phase II trial of RAD001 and bicalutamide for castration-resistant prostate cancer
-
Nakabayashi M, Werner L, Courtney KD, et al. Phase II trial of RAD001 and bicalutamide for castration-resistant prostate cancer. BJU Int. 2012;110:1729-1735.
-
(2012)
BJU Int
, vol.110
, pp. 1729-1735
-
-
Nakabayashi, M.1
Werner, L.2
Courtney, K.D.3
-
29
-
-
51349164790
-
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
-
Carracedo A, Ma L, Teruya-Feldstein J, et al. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest. 2008;118:3065-3074.
-
(2008)
J Clin Invest
, vol.118
, pp. 3065-3074
-
-
Carracedo, A.1
Ma, L.2
Teruya-Feldstein, J.3
-
30
-
-
79955975429
-
Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
-
Carver BS, Chapinski C, Wongvipat J, et al. Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell. 2011;19:575-586.
-
(2011)
Cancer Cell
, vol.19
, pp. 575-586
-
-
Carver, B.S.1
Chapinski, C.2
Wongvipat, J.3
-
31
-
-
0033523268
-
The Breast Cancer Linkage Consortium
-
Cancer risks in BRCA2 mutation carriers
-
Cancer risks in BRCA2 mutation carriers. The Breast Cancer Linkage Consortium. J Natl Cancer Inst. 1999;91:1310-1316.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 1310-1316
-
-
-
33
-
-
84882448718
-
Distinct ERG rearrangement prevalence in prostate cancer: Higher frequency in young age and in low PSA prostate cancer
-
Schaefer G, Mosquera JM, Ramoner R, et al. Distinct ERG rearrangement prevalence in prostate cancer: higher frequency in young age and in low PSA prostate cancer. Prostate Cancer Prostatic Dis. 2013;16:132-138.
-
(2013)
Prostate Cancer Prostatic Dis
, vol.16
, pp. 132-138
-
-
Schaefer, G.1
Mosquera, J.M.2
Ramoner, R.3
-
34
-
-
66749188650
-
Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate
-
Carver BS, Tran J, Gopalan A, et al. Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate. Nat Genet. 2009;41:619-624.
-
(2009)
Nat Genet
, vol.41
, pp. 619-624
-
-
Carver, B.S.1
Tran, J.2
Gopalan, A.3
-
35
-
-
79955968629
-
Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer
-
Brenner JC, Ateeq B, Li Y, et al. Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer. Cancer Cell. 2011;19:664-678.
-
(2011)
Cancer Cell
, vol.19
, pp. 664-678
-
-
Brenner, J.C.1
Ateeq, B.2
Li, Y.3
-
36
-
-
67650471685
-
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
Fong PC, Boss DS, Yap TA, et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med. 2009;361:123-134.
-
(2009)
N Engl J Med
, vol.361
, pp. 123-134
-
-
Fong, P.C.1
Boss, D.S.2
Yap, T.A.3
-
37
-
-
84872611530
-
Pilot study of veliparib (ABT-888) with temozolomide in patients with metastatic castration-resistant prostate cancer
-
abstr 224
-
Hussain M, Carducci M, Slovin S, et al. Pilot study of veliparib (ABT-888) with temozolomide in patients with metastatic castration-resistant prostate cancer. J Clin Oncol. 2012;30(suppl 5):abstr 224.
-
(2012)
J Clin Oncol
, vol.30
-
-
Hussain, M.1
Carducci, M.2
Slovin, S.3
-
38
-
-
35948950583
-
Cooperative interactions between androgen receptor (AR) and heat-shock protein 27 facilitate AR transcriptional activity
-
Zoubeidi A, Zardan A, Beraldi E, et al. Cooperative interactions between androgen receptor (AR) and heat-shock protein 27 facilitate AR transcriptional activity. Cancer Res. 2007;67:10455-10465.
-
(2007)
Cancer Res
, vol.67
, pp. 10455-10465
-
-
Zoubeidi, A.1
Zardan, A.2
Beraldi, E.3
-
39
-
-
77950518207
-
Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E
-
Andrieu C, Taieb D, Baylot V, et al. Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E. Oncogene. 2010;29:1883-1896.
-
(2010)
Oncogene
, vol.29
, pp. 1883-1896
-
-
Andrieu, C.1
Taieb, D.2
Baylot, V.3
-
40
-
-
33749554554
-
Small interference RNA targeting heat-shock protein 27 inhibits the growth of prostatic cell lines and induces apoptosis via caspase-3 activation in vitro
-
Rocchi P, Jugpal P, So A, et al. Small interference RNA targeting heat-shock protein 27 inhibits the growth of prostatic cell lines and induces apoptosis via caspase-3 activation in vitro. BJU Int. 2006;98:1082-1089.
-
(2006)
BJU Int
, vol.98
, pp. 1082-1089
-
-
Rocchi, P.1
Jugpal, P.2
So, A.3
-
41
-
-
4644237335
-
Heat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancer
-
Rocchi P, So A, Kojima S, et al. Heat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancer. Cancer Res. 2004;64:6595-6602.
-
(2004)
Cancer Res
, vol.64
, pp. 6595-6602
-
-
Rocchi, P.1
So, A.2
Kojima, S.3
-
42
-
-
84855826122
-
Phase I trial of OGX-427, a 2'-methoxyethyl antisense oligonucleotide (ASO), against heat shock protein 27 (Hsp27): Final results
-
Hotte SJ, Yu EY, Hirte HW, et al. Phase I trial of OGX-427, a 2'-methoxyethyl antisense oligonucleotide (ASO), against heat shock protein 27 (Hsp27): final results. J Clin Oncol. 2010;28:15s.
-
(2010)
J Clin Oncol
, vol.28
-
-
Hotte, S.J.1
Yu, E.Y.2
Hirte, H.W.3
-
43
-
-
84873742677
-
A randomized phase II study of OGX-427 plus prednisone (P) versus P alone in patients (pts) with metastatic castration resistant prostate cancer (CRPC)
-
abstr 4514
-
Chi KN, Hotte SJ, Ellard S, et al. A randomized phase II study of OGX-427 plus prednisone (P) versus P alone in patients (pts) with metastatic castration resistant prostate cancer (CRPC). J Clin Oncol. 2012;30(suppl):abstr 4514.
-
(2012)
J Clin Oncol
, vol.30
-
-
Chi, K.N.1
Hotte, S.J.2
Ellard, S.3
-
44
-
-
76749144766
-
Targeting the cytoprotective chaperone, clusterin, for treatment of advanced cancer
-
Zoubeidi A, Chi K, Gleave M. Targeting the cytoprotective chaperone, clusterin, for treatment of advanced cancer. Clin Cancer Res. 2010;16:1088-1093.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1088-1093
-
-
Zoubeidi, A.1
Chi, K.2
Gleave, M.3
-
45
-
-
75149124457
-
Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells
-
Zoubeidi A, Ettinger S, Beraldi E, et al. Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells. Mol Cancer Res. 2010;8:119-130.
-
(2010)
Mol Cancer Res
, vol.8
, pp. 119-130
-
-
Zoubeidi, A.1
Ettinger, S.2
Beraldi, E.3
-
46
-
-
15944390264
-
Use of antisense oligonucleotides targeting the cytoprotective gene, clusterin, to enhance androgen- and chemo-sensitivity in prostate cancer
-
Gleave M, Miyake H. Use of antisense oligonucleotides targeting the cytoprotective gene, clusterin, to enhance androgen- and chemo-sensitivity in prostate cancer. World J Urol. 2005; 23:38-46.
-
(2005)
World J Urol
, vol.23
, pp. 38-46
-
-
Gleave, M.1
Miyake, H.2
-
47
-
-
47649133156
-
Clusterin knockdown using the antisense oligonucleotide OGX-011 re-sensitizes docetaxel-refractory prostate cancer PC-3 cells to chemotherapy
-
Sowery RD, Hadaschik BA, So AI, et al. Clusterin knockdown using the antisense oligonucleotide OGX-011 re-sensitizes docetaxel-refractory prostate cancer PC-3 cells to chemotherapy. BJU Int. 2008; 102:389-397.
-
(2008)
BJU Int
, vol.102
, pp. 389-397
-
-
Sowery, R.D.1
Hadaschik, B.A.2
So, A.I.3
-
48
-
-
24744470522
-
A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2'-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer
-
Chi KN, Eisenhauer E, Fazli L, et al. A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2'-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer. J Natl Cancer Inst. 2005; 97:1287-1296.
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 1287-1296
-
-
Chi, K.N.1
Eisenhauer, E.2
Fazli, L.3
-
49
-
-
38949153810
-
A phase I study of OGX-011, a 2'-methoxyethyl phosphorothioate antisense to clusterin, in combination with docetaxel in patients with advanced cancer
-
Chi KN, Siu LL, Hirte H, et al. A phase I study of OGX-011, a 2'-methoxyethyl phosphorothioate antisense to clusterin, in combination with docetaxel in patients with advanced cancer. Clin Cancer Res. 2008; 14:833-839.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 833-839
-
-
Chi, K.N.1
Siu, L.L.2
Hirte, H.3
-
50
-
-
77957957234
-
Randomized phase II study of docetaxel and prednisone with or without OGX-011 in patients with metastatic castration-resistant prostate cancer
-
Chi KN, Hotte SJ, Yu EY, et al. Randomized phase II study of docetaxel and prednisone with or without OGX-011 in patients with metastatic castration-resistant prostate cancer. J Clin Oncol. 2010;28:4247-4254.
-
(2010)
J Clin Oncol
, vol.28
, pp. 4247-4254
-
-
Chi, K.N.1
Hotte, S.J.2
Yu, E.Y.3
-
51
-
-
0021241398
-
Molecular cloning of a new transforming gene from a chemically transformed human cell line
-
Cooper CS, Park M, Blair DG, et al. Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature. 1984;311:29-33.
-
(1984)
Nature
, vol.311
, pp. 29-33
-
-
Cooper, C.S.1
Park, M.2
Blair, D.G.3
-
52
-
-
0024427178
-
Molecular cloning and expression of human hepatocyte growth factor
-
Nakamura T, Nishizawa T, Hagiya M, et al. Molecular cloning and expression of human hepatocyte growth factor. Nature. 1989; 342:440-443.
-
(1989)
Nature
, vol.342
, pp. 440-443
-
-
Nakamura, T.1
Nishizawa, T.2
Hagiya, M.3
-
53
-
-
0025119463
-
Scatter factor: Molecular characteristics and effect on the invasiveness of epithelial cells
-
Weidner KM, Behrens J, Vandekerckhove J, Birchmeier W. Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells. J Cell Biol. 1990;111:2097-2108.
-
(1990)
J Cell Biol
, vol.111
, pp. 2097-2108
-
-
Weidner, K.M.1
Behrens, J.2
Vandekerckhove, J.3
Birchmeier, W.4
-
54
-
-
0345601083
-
Met, metastasis, motility and more
-
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF. Met, metastasis, motility and more. Nat Rev Mol Cell Biol. 2003;4:915-925.
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 915-925
-
-
Birchmeier, C.1
Birchmeier, W.2
Gherardi, E.3
Vande, W.G.F.4
-
55
-
-
83355166909
-
Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth
-
Yakes FM, Chen J, Tan J, et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther. 2011;10:2298-2308.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 2298-2308
-
-
Yakes, F.M.1
Chen, J.2
Tan, J.3
-
56
-
-
79959936054
-
Activity of XL184 (cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer
-
Kurzrock R, Sherman SI, Ball DW, et al. Activity of XL184 (cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer. J Clin Oncol. 2011;29:2660-2666.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2660-2666
-
-
Kurzrock, R.1
Sherman, S.I.2
Ball, D.W.3
-
57
-
-
84874787799
-
Cabozantinib in patients with advanced prostate cancer: Results of a phase II randomized discontinuation trial
-
Smith DC, Smith MR, Sweeney C, et al. Cabozantinib in patients with advanced prostate cancer: results of a phase II randomized discontinuation trial. J Clin Oncol. 2013;31:412-419.
-
(2013)
J Clin Oncol
, vol.31
, pp. 412-419
-
-
Smith, D.C.1
Smith, M.R.2
Sweeney, C.3
-
58
-
-
0028114985
-
The implications of angiogenesis for the biology and therapy of cancer metastasis
-
Fidler IJ, Ellis LM. The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell. 1994;79:185-188.
-
(1994)
Cell
, vol.79
, pp. 185-188
-
-
Fidler, I.J.1
Ellis, L.M.2
-
59
-
-
0031039243
-
The biology of vascular endothelial growth factor
-
Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev. 1997;18:4-25.
-
(1997)
Endocr Rev
, vol.18
, pp. 4-25
-
-
Ferrara, N.1
Davis-Smyth, T.2
-
60
-
-
0032710319
-
Clinical applications of angiogenic growth factors and their inhibitors
-
Ferrara N, Alitalo K. Clinical applications of angiogenic growth factors and their inhibitors. Nat Med. 1999;5:1359-1364.
-
(1999)
Nat Med
, vol.5
, pp. 1359-1364
-
-
Ferrara, N.1
Alitalo, K.2
-
61
-
-
0035176826
-
Vascular endothelial growth factor expression and tumor angiogenesis are regulated by androgens in hormone responsive human prostate carcinoma: Evidence for androgen dependent destabilization of vascular endothelial growth factor transcripts
-
Stewart RJ, Panigrahy D, Flynn E, Folkman J. Vascular endothelial growth factor expression and tumor angiogenesis are regulated by androgens in hormone responsive human prostate carcinoma: evidence for androgen dependent destabilization of vascular endothelial growth factor transcripts. J Urol. 2001;165:688-693.
-
(2001)
J Urol
, vol.165
, pp. 688-693
-
-
Stewart, R.J.1
Panigrahy, D.2
Flynn, E.3
Folkman, J.4
-
62
-
-
0035870297
-
The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors
-
Sweeney CJ, Miller KD, Sissons SE, et al. The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors. Cancer Res. 2001;61:3369-3372.
-
(2001)
Cancer Res
, vol.61
, pp. 3369-3372
-
-
Sweeney, C.J.1
Miller, K.D.2
Sissons, S.E.3
-
63
-
-
53249135560
-
Combination of bevacizumab and docetaxel in docetaxel-pretreated hormone-refractory prostate cancer: A phase 2 study
-
Di Lorenzo G, Figg WD, Fossa SD, et al. Combination of bevacizumab and docetaxel in docetaxel-pretreated hormone-refractory prostate cancer: a phase 2 study. Eur Urol. 2008;54:1089-1094.
-
(2008)
Eur Urol
, vol.54
, pp. 1089-1094
-
-
Di Lorenzo, G.1
Figg, W.D.2
Fossa, S.D.3
-
64
-
-
84861690508
-
Randomized, double-blind, placebo-controlled phase III trial comparing docetaxel and prednisone with or without bevacizumab in men with metastatic castration-resistant prostate cancer: CALGB 90401
-
Kelly WK, Halabi S, Carducci M, et al. Randomized, double-blind, placebo-controlled phase III trial comparing docetaxel and prednisone with or without bevacizumab in men with metastatic castration-resistant prostate cancer: CALGB 90401. J Clin Oncol. 2012;30:1534-1540.
-
(2012)
J Clin Oncol
, vol.30
, pp. 1534-1540
-
-
Kelly, W.K.1
Halabi, S.2
Carducci, M.3
-
65
-
-
81255175385
-
Randomized, placebo-controlled, phase III trial of sunitinib in combination with prednisone (SU+P) versus prednisone (P) alone in men with progressive metastatic castration-resistant prostate cancer (mCRPC)
-
abstr 4515
-
Michaelson MD, Oudard S, Ou Y, et al. Randomized, placebo-controlled, phase III trial of sunitinib in combination with prednisone (SU+P) versus prednisone (P) alone in men with progressive metastatic castration-resistant prostate cancer (mCRPC). J Clin Oncol. 2011;29(suppl):abstr 4515.
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL
-
-
Michaelson, M.D.1
Oudard, S.2
Ou, Y.3
-
66
-
-
84876297409
-
Aflibercept versus placebo in combination with docetaxel/prednisone for first-line treatment of men with metastatic castration-resistant prostate cancer (mCRPC): Results from the multinational phase III trial (VENICE)
-
abstr 13
-
Tannock I, Fizazi K, Ivanov S, et al. Aflibercept versus placebo in combination with docetaxel/prednisone for first-line treatment of men with metastatic castration-resistant prostate cancer (mCRPC): Results from the multinational phase III trial (VENICE). J Clin Oncol. 2013;31(suppl 6):abstr 13.
-
(2013)
J Clin Oncol
, vol.31
, Issue.SUPPL 6
-
-
Tannock, I.1
Fizazi, K.2
Ivanov, S.3
-
67
-
-
84873865670
-
A Phase 3 Study to Evaluate the Efficacy and Safety of Docetaxel and Prednisone With Or Without Lenalidomide In Patients With Castrate-resistant Prostate Cancer (CRPC): The MAINSAIL Trial
-
2012 ESMO Congress, Abstr LBA24
-
Petrylak DP, Fizazi K, Sternberg CN, et al. A phase 3 study to evaluate the efficacy and safety of docetaxel and prednisone with or without lenalidomide in patients with castrate-resistant prostate cancer (CRPC): The MAINSAIL trial. 2012 ESMO Congress. 2012;Abstr LBA24.
-
(2012)
-
-
Petrylak, D.P.1
Fizazi, K.2
Sternberg, C.N.3
-
68
-
-
34248192988
-
The quinoline-3-carboxamide anti-angiogenic agent, tasquinimod, enhances the anti-prostate cancer efficacy of androgen ablation and taxotere without effecting serum PSA directly in human xenografts
-
Dalrymple SL, Becker RE, Isaacs JT. The quinoline-3-carboxamide anti-angiogenic agent, tasquinimod, enhances the anti-prostate cancer efficacy of androgen ablation and taxotere without effecting serum PSA directly in human xenografts. Prostate. 2007;67:790-797.
-
(2007)
Prostate
, vol.67
, pp. 790-797
-
-
Dalrymple, S.L.1
Becker, R.E.2
Isaacs, J.T.3
-
69
-
-
70349952393
-
Open-label, clinical phase I studies of tasquinimod in patients with castration-resistant prostate cancer
-
Bratt O, Haggman M, Ahlgren G, et al. Open-label, clinical phase I studies of tasquinimod in patients with castration-resistant prostate cancer. Br J Cancer. 2009;101:1233-1240.
-
(2009)
Br J Cancer
, vol.101
, pp. 1233-1240
-
-
Bratt, O.1
Haggman, M.2
Ahlgren, G.3
-
70
-
-
80054761310
-
Phase II randomized, double-blind, placebo-controlled study of tasquinimod in men with minimally symptomatic metastatic castrate-resistant prostate cancer
-
Pili R, Haggman M, Stadler WM, et al. Phase II randomized, double-blind, placebo-controlled study of tasquinimod in men with minimally symptomatic metastatic castrate-resistant prostate cancer. J Clin Oncol. 2011;29:4022-4028.
-
(2011)
J Clin Oncol
, vol.29
, pp. 4022-4028
-
-
Pili, R.1
Haggman, M.2
Stadler, W.M.3
-
71
-
-
84856071447
-
Phase I, dose-escalation study of BKM120, an oral pan-class I PI3K inhibitor, in patients with advanced solid tumors
-
Bendell JC, Rodon J, Burris HA, et al. Phase I, dose-escalation study of BKM120, an oral pan-class I PI3K inhibitor, in patients with advanced solid tumors. J Clin Oncol. 2012;30:282-290.
-
(2012)
J Clin Oncol
, vol.30
, pp. 282-290
-
-
Bendell, J.C.1
Rodon, J.2
Burris, H.A.3
-
72
-
-
83255162603
-
First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors
-
Yap TA, Yan L, Patnaik A, et al. First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors. J Clin Oncol. 2011;29:4688-4695.
-
(2011)
J Clin Oncol
, vol.29
, pp. 4688-4695
-
-
Yap, T.A.1
Yan, L.2
Patnaik, A.3
|