Effect of amitriptyline on gastrointestinal function and brain-gut peptides: A double-blind trial

World Journal of Gastroenterology

Volumn 19, Issue 26, 2013, Pages 4214-4220

  Huang, Wei ^a   Jiang, Shu Man ^a   Jia, Lin ^a   You, Le Qing ^a   Huang, Yao Xing ^a   Gong, Yan Mei ^a   Wang, Gui Qin ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Amitriptyline; Brain gut peptides; Gastric emptying; Orocecal transit time; Visceral hypersensitivity

Indexed keywords

ISOSORBIDE MONONITRATE; PROPRANOLOL;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DOSE INCREASE; DRUG DOSE TITRATION; ESOPHAGUS MANOMETRY; ESOPHAGUS VARICES; FEMALE; FOLLOW UP; HEADACHE; HIGH RISK POPULATION; HUMAN; HYPOTENSION; KIDNEY FAILURE; LIVER FAILURE; MALE; RANDOMIZED CONTROLLED TRIAL; SCHISTOSOMIASIS; VENOUS PRESSURE;

EID: 84880109764     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v19.i26.4214     Document Type: Article

References (27)

1. Ohman L, Simrén M. Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions. Nat Rev Gastroenterol Hepatol 2010; 7: 163-173 [PMID: 20101257 DOI: 10.1038/nrgastro.2010.4]
2. Camilleri M, Tack JF. Current medical treatments of dyspepsia and irritable bowel syndrome. Gastroenterol Clin North Am 2010; 39: 481-493 [PMID: 20951913 DOI: 10.1016/ j. gtc.2010.08.005]
3. Rahimi R, Nikfar S, Rezaie A, Abdollahi M. Efficacy of tricyclic antidepressants in irritable bowel syndrome: a metaanalysis. World J Gastroenterol 2009; 15: 1548-1553 [PMID: 19340896]
4. Annese V, Janssens J, Vantrappen G, Tack J, Peeters TL, Willemse P, Van Cutsem E. Erythromycin accelerates gastric emptying by inducing antral contractions and improved gastroduodenal coordination. Gastroenterology 1992; 102: 823-828 [PMID: 1537520]
5. Kamerling IM, Van Haarst AD, Burggraaf J, Schoemaker RC, Biemond I, Heinzerling H, Jones R, Cohen AF, Masclee AA. Motilin effects on the proximal stomach in patients with functional dyspepsia and healthy volunteers. Am J Physiol Gastrointest Liver Physiol 2003; 284: G776-G781 [PMID: 12519743]
6. Lee KJ, Cha DY, Cheon SJ, Yeo M, Cho SW. Plasma ghrelin levels and their relationship with gastric emptying in patients with dysmotility-like functional dyspepsia. Digestion 2009; 80: 58-63 [PMID: 19494492 DOI: 10.1159/000215389]
7. Forbes S, Herzog H, Cox HM. A role for neuropeptide Y in the gender-specific gastrointestinal, corticosterone and feeding responses to stress. Br J Pharmacol 2012; 166: 2307-2316 [PMID: 22404240 DOI: 10.1111/j.1476-5381.2012.01939. x]
8. Ballesteros J, Bobes J, Bulbena A, Luque A, Dal-Ré R, Ibarra N, Güemes I. Sensitivity to change, discriminative performance, and cutoff criteria to define remission for embedded short scales of the Hamilton depression rating scale (HAMD). J Affect Disord 2007; 102: 93-99 [PMID: 17258323]
9. Matza LS, Morlock R, Sexton C, Malley K, Feltner D. Identifying HAM-A cutoffs for mild, moderate, and severe generalized anxiety disorder. Int J Methods Psychiatr Res 2010; 19: 223-232 [PMID: 20718076 DOI: 10.1002/mpr.323]
10. Kato M, Nishida U, Nishida M, Hata T, Asaka R, Haneda M, Yamamoto K, Imai A, Yoshida T, Ono S, Shimizu Y, Asaka M. Pathophysiological classification of functional dyspepsia using a novel drinking-ultrasonography test. Digestion 2010; 82: 162-166 [PMID: 20588028 DOI: 10.1159/000308363]
11. Rana S, Bhansali A, Bhadada S, Sharma S, Kaur J, Singh K. Orocecal transit time and small intestinal bacterial overgrowth in type 2 diabetes patients from North India. Diabetes Technol Ther 2011; 13: 1115-1120 [PMID: 21770765 DOI: 10.1089/dia.2011.0078]
12. Mertz H, Fass R, Kodner A, Yan-Go F, Fullerton S, Mayer EA. Effect of amitriptyline on symptoms, sleep, and visceral perception in patients with functional dyspepsia. Am J Gastroenterol 1998; 93: 160-165 [PMID: 9468233]
13. Thoua NM, Murray CD, Winchester WJ, Roy AJ, Pitcher MC, Kamm MA, Emmanuel AV. Amitriptyline modifies the visceral hypersensitivity response to acute stress in the irritable bowel syndrome. Aliment Pharmacol Ther 2009; 29: 552-560 [PMID: 19076934 DOI: 10.1111/j.1365-2036.2008.03918. x]
14. Vahedi H, Merat S, Momtahen S, Kazzazi AS, Ghaffari N, Olfati G, Malekzadeh R. Clinical trial: the effect of amitriptyline in patients with diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther 2008; 27: 678-684 [PMID: 18248658 DOI: 10.1111/j.1365-2036.2008.03633. x]
15. Braak B, Klooker TK, Wouters MM, Lei A, van den Wijngaard RM, Boeckxstaens GE. Randomised clinical trial: the effects of amitriptyline on drinking capacity and symptoms in patients with functional dyspepsia, a double-blind placebo-controlled study. Aliment Pharmacol Ther 2011; 34: 638-648 [PMID: 21767283 DOI: 10.1111/j.1365-2036.2011.04775. x]
16. Morgan V, Pickens D, Gautam S, Kessler R, Mertz H. Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome. Gut 2005; 54: 601-607 [PMID: 15831901]
17. Camilleri M, McKinzie S, Busciglio I, Low PA, Sweetser S, Burton D, Baxter K, Ryks M, Zinsmeister AR. Prospective study of motor, sensory, psychologic, and autonomic functions in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 2008; 6: 772-781 [PMID: 18456567 DOI: 10.1016/j. cgh.2008.02.060]
18. Bouras EP, Talley NJ, Camilleri M, Burton DD, Heckman MG, Crook JE, Richelson E. Effects of amitriptyline on gastric sensorimotor function and postprandial symptoms in healthy individuals: a randomized, double-blind, placebocontrolled trial. Am J Gastroenterol 2008; 103: 2043-2050 [PMID: 18803000]
19. Bodé S, Dreyer M, Greisen G. Gastric emptying and small intestinal transit time in preterm infants: a scintigraphic method. J Pediatr Gastroenterol Nutr 2004; 39: 378-382 [PMID: 15448428]
20. Gorard DA, Libby GW, Farthing MJ. Effect of a tricyclic antidepressant on small intestinal motility in health and diarrhea-predominant irritable bowel syndrome. Dig Dis Sci 1995; 40: 86-95 [PMID: 7821126]
21. Ziessman HA, Okolo PI, Mullin GE, Chander A. Liquid gastric emptying is often abnormal when solid emptying is normal. J Clin Gastroenterol 2009; 43: 639-643 [PMID: 19623689]
22. Sarnelli G, Vos R, Cuomo R, Janssens J, Tack J. Reproducibility of gastric barostat studies in healthy controls and in dyspeptic patients. Am J Gastroenterol 2001; 96: 1047-1053 [PMID: 11316145]
23. Allen JM, Christofides ND, Cramer PA, Steinert J, Bloom SR. Elevated motilin levels in patients treated with antidepressant and neuroleptic drugs. Br J Psychiatry 1982; 141: 27-29 [PMID: 6126240]
24. Kojima M, Hosoda H, Kangawa K. Clinical endocrinology and metabolism. Ghrelin, a novel growth-hormonereleasing and appetite-stimulating peptide from stomach. Best Pract Res Clin Endocrinol Metab 2004; 18: 517-530 [PMID: 15533773]
25. Caproni S, Corbelli I, Pini LA, Cupini ML, Calabresi P, Sarchielli P. Migraine preventive drug-induced weight gain may be mediated by effects on hypothalamic peptides: the results of a pilot study. Cephalalgia 2011; 31: 543-549 [PMID: 21216871 DOI: 10.1177/0333102410392605]
26. Holzer P, Reichmann F, Farzi A. Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis. Neuropeptides 2012; 46: 261-274 [PMID: 22979996 DOI: 10.1016/ j. npep.2012.08.005]
27. Mearin F. Postinfectious functional gastrointestinal disorders. J Clin Gastroenterol 2011; 45 Suppl: S102-S105 [PMID: 21666422 DOI: 10.1097/MCG.0b013e31821fbf58]