Histidine-rich protein 2 plasma levels predict progression to cerebral malaria in malawian children with plasmodium falciparum infection

Journal of Infectious Diseases

Volumn 208, Issue 3, 2013, Pages 500-503

  Fox, Lindsay L ^a,b   Taylor, Terrie E ^a,b   Pensulo, Paul ^b   Liomba, Alice ^b   Mpakiza, Ashley ^b   Varela, Amanda ^b   Glover, Simon J ^b   Reeves, Mathew J ^c   Seydel, Karl B ^a,b  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b UNIVERSITY OF MALAWI   (Malawi)

^c MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

cerebral malaria; HRP2; malaria diagnostics

Indexed keywords

HISTIDINE RICH PROTEIN 2; PEPTIDES AND PROTEINS; QUININE; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; BRAIN MALARIA; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE COURSE; DISEASE SEVERITY; ETHNIC GROUP; HUMAN; MALARIA FALCIPARUM; MALAWIAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY;

CEREBRAL MALARIA; HRP2; MALARIA DIAGNOSTICS;

ANTIGENS, PROTOZOAN; BIOLOGICAL MARKERS; CHILD; DISEASE PROGRESSION; HUMANS; MALARIA, CEREBRAL; MALARIA, FALCIPARUM; MALAWI; PLASMA; PROTOZOAN PROTEINS; SENSITIVITY AND SPECIFICITY;

EID: 84880233869     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit176     Document Type: Article

References (12)

1. Murray CJ, Rosenfeld LC, Lim SS, et al. Global malaria mortality between 1980 and 2010: a systematic analysis. Lancet 2012; 379: 413-31.
2. [No authors listed]. Severe falciparum malaria. World Health Organization, Communicable Diseases Cluster. Trans R Soc Trop Med Hyg 2000; 94(Suppl 1):S1-90.
3. Beare NA, Taylor TE, Harding SP, Lewallen S, Molyneux ME. Malarial retinopathy: a newly established diagnostic sign in severe malaria. Am J Trop Med Hyg 2006; 75:790-7.
4. Desakorn V, Dondorp AM, Silamut K, et al. Stage-dependent production and release of histidine-rich protein 2 by Plasmodium falciparum. Trans R Soc Trop Med Hyg 2005; 99:517-24.
5. Desakorn V, Silamut K, Angus B, et al. Semi-quantitative measurement of Plasmodium falciparum antigen PfHRP2 in blood and plasma. Trans R Soc Trop Med Hyg 1997; 91:479-83.
6. Hendriksen IC, Mwanga-Amumpaire J, von Seidlein L, et al. Diagnosing severe falciparum malaria in parasitaemic African children: a prospective evaluation of plasma PfHRP2 Measurement. PLoS Med 2012; 9:e1001297.
7. Hendriksen IC, White LJ, Veenemans J, et al. Defining falciparum-malaria-attributable severe febrile illness in moderate-to-high transmission settings on the basis of plasma PfHRP2 concentration. J Infect Dis 2013; 207:351-61.
8. Seydel KB, Fox LL, Glover SJ, et al. Plasma concentrations of parasite histidine-rich protein 2 distinguish between retinopathy-positive and retinopathy-negative cerebral malaria in Malawian children. J Infect Dis 2012; 206:309-18.
9. Gravenor MB, van Hensbroek MB, Kwiatkowski D. Estimating sequestered parasite population dynamics in cerebral malaria. Proc Natl Acad Sci U S A 1998; 95:7620-4.
10. Dondorp AM, Desakorn V, Pongtavornpinyo W, et al. Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2. PLoS Med 2005; 2:e204.
11. Ochola LB, Marsh K, Lowe B, Gal S, Pluschke G, Smith T. Estimation of the sequestered parasite load in severe malaria patients using both host and parasite markers. Parasitology 2005; 131:449-58.
12. Rubach MP, Mukemba J, Florence S, et al. Plasma Plasmodium falcipa-rum histidine-rich protein-2 concentrations are associated with malaria severity and mortality in Tanzanian children. PLoS One 2012; 7: e35985.