The effects of lornoxicam on brain edema and blood brain barrier following diffuse traumatic brain injury in rats;Lornoksikamin siçanlarda diffüz travmatik beyin hasarinda beyin ödemi ve kan beyin bariyeri üzerine etkileri

Ulusal Travma ve Acil Cerrahi Dergisi

Volumn 19, Issue 4, 2013, Pages 294-298

  Topçu, Ismet ^a   Gümüşer, Gül ^a   Bayram, Eda ^a   Aras, Feray ^a   Çetin, Ismail ^a   Temiz, Cüneyt ^a   Çivi, Melek ^a  

^a CELAL BAYAR UNIVERSITY   (Turkey)

Author keywords

Blood brain barrier; Brain edema; Lornoxicam; Traumatic brain injury

Indexed keywords

LORNOXICAM; NEUROPROTECTIVE AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN WATER; CERVICAL SPINE DISLOCATION; CONTROLLED STUDY; IMAGING; MALE; NONHUMAN; RAT; TRAUMATIC BRAIN INJURY; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN INJURIES; DRUG EFFECTS; METABOLISM; PATHOLOGY; RANDOMIZATION; WISTAR RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOOD-BRAIN BARRIER; BRAIN EDEMA; BRAIN INJURIES; MALE; NEUROPROTECTIVE AGENTS; PIROXICAM; RANDOM ALLOCATION; RATS; RATS, WISTAR;

EID: 84880129294     PISSN: 1306696X     EISSN: None     Source Type: Journal    
DOI: 10.5505/tjtes.2013.32458     Document Type: Article

References (23)

1. Adams JH, Doyle D, Ford I, Gennarelli TA, Graham DI, McLellan DR. Diffuse axonal injury in head injury: definition, diagnosis and grading. Histopathology 1989;15:49-59.
2. Lu J, Marmarou A, Choi S, Maas A, Murray G, Steyerberg EW; Impact and Abic Study Group. Mortality from traumatic brain injury. Acta Neurochir Suppl 2005;95:281-5.
3. McIntosh TK. Novel pharmacologic therapies in the treatment of experimental traumatic brain injury: a review. J Neurotrauma 1993;10:215-61.
4. McIntosh TK, Juhler M, Wieloch T. Novel pharmacologic strategies in the treatment of experimental traumatic brain injury: 1998. J Neurotrauma 1998;15:731-69.
5. Faden AI, Salzman S. Pharmacological strategies in CNS trauma. Trends Pharmacol Sci 1992;13:29-35.
6. Golding EM. Sequelae following traumatic brain injury. The cerebrovascular perspective. Brain Res Brain Res Rev 2002;38:377-88.
7. Esen F, Erdem T, Aktan D, Kalayci R, Cakar N, Kaya M, et al. Effects of magnesium administration on brain edema and blood-brain barrier breakdown after experimental traumatic brain injury in rats. J Neurosurg Anesthesiol 2003;15:119-25.
8. Ellis EF, Police RJ, Rice LY, Grabeel M, Holt S. Increased plasma PGE2, 6-keto-PGF1 alpha, and 12-HETE levels following experimental concussive brain injury. J Neurotrauma 1989;6:31-7.
9. Dewitt DS, Kong DL, Lyeth BG, Jenkins LW, Hayes RL, Wooten ED, et al. Experimental traumatic brain injury elevates brain prostaglandin E2 and thromboxane B2 levels in rats. J Neurotrauma 1988;5:303-13.
10. Ting P. Indomethacin attenuates early postischemic vasogenic edema and cerebral injury. Adv Neurol 1990;52:119-26.
11. Hewett SJ, Silakova JM, Hewett JA. Oral treatment with rofecoxib reduces hippocampal excitotoxic neurodegeneration. J Pharmacol Exp Ther 2006;319:1219-24.
12. Marmarou A, Foda MA, van den Brink W, Campbell J, Kita H, Demetriadou K. A new model of diffuse brain injury in rats. Part I: Pathophysiology and biomechanics. J Neurosurg 1994;80:291-300.
13. Chan PH, Yang GY, Chen SF, Carlson E, Epstein CJ. Coldinduced brain edema and infarction are reduced in transgenic mice overexpressing CuZn-superoxide dismutase. Ann Neurol 1991;29:482-6.
14. Louin G, Marchand-Verrecchia C, Palmier B, Plotkine M, Jafarian-Tehrani M. Selective inhibition of inducible nitric oxide synthase reduces neurological deficit but not cerebral edema following traumatic brain injury. Neuropharmacology 2006;50:182-90.
15. Habgood MD, Bye N, Dziegielewska KM, Ek CJ, Lane MA, Potter A, et al. Changes in blood-brain barrier permeability to large and small molecules following traumatic brain injury in mice. Eur J Neurosci 2007;25:231-8.
16. Barth A, Haldemann AR, Reubi JC, Godoy N, Rösler H, Kinser JA, et al. Noninvasive differentiation of meningiomas from other brain tumours using combined 111Indiumoctreotide/99mtechnetium-DTPA brain scintigraphy. Acta Neurochir (Wien) 1996;138:1179-85.
17. Lorberboym M, Lampl Y, Sadeh M. Correlation of 99mTcDTPA SPECT of the blood-brain barrier with neurologic outcome after acute stroke. J Nucl Med 2003;44:1898-904.
18. Strauss KI, Barbe MF, Marshall RM, Raghupathi R, Mehta S, Narayan RK. Prolonged cyclooxygenase-2 induction in neurons and glia following traumatic brain injury in the rat. J Neurotrauma 2000;17:695-711.
19. Kontos HA, Dietrich WD, Wei EP, Ellis EF, Povlishock JT. Abnormalities of the cerebral microcirculation after traumatic injury: the relationship of hypertension and prostaglandins. Adv Exp Med Biol 1980;131:243-56.
20. Hurley SD, Olschowka JA, O'Banion MK. Cyclooxygenase inhibition as a strategy to ameliorate brain injury. J Neurotrauma 2002;19:1-15.
21. Hakan T, Toklu HZ, Biber N, Ozevren H, Solakoglu S, Demirturk P, et al. Effect of COX-2 inhibitor meloxicam against traumatic brain injury-induced biochemical, histopathological changes and blood-brain barrier permeability. Neurol Res 2010;32:629-35.
22. Ayer R, Jadhav V, Sugawara T, Zhang JH. The neuroprotective effects of cyclooxygenase-2 inhibition in a mouse model of aneurysmal subarachnoid hemorrhage. Acta Neurochir Suppl 2011;111:145-9.
23. Chu K, Jeong SW, Jung KH, Han SY, Lee ST, Kim M, et al. Celecoxib induces functional recovery after intracerebral hemorrhage with reduction of brain edema and perihematomal cell death. J Cereb Blood Flow Metab 2004;24:926-33.