메뉴 건너뛰기




Volumn 9, Issue 7, 2013, Pages 925-927

The potential for targeting the STAT3 pathway as a novel therapy for melanoma

Author keywords

cytokine; immunotherapy; Jak STAT; Jak2; melanoma; STAT3

Indexed keywords

JANUS KINASE 2 INHIBITOR; STAT3 PROTEIN;

EID: 84880233868     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.13.83     Document Type: Review
Times cited : (26)

References (20)
  • 1
    • 77956030786 scopus 로고    scopus 로고
    • Inhibition of mutated, activated BRAF in metastatic melanoma
    • Flaherty KT, Puzanov I, Kim KB et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N. Engl. J. Med. 363(9), 809-819 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , Issue.9 , pp. 809-819
    • Flaherty, K.T.1    Puzanov, I.2    Kim, K.B.3
  • 3
    • 21544473172 scopus 로고    scopus 로고
    • Targeting STAT3 affects melanoma on multiple fronts
    • Kortylewski M, Jove R, Yu H. Targeting STAT3 affects melanoma on multiple fronts. Cancer Metastasis Rev. 24(2), 315-327 (2005).
    • (2005) Cancer Metastasis Rev. , vol.24 , Issue.2 , pp. 315-327
    • Kortylewski, M.1    Jove, R.2    Yu, H.3
  • 4
    • 18644380911 scopus 로고    scopus 로고
    • Roles of activated Src and STAT3 signaling in melanoma tumor cell growth
    • Niu G, Bowman T, Huang M et al. Roles of activated Src and STAT3 signaling in melanoma tumor cell growth. Oncogene 21(46), 7001-7010 (2002).
    • (2002) Oncogene , vol.21 , Issue.46 , pp. 7001-7010
    • Niu, G.1    Bowman, T.2    Huang, M.3
  • 5
    • 33645532055 scopus 로고    scopus 로고
    • Activation of STAT3 in human melanoma promotes brain metastasis
    • Xie TX, Huang FJ, Aldape KD et al. Activation of STAT3 in human melanoma promotes brain metastasis. Cancer Res. 66(6), 3188-3196 (2006).
    • (2006) Cancer Res. , vol.66 , Issue.6 , pp. 3188-3196
    • Xie, T.X.1    Huang, F.J.2    Aldape, K.D.3
  • 6
    • 0034657958 scopus 로고    scopus 로고
    • Roles of STAT3 defined by tissue-specific gene targeting
    • Akira S. Roles of STAT3 defined by tissue-specific gene targeting. Oncogene 19(21), 2607-2611 (2000).
    • (2000) Oncogene , vol.19 , Issue.21 , pp. 2607-2611
    • Akira, S.1
  • 7
    • 0030935260 scopus 로고    scopus 로고
    • Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
    • Takeda K, Noguchi K, Shi W et al. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc. Natl Acad. Sci. USA 94(8), 3801-3804 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , Issue.8 , pp. 3801-3804
    • Takeda, K.1    Noguchi, K.2    Shi, W.3
  • 8
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: A leading role for STAT3. Nat. Rev. Cancer 9(11), 798-809 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , Issue.11 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 9
    • 84862193781 scopus 로고    scopus 로고
    • Orally bioavailable small-molecule inhibitor of transcription factor STAT3 regresses human breast and lung cancer xenografts
    • Zhang X, Yue P, Page BD et al. Orally bioavailable small-molecule inhibitor of transcription factor STAT3 regresses human breast and lung cancer xenografts. Proc. Natl Acad. Sci. USA 109(24), 9623-9628 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , Issue.24 , pp. 9623-9628
    • Zhang, X.1    Yue, P.2    Page, B.D.3
  • 10
    • 64849111865 scopus 로고    scopus 로고
    • Targeting STAT3 in cancer: How successful are we?
    • Yue P, Turkson J. Targeting STAT3 in cancer: How successful are we? Expert Opin. Investig. Drugs 18(1), 45-56 (2009).
    • (2009) Expert Opin. Investig. Drugs , vol.18 , Issue.1 , pp. 45-56
    • Yue, P.1    Turkson, J.2
  • 11
    • 65549129226 scopus 로고    scopus 로고
    • Sunitinib inhibition of STAT3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells
    • Xin H, Zhang C, Herrmann A, Du Y, Figlin R, Yu H. Sunitinib inhibition of STAT3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells. Cancer Res. 69(6), 2506-2513 (2009).
    • (2009) Cancer Res. , vol.69 , Issue.6 , pp. 2506-2513
    • Xin, H.1    Zhang, C.2    Herrmann, A.3    Du, Y.4    Figlin, R.5    Yu, H.6
  • 12
    • 77951707745 scopus 로고    scopus 로고
    • Inhibition of p-STAT3 enhances IFN-alpha efficacy against metastatic melanoma in a murine model
    • Kong LY, Gelbard A, Wei J et al. Inhibition of p-STAT3 enhances IFN-alpha efficacy against metastatic melanoma in a murine model. Clin. Cancer Res. 16(9), 2550-2561 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , Issue.9 , pp. 2550-2561
    • Kong, L.Y.1    Gelbard, A.2    Wei, J.3
  • 13
    • 70349971417 scopus 로고    scopus 로고
    • In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses
    • Kortylewski M, Swiderski P, Herrmann A et al. In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses. Nat. Biotechnol. 27(10), 925-932 (2009).
    • (2009) Nat. Biotechnol. , vol.27 , Issue.10 , pp. 925-932
    • Kortylewski, M.1    Swiderski, P.2    Herrmann, A.3
  • 14
    • 78649916060 scopus 로고    scopus 로고
    • Targeting STAT3 in adoptively transferred T cells promotes their in vivo expansion and antitumor effects
    • Kujawski M, Zhang C, Herrmann A et al. Targeting STAT3 in adoptively transferred T cells promotes their in vivo expansion and antitumor effects. Cancer Res. 70(23), 9599-9610 (2010).
    • (2010) Cancer Res. , vol.70 , Issue.23 , pp. 9599-9610
    • Kujawski, M.1    Zhang, C.2    Herrmann, A.3
  • 15
    • 77954613878 scopus 로고    scopus 로고
    • The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity
    • Bill MA, Fuchs JR, Li C et al. The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity. Mol. Cancer 9, 165 (2010).
    • (2010) Mol. Cancer , vol.9 , pp. 165
    • Bill, M.A.1    Fuchs, J.R.2    Li, C.3
  • 16
    • 84864996651 scopus 로고    scopus 로고
    • Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines
    • Bill MA, Nicholas C, Mace TA et al. Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines. PLoS ONE 7(8), e40724 (2012).
    • (2012) PLoS ONE , vol.7 , Issue.8
    • Bill, M.A.1    Nicholas, C.2    Mace, T.A.3
  • 17
    • 84880325633 scopus 로고    scopus 로고
    • STAT3-targeted therapies overcome the acquired resistance to vemurafenib in melanomas
    • doi:10.1038/jid.2013.32 Epub ahead of print
    • Liu F, Cao J, Wu J et al. STAT3-targeted therapies overcome the acquired resistance to vemurafenib in melanomas. J. Invest.Dermatol. doi:10.1038/jid. 2013.32 (2013) (Epub ahead of print).
    • (2013) J. Invest.Dermatol.
    • Liu, F.1    Cao, J.2    Wu, J.3
  • 18
    • 84896691873 scopus 로고    scopus 로고
    • Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor
    • doi:10.1038/onc.2013.45 Epub ahead of print
    • Becker TM, Boyd SC, Mijatov B et al. Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor. Oncogene doi:10.1038/onc.2013.45 (2013) (Epub ahead of print).
    • (2013) Oncogene
    • Becker, T.M.1    Boyd, S.C.2    Mijatov, B.3
  • 19
    • 84873907015 scopus 로고    scopus 로고
    • Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma
    • Girotti MR, Pedersen M, Sanchez-Laorden B et al. Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma. Cancer Discov. 3(2), 158-167 (2013).
    • (2013) Cancer Discov. , vol.3 , Issue.2 , pp. 158-167
    • Girotti, M.R.1    Pedersen, M.2    Sanchez-Laorden, B.3
  • 20
    • 84877095601 scopus 로고    scopus 로고
    • Molecular pathways: JAK/STAT pathway: Mutations, inhibitors, and resistance
    • Quintás-Cardama A, Verstovsek S. Molecular Pathways: JAK/STAT pathway: Mutations, inhibitors, and resistance. Clin. Cancer Res. 19(8), 1933-1940 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , Issue.8 , pp. 1933-1940
    • Quintás-Cardama, A.1    Verstovsek, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.