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Volumn 2013, Issue , 2013, Pages

MMP-3 contributes to nigrostriatal dopaminergic neuronal loss, BBB damage, and neuroinflammation in an MPTP mouse model of Parkinson's disease

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ALBUMIN; FLUORESCEIN ISOTHIOCYANATE; STROMELYSIN; TYROSINE 3 MONOOXYGENASE; DOPAMINE; MMP3 PROTEIN, MOUSE;

EID: 84880273031     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2013/370526     Document Type: Article
Times cited : (77)

References (51)
  • 1
    • 33745847479 scopus 로고    scopus 로고
    • Diagnosis and treatment of Parkinson disease: Molecules to medicine
    • 2-s2.0-33745847479 10.1172/JCI29178
    • Savitt J. M., Dawson V. L., Dawson T. M., Diagnosis and treatment of Parkinson disease: molecules to medicine. Journal of Clinical Investigation 2006 116 7 1744 1754 2-s2.0-33745847479 10.1172/JCI29178
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.7 , pp. 1744-1754
    • Savitt, J.M.1    Dawson, V.L.2    Dawson, T.M.3
  • 2
    • 61749097003 scopus 로고    scopus 로고
    • + T cells mediate cytotoxicity in neurodegenerative diseases
    • 2-s2.0-61749097003 10.1172/JCI38096
    • + T cells mediate cytotoxicity in neurodegenerative diseases. Journal of Clinical Investigation 2009 119 1 13 15 2-s2.0-61749097003 10.1172/JCI38096
    • (2009) Journal of Clinical Investigation , vol.119 , Issue.1 , pp. 13-15
    • Appel, S.H.1
  • 3
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
    • 2-s2.0-33845768784 10.1038/nrn2038
    • Block M. L., Zecca L., Hong J.-S., Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nature Reviews Neuroscience 2007 8 1 57 69 2-s2.0-33845768784 10.1038/nrn2038
    • (2007) Nature Reviews Neuroscience , vol.8 , Issue.1 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.-S.3
  • 4
    • 63249115678 scopus 로고    scopus 로고
    • The blood-brain barrier in brain homeostasis and neurological diseases
    • 2-s2.0-63249115678 10.1016/j.bbamem.2008.10.022
    • Weiss N., Miller F., Cazaubon S., Couraud P.-O., The blood-brain barrier in brain homeostasis and neurological diseases. Biochimica et Biophysica Acta 2009 1788 4 842 857 2-s2.0-63249115678 10.1016/j.bbamem.2008.10.022
    • (2009) Biochimica et Biophysica Acta , vol.1788 , Issue.4 , pp. 842-857
    • Weiss, N.1    Miller, F.2    Cazaubon, S.3    Couraud, P.-O.4
  • 7
    • 0033586471 scopus 로고    scopus 로고
    • Blood vessels change in the mesencephalon of patients with Parkinson's disease
    • 2-s2.0-0033586471
    • Faucheux B. A., Bonnet A.-M., Agid Y., Hirsch E. C., Blood vessels change in the mesencephalon of patients with Parkinson's disease. The Lancet 1999 353 9157 981 982 2-s2.0-0033586471
    • (1999) The Lancet , vol.353 , Issue.9157 , pp. 981-982
    • Faucheux, B.A.1    Bonnet, A.-M.2    Agid, Y.3    Hirsch, E.C.4
  • 8
    • 71749083461 scopus 로고    scopus 로고
    • Mesenchymal stem cell transplantation attenuates blood brain barrier damage and neuroinflammation and protects dopaminergic neurons against MPTP toxicity in the substantia nigra in a model of Parkinson's disease
    • 2-s2.0-71749083461 10.1016/j.jneuroim.2009.09.003
    • Chao Y. X., He B. P., Tay S. S. W., Mesenchymal stem cell transplantation attenuates blood brain barrier damage and neuroinflammation and protects dopaminergic neurons against MPTP toxicity in the substantia nigra in a model of Parkinson's disease. Journal of Neuroimmunology 2009 216 1-2 39 50 2-s2.0-71749083461 10.1016/j.jneuroim.2009.09.003
    • (2009) Journal of Neuroimmunology , vol.216 , Issue.1-2 , pp. 39-50
    • Chao, Y.X.1    He, B.P.2    Tay, S.S.W.3
  • 9
    • 33947323582 scopus 로고    scopus 로고
    • TNF- α knockout and minocycline treatment attenuates blood-brain barrier leakage in MPTP-treated mice
    • 2-s2.0-33947323582 10.1016/j.nbd.2006.11.012
    • Zhao C., Ling Z., Newman M. B., Bhatia A., Carvey P. M., TNF- α knockout and minocycline treatment attenuates blood-brain barrier leakage in MPTP-treated mice. Neurobiology of Disease 2007 26 1 36 46 2-s2.0-33947323582 10.1016/j.nbd.2006.11.012
    • (2007) Neurobiology of Disease , vol.26 , Issue.1 , pp. 36-46
    • Zhao, C.1    Ling, Z.2    Newman, M.B.3    Bhatia, A.4    Carvey, P.M.5
  • 10
    • 78650099684 scopus 로고    scopus 로고
    • Role of matrix metalloproteinase-3 in neurodegeneration
    • 2-s2.0-78650099684 10.1111/j.1471-4159.2010.07082.x
    • Kim E.-M., Hwang O., Role of matrix metalloproteinase-3 in neurodegeneration. Journal of Neurochemistry 2011 116 1 22 32 2-s2.0-78650099684 10.1111/j.1471-4159.2010.07082.x
    • (2011) Journal of Neurochemistry , vol.116 , Issue.1 , pp. 22-32
    • Kim, E.-M.1    Hwang, O.2
  • 12
    • 34547665538 scopus 로고    scopus 로고
    • Functional interaction between matrix metalloproteinase-3 and semaphorin-3C during cortical axonal growth and guidance
    • 2-s2.0-34547665538 10.1093/cercor/bhl082
    • Gonthier B., Nasarre C., Roth L., Perraut M., Thomasset N., Roussel G., Aunis D., Bagnard D., Functional interaction between matrix metalloproteinase-3 and semaphorin-3C during cortical axonal growth and guidance. Cerebral Cortex 2007 17 7 1712 1721 2-s2.0-34547665538 10.1093/cercor/bhl082
    • (2007) Cerebral Cortex , vol.17 , Issue.7 , pp. 1712-1721
    • Gonthier, B.1    Nasarre, C.2    Roth, L.3    Perraut, M.4    Thomasset, N.5    Roussel, G.6    Aunis, D.7    Bagnard, D.8
  • 14
    • 33645103421 scopus 로고    scopus 로고
    • Effects of extracellular matrix-degrading proteases matrix metalloproteinases 3 and 9 on spatial learning and synaptic plasticity
    • 2-s2.0-33645103421 10.1111/j.1471-4159.2005.03565.x
    • Meighan S. E., Meighan P. C., Choudhury P., Davis C. J., Olson M. L., Zornes P. A., Wright J. W., Harding J. W., Effects of extracellular matrix-degrading proteases matrix metalloproteinases 3 and 9 on spatial learning and synaptic plasticity. Journal of Neurochemistry 2006 96 5 1227 1241 2-s2.0-33645103421 10.1111/j.1471-4159.2005.03565.x
    • (2006) Journal of Neurochemistry , vol.96 , Issue.5 , pp. 1227-1241
    • Meighan, S.E.1    Meighan, P.C.2    Choudhury, P.3    Davis, C.J.4    Olson, M.L.5    Zornes, P.A.6    Wright, J.W.7    Harding, J.W.8
  • 15
    • 17044432238 scopus 로고    scopus 로고
    • Matrix metalloproteinase-3: A novel signaling proteinase from apoptotic neuronal cells that activates microglia
    • 2-s2.0-17044432238 10.1523/JNEUROSCI.4346-04.2005
    • Kim Y. S., Kim S. S., Cho J. J., Choi D. H., Hwang O., Shin D. H., Chun H. S., Beal M. F., Joh T. H., Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia. Journal of Neuroscience 2005 25 14 3701 3711 2-s2.0-17044432238 10.1523/JNEUROSCI.4346-04. 2005
    • (2005) Journal of Neuroscience , vol.25 , Issue.14 , pp. 3701-3711
    • Kim, Y.S.1    Kim, S.S.2    Cho, J.J.3    Choi, D.H.4    Hwang, O.5    Shin, D.H.6    Chun, H.S.7    Beal, M.F.8    Joh, T.H.9
  • 16
    • 33745170052 scopus 로고    scopus 로고
    • Blood-brain barrier disruption by stromelysin-1 facilitates neutrophil infiltration in neuroinflammation
    • 2-s2.0-33745170052 10.1016/j.nbd.2006.02.006
    • Gurney K. J., Estrada E. Y., Rosenberg G. A., Blood-brain barrier disruption by stromelysin-1 facilitates neutrophil infiltration in neuroinflammation. Neurobiology of Disease 2006 23 1 87 96 2-s2.0-33745170052 10.1016/j.nbd.2006.02.006
    • (2006) Neurobiology of Disease , vol.23 , Issue.1 , pp. 87-96
    • Gurney, K.J.1    Estrada, E.Y.2    Rosenberg, G.A.3
  • 17
    • 45249115717 scopus 로고    scopus 로고
    • A novel intracellular role of matrix metalloproteinase-3 during apoptosis of dopaminergic cells
    • 2-s2.0-45249115717 10.1111/j.1471-4159.2008.05399.x
    • Choi D. H., Kim E.-M., Son H. J., Joh T. H., Kim Y. S., Kim D., Flint Beal M., Hwang O., A novel intracellular role of matrix metalloproteinase-3 during apoptosis of dopaminergic cells. Journal of Neurochemistry 2008 106 1 405 415 2-s2.0-45249115717 10.1111/j.1471-4159.2008.05399.x
    • (2008) Journal of Neurochemistry , vol.106 , Issue.1 , pp. 405-415
    • Choi, D.H.1    Kim, E.-M.2    Son, H.J.3    Joh, T.H.4    Kim, Y.S.5    Kim, D.6    Flint Beal, M.7    Hwang, O.8
  • 18
    • 73449128954 scopus 로고    scopus 로고
    • Matrix metalloproteinase-3 contributes to vulnerability of the nigral dopaminergic neurons
    • 2-s2.0-73449128954 10.1016/j.neuint.2009.09.014
    • Kim S. T., Kim E.-M., Choi J. H., Son H. J., Ji I. J., Joh T. H., Chung S. J., Hwang O., Matrix metalloproteinase-3 contributes to vulnerability of the nigral dopaminergic neurons. Neurochemistry International 2010 56 1 161 167 2-s2.0-73449128954 10.1016/j.neuint.2009.09.014
    • (2010) Neurochemistry International , vol.56 , Issue.1 , pp. 161-167
    • Kim, S.T.1    Kim, E.-M.2    Choi, J.H.3    Son, H.J.4    Ji, I.J.5    Joh, T.H.6    Chung, S.J.7    Hwang, O.8
  • 19
    • 21644446495 scopus 로고    scopus 로고
    • Proteolytic cleavage of extracellular secreted α -synuclein via matrix metalloproteinases
    • 2-s2.0-21644446495 10.1074/jbc.M503341200
    • Sung J. Y., Park S. M., Lee C.-H., Um J. W., Lee H. J., Kim J., Oh Y. J., Lee S.-T., Paik S. R., Chung K. C., Proteolytic cleavage of extracellular secreted α -synuclein via matrix metalloproteinases. Journal of Biological Chemistry 2005 280 26 25216 25224 2-s2.0-21644446495 10.1074/jbc.M503341200
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.26 , pp. 25216-25224
    • Sung, J.Y.1    Park, S.M.2    Lee, C.-H.3    Um, J.W.4    Lee, H.J.5    Kim, J.6    Oh, Y.J.7    Lee, S.-T.8    Paik, S.R.9    Chung, K.C.10
  • 20
    • 79954609544 scopus 로고    scopus 로고
    • Role of matrix metalloproteinase 3-mediated α -synuclein cleavage in dopaminergic cell death
    • 2-s2.0-79954609544 10.1074/jbc.M111.222430
    • Choi D.-H., Kim Y.-J., Kim Y.-G., Joh T. H., Beal M. F., Kim Y.-S., Role of matrix metalloproteinase 3-mediated α -synuclein cleavage in dopaminergic cell death. Journal of Biological Chemistry 2011 286 16 14168 14177 2-s2.0-79954609544 10.1074/jbc.M111.222430
    • (2011) Journal of Biological Chemistry , vol.286 , Issue.16 , pp. 14168-14177
    • Choi, D.-H.1    Kim, Y.-J.2    Kim, Y.-G.3    Joh, T.H.4    Beal, M.F.5    Kim, Y.-S.6
  • 21
    • 70349334516 scopus 로고    scopus 로고
    • Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson's disease
    • 2-s2.0-70349334516 10.1677/JOE-09-0132
    • Kim S., Moon M., Park S., Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson's disease. Journal of Endocrinology 2009 202 3 431 439 2-s2.0-70349334516 10.1677/JOE-09-0132
    • (2009) Journal of Endocrinology , vol.202 , Issue.3 , pp. 431-439
    • Kim, S.1    Moon, M.2    Park, S.3
  • 22
    • 70449527787 scopus 로고    scopus 로고
    • Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine mouse model of parkinson's disease by blocking microglial activation
    • 2-s2.0-70449527787 10.1007/s12640-009-9037-x
    • Moon M., Kim H. G., Hwang L., Seo J.-H., Kim S., Hwang S., Kim S., Lee D., Chung H., Oh M. S., Lee K.-T., Park S., Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of parkinson's disease by blocking microglial activation. Neurotoxicity Research 2009 15 4 332 347 2-s2.0-70449527787 10.1007/s12640-009-9037-x
    • (2009) Neurotoxicity Research , vol.15 , Issue.4 , pp. 332-347
    • Moon, M.1    Kim, H.G.2    Hwang, L.3    Seo, J.-H.4    Kim, S.5    Hwang, S.6    Kim, S.7    Lee, D.8    Chung, H.9    Oh, M.S.10    Lee, K.-T.11    Park, S.12
  • 24
    • 83755178512 scopus 로고    scopus 로고
    • Cannabinoid receptor type 1 protects nigrostriatal dopaminergic neurons against MPTP neurotoxicity by inhibiting microglial activation
    • 2-s2.0-83755178512 10.4049/jimmunol.1102435
    • Chung Y. C., Bok E., Huh S. H., Park J.-Y., Yoon S.-H., Kim S. R., Kim Y.-S., Maeng S., Park S. H., Jin B. K., Cannabinoid receptor type 1 protects nigrostriatal dopaminergic neurons against MPTP neurotoxicity by inhibiting microglial activation. Journal of Immunology 2011 187 12 6508 6517 2-s2.0-83755178512 10.4049/jimmunol.1102435
    • (2011) Journal of Immunology , vol.187 , Issue.12 , pp. 6508-6517
    • Chung, Y.C.1    Bok, E.2    Huh, S.H.3    Park, J.-Y.4    Yoon, S.-H.5    Kim, S.R.6    Kim, Y.-S.7    Maeng, S.8    Park, S.H.9    Jin, B.K.10
  • 25
    • 77955504380 scopus 로고    scopus 로고
    • Paroxetine prevents loss of nigrostriatal dopaminergic neurons by inhibiting brain inflammation and oxidative stress in an experimental model of Parkinson's disease
    • 2-s2.0-77955504380 10.4049/jimmunol.1000208
    • Chung Y. C., Kim S. R., Jin B. K., Paroxetine prevents loss of nigrostriatal dopaminergic neurons by inhibiting brain inflammation and oxidative stress in an experimental model of Parkinson's disease. Journal of Immunology 2010 185 2 1230 1237 2-s2.0-77955504380 10.4049/jimmunol.1000208
    • (2010) Journal of Immunology , vol.185 , Issue.2 , pp. 1230-1237
    • Chung, Y.C.1    Kim, S.R.2    Jin, B.K.3
  • 26
    • 79960501774 scopus 로고    scopus 로고
    • Ethyl pyruvate rescues nigrostriatal dopaminergic neurons by regulating glial activation in a mouse model of Parkinson's disease
    • 2-s2.0-79960501774 10.4049/jimmunol.1100009
    • Huh S. H., Chung Y. C., Piao Y., Jin M. Y., Son H. J., Yoon N. S., Hong J. Y., Pak Y. K., Kim Y. S., Hong J. K., Hwang O., Jin B. K., Ethyl pyruvate rescues nigrostriatal dopaminergic neurons by regulating glial activation in a mouse model of Parkinson's disease. Journal of Immunology 2011 187 2 960 969 2-s2.0-79960501774 10.4049/jimmunol.1100009
    • (2011) Journal of Immunology , vol.187 , Issue.2 , pp. 960-969
    • Huh, S.H.1    Chung, Y.C.2    Piao, Y.3    Jin, M.Y.4    Son, H.J.5    Yoon, N.S.6    Hong, J.Y.7    Pak, Y.K.8    Kim, Y.S.9    Hong, J.K.10    Hwang, O.11    Jin, B.K.12
  • 28
    • 0026339976 scopus 로고
    • Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
    • 2-s2.0-0026339976
    • West M. J., Slomianka L., Gundersen H. J. G., Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anatomical Record 1991 231 4 482 497 2-s2.0-0026339976
    • (1991) Anatomical Record , vol.231 , Issue.4 , pp. 482-497
    • West, M.J.1    Slomianka, L.2    Gundersen, H.J.G.3
  • 29
    • 83455181339 scopus 로고    scopus 로고
    • Partial dopamine depletion in MPTP-treated mice differentially altered motor skill learning and action control
    • 2-s2.0-83455181339 10.1016/j.bbr.2011.11.019
    • Chagniel L., Robitaille C., Lacharité-Mueller C., Bureau G., Cyr M., Partial dopamine depletion in MPTP-treated mice differentially altered motor skill learning and action control. Behavioural Brain Research 2012 228 1 9 15 2-s2.0-83455181339 10.1016/j.bbr.2011.11.019
    • (2012) Behavioural Brain Research , vol.228 , Issue.1 , pp. 9-15
    • Chagniel, L.1    Robitaille, C.2    Lacharité-Mueller, C.3    Bureau, G.4    Cyr, M.5
  • 31
    • 54349106751 scopus 로고    scopus 로고
    • Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum
    • 2-s2.0-54349106751 10.1111/j.1471-4159.2008.05697.x
    • Chen X., Lan X., Roche I., Liu R., Geiger J. D., Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum. Journal of Neurochemistry 2008 107 4 1147 1157 2-s2.0-54349106751 10.1111/j.1471-4159. 2008.05697.x
    • (2008) Journal of Neurochemistry , vol.107 , Issue.4 , pp. 1147-1157
    • Chen, X.1    Lan, X.2    Roche, I.3    Liu, R.4    Geiger, J.D.5
  • 32
    • 77953501722 scopus 로고    scopus 로고
    • The role of neuroinflammation on the pathogenesis of Parkinson's disease
    • 2-s2.0-77953501722
    • Chung Y. C., Ko H. W., Bok E., Park E. S., Huh S. H., Nam J. H., Jin B. K., The role of neuroinflammation on the pathogenesis of Parkinson's disease. BMB Reports 2010 43 4 225 232 2-s2.0-77953501722
    • (2010) BMB Reports , vol.43 , Issue.4 , pp. 225-232
    • Chung, Y.C.1    Ko, H.W.2    Bok, E.3    Park, E.S.4    Huh, S.H.5    Nam, J.H.6    Jin, B.K.7
  • 33
    • 84866716167 scopus 로고    scopus 로고
    • Brain-resident microglia predominate over infiltrating myeloid cells in activation, phagocytosis and interaction with T-lymphocytes in the MPTP mouse model of Parkinson disease
    • 10.1016/j.expneurol.2012.08.020
    • Depboylu C., Stricker S., Ghobril J. P., Oertel W. H., Priller J., glinger GU H., Brain-resident microglia predominate over infiltrating myeloid cells in activation, phagocytosis and interaction with T-lymphocytes in the MPTP mouse model of Parkinson disease. Experimental Neurology 2012 238 2 183 191 10.1016/j.expneurol.2012.08.020
    • (2012) Experimental Neurology , vol.238 , Issue.2 , pp. 183-191
    • Depboylu, C.1    Stricker, S.2    Ghobril, J.P.3    Oertel, W.H.4    Priller, J.5    Glinger Gu, H.6
  • 34
    • 33748447845 scopus 로고    scopus 로고
    • Microglia, major player in the brain inflammation: Their roles in the pathogenesis of Parkinson's disease
    • 2-s2.0-33748447845
    • Kim Y. S., Joh T. H., Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease. Experimental and Molecular Medicine 2006 38 4 333 347 2-s2.0-33748447845
    • (2006) Experimental and Molecular Medicine , vol.38 , Issue.4 , pp. 333-347
    • Kim, Y.S.1    Joh, T.H.2
  • 35
    • 77952764016 scopus 로고    scopus 로고
    • Matrix metalloproteinase-3 is increased and participates in neuronal apoptotic signaling downstream of caspase-12 during endoplasmic reticulum stress
    • 2-s2.0-77952764016 10.1074/jbc.M109.093799
    • Kim E.-M., Shin E.-J., Choi J. H., Son H. J., Park I.-S., Joh T. H., Hwang O., Matrix metalloproteinase-3 is increased and participates in neuronal apoptotic signaling downstream of caspase-12 during endoplasmic reticulum stress. Journal of Biological Chemistry 2010 285 22 16444 16452 2-s2.0-77952764016 10.1074/jbc.M109.093799
    • (2010) Journal of Biological Chemistry , vol.285 , Issue.22 , pp. 16444-16452
    • Kim, E.-M.1    Shin, E.-J.2    Choi, J.H.3    Son, H.J.4    Park, I.-S.5    Joh, T.H.6    Hwang, O.7
  • 36
    • 74949110283 scopus 로고    scopus 로고
    • Doxycycline is neuroprotective against nigral dopaminergic degeneration by a dual mechanism involving MMP-3
    • 2-s2.0-74949110283 10.1007/s12640-009-9078-1
    • Cho Y., Son H. J., Kim E.-M., Choi J. H., Kim S. T., Ji I. J., Choi D. H., Joh T. H., Kim Y. S., Hwang O., Doxycycline is neuroprotective against nigral dopaminergic degeneration by a dual mechanism involving MMP-3. Neurotoxicity Research 2009 16 4 361 371 2-s2.0-74949110283 10.1007/s12640-009- 9078-1
    • (2009) Neurotoxicity Research , vol.16 , Issue.4 , pp. 361-371
    • Cho, Y.1    Son, H.J.2    Kim, E.-M.3    Choi, J.H.4    Kim, S.T.5    Ji, I.J.6    Choi, D.H.7    Joh, T.H.8    Kim, Y.S.9    Hwang, O.10
  • 37
    • 84863248744 scopus 로고    scopus 로고
    • A novel compound PTIQ protects the nigral dopaminergic neurones in an animal model of Parkinson's disease induced by MPTP
    • 2-s2.0-84858266820 10.1111/j.1476-5381.2011.01692.x
    • Son H. J., Lee J. A., Shin N., Choi J. H., Seo J. W., Chi D. Y., Lee C. S., Kim E.-M., Choe H., Hwang O., A novel compound PTIQ protects the nigral dopaminergic neurones in an animal model of Parkinson's disease induced by MPTP. British Journal of Pharmacology 2012 165 7 2213 2227 2-s2.0-84858266820 10.1111/j.1476-5381.2011.01692.x
    • (2012) British Journal of Pharmacology , vol.165 , Issue.7 , pp. 2213-2227
    • Son, H.J.1    Lee, J.A.2    Shin, N.3    Choi, J.H.4    Seo, J.W.5    Chi, D.Y.6    Lee, C.S.7    Kim, E.-M.8    Choe, H.9    Hwang, O.10
  • 38
    • 62549133546 scopus 로고    scopus 로고
    • Neuroinflammation in Parkinson's disease: A target for neuroprotection?
    • 2-s2.0-62549133546 10.1016/S1474-4422(09)70062-6
    • Hirsch E. C., Hunot S., Neuroinflammation in Parkinson's disease: a target for neuroprotection? The Lancet Neurology 2009 8 4 382 397 2-s2.0-62549133546 10.1016/S1474-4422(09)70062-6
    • (2009) The Lancet Neurology , vol.8 , Issue.4 , pp. 382-397
    • Hirsch, E.C.1    Hunot, S.2
  • 39
    • 75949087271 scopus 로고    scopus 로고
    • Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention
    • 2-s2.0-75949087271 10.1016/j.nbd.2009.11.004
    • Tansey M. G., Goldberg M. S., Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention. Neurobiology of Disease 2010 37 3 510 518 2-s2.0-75949087271 10.1016/j.nbd.2009.11.004
    • (2010) Neurobiology of Disease , vol.37 , Issue.3 , pp. 510-518
    • Tansey, M.G.1    Goldberg, M.S.2
  • 40
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • 2-s2.0-29244463365 10.1038/nrn1824
    • Abbott N. J., Rönnbäck L., Hansson E., Astrocyte-endothelial interactions at the blood-brain barrier. Nature Reviews Neuroscience 2006 7 1 41 53 2-s2.0-29244463365 10.1038/nrn1824
    • (2006) Nature Reviews Neuroscience , vol.7 , Issue.1 , pp. 41-53
    • Abbott, N.J.1    Rönnbäck, L.2    Hansson, E.3
  • 41
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • 2-s2.0-22944483792 10.1124/pr.57.2.4
    • Hawkins B. T., Davis T. P., The blood-brain barrier/neurovascular unit in health and disease. Pharmacological Reviews 2005 57 2 173 185 2-s2.0-22944483792 10.1124/pr.57.2.4
    • (2005) Pharmacological Reviews , vol.57 , Issue.2 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 43
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • 2-s2.0-38149090292 10.1016/j.neuron.2008.01.003
    • Zlokovic B. V., The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008 57 2 178 201 2-s2.0-38149090292 10.1016/j.neuron.2008.01.003
    • (2008) Neuron , vol.57 , Issue.2 , pp. 178-201
    • Zlokovic, B.V.1
  • 45
    • 34249817563 scopus 로고    scopus 로고
    • Blood-brain barrier disruption induces in vivo degeneration of nigral dopaminergic neurons
    • 2-s2.0-34249817563 10.1111/j.1471-4159.2007.04567.x
    • Rite I., Machado A., Cano J., Venero J. L., Blood-brain barrier disruption induces in vivo degeneration of nigral dopaminergic neurons. Journal of Neurochemistry 2007 101 6 1567 1582 2-s2.0-34249817563 10.1111/j.1471-4159. 2007.04567.x
    • (2007) Journal of Neurochemistry , vol.101 , Issue.6 , pp. 1567-1582
    • Rite, I.1    Machado, A.2    Cano, J.3    Venero, J.L.4
  • 46
    • 34250623663 scopus 로고    scopus 로고
    • Blood-brain barrier pathology in Alzheimer's and Parkinson's disease: Implications for drug therapy
    • 2-s2.0-34250623663
    • Desai B. S., Monahan A. J., Carvey P. M., Hendey B., Blood-brain barrier pathology in Alzheimer's and Parkinson's disease: implications for drug therapy. Cell Transplantation 2007 16 3 285 299 2-s2.0-34250623663
    • (2007) Cell Transplantation , vol.16 , Issue.3 , pp. 285-299
    • Desai, B.S.1    Monahan, A.J.2    Carvey, P.M.3    Hendey, B.4
  • 47
    • 44149103168 scopus 로고    scopus 로고
    • Neuroinflammation and peripheral immune infiltration in Parkinson's disease: An autoimmune hypothesis
    • 2-s2.0-44149103168
    • Monahan A. J., Warren M., Carvey P. M., Neuroinflammation and peripheral immune infiltration in Parkinson's disease: an autoimmune hypothesis. Cell Transplantation 2008 17 4 363 372 2-s2.0-44149103168
    • (2008) Cell Transplantation , vol.17 , Issue.4 , pp. 363-372
    • Monahan, A.J.1    Warren, M.2    Carvey, P.M.3
  • 49
    • 38449091547 scopus 로고    scopus 로고
    • Biochemistry of postmortem brains in Parkinson's disease: Historical overview and future prospects
    • 2-s2.0-38449091547 10.1007/978-3-211-73574-9-14
    • Nagatsu T., Sawada M., Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects. Journal of Neural Transmission 2007 72 113 120 2-s2.0-38449091547 10.1007/978-3-211-73574-9-14
    • (2007) Journal of Neural Transmission , Issue.72 , pp. 113-120
    • Nagatsu, T.1    Sawada, M.2
  • 51
    • 0036522967 scopus 로고    scopus 로고
    • Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease
    • 2-s2.0-0036522967
    • Wu D. C., Jackson-Lewis V., Vila M., Tieu K., Teismann P., Vadseth C., Choi D.-K., Ischiropoulos H., Przedborski S., Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. Journal of Neuroscience 2002 22 5 1763 1771 2-s2.0-0036522967
    • (2002) Journal of Neuroscience , vol.22 , Issue.5 , pp. 1763-1771
    • Wu, D.C.1    Jackson-Lewis, V.2    Vila, M.3    Tieu, K.4    Teismann, P.5    Vadseth, C.6    Choi, D.-K.7    Ischiropoulos, H.8    Przedborski, S.9


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