Anti-factor H antibody affecting factor H cofactor activity in a patient with dense deposit disease

Clinical Kidney Journal

Volumn 5, Issue 2, 2012, Pages 133-136

  Nozal, Pilar ^a   Strobel, Stefanie ^b   Ibernon, Meritxell ^c   López, Dolores ^c   Sánchez Corral, Pilar ^a   Rodríguez De Córdoba, Santiago ^d   Józsi, Mihály ^b   López Trascasa, Margarita ^a  

^a HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^b HANS KNÖLL INSTITUTE   (Germany)

^c HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^d CSIC   (Spain)

Author keywords

anti factor H autoantibodies; complement; dense deposit disease; monoclonal gammapathy

Indexed keywords

ALBUMIN; AUTOANTIBODY; BENCE JONES PROTEIN; COMPLEMENT COMPONENT C3B; COMPLEMENT FACTOR H; CREATININE; CYCLOPHOSPHAMIDE; DEXAMETHASONE; FACTOR H ANTIBODY; IMMUNOGLOBULIN LAMBDA CHAIN; UNCLASSIFIED DRUG; UREA;

ACUTE KIDNEY FAILURE; AGED; ANEMIA; ARTICLE; CASE REPORT; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT DISORDER; CORTICOSTEROID THERAPY; DENSE DEPOSIT DISEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GAMMOPATHY; GENERALIZED EDEMA; GLOMERULOPATHY; HEMATURIA; HUMAN; HUMAN TISSUE; IMMUNE COMPLEX DEPOSITION; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BIOPSY; KIDNEY HYPERTROPHY; MACROHEMATURIA; MASS SPECTROMETRY; PALLOR; PATIENT ASSESSMENT; PHYSICAL EXAMINATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEINURIA; WESTERN BLOTTING;

EID: 84880102859     PISSN: 20488505     EISSN: 20488513     Source Type: Journal    
DOI: 10.1093/ckj/sfs002     Document Type: Article

References (10)

1. Smith RJ, Alexander J, Barlow PN et al. New approaches to the treatment of dense deposit disease. J Am Soc Nephrol 2007; 18: 2447-2456 (Pubitemid 47378860)
2. Walker PD. Dense deposit disease: new insights. Curr Opin Nephrol Hypertens 2007; 16: 204-212 (Pubitemid 46613706)
3. Pickering MC, Cook HT. Translational mini-review series on complement factor H: renal diseases associated with complement factor H: novel insights from humans and animals. Clin Exp Immunol 2008; 151: 210-230
4. Zipfel PF, Heinen S, Jozsi M et al. Complement and diseases: defective alternative pathway control results in kidney and eye diseases. Mol Immunol 2006; 43: 97-106 (Pubitemid 41021526)
5. Strobel S, Zimmering M, Papp K et al. Anti-factor B autoantibody in dense deposit disease. Mol Immunol 2010; 47: 1476-1483
6. Licht C, Fremeaux-Bacchi V. Hereditary and acquired complement dysregulation in membranoproliferative glomerulonephritis. Thromb Haemost 2009; 101: 271-278
7. Jokiranta TS, Solomon A, Pangburn MK et al. Nephritogenic lambda light chain dimer: a unique human miniautoantibody against complement factor H. J Immunol 1999; 163: 4590-4596 (Pubitemid 29474530)
8. Sethi S, Sukov WR, Zhang Y et al. Dense deposit disease associated with monoclonal gammopathy of undetermined significance. Am J Kidney Dis 2010; 56: 977-982
9. Licht C, Heinen S, Jozsi M et al. Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II). Kidney Int 2006; 70: 42-50 (Pubitemid 44000119)
10. Seling A, Siegel C, Fingerle V et al. Functional characterization of Borrelia Spielmanii outer surface proteins that interact with distinct members of the human factor H protein family and with plasminogen. Infect Immun 2010; 78: 39-48