Intravitreal fasudil combined with bevacizumab for persistent diabetic macular edema: A novel treatment

JAMA Ophthalmology

Volumn 131, Issue 7, 2013, Pages 923-924

  Ahmadieh, Hamid ^a   Nourinia, Ramin ^a   Hafezi Moghadam, Ali ^b  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; FASUDIL;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DIABETIC MACULAR EDEMA; FEMALE; HUMAN; LASER COAGULATION; MALE; OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; RETINA EDEMA; TREATMENT OUTCOME;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; AGED; ANGIOGENESIS INHIBITORS; ANTIBODIES, MONOCLONAL, HUMANIZED; DIABETIC RETINOPATHY; DRUG THERAPY, COMBINATION; ELECTRORETINOGRAPHY; FEMALE; HUMANS; INTRAVITREAL INJECTIONS; MACULAR EDEMA; MALE; MIDDLE AGED; PILOT PROJECTS; PROSPECTIVE STUDIES; PROTEIN KINASE INHIBITORS; RETINA; TOMOGRAPHY, OPTICAL COHERENCE; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VISUAL ACUITY;

EID: 84880274493     PISSN: 21686165     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaophthalmol.2013.143     Document Type: Article

References (6)

1. Adamis AP, Shima DT. The role of vascular endothelial growth factor in ocular health and disease. Retina. 2005;25(2):111-118.
2. Arita R, Hata Y, Nakao S, et al. Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage. Diabetes. 2009;58(1): 215-226.
3. Ming XF, Viswambharan H, Barandier C, et al. Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells. Mol Cell Biol. 2002;22(24): 8467-8477.
4. Lee H, Lin CI, Liao JJ, et al. Lysophospholipids increase ICAM-1 expression in HUVEC through a Giand NF-kappaB-dependent mechanism. Am J Physiol Cell Physiol. 2004;287(6):C1657-C1666.
5. Kimura K, Ito M, Amano M, et al. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science. 1996;273(5272): 245-248.
6. Kita T, Hata Y, Arita R, et al. Role of TGF-? in proliferative vitreoretinal diseases and ROCK as a therapeutic target. Proc Natl Acad Sci U S A. 2008;105(45):17504-17509.