Extraperitoneal response to intraperitoneal immunotherapy with catumaxomab in a patient with cutaneous lymphangiosis carcinomatosa from ovarian cancer: A case report and review of the literature

Medical Oncology

Volumn 29, Issue 5, 2012, Pages 3416-3420

  Woopen, H ^a   Pietzner, K ^a   Darb Esfahani, S ^a   Oskay Oezcelik, G ^a   Sehouli, J ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Catumaxomab; Ovarian cancer; Skin metastasis

Indexed keywords

CARBOPLATIN; CATUMAXOMAB; PACLITAXEL; ANTINEOPLASTIC AGENT; BISPECIFIC ANTIBODY;

ADULT; ARTICLE; CANCER LOCALIZATION; CASE REPORT; COLON RESECTION; CUTANEOUS LYMPHANGIOSIS CARCINOMATOSA; CYTOREDUCTIVE SURGERY; END TO END ANASTOMOSIS; FEMALE; HUMAN; HYSTERECTOMY; IMMUNOHISTOCHEMISTRY; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; MALIGNANT ASCITES; MULTIPLE CYCLE TREATMENT; OMENTECTOMY; OVARY ADENOCARCINOMA; PLEURA EFFUSION; PRIORITY JOURNAL; PUNCH BIOPSY; SALPINGOOOPHORECTOMY; SKIN METASTASIS; TREATMENT RESPONSE; URINE RETENTION; ADENOCARCINOMA; ASCITES; IMMUNOTHERAPY; INFUSION; METASTASIS; METHODOLOGY; MIDDLE AGED; OVARY TUMOR; PATHOLOGY; PERITONEUM TUMOR; REVIEW; SKIN TUMOR; TUMOR SEEDING;

ADENOCARCINOMA, PAPILLARY; ANTIBODIES, BISPECIFIC; ANTINEOPLASTIC AGENTS; ASCITES; FEMALE; HUMANS; IMMUNOTHERAPY; INFUSIONS, PARENTERAL; MIDDLE AGED; NEOPLASM SEEDING; OVARIAN NEOPLASMS; PERITONEAL NEOPLASMS; SKIN NEOPLASMS;

EID: 84880264729     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-012-0285-x     Document Type: Article

References (30)

1. Rose PG, Piver MS, Tsukada Y, Lau TS. Metastatic patterns in histologic variants of ovarian cancer. An autopsy study. Cancer. 1989;64(7):1508-13.
2. Cormio G, Rossi C, Cazzolla A, et al. Distant metastases in ovarian carcinoma. Int J Gynecol Cancer. 2003;13(2):125-9.
3. Spencer PS, Helm TN. Skin metastases in cancer patients. Cutis. 1987;39(2):119-21.
4. Dauplat J, Hacker NF, Nieberg RK, Berek JS, Rose TP, Sagae S. Distant metastases in epithelial ovarian carcinoma. Cancer. 1987;60(7):1561-6.
5. Haughney RV, Slade RJ, Brain AN. An isolated abdominal wall metastasis of ovarian carcinoma ten years after primary surgery. Eur J Gynaecol Oncol. 2001;22(2):102-3.
6. Sood AK, Sorosky JI, Dolan M, Anderson B, Buller RE. Distant metastases in ovarian cancer: association with p53 mutations. Clin Cancer Res. 1999;5(9):2485-90.
7. Brownstein MH, Helwig EB. Patterns of cutaneous metastasis. Arch Dermatol. 1972;105(6):862-8.
8. Yilmaz Z, Bese T, Demirkiran F, et al. Skin metastasis in ovarian carcinoma. Int J Gynecol Cancer. 2006;16(Suppl 1):414-8.
9. Matsui H, Suzuka K, Yamazawa K, et al. Scalp metastasis of a serous ovarian cancer. Acta Obstet Gynecol Scand. 2002;81(6):577-8.
10. Traiman P, de Luca LA, Bacchi CE. An extremely large, cauliflower-type, cutaneous metastasis of ovarian cancer associated with good prognosis. Gynecol Oncol. 1994;53(2):239-41.
11. Schonmann R, Altaras M, Biron T, Bernheim J, Fishman A. Inflammatory skin metastases from ovarian carcinoma - a case report and review of the literature. Gynecol Oncol. 2003;90(3):670-2.
12. Sehouli Jalid. Symptomorientierte Therapien: Aszites. In: Multimodales Management des Ovarialkarzinoms. Bremen: UNI-MED; 2006.
13. Ruf P, Gires O, Jäger M, Fellinger K, Atz J, Lindhofer H. Characterisation of the new EpCAM-specific antibody HO-3: implications for trifunctional antibody immunotherapy of cancer. Br J Cancer. 2007;97(3):315-21.
14. Balzar M, Winter MJ, de Boer CJ, Litvinov SV. The biology of the 17-1A antigen (Ep-CAM). J Mol Med. 1999;77(10):699-712.
15. Went PT, Lugli A, Meier S, et al. Frequent EpCam protein expression in human carcinomas. Hum Pathol. 2004;35(1):122-8.
16. Spizzo G, Fong D, Wurm M, et al. EpCAM expression in primary tumour tissues and metastases: an immunohistochemical analysis. J Clin Pathol. 2011;64(5):415-20.
17. Jäger M, Schoberth A, Ruf P, et al. Immunomonitoring results of a phase II/III study of malignant ascites patients treated with the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3). Cancer Res. 2012;72(1):24-32.
18. Burges A, Wimberger P, Kümper C, et al. Effective relief of malignant ascites in patients with advanced ovarian cancer by a trifunctional anti-EpCAM x anti-CD3 antibody: a phase I/II study. Clin Cancer Res. 2007;13(13):3899-905.
19. Heiss MM, Murawa P, Koralewski P, et al. The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: results of a prospective randomized phase II/III trial. Int J Cancer. 2010;127(9):2209-21.
20. Wimberger P, Heubner M, Lindhofer H, Jäger M, Kimmig R, Kasimir-Bauer S. Influence of catumaxomab on tumor cells in bone marrow and blood in ovarian cancer. Anticancer Res. 2009;29(5):1787-91.
21. Ströhlein MA, Siegel R, Jäger M, Lindhofer H, Jauch K-W, Heiss MM. Induction of anti-tumor immunity by trifunctional antibodies in patients with peritoneal carcinomatosis. J Exp Clin Cancer Res. 2009;28:18.
22. Cheng B, Lu W, Xiaoyun W, YaXia C, Xie X. Extra-abdominal metastases from epithelial ovarian carcinoma: an analysis of 20 cases. Int J Gynecol Cancer. 2009;19(4):611-4.
23. Cormio G, Capotorto M, Di Vagno G, Cazzolla A, Carriero C, Selvaggi L. Skin metastases in ovarian carcinoma: a report of nine cases and a review of the literature. Gynecol Oncol. 2003;90(3):682-5.
24. Demirci S, Yavas F, Ozsaran Z, et al. Palliative radiotherapy for the skin metastasis of ovarian cancer: a case report and review of the literature. Med Oncol. 2010;27(3):628-31.
25. Patsner B, Mann WJ, Chumas J, Loesch M. Herpetiform cutaneous metastases following negative second look laparotomy for ovarian adenocarcinoma. Arch Gynecol Obstet. 1988;244(1):63-7.
26. Flam F, Skoog L, Wilking N. Subcutaneous metastasis from an ovarian carcinoma disappeared following tamoxifen therapy. Eur J Obstet Gynecol Reprod Biol. 1996;64(2):225-6.
27. Ruf P, Kluge M, Jäger M, et al. Pharmacokinetics, immunogenicity and bioactivity of the therapeutic antibody catumaxomab intraperitoneally administered to cancer patients. Br J Clin Pharmacol. 2010;69(6):617-25.
28. Merimsky O, Chaitchik S, Inbar M. Skin metastasis of ovarian cancer: report of three cases. Tumori. 1991;77(3):268-70.
29. Karpate SJ, Samal SL, Jain SM. Recurrent ovarian malignancy presenting as cutaneous metastasis. Indian J Dermatol. 2009;54(4):380-1.
30. Lalich D, Tawfik O, Chapman J, Fraga G. Cutaneous metastasis of ovarian carcinoma with shadow cells mimicking a primary pilomatrical neoplasm. Am J Dermatopathol. 2010;32(5):500-4.