Acute Appendicitis in the Twenty-First Century: Should We Modify the Management Protocol?

Journal of Gastrointestinal Surgery

Volumn 17, Issue 8, 2013, Pages 1462-1470

  Sadot, Eran ^a,c   Wasserberg, Nir ^a,c   Shapiro, Ron ^b,c   Keidar, Andrei ^a,c   Oberman, Bernice ^c,d   Sadetzki, Siegal ^c,d  

^a RABIN MEDICAL CENTER   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

^d GERTNER INSTITUTE FOR EPIDEMIOLOGY AND HEALTH POLICY RESEARCH   (Israel)

Author keywords

Appendectomy; Appendicitis; Delay; Outcomes; Perforation; Time; Timing

Indexed keywords

ADOLESCENT; ADULT; AGE; APPENDECTOMY; APPENDICITIS; ARTICLE; BLOOD; BODY TEMPERATURE; CHILD; DISEASE COURSE; FEMALE; HUMAN; LEUKOCYTE COUNT; MALE; MIDDLE AGED; PATHOLOGY; RISK FACTOR; TIME; TIME TO TREATMENT; YOUNG ADULT;

ADOLESCENT; ADULT; AGE FACTORS; APPENDECTOMY; APPENDICITIS; BODY TEMPERATURE; CHILD; DISEASE PROGRESSION; FEMALE; HUMANS; LEUKOCYTE COUNT; MALE; MIDDLE AGED; RISK FACTORS; TIME FACTORS; TIME-TO-TREATMENT; YOUNG ADULT;

EID: 84880131789     PISSN: 1091255X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11605-013-2232-3     Document Type: Article

References (40)

1. Rocha FF, Soares FM, Correa H, Rocha RF, Teixeira AL. Increased surgical morbidity of psychiatric patients submitted to appendectomy. Rev Bras Psiquiatr. 2007 Jun;29(2): 192-3. PubMed PMID: 17639263. Epub 2007/07/20. eng.
2. Fitz R. Perforating inflammation of the vermiform appendix with special reference to it's early diagnosis and treatment. Tran Assoc Am Physicians. 1886: 107-44.
3. Chan MY, Teo BS, Ng BL. The Alvarado score and acute appendicitis. Ann Acad Med Singapore. 2001 Sep;30(5): 510-2. PubMed PMID: 11603135. Epub 2001/10/18. eng.
4. Sadot E, Telem DA, Arora M, Butala P, Nguyen SQ, Divino CM. Laparoscopy: a safe approach to appendicitis during pregnancy. Surg Endosc. 2010 Feb;24(2): 383-9. PubMed PMID: 19551438.
5. Flum DR, Koepsell T. The clinical and economic correlates of misdiagnosed appendicitis: nationwide analysis. Arch Surg. 2002 Jul;137(7): 799-804. discussion. PubMed PMID: 12093335. Epub 2002/07/03. eng.
6. Abou-Nukta F, Bakhos C, Arroyo K, Koo Y, Martin J, Reinhold R, et al. Effects of delaying appendectomy for acute appendicitis for 12 to 24 hours. Arch Surg. 2006 May;141(5): 504-6.; discussion 6-7. PubMed PMID: 16702523. Epub 2006/05/17. eng.
7. Stahlfeld K, Hower J, Homitsky S, Madden J. Is acute appendicitis a surgical emergency? Am Surg. 2007 Jun;73(6): 626-9.; discussion 9-30. PubMed PMID: 17658102. Epub 2007/07/31. eng.
8. Augustin T, Cagir B, Vandermeer TJ. Characteristics of perforated appendicitis: effect of delay is confounded by age and gender. J Gastrointest Surg. 2011 Jul;15(7): 1223-31. PubMed PMID: 21557019. Epub 2011/05/11. eng.
9. Ingraham AM, Cohen ME, Bilimoria KY, Ko CY, Hall BL, Russell TR, et al. Effect of delay to operation on outcomes in adults with acute appendicitis. Arch Surg. 2010 Sep;145(9): 886-92. PubMed PMID: 20855760. Epub 2010/09/22. eng.
10. Nagpal K, Udgiri N, Sharma N, Curras E, Cosgrove JM, Farkas DT. Delaying an appendectomy: is it safe? Am Surg. 2012 Aug;78(8): 897-900. PubMed PMID: 22856499. Epub 2012/08/04. eng.
11. Teixeira PG, Sivrikoz E, Inaba K, Talving P, Lam L, Demetriades D. Appendectomy timing: waiting until the next morning increases the risk of surgical site infections. Ann Surg. 2012 Sep;256(3): 538-43. PubMed PMID: 22842128. Epub 2012/07/31. eng.
12. Campbell MR, Johnston SL, 3rd, Marshburn T, Kane J, Lugg D. Nonoperative treatment of suspected appendicitis in remote medical care environments: implications for future spaceflight medical care. J Am Coll Surg. 2004 May;198(5): 822-30. PubMed PMID: 15110816. Epub 2004/04/28. eng.
13. Kolla SB, Aggarwal S, Kumar A, Kumar R, Chumber S, Parshad R, et al. Early versus delayed laparoscopic cholecystectomy for acute cholecystitis: a prospective randomized trial. Surg Endosc. 2004 Sep;18(9): 1323-7. PubMed PMID: 15803229. Epub 2005/04/02. eng.
14. Broderick-Villa G, Burchette RJ, Collins JC, Abbas MA, Haigh PI. Hospitalization for acute diverticulitis does not mandate routine elective colectomy. Arch Surg. 2005 Jun;140(6): 576-81.; discussion 81-3. PubMed PMID: 15967905. Epub 2005/06/22. eng.
15. Hansson J, Korner U, Khorram-Manesh A, Solberg A, Lundholm K. Randomized clinical trial of antibiotic therapy versus appendicectomy as primary treatment of acute appendicitis in unselected patients. Br J Surg. 2009 May;96(5): 473-81. PubMed PMID: 19358184. Epub 2009/04/10. eng.
16. Steinbrook R. The debate over residents' work hours. N Engl J Med. 2002 Oct 17;347(16): 1296-302. PubMed PMID: 12393837. Epub 2002/10/24. eng.
17. Taffinder NJ, McManus IC, Gul Y, Russell RC, Darzi A. Effect of sleep deprivation on surgeons' dexterity on laparoscopy simulator. Lancet. 1998 Oct 10;352(9135): 1191. PubMed PMID: 9777838. Epub 1998/10/20. eng.
18. Weinger MB, Ancoli-Israel S. Sleep deprivation and clinical performance. JAMA. 2002 Feb 27;287(8): 955-7. PubMed PMID: 11866625. Epub 2002/02/28. eng.
19. Bickell NA, Aufses AH, Jr., Rojas M, Bodian C. How time affects the risk of rupture in appendicitis. J Am Coll Surg. 2006 Mar;202(3): 401-6. PubMed PMID: 16500243. Epub 2006/02/28. eng.
20. Musunuru S, Chen H, Rikkers LF, Weber SM. Computed tomography in the diagnosis of acute appendicitis: definitive or detrimental? J Gastrointest Surg. 2007 Nov;11(11): 1417-21.; discussion 21-2. PubMed PMID: 17701439. Epub 2007/08/19. eng.
21. Braveman P, Schaaf VM, Egerter S, Bennett T, Schecter W. Insurance-related differences in the risk of ruptured appendix. N Engl J Med. 1994 Aug 18;331(7): 444-9. PubMed PMID: 7880234. Epub 1994/08/18. eng.
22. Gadomski A, Jenkins P. Ruptured appendicitis among children as an indicator of access to care. Health Serv Res. 2001 Apr;36(1 Pt 1): 129-42. PubMed PMID: 11324740. Epub 2001/04/28. eng.
23. Maroju NK, Robinson Smile S, Sistla SC, Narasimhan R, Sahai A. Delay in surgery for acute appendicitis. ANZ J Surg. 2004 Sep;74(9): 773-6. PubMed PMID: 15379809. Epub 2004/09/24. eng.
24. Temple CL, Huchcroft SA, Temple WJ. The natural history of appendicitis in adults. A prospective study. Ann Surg. 1995 Mar;221(3): 278-81. PubMed PMID: 7717781. Epub 1995/03/01. eng.
25. Ditillo MF, Dziura JD, Rabinovici R. Is it safe to delay appendectomy in adults with acute appendicitis? Ann Surg. 2006 Nov;244(5): 656-60. PubMed PMID: 17060754. Epub 2006/10/25. eng.
26. Varadhan KK, Humes DJ, Neal KR, Lobo DN. Antibiotic therapy versus appendectomy for acute appendicitis: a meta-analysis. World J Surg. 2010 Feb;34(2): 199-209. PubMed PMID: 20041249. Epub 2009/12/31. eng.
27. Mason RJ, Moazzez A, Sohn H, Katkhouda N. Meta-analysis of randomized trials comparing antibiotic therapy with appendectomy for acute uncomplicated (no abscess or phlegmon) appendicitis. Surg Infect (Larchmt). 2012 Apr;13(2): 74-84. PubMed PMID: 22364604. Epub 2012/03/01. eng.
28. Varadhan KK, Neal KR, Lobo DN. Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials. BMJ. 2012;344: e2156. PubMed PMID: 22491789. PubMed Central PMCID: 3320713. Epub 2012/04/12. eng.
29. Styrud J, Eriksson S, Nilsson I, Ahlberg G, Haapaniemi S, Neovius G, et al. Appendectomy versus antibiotic treatment in acute appendicitis. a prospective multicenter randomized controlled trial. World J Surg. 2006 Jun;30(6): 1033-7. PubMed PMID: 16736333. Epub 2006/06/01. eng.
30. Bachoo P, Mahomed AA, Ninan GK, Youngson GG. Acute appendicitis: the continuing role for active observation. Pediatr Surg Int. 2001 Mar;17(2-3): 125-8. PubMed PMID: 11315270. Epub 2001/04/24. eng. -->.
31. Clyde C, Bax T, Merg A, MacFarlane M, Lin P, Beyersdorf S, et al. Timing of intervention does not affect outcome in acute appendicitis in a large community practice. Am J Surg. 2008 May;195(5): 590-2.; discussion 2-3. PubMed PMID: 18367138. Epub 2008/03/28. eng.
32. Yardeni D, Hirschl RB, Drongowski RA, Teitelbaum DH, Geiger JD, Coran AG. Delayed versus immediate surgery in acute appendicitis: do we need to operate during the night? J Pediatr Surg. 2004 Mar;39(3): 464-9.; discussion -9. PubMed PMID: 15017571. Epub 2004/03/16. eng.
33. Livingston EH, Woodward WA, Sarosi GA, Haley RW. Disconnect between incidence of nonperforated and perforated appendicitis: implications for pathophysiology and management. Ann Surg. 2007 Jun;245(6): 886-92. PubMed PMID: 17522514. PubMed Central PMCID: 1876946. Epub 2007/05/25. eng.
34. Andersson RE. The natural history and traditional management of appendicitis revisited: spontaneous resolution and predominance of prehospital perforations imply that a correct diagnosis is more important than an early diagnosis. World J Surg. 2007 Jan;31(1): 86-92. PubMed PMID: 17180556. Epub 2006/12/21. eng.
35. Eldar S, Nash E, Sabo E, Matter I, Kunin J, Mogilner JG, et al. Delay of surgery in acute appendicitis. Am J Surg. 1997 Mar;173(3): 194-8. PubMed PMID: 9124625. Epub 1997/03/01. eng.
36. Deck KB, Pettitt BJ, Harrison MR. The length-time correlate in appendicitis. JAMA. 1980 Aug 22-29;244(8): 806-7. PubMed PMID: 7392191. Epub 1980/08/22. eng.
37. Williams N, Bello M. Perforation rate relates to delayed presentation in childhood acute appendicitis. J R Coll Surg Edinb. 1998 Apr;43(2): 101-2. PubMed PMID: 9621533. Epub 1998/06/11. eng.
38. Cappendijk VC, Hazebroek FW. The impact of diagnostic delay on the course of acute appendicitis. Arch Dis Child. 2000 Jul;83(1): 64-6. PubMed PMID: 10869003. Epub 2000/06/27. eng.
39. Chande VT, Kinnane JM. Role of the primary care provider in expediting care of children with acute appendicitis. Arch Pediatr Adolesc Med. 1996 Jul;150(7): 703-6. PubMed PMID: 8673194. Epub 1996/07/01. eng.
40. Buckley RG, Distefan J, Gubler KD, Slymen D. The risk of appendiceal rupture based on hospital admission source. Acad Emerg Med. 1999 Jun;6(6): 596-601. PubMed PMID: 10386676. Epub 1999/07/01. eng.